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Influence of Size and Shape on the Anatomical Distribution of Endotoxin-Free Gold Nanoparticles

  • Laura Talamini
    Laura Talamini
    IRCCS-Istituto di Ricerche Farmacologiche Mario , Negri, Milan, 20156, Italy
  • Martina B. Violatto
    Martina B. Violatto
    IRCCS-Istituto di Ricerche Farmacologiche Mario , Negri, Milan, 20156, Italy
  • Qi Cai
    Qi Cai
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin , Dublin, Dublin 4, Ireland
    More by Qi Cai
  • Marco P. Monopoli
    Marco P. Monopoli
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin , Dublin, Dublin 4, Ireland
    RCSI Pharmaceutical and Medical Chemistry, Royal College of Surgeons in Ireland , St. Stephen’s Green, Dublin, Dublin 2, Ireland
  • Karsten Kantner
    Karsten Kantner
    Fachbereich Physik, Philipps University of Marburg , Marburg, 35037, Germany
  • Željka Krpetić
    Željka Krpetić
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin , Dublin, Dublin 4, Ireland
    School of Environment and Life Sciences, University of Salford Manchester , Salford, M5 4WT, United Kingdom
  • André Perez-Potti
    André Perez-Potti
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin , Dublin, Dublin 4, Ireland
  • Jennifer Cookman
    Jennifer Cookman
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin , Dublin, Dublin 4, Ireland
  • David Garry
    David Garry
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin , Dublin, Dublin 4, Ireland
    More by David Garry
  • Camila P. Silveira
    Camila P. Silveira
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin , Dublin, Dublin 4, Ireland
  • Luca Boselli
    Luca Boselli
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin , Dublin, Dublin 4, Ireland
    More by Luca Boselli
  • Beatriz Pelaz
    Beatriz Pelaz
    Fachbereich Physik, Philipps University of Marburg , Marburg, 35037, Germany
  • Tommaso Serchi
    Tommaso Serchi
    Environmental Health group, Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology (LIST) , L-4362, Luxembourg
  • Sébastien Cambier
    Sébastien Cambier
    Environmental Health group, Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology (LIST) , L-4362, Luxembourg
  • Arno C. Gutleb
    Arno C. Gutleb
    Environmental Health group, Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology (LIST) , L-4362, Luxembourg
  • Neus Feliu
    Neus Feliu
    Fachbereich Physik, Philipps University of Marburg , Marburg, 35037, Germany
    Department of Laboratory Medicine (LABMED), Karolinska Institutet , Stockholm, 171 77, Sweden
    Medcom Advance S.A., Barcelona, 08840, Spain
    More by Neus Feliu
  • Yan Yan
    Yan Yan
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin , Dublin, Dublin 4, Ireland
    More by Yan Yan
  • Mario Salmona
    Mario Salmona
    IRCCS-Istituto di Ricerche Farmacologiche Mario , Negri, Milan, 20156, Italy
  • Wolfgang J. Parak*
    Wolfgang J. Parak
    Fachbereich Physik, Philipps University of Marburg , Marburg, 35037, Germany
    *E-mail: [email protected]
  • Kenneth A. Dawson*
    Kenneth A. Dawson
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin , Dublin, Dublin 4, Ireland
    *E-mail: [email protected]
  • , and 
  • Paolo Bigini*
    Paolo Bigini
    IRCCS-Istituto di Ricerche Farmacologiche Mario , Negri, Milan, 20156, Italy
    *E-mail: [email protected]. W.J.P., K.A.D., and P.B. equally contributed to the coordination of this study.
    More by Paolo Bigini
Cite this: ACS Nano 2017, 11, 6, 5519–5529
Publication Date (Web):May 30, 2017
https://doi.org/10.1021/acsnano.7b00497
Copyright © 2017 American Chemical Society

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    Abstract

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    The transport and the delivery of drugs through nanocarriers is a great challenge of pharmacology. Since the production of liposomes to reduce the toxicity of doxorubicin in patients, a plethora of nanomaterials have been produced and characterized. Although it is widely known that elementary properties of nanomaterials influence their in vivo kinetics, such interaction is often poorly investigated in many preclinical studies. The present study aims to evaluate the actual effect of size and shape on the biodistribution of a set of gold nanoparticles (GNPs) after intravenous administration in mice. To this goal, quantitative data achieved by inductively coupled plasma mass spectrometry and observational results emerging from histochemistry (autometallography and enhanced dark-field hyperspectral microscopy) were combined. Since the immune system plays a role in bionano-interaction we used healthy immune-competent mice. To keep the immune surveillance on the physiological levels we synthesized endotoxin-free GNPs to be tested in specific pathogen-free animals. Our study mainly reveals that (a) the size and the shape greatly influence the kinetics of accumulation and excretion of GNPs in filter organs; (b) spherical and star-like GNPs showed the same percentage of accumulation, but a different localization in liver; (c) only star-like GNPs are able to accumulate in lung; (d) changes in the geometry did not improve the passage of the blood brain barrier. Overall, this study can be considered as a reliable starting point to drive the synthesis and the functionalization of potential candidates for theranostic purposes in many fields of research.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsnano.7b00497.

    • GNP synthesis and characterization, LPS detection, analytical methods, histology, and nanoscopy (PDF)

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