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Biomimetic Spiral-Cylindrical Scaffold Based on Hybrid Chitosan/Cellulose/Nano-Hydroxyapatite Membrane for Bone Regeneration

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    Research Article

    Biomimetic Spiral-Cylindrical Scaffold Based on Hybrid Chitosan/Cellulose/Nano-Hydroxyapatite Membrane for Bone Regeneration
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    † Department of Biomedical Materials Science, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, P. R. China
    ‡ Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, P. R. China
    *E-mail: [email protected]. Tel: +86 28 85412847. Fax: +86 28 85417273.
    *E-mail: [email protected]. Tel.: +86 23 68772482. Fax: +86 23 68772482.
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    Cite this: ACS Appl. Mater. Interfaces 2013, 5, 22, 12036–12044
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    https://doi.org/10.1021/am4038432
    Published November 5, 2013
    Copyright © 2013 American Chemical Society
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    Natural bone is a complex material with well-designed architecture. To achieve successful bone integration and regeneration, the constituent and structure of bone-repairing scaffolds need to be functionalized synergistically based on biomimetics. In this study, a hybrid membrane composed of chitosan (CS), sodium carboxymethyl cellulose (CMC), and nano-hydroxyapatite (n-HA) was curled in a concentric manner to generate an anisotropic spiral-cylindrical scaffold, with compositional and structural properties mimicking natural bone. After optimization in terms of morphology, hydrophilicity, swelling and degradation pattern, the osteoblast cells seeded on the membrane of 60 wt% n-HA exhibited the highest cell viability and osteocalcin expression. In vivo osteogenesis assessment revealed that the spiral-cylindrical architecture played a dominant role in bone regeneration and osseointegration. Newly formed bone tissue grew through the longitudinal direction of the cylinder-shaped scaffold bridging both ends of the defect, bone marrow penetrated the entire scaffold and formed a medullary cavity in the center of the spiral cylinder. This study for the first time demonstrates that the spiral-cylindrical scaffold can promote complete infiltration of bone tissues in vivo, leading to successful osteointegration and functional reconstruction of bone defects. It suggests that the biomimetic spiral-cylindrical scaffold could be a promising candidate for bone regeneration applications.

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    Cite this: ACS Appl. Mater. Interfaces 2013, 5, 22, 12036–12044
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