A Spontaneous Membrane-Adsorption Approach to Enhancing Second Near-Infrared Deep-Imaging-Guided Intracranial Tumor TherapyClick to copy article linkArticle link copied!
- Luoyuan LiLuoyuan LiSchool of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, 100084 Beijing, P.R. ChinaMore by Luoyuan Li
- Bei ZhangBei ZhangSchool of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, 100084 Beijing, P.R. ChinaMore by Bei Zhang
- Yuxin LiuYuxin LiuDepartment of Chemistry, Capital Normal University, Beijing 100048, P.R. ChinaMore by Yuxin Liu
- Rongyao GaoRongyao GaoDepartment of Chemistry, Renmin University of China, Beijing 100872, P.R. ChinaMore by Rongyao Gao
- Jing Zhou*Jing Zhou*Email: [email protected]; Tel.: +86-10-68902491Department of Chemistry, Capital Normal University, Beijing 100048, P.R. ChinaMore by Jing Zhou
- Li-Min Fu*Li-Min Fu*Email: [email protected]; Tel.: +86-10-62516604Department of Chemistry, Renmin University of China, Beijing 100872, P.R. ChinaMore by Li-Min Fu
- Jian Wang*Jian Wang*Email: [email protected]; Tel.: +86-10-62772583School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, 100084 Beijing, P.R. ChinaMore by Jian Wang
Abstract

Herein, a functional class of microenvironment-associated nanomaterials is reported for improving the second near-infrared (NIR-II) imaging and photothermal therapeutic effect on intracranial tumors via a spontaneous membrane-adsorption approach. Specific peptides, photothermal agents, and biological alkylating agents were designed to endow the nanogels with high targeting specificity, photothermal properties, and pharmacological effects. Importantly, the frozen scanning electron microscopy technology (cryo-SEM) was utilized to observe the self-association of nanomaterials on tumor cells. Interestingly, the spontaneous membrane-adsorption behavior of nanomaterials was captured through direct imaging evidence. Histological analysis showed that the cross-linking adhesion in intracranial tumor and monodispersity in normal tissues of the nanogels not only enhanced the retention time but also ensured excellent biocompatibility. Impressively, in vivo data confirmed that the microenvironment-associated nanogels could significantly enhance brain tumor clearance rate within a short treatment timeframe (only two weeks). In short, utilizing the spontaneous membrane-adsorption strategy can significantly improve NIR-II diagnosis and phototherapy in brain diseases while avoiding high-risk complications.
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