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Transactivation of the rat CYP2C13 gene promoter involves HNF-1, HNF-3, and members of the orphan receptor subfamily

Cite this: Biochemistry 1994, 33, 33, 9889–9897
Publication Date (Print):August 1, 1994
https://doi.org/10.1021/bi00199a010
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    Cited By

    This article is cited by 29 publications.

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    4. Tracy C. DeLozier, Cheng-Chung Tsao, Sherry J. Coulter, Julie Foley, J. Alyce Bradbury, Darryl C. Zeldin, Joyce A. Goldstein. CYP2C44, a New Murine CYP2C That Metabolizes Arachidonic Acid to Unique Stereospecific Products. Journal of Pharmacology and Experimental Therapeutics 2004, 310 (3) , 845-854. https://doi.org/10.1124/jpet.104.067819
    5. Roque Bort, M.José Gómez-Lechón, José V Castell, Ramiro Jover. Role of hepatocyte nuclear factor 3γ in the expression of human CYP2C genes. Archives of Biochemistry and Biophysics 2004, 426 (1) , 63-72. https://doi.org/10.1016/j.abb.2004.03.032
    6. Joyce K. Divine, Sean P. McCaul, Theodore C. Simon. HNF-1α and endodermal transcription factors cooperatively activate Fabpl : MODY3 mutations abrogate cooperativity. American Journal of Physiology-Gastrointestinal and Liver Physiology 2003, 285 (1) , G62-G72. https://doi.org/10.1152/ajpgi.00074.2003
    7. C. Rodrı́guez-Antona, R. Bort, R. Jover, N. Tindberg, M. Ingelman-Sundberg, M. J. Gómez-Lechón, J. V. Castell. Transcriptional Regulation of Human CYP3A4 Basal Expression by CCAAT Enhancer-Binding Protein α and Hepatocyte Nuclear Factor-3γ. Molecular Pharmacology 2003, 63 (5) , 1180-1189. https://doi.org/10.1124/mol.63.5.1180
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    10. Jürgen Borlak, Thomas Thum. Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures11Abbreviations: Ah, aryl hydrocarbon; c/EBP, CCAAT/enhancer-binding protein; cDNA, complementary DNA CYP, cytochrome P450; EROD, ethoxyresorufin-O-deethylase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GSTA, glutathione S-transferase alpha; HNF, hepatic nuclear factor; RT–PCR, reverse transcription–polymerase chain reaction; and TF, transcription factor.. Biochemical Pharmacology 2001, 61 (2) , 145-153. https://doi.org/10.1016/S0006-2952(00)00537-2
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    19. Fausto G. Hegardt. Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis. Biochimie 1998, 80 (10) , 803-806. https://doi.org/10.1016/S0300-9084(00)88874-4
    20. Gang Luo, Darryl C. Zeldin, Joyce A. Blaisdell, Ernest Hodgson, Joyce A. Goldstein. Cloning and Expression of Murine CYP2Cs and Their Ability to Metabolize Arachidonic Acid. Archives of Biochemistry and Biophysics 1998, 357 (1) , 45-57. https://doi.org/10.1006/abbi.1998.0806
    21. H. Nakshatri, P. Bhat-Nakshatri. Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-1, PPAR, RAR and RXR through common response elements. Nucleic Acids Research 1998, 26 (10) , 2491-2499. https://doi.org/10.1093/nar/26.10.2491
    22. A. Mode, R. AhIgren, O. Lahuna, J.-Å. Gustafsson. Gender differences in rat hepaticCYP2C gene expression — regulation by growth hormone. Growth Hormone & IGF Research 1998, 8 , 61-67. https://doi.org/10.1016/S1096-6374(98)80025-7
    23. Olivier Lahuna, Leandro Fernandez, Hanna Karlsson, Dominique Maiter, Frederic P. Lemaigre, Guy G. Rousseau, Jan-Åke Gustafsson, Agneta Mode. Expression of hepatocyte nuclear factor 6 in rat liver is sex-dependent and regulated by growth hormone. Proceedings of the National Academy of Sciences 1997, 94 (23) , 12309-12313. https://doi.org/10.1073/pnas.94.23.12309
    24. Gwendal Lazennec, Laurence Kern, Yves Valotaire, Gilles Salbert. The Nuclear Orphan Receptors COUP-TF and ARP-1 Positively Regulate the Trout Estrogen Receptor Gene through Enhancing Autoregulation. Molecular and Cellular Biology 1997, 17 (9) , 5053-5066. https://doi.org/10.1128/MCB.17.9.5053
    25. ANTONY J. HANSEN, YING-HUE LEE, FRANK J. GONZALEZ, PETER I. MACKENZIE. HNFl α Activates the Rat UDP Glucuronosyltransferase UGT2B1 Gene Promoter. DNA and Cell Biology 1997, 16 (2) , 207-214. https://doi.org/10.1089/dna.1997.16.207
    26. Linda A. Nolten, Paul H. Steenbergh, John S. Sussenbach. The Hepatocyte Nuclear Factor 3β Stimulates the Transcription of the Human Insulin-like Growth Factor I Gene in a Direct and Indirect Manner. Journal of Biological Chemistry 1996, 271 (50) , 31846-31854. https://doi.org/10.1074/jbc.271.50.31846
    27. Uzma Samadani, Robert H. Costa. The Transcriptional Activator Hepatocyte Nuclear Factor 6 Regulates Liver Gene Expression. Molecular and Cellular Biology 1996, 16 (11) , 6273-6284. https://doi.org/10.1128/MCB.16.11.6273
    28. FABIENNE ROUSSEL, SANDRINE MARIE, THIERRY CRESTEIL. Gene Structure and Promoter Analysis of the Rat Constitutive CYP2C23 Gene. DNA and Cell Biology 1995, 14 (9) , 777-788. https://doi.org/10.1089/dna.1995.14.777
    29. Anders Ström, Stefan Westin, Hidetaka Eguchi, Jan-Åke Gustafsson, Agneta Mode. Characterization of Orphan Nuclear Receptor Binding Elements in Sex-differentiated Members of the cyp2c Gene Family Expressed in Rat Liver. Journal of Biological Chemistry 1995, 270 (19) , 11276-11281. https://doi.org/10.1074/jbc.270.19.11276