Article

Poly(dimethylsiloxane) as a Material for Fabricating Microfluidic Devices

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138
Acc. Chem. Res., 2002, 35 (7), pp 491–499
DOI: 10.1021/ar010110q
Publication Date (Web): April 24, 2002
Copyright © 2002 American Chemical Society

J. Cooper McDonald was born in Athens, AL, in 1974. He received his B.S. Degree from Erskine College in 1996 and his Ph.D. degree with George M. Whitesides from Harvard University in 2001. He is now a Technology Specialist in the intellectual property law firm Clark & Elbing in Boston, MA.

George M. Whitesides was born in Lexignton, KY, in 1939. He received his A.B. degree from Harvard University in 1960 and his Ph.D. degree with John D. Roberts from the California Institute of Technology in 1964. He was a member of the faculty of the Massachusetts Institute of Technology from 1963 to 1982. He joined the Department of Chemistry at Harvard University in 1982, where he is now the Mallinckrodt Professor of Chemistry. His research interests include microfabrication, materials science, surface chemistry, self-assembly, rational drug design, and molecular recognition.

Abstract

This Account summarizes techniques for fabrication and applications in biomedicine of microfluidic devices fabricated in poly(dimethylsiloxane) (PDMS). The methods and applications described focus on the exploitation of the physical and chemical properties of PDMS in the fabrication or actuation of the devices. Fabrication of channels in PDMS is simple, and it can be used to incorporate other materials and structures through encapsulation or sealing (both reversible and irreversible).

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Article Views: 14,078 Times
Received 19 September 2001
Published online 24 April 2002
Published in print 1 July 2002
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