Fungal Glutathione Transferases as Tools to Explore the Chemical Diversity of Amazonian Wood ExtractivesClick to copy article linkArticle link copied!
- Thomas Perrot
- Mathieu Schwartz
- Fanny Saiag
- Guillaume Salzet
- Stéphane DumarçayStéphane DumarçayUniversité de Lorraine, INRA, LERMAB, F-54000 Nancy, FranceMore by Stéphane Dumarçay
- Frédérique Favier
- Philippe GérardinPhilippe GérardinUniversité de Lorraine, INRA, LERMAB, F-54000 Nancy, FranceMore by Philippe Gérardin
- Jean-Michel GirardetJean-Michel GirardetUniversité de Lorraine, INRA, IAM, F-54000 Nancy, FranceMore by Jean-Michel Girardet
- Rodnay Sormani
- Mélanie Morel-RouhierMélanie Morel-RouhierUniversité de Lorraine, INRA, IAM, F-54000 Nancy, FranceMore by Mélanie Morel-Rouhier
- Nadine AmusantNadine AmusantCIRAD, UMR Ecofog (AgroParisTech, CIRAD, CNRS, INRA, UA), BF701−97310 Kourou, Cedex, FranceMore by Nadine Amusant
- Claude Didierjean
- Eric Gelhaye*Eric Gelhaye*E-mail: [email protected]Université de Lorraine, INRA, IAM, F-54000 Nancy, FranceMore by Eric Gelhaye
Abstract
The natural durability of wood is linked to its chemical composition and in particular the presence of metabolites called extractives that often possess chemical reactivity. For dealing with these compounds, wood degraders have developed detoxification systems usually involving enzyme families. Among these enzymes, glutathione transferases (GSTs) are involved in the decrease of the reactivity of toxic compounds. In this study, the hypothesis that the detoxification systems of wood decaying fungi could be indicators of the chemical reactivity of wood extracts has been tested. This approach has been evaluated using 32 wood extracts coming from French Guiana species, testing their antimicrobial ability, antioxidative properties, and reactivity against six GSTs from the white rot Trametes versicolor. From the obtained data, a significant correlation between the antimicrobial and antioxidative properties of the tested wood extracts and GST interactions was established. In addition, the chemical analysis performed on one of the most reactive extracts (an acetonic extract of Bagassa guianensis) has demonstrated oxyresveratrol as a major constituent. We were able to cocrystallize one GST with this commercially interesting compound. Taken together, the presented data support the hypothesis that detoxifying enzymes could be used to identify the presence of molecules of industrial interest in wood extracts.
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