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A Spontaneous Membrane-Adsorption Approach to Enhancing Second Near-Infrared Deep-Imaging-Guided Intracranial Tumor Therapy
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    A Spontaneous Membrane-Adsorption Approach to Enhancing Second Near-Infrared Deep-Imaging-Guided Intracranial Tumor Therapy
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    • Luoyuan Li
      Luoyuan Li
      School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, 100084 Beijing, P.R. China
      More by Luoyuan Li
    • Bei Zhang
      Bei Zhang
      School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, 100084 Beijing, P.R. China
      More by Bei Zhang
    • Yuxin Liu
      Yuxin Liu
      Department of Chemistry, Capital Normal University, Beijing 100048, P.R. China
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    • Rongyao Gao
      Rongyao Gao
      Department of Chemistry, Renmin University of China, Beijing 100872, P.R. China
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    • Jing Zhou*
      Jing Zhou
      Department of Chemistry, Capital Normal University, Beijing 100048, P.R. China
      *Email: [email protected]; Tel.: +86-10-68902491
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    • Li-Min Fu*
      Li-Min Fu
      Department of Chemistry, Renmin University of China, Beijing 100872, P.R. China
      *Email: [email protected]; Tel.: +86-10-62516604
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    • Jian Wang*
      Jian Wang
      School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, 100084 Beijing, P.R. China
      *Email: [email protected]; Tel.: +86-10-62772583
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    ACS Nano

    Cite this: ACS Nano 2021, 15, 3, 4518–4533
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    https://doi.org/10.1021/acsnano.0c08532
    Published February 23, 2021
    Copyright © 2021 American Chemical Society

    Abstract

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    Herein, a functional class of microenvironment-associated nanomaterials is reported for improving the second near-infrared (NIR-II) imaging and photothermal therapeutic effect on intracranial tumors via a spontaneous membrane-adsorption approach. Specific peptides, photothermal agents, and biological alkylating agents were designed to endow the nanogels with high targeting specificity, photothermal properties, and pharmacological effects. Importantly, the frozen scanning electron microscopy technology (cryo-SEM) was utilized to observe the self-association of nanomaterials on tumor cells. Interestingly, the spontaneous membrane-adsorption behavior of nanomaterials was captured through direct imaging evidence. Histological analysis showed that the cross-linking adhesion in intracranial tumor and monodispersity in normal tissues of the nanogels not only enhanced the retention time but also ensured excellent biocompatibility. Impressively, in vivo data confirmed that the microenvironment-associated nanogels could significantly enhance brain tumor clearance rate within a short treatment timeframe (only two weeks). In short, utilizing the spontaneous membrane-adsorption strategy can significantly improve NIR-II diagnosis and phototherapy in brain diseases while avoiding high-risk complications.

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsnano.0c08532.

    • FTIR spectra, absorption spectra, the curve of weight percentage vs temperature, spontaneous hydrolysis of Tem, the mass spectra and high performance liquid chromatography analysis of Angiopep-2, energy transfer scheme, photothermal conversion curves, photostability, cell viability, EDS spectroscopy, fluorescence microscopic images of U87MG and HeLa cells, the content of LDLP and U87MG cells stained with Trypan blue, H&E staining analysis, in vitro/vivo biocompatibility analysis, serum biochemistry, brain dissections, and high-resolution fluorescence microscopic images of U87MG (PDF)

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    This article is cited by 11 publications.

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    ACS Nano

    Cite this: ACS Nano 2021, 15, 3, 4518–4533
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acsnano.0c08532
    Published February 23, 2021
    Copyright © 2021 American Chemical Society

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