Ionic Liquid-Mediated Processing of SAIB-Chitin Scaffolds
- Cristiana Gonçalves*Cristiana Gonçalves*E-mail: [email protected]3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalICVS/3B’s-PT Government Associate Laboratory, 4805-017 Guimarães/4710-057 Braga, PortugalThe Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, 4805-017 Guimarães, PortugalMore by Cristiana Gonçalves,
- Simone S. SilvaSimone S. Silva3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalICVS/3B’s-PT Government Associate Laboratory, 4805-017 Guimarães/4710-057 Braga, PortugalMore by Simone S. Silva,
- Joana M. GomesJoana M. Gomes3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalICVS/3B’s-PT Government Associate Laboratory, 4805-017 Guimarães/4710-057 Braga, PortugalMore by Joana M. Gomes,
- Isabel M. OliveiraIsabel M. Oliveira3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalICVS/3B’s-PT Government Associate Laboratory, 4805-017 Guimarães/4710-057 Braga, PortugalMore by Isabel M. Oliveira,
- Raphaël F. CanadasRaphaël F. Canadas3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalICVS/3B’s-PT Government Associate Laboratory, 4805-017 Guimarães/4710-057 Braga, PortugalMore by Raphaël F. Canadas,
- F. Raquel MaiaF. Raquel Maia3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalICVS/3B’s-PT Government Associate Laboratory, 4805-017 Guimarães/4710-057 Braga, PortugalThe Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, 4805-017 Guimarães, PortugalMore by F. Raquel Maia,
- Hajer RadhouaniHajer Radhouani3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalICVS/3B’s-PT Government Associate Laboratory, 4805-017 Guimarães/4710-057 Braga, PortugalThe Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, 4805-017 Guimarães, PortugalMore by Hajer Radhouani,
- Rui L. ReisRui L. Reis3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalICVS/3B’s-PT Government Associate Laboratory, 4805-017 Guimarães/4710-057 Braga, PortugalThe Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, 4805-017 Guimarães, PortugalMore by Rui L. Reis, and
- Joaquim M. OliveiraJoaquim M. Oliveira3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, PortugalICVS/3B’s-PT Government Associate Laboratory, 4805-017 Guimarães/4710-057 Braga, PortugalThe Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Barco, 4805-017 Guimarães, PortugalMore by Joaquim M. Oliveira
Abstract
This study proposes a green and innovative ionic liquid (IL) methodology for processing sucrose acetate isobutyrate (SAIB) porous structures for tissue engineering. The solubilization of SAIB in an IL, namely, 1-butyl-imidazolium acetate, was achieved, for the first time, allowing the development of SAIB-based scaffolds. In the early stages of the process development, it was needed to add chitin in the scaffold’s compositions to provide a steady structure. Physicochemical, mechanical, and biological techniques evaluated the characteristics of the produced scaffolds. The Fourier transform infrared spectroscopy results confirmed the presence of chitin and SAIB, as well as the influence of the applied solvent for the IL removal. The X-ray diffraction analysis shows that the presence of SAIB contributes to a decrease in the crystallinity of the scaffolds. Moreover, the morphology of the structures varied upon the preparation conditions used, demonstrating that it is possible to obtain scaffolds with different values of porosity (ranging from 52 to 85%). No cytotoxicity was found when culturing in vitro human adipose-derived stem cells onto the surface of the produced scaffolds during 72 h. This study showed that processing SAIB-based scaffolds is feasible using ILs and that these structures exhibit promising features for tissue engineering scaffolding applications.
Cited By
This article is cited by 2 publications.
- Joana M. Gomes, Simone S. Silva, Rui L. Reis. Exploring the Use of Choline Acetate on the Sustainable Development of α-Chitin-Based Sponges. ACS Sustainable Chemistry & Engineering 2020, 8 (35) , 13507-13516. https://doi.org/10.1021/acssuschemeng.0c05076
- Simone S. Silva, Joana M. Gomes, Luísa C. Rodrigues, Rui L. Reis. Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications. Marine Drugs 2020, 18 (7) , 346. https://doi.org/10.3390/md18070346