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Current Status and Future Challenges in Molecular Design for Reduced Hazard

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† School of Forestry and Environmental Studies, Yale University, 195 Prospect Street, New Haven, Connecticut 06520, United States
‡ Department of Environmental Science, Baylor University, One Bear Place #97266, Waco, Texas 76798-7266, United States
§ Department of Environmental & Occupational Health Sciences, University of Washington, Box 354695, Seattle, Washington 98195, United States
∥ Department of Chemistry, The George Washington University, 800 22nd Street NW, Washington, DC 20052, United States
⊥ Department of Chemical and Environmental Engineering, Yale University, 10 Hillhouse Avenue, P.O. Box 208267, New Haven, Connecticut 06520−8267, United States
*P. T. Anastas. Email: [email protected]
Cite this: ACS Sustainable Chem. Eng. 2016, 4, 11, 5900–5906
Publication Date (Web):October 25, 2016
https://doi.org/10.1021/acssuschemeng.6b02089
Copyright © 2016 American Chemical Society
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    Abstract

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    Synthetic chemicals and materials are the basis of our society and our economy. Yet, in spite of all the advances in toxicology that have helped us understand and even predict toxicity associated with industrial chemicals, fundamental scientific questions crucial to the development of safer chemicals are left unanswered. Alternative strategies, such as in silico toxicity predictions, are considered the next frontier in molecular design for reduced hazard; however, such strategies are still not sufficiently developed to meet existing needs. Design strategies need to incorporate information and data at the nexus of multiple disciplines. Critically, there is a need for the incorporation of toxicology into the design phase of the molecular design process. In this Feature, we discuss the current status and future challenges in molecular design for reduced hazard.

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