logo

OR SEARCH CITATIONS

My Activity
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Nano 2017, 11, 7, 7349-7354
RETURN TO ISSUEPREVArticleNEXT

Disassembly of Dipeptide Single Crystals Can Transform the Lipid Membrane into a Network

View Author Information
† Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid, Interface and Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, 100190 Beijing, China
‡ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 100190 Beijing, China
§ University of Chinese Academy of Sciences, 100049 Beijing, China
∥ Division of Physical Chemistry, Department of Chemistry, Lund University, P.O. Box 124, SE-22100 Lund, Sweden
*[email protected]
Cite this: ACS Nano 2017, 11, 7, 7349–7354
Publication Date (Web):June 28, 2017
https://doi.org/10.1021/acsnano.7b03468
Copyright © 2017 American Chemical Society
RIGHTS & PERMISSIONS
Article Views
920
Altmetric
-
Citations
20
LEARN ABOUT THESE METRICS

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.

Read OnlinePDF (6 MB)
Supporting Info (5)»
SUBJECTS:

Abstract

Abstract Image

Coupling between cytoskeleton and membranes is critical to cell movement as well as organelle formation. Here, we demonstrate that self-assembled single crystals of a dipeptide, diphenylalanine (FF), can interact with liposomes to form cytoskeleton-like structures. Under a physiological condition, disassembly of FF crystals deforms and translocates supported lipid membrane. The system exhibits similar dynamic characteristics to the endoplasmic reticulum (ER) network in cells. This bottom-up system thus indicates that external matter can participate in the deformation of liposomes, and disassembly of the nanostructures enables a system with distinct dynamic behaviors.

KEYWORDS:

Supporting Information

ARTICLE SECTIONS
Jump To

The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsnano.7b03468.

  • POM images of the FF assembly and XRD pattern of FF-lipid complexes, FTIR images of FF crystal and FF-lipid complexes, bright field images showing movement of the vesicles and vesicle fusion induced by dissolution of FF crystals, images of FF–lipid complexes in PBS-CS and PBS, membrane tubular structures induced by disassembly of FF single crystals in DMEM, fluorescent images and profiles of FF–lipid complexes at different molar ratios, and multilayer properties of the vesicles (PDF)

  • Dissolution of FF crystals in cell culture medium (AVI)

  • Lipid membranes are deformed into vesicles in cell culture medium (AVI)

  • Lipid membranes are deformed into tubular structures in DMEM (AVI)

  • Lipid membranes are deformed into networks in DMEM (AVI)

Terms & Conditions

Electronic Supporting Information files are available without a subscription to ACS Web Editions. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting Information. Files available from the ACS website may be downloaded for personal use only. Users are not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information from the ACS website, either in whole or in part, in either machine-readable form or any other form without permission from the American Chemical Society. For permission to reproduce, republish and redistribute this material, requesters must process their own requests via the RightsLink permission system. Information about how to use the RightsLink permission system can be found at http://pubs.acs.org/page/copyright/permissions.html.

Cited By

This article is cited by 20 publications.

  1. Chao Li, Qingchuan Li, Zhao Wang, Xiaojun Han. Phospholipid Self-Assemblies Shaped Like Ancient Chinese Coins for Artificial Organelles. Analytical Chemistry 2020, 92 (8) , 6060-6064. https://doi.org/10.1021/acs.analchem.0c00430
  2. Barbara B. Gerbelli, Isabelle Ly, Sandra Pedemay, Wendel A. Alves, Elisabeth A. de Oliveira. The Role of Amylogenic Fiber Aggregation on the Elasticity of a Lipid Membrane. ACS Applied Bio Materials 2020, 3 (2) , 815-822. https://doi.org/10.1021/acsabm.9b00861
  3. Pablo G. Argudo, Rafael Contreras-Montoya, Luis Álvarez de Cienfuegos, María T. Martín-Romero, Luis Camacho, Juan J. Giner-Casares. Optimization of Amino Acid Sequence of Fmoc-Dipeptides for Interaction with Lipid Membranes. The Journal of Physical Chemistry B 2019, 123 (17) , 3721-3730. https://doi.org/10.1021/acs.jpcb.9b01132
  4. Cuiyun Zhou, Xuenan Feng, Rong Wang, Gengxiang Yang, Tianyu Wang, Jianzhuang Jiang. Hierarchical Assembly of l-Phenylalanine-Terminated Bolaamphiphile with Porphyrin Show Tunable Nanostructures and Photocatalytic Properties. ACS Omega 2018, 3 (9) , 10638-10646. https://doi.org/10.1021/acsomega.8b01822
  5. Manzar Abbas, Ruirui Xing, Ning Zhang, Qianli Zou, Xuehai Yan. Antitumor Photodynamic Therapy Based on Dipeptide Fibrous Hydrogels with Incorporation of Photosensitive Drugs. ACS Biomaterials Science & Engineering 2018, 4 (6) , 2046-2052. https://doi.org/10.1021/acsbiomaterials.7b00624
  6. Lu Xu, Gordon Bosiljevac, Kyle Yu, Yi Y. Zuo. Melting of the Dipalmitoylphosphatidylcholine Monolayer. Langmuir 2018, 34 (15) , 4688-4694. https://doi.org/10.1021/acs.langmuir.8b00579
  7. Barbara Bianca Gerbelli, Emerson Rodrigo da Silva, Bruna Miranda Soares, Wendel Andrade Alves, and Elisabeth Andreoli de Oliveira . Multilamellar-to-Unilamellar Transition Induced by Diphenylalanine in Lipid Vesicles. Langmuir 2018, 34 (5) , 2171-2179. https://doi.org/10.1021/acs.langmuir.7b03869
  8. Jingwen Song, Ruirui Xing, Tifeng Jiao, Qiuming Peng, Chengqian Yuan, Helmuth Möhwald, and Xuehai Yan . Crystalline Dipeptide Nanobelts Based on Solid–Solid Phase Transformation Self-Assembly and Their Polarization Imaging of Cells. ACS Applied Materials & Interfaces 2018, 10 (3) , 2368-2376. https://doi.org/10.1021/acsami.7b17933
  9. Meiwen Cao, Sha Lu, Wenjing Zhao, Li Deng, Meng Wang, Jiqian Wang, Peng Zhou, Dong Wang, Hai Xu, and Jian R. Lu . Peptide Self-Assembled Nanostructures with Distinct Morphologies and Properties Fabricated by Molecular Design. ACS Applied Materials & Interfaces 2017, 9 (45) , 39174-39184. https://doi.org/10.1021/acsami.7b11681
  10. Douglas Andrade, Leonardo Bruno Assis Oliveira, Guilherme Colherinhas. Design and analysis of polypeptide nanofiber using full atomistic Molecular Dynamic. Journal of Molecular Liquids 2020, 302 , 112610. https://doi.org/10.1016/j.molliq.2020.112610
  11. Soumya Kanti De, Anjan Chakraborty. Interaction of monomeric and self-assembled aromatic amino acids with model membranes: self-reproduction phenomena. Chemical Communications 2019, 55 (100) , 15109-15112. https://doi.org/10.1039/C9CC08495A
  12. Angelina Angelova, Markus Drechsler, Vasil M. Garamus, Borislav Angelov. Pep‐Lipid Cubosomes and Vesicles Compartmentalized by Micelles from Self‐Assembly of Multiple Neuroprotective Building Blocks Including a Large Peptide Hormone PACAP‐DHA. ChemNanoMat 2019, 5 (11) , 1381-1389. https://doi.org/10.1002/cnma.201900468
  13. Hiroshi Inaba, Takahisa Yamamoto, Arif Md. Rashedul Kabir, Akira Kakugo, Kazuki Sada, Kazunori Matsuura. Molecular Encapsulation Inside Microtubules Based on Tau-Derived Peptides. Chemistry - A European Journal 2018, 24 (56) , 14958-14967. https://doi.org/10.1002/chem.201802617
  14. Meifang Fu, Junbai Li. Spontaneous Membrane Generation and Extension in a Dipeptide Single Crystal and Phospholipid Mixed System. Angewandte Chemie 2018, 130 (35) , 11574-11577. https://doi.org/10.1002/ange.201806347
  15. Meifang Fu, Junbai Li. Spontaneous Membrane Generation and Extension in a Dipeptide Single Crystal and Phospholipid Mixed System. Angewandte Chemie International Edition 2018, 57 (35) , 11404-11407. https://doi.org/10.1002/anie.201806347
  16. Shukun Li, Ruirui Xing, Rui Chang, Qianli Zou, Xuehai Yan. Nanodrugs based on peptide-modulated self-assembly: Design, delivery and tumor therapy. Current Opinion in Colloid & Interface Science 2018, 35 , 17-25. https://doi.org/10.1016/j.cocis.2017.12.004
  17. Yurong Zhao, Wei Yang, Cuixia Chen, Jiqian Wang, Limin Zhang, Hai Xu. Rational design and self-assembly of short amphiphilic peptides and applications. Current Opinion in Colloid & Interface Science 2018, 35 , 112-123. https://doi.org/10.1016/j.cocis.2018.02.009
  18. Wei Ji, Shijin Zhang, Sachie Yukawa, Shogo Onomura, Toshio Sasaki, Kun'ichi Miyazawa, Ye Zhang. Regulating Higher-Order Organization through the Synergy of Two Self-Sorted Assemblies. Angewandte Chemie 2018, 130 (14) , 3698-3702. https://doi.org/10.1002/ange.201712575
  19. Wei Ji, Shijin Zhang, Sachie Yukawa, Shogo Onomura, Toshio Sasaki, Kun'ichi Miyazawa, Ye Zhang. Regulating Higher-Order Organization through the Synergy of Two Self-Sorted Assemblies. Angewandte Chemie International Edition 2018, 57 (14) , 3636-3640. https://doi.org/10.1002/anie.201712575
  20. Venkanna Muripiti, Hari Krishnareddy Rachamalla, Rajkumar Banerjee, Srilakshmi. V. Patri. α-Tocopherol-based cationic amphiphiles with a novel pH sensitive hybrid linker for gene delivery. Organic & Biomolecular Chemistry 2018, 16 (16) , 2932-2946. https://doi.org/10.1039/C8OB00276B

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

OOPS

You have to login with your ACS ID befor you can login with your Mendeley account.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect

This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy.

CONTINUE