ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
CONTENT TYPES

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

Cite this: Biochemistry 1984, 23, 21, 5036–5041
Publication Date (Print):October 9, 1984
https://doi.org/10.1021/bi00316a032
    ACS Legacy Archive

    Article Views

    1282

    Altmetric

    -

    Citations

    LEARN ABOUT THESE METRICS
    PDF (784 KB)

    Note: In lieu of an abstract, this is the article's first page.

    Free first page

    Cited By

    This article is cited by 2097 publications.

    1. Javier García-Cárceles, Elena Caballero, Carmen Gil, Ana Martínez. Kinase Inhibitors as Underexplored Antiviral Agents. Journal of Medicinal Chemistry 2022, 65 (2) , 935-954. https://doi.org/10.1021/acs.jmedchem.1c00302
    2. Cecilia C. Ayala-Aguilera, Teresa Valero, Álvaro Lorente-Macías, Daniel J. Baillache, Stephen Croke, Asier Unciti-Broceta. Small Molecule Kinase Inhibitor Drugs (1995–2021): Medical Indication, Pharmacology, and Synthesis. Journal of Medicinal Chemistry 2022, 65 (2) , 1047-1131. https://doi.org/10.1021/acs.jmedchem.1c00963
    3. Robin Lorenz, Jian Wu, Friedrich W. Herberg, Susan S. Taylor, Richard A. Engh. Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics. Biochemistry 2021, 60 (46) , 3470-3484. https://doi.org/10.1021/acs.biochem.1c00359
    4. Ferah Comert Onder, Nermin Kahraman, Esen Bellur Atici, Ali Cagir, Hakan Kandemir, Gizem Tatar, Tugba Taskin Tok, Goknur Kara, Bekir Karliga, Serdar Durdagi, Mehmet Ay, Bulent Ozpolat. Target-Driven Design of a Coumarinyl Chalcone Scaffold Based Novel EF2 Kinase Inhibitor Suppresses Breast Cancer Growth In Vivo. ACS Pharmacology & Translational Science 2021, 4 (2) , 926-940. https://doi.org/10.1021/acsptsci.1c00030
    5. Rebecca K. Donegan and Raquel L. Lieberman . Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions. Journal of Medicinal Chemistry 2016, 59 (3) , 788-809. https://doi.org/10.1021/acs.jmedchem.5b00828
    6. Stephen G. Davies, Peter D. Kennewell, Angela J. Russell, Peter T. Seden, Robert Westwood, and Graham M. Wynne . Stemistry: The Control of Stem Cells in Situ Using Chemistry. Journal of Medicinal Chemistry 2015, 58 (7) , 2863-2894. https://doi.org/10.1021/jm500838d
    7. Isabelle Landrieu,, Ludovic Lacosse,, Arnaud Leroy,, Jean-Michel Wieruszeski,, Xavier Trivelli,, Alain Sillen,, Nathalie Sibille,, Harald Schwalbe,, Krishna Saxena,, Thomas Langer, and, Guy Lippens. NMR Analysis of a Tau Phosphorylation Pattern. Journal of the American Chemical Society 2006, 128 (11) , 3575-3583. https://doi.org/10.1021/ja054656+
    8. Philippe H. Hünenberger,, Volkhard Helms,, Narendra Narayana,, Susan S. Taylor, and, J. Andrew McCammon. Determinants of Ligand Binding to cAMP-Dependent Protein Kinase. Biochemistry 1999, 38 (8) , 2358-2366. https://doi.org/10.1021/bi982064g
    9. Mikiko Sodeoka,, Midori A. Arai,, Koji Adachi,, Koichiro Uotsu, and, Masakatsu Shibasaki. Rational Design, Synthesis, and Evaluation of a New Type of PKC Inhibitor. Journal of the American Chemical Society 1998, 120 (2) , 457-458. https://doi.org/10.1021/ja971270t
    10. Canan G. Nebigil, Maria N. Garnovskaya, Shirley J. Casanas, Janet G. Mulheron, Eric M. Parker, Thomas W. Gettys, and John R. Raymond. Agonist-induced desensitization and phosphorylation of human 5-HT1A receptor expressed in Sf9 insect cells. Biochemistry 1995, 34 (37) , 11954-11962. https://doi.org/10.1021/bi00037a037
    11. Bryant A. Gilbert, Young-Hee Lim, Jiabing Ding, John A. Badwey, and Robert R. Rando. Farnesyl Thiotriazole, A Potent Neutrophil Agonist and Structurally Novel Activator of Protein Kinase C. Biochemistry 1995, 34 (12) , 3916-3920. https://doi.org/10.1021/bi00012a007
    12. Patrick W. Dunne, E. Timothy Walch, and Henry F. Epstein. Phosphorylation Reactions of Recombinant Human Myotonic Dystrophy Protein Kinase and Their Inhibition. Biochemistry 1994, 33 (35) , 10809-10814. https://doi.org/10.1021/bi00201a031
    13. Isabelle H. Lelong, Carol O. Cardarelli, Michael M. Gottesman, and Ira Pastan. GTP-Stimulated Phosphorylation of P-Glycoprotein in Transporting Vesicles from KB-V1 Multidrug Resistant Cells. Biochemistry 1994, 33 (30) , 8921-8929. https://doi.org/10.1021/bi00196a009
    14. Rakesh Datta, Dennis E. Hallahan, Surender M. Kharbanda, Eric Rubin, Matthew L. Sherman, Eliezer Huberman, Ralph R. Weichselbaum, and Donald W. Kufe. Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation. Biochemistry 1992, 31 (35) , 8300-8306. https://doi.org/10.1021/bi00150a025
    15. Nancy E. Ward and Catherine A. O'Brian. The intrinsic ATPase activity of protein kinase C is catalyzed at the active site of the enzyme. Biochemistry 1992, 31 (25) , 5905-5911. https://doi.org/10.1021/bi00140a029
    16. Kazuko Handa, Yasuyuki Igarashi, Mohammad Nisar, and Senitiroh Hakomori. Downregulation of GMP-140 (CD62 or PADGEM) expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine. Biochemistry 1991, 30 (50) , 11682-11686. https://doi.org/10.1021/bi00114a011
    17. Surender Kharbanda, Rakesh Datta, and Donald Kufe. Regulation of c-jun gene expression in HL-60 leukemia cells by 1-.beta.-D-arabinofuranosylcytosine. Potential involvement of a protein kinase C dependent mechanism. Biochemistry 1991, 30 (32) , 7947-7952. https://doi.org/10.1021/bi00246a011
    18. Krzysztof Palczewski, Nikhat Kahn, and Paul A. Hargrave. Nucleoside inhibitors of rhodopsin kinase. Biochemistry 1990, 29 (26) , 6276-6282. https://doi.org/10.1021/bi00478a024
    19. Catherine A. O'Brian and Nancy E. Ward. Characterization of a calcium- and phospholipid-dependent ATPase reaction catalyzed by rat brain protein kinase C. Biochemistry 1990, 29 (18) , 4278-4282. https://doi.org/10.1021/bi00470a003
    20. Berta Strulovici, Sarkiz Daniel-Issakani, Edwin Oto, John Nestor, Jr., Hardy Chan, and Ann Ping Tsou. Activation of distinct protein kinase C isozymes by phorbol esters: correlation with induction of interleukin 1.beta. gene expression. Biochemistry 1989, 28 (8) , 3569-3576. https://doi.org/10.1021/bi00434a063
    21. David R. Morris, Margaret L. Allen, Peter S. Rabinovitch, Christine A. Kuepfer, and Michael W. White. Mitogenic signaling pathways regulating expression of c-myc and ornithine decarboxylase genes in bovine T-lymphocytes. Biochemistry 1988, 27 (23) , 8689-8693. https://doi.org/10.1021/bi00423a027
    22. Erzsebet Ligeti, Jacques Doussiere, and Pierre V. Vignais. Activation of the superoxide radical generating oxidase in plasma membrane from bovine polymorphonuclear neutrophils by arachidonic acid, a cytosolic factor of protein nature, and nonhydrolyzable analogs of GTP. Biochemistry 1988, 27 (1) , 193-200. https://doi.org/10.1021/bi00401a029
    23. Masaaki Ito, Toshio Tanaka, Masaki Inagaki, Koji Nakanishi, and Hiroyoshi Hidaka. N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C. Biochemistry 1986, 25 (15) , 4179-4184. https://doi.org/10.1021/bi00363a002
    24. Yuri A. Blednov, Adriana Da Costa, Sonia Mason, Jody Mayfield, Robert O. Messing. Selective PDE4B and PDE4D inhibitors produce distinct behavioral responses to ethanol and GABAergic drugs in mice. Neuropharmacology 2023, 231 , 109508. https://doi.org/10.1016/j.neuropharm.2023.109508
    25. Patrick Finkelstein, Julia C. Reisenbauer, Bence B. Botlik, Ori Green, Andri Florin, Bill Morandi. Nitrogen atom insertion into indenes to access isoquinolines. Chemical Science 2023, 14 (11) , 2954-2959. https://doi.org/10.1039/D2SC06952K
    26. Paul J. Hartman, David L. Cooke, Henry H. Hsu, Jeanette Stewart, Kengo Sumi, Yoko Yoshida, Hiroyoshi Hidaka, Gary D. Novack. Phase Ⅰ/Ⅱ, Double-Masked, Randomized, Vehicle-Controlled Study of H-1337 Ophthalmic Solution for Glaucoma and Ocular Hypertension. Ophthalmology Glaucoma 2023, 6 (2) , 198-205. https://doi.org/10.1016/j.ogla.2022.08.015
    27. Carmen Avendaño, J. Carlos Menéndez. Anticancer drugs acting on signaling pathways, part 1: Tyrosine kinase inhibitors. 2023, 493-563. https://doi.org/10.1016/B978-0-12-818549-0.00018-2
    28. Yuri A. Blednov, Adriana Da Costa, Sonia Mason, Jody Mayfield, Stephen J. Moss, Robert O. Messing. Apremilast-induced increases in acute ethanol intoxication and decreases in ethanol drinking in mice involve PKA phosphorylation of GABAA β3 subunits. Neuropharmacology 2022, 220 , 109255. https://doi.org/10.1016/j.neuropharm.2022.109255
    29. Svetlana V. Minina, Nikita E. Shklovskiy-Kordi. Neuron quantum computers and a way to unification of science: A compendium of Efim Liberman's scientific work. Biosystems 2022, 217 , 104684. https://doi.org/10.1016/j.biosystems.2022.104684
    30. Silvia Ghione, Cindy Racoeur, Nesrine Mabrouk, Jingxuan Shan, Emma Groetz, Elise Ballot, Caroline Truntzer, Lotfi Chouchane, Frédérique Végran, Catherine Paul, Stéphanie Plenchette, Ali Bettaieb. Protein Kinase Inhibitor-Mediated Immunoprophylactic and Immunotherapeutic Control of Colon Cancer. Frontiers in Immunology 2022, 13 https://doi.org/10.3389/fimmu.2022.875764
    31. Xiang-Yu Lin, Yu-Wei Huang, You-Wei Fan, Yun-Ti Chen, Nikhil Pathak, Yen-Chao Hsu, Jinn-Moon Yang. Identification of pan-kinase-family inhibitors using graph convolutional networks to reveal family-sensitive pre-moieties. BMC Bioinformatics 2022, 23 (S4) https://doi.org/10.1186/s12859-022-04773-0
    32. Sho Fukuyasu, Hiroki Kayashima, Akihito Moribayashi, Shu Matsuoka, Atsuhiro Nagasaki, Hiroko Okawa, Hirofumi Yatani, Makio Saeki, Hiroshi Egusa. Cell-Based Double-Screening Method to Identify a Reliable Candidate for Osteogenesis-Targeting Compounds. Biomedicines 2022, 10 (2) , 426. https://doi.org/10.3390/biomedicines10020426
    33. Azadeh Hekmat, Ali Akbar Saboury. Protein kinase inhibitors and cancer targeted therapy. 2022, 23-70. https://doi.org/10.1016/B978-0-323-91287-7.00022-3
    34. Sabeeha Ali, Manzar Alam, Md. Imtaiyaz Hassan. Kinase inhibitors: An overview. 2022, 1-22. https://doi.org/10.1016/B978-0-323-91287-7.00026-0
    35. Dominic P. Byrne, Mitchell H. Omar, Eileen J. Kennedy, Patrick A. Eyers, John D. Scott. Biochemical Analysis of AKAP-Anchored PKA Signaling Complexes. 2022, 297-317. https://doi.org/10.1007/978-1-0716-2245-2_19
    36. Dana J. Ramms, Francesco Raimondi, Nadia Arang, Friedrich W. Herberg, Susan S. Taylor, J. Silvio Gutkind, . G α s–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant G α s-PKA Signaling. Pharmacological Reviews 2021, 73 (4) , 1326-1368. https://doi.org/10.1124/pharmrev.120.000269
    37. Kalpana K. Bhanumathy, Amrutha Balagopal, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Andrew Freywald, Vincenzo Giambra. Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia. Cancers 2021, 13 (2) , 184. https://doi.org/10.3390/cancers13020184
    38. Corentin Dumortier, Rogatien Charlet, Ali Bettaieb, Samir Jawhara. H89 Treatment Reduces Intestinal Inflammation and Candida albicans Overgrowth in Mice. Microorganisms 2020, 8 (12) , 2039. https://doi.org/10.3390/microorganisms8122039
    39. Yuri A. Blednov, Cecilia M. Borghese, Michael P. Dugan, Swetak Pradhan, Thanvi M. Thodati, Nikhita R. Kichili, R. Adron Harris, Robert O. Messing. Apremilast regulates acute effects of ethanol and other GABAergic drugs via protein kinase A-dependent signaling. Neuropharmacology 2020, 178 , 108220. https://doi.org/10.1016/j.neuropharm.2020.108220
    40. Leonardo G. da Fonseca, Maria Reig, Jordi Bruix. Tyrosine Kinase Inhibitors and Hepatocellular Carcinoma. Clinics in Liver Disease 2020, 24 (4) , 719-737. https://doi.org/10.1016/j.cld.2020.07.012
    41. Lorenzo A. Pinna. IPK2019: David Shugar and the genesis of the IPK conferences. IUBMB Life 2020, 72 (6) , 1097-1102. https://doi.org/10.1002/iub.2245
    42. Boris Manoury, Sarah Idres, Véronique Leblais, Rodolphe Fischmeister. Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation. Pharmacology & Therapeutics 2020, 209 , 107499. https://doi.org/10.1016/j.pharmthera.2020.107499
    43. Athina Moschopoulou, Stefan Zwirner, Lars Zender, Daniel Dauch. Exploiting Kinase Inhibitors for Cancer Treatment: An Overview of Clinical Results and Outlook. 2020, 125-153. https://doi.org/10.1007/7355_2020_100
    44. Christopher M. Adams, Julien P. N. Papillon. Recent Developments for the Treatment of Glaucoma. 2020, 189-256. https://doi.org/10.1007/7355_2019_92
    45. Melanie H. Wong, Alexandra B. Samal, Mike Lee, Jiri Vlach, Nikolai Novikov, Anita Niedziela-Majka, Joy Y. Feng, Dmitry O. Koltun, Katherine M. Brendza, Hyock Joo Kwon, Brian E. Schultz, Roman Sakowicz, Jamil S. Saad, Giuseppe A. Papalia. The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM. Journal of Molecular Biology 2019, 431 (7) , 1440-1459. https://doi.org/10.1016/j.jmb.2019.02.001
    46. Khushwant S. Bhullar, Naiara Orrego Lagarón, Eileen M. McGowan, Indu Parmar, Amitabh Jha, Basil P. Hubbard, H. P. Vasantha Rupasinghe. Kinase-targeted cancer therapies: progress, challenges and future directions. Molecular Cancer 2018, 17 (1) https://doi.org/10.1186/s12943-018-0804-2
    47. Man Yu, Ting Liu, Yicheng Chen, Yafang Li, Wenhua Li. Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy. Journal of Experimental & Clinical Cancer Research 2018, 37 (1) https://doi.org/10.1186/s13046-018-0779-2
    48. Peng Wu, Amit Choudhary. Kinase Inhibitor Drugs. 2018, 65-93. https://doi.org/10.1002/9783527808694.ch3
    49. Ishan H. Raval, Arvind Kumar Singh Chandel. Enzymatic Research Having Pharmaceutical Significance. 2018, 141-158. https://doi.org/10.4018/978-1-5225-5237-6.ch007
    50. Toshihiro Inoue, Hidenobu Tanihara. Ripasudil hydrochloride hydrate: targeting Rho kinase in the treatment of glaucoma. Expert Opinion on Pharmacotherapy 2017, 18 (15) , 1669-1673. https://doi.org/10.1080/14656566.2017.1378344
    51. Mike Bührmann, Bianca M. Wiedemann, Matthias P. Müller, Julia Hardick, Maria Ecke, Daniel Rauh, . Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK. PLOS ONE 2017, 12 (9) , e0184627. https://doi.org/10.1371/journal.pone.0184627
    52. Mariángeles Clauzure, Ángel G. Valdivieso, María M. Massip-Copiz, Consuelo Mori, Andrea V. Dugour, Juan M. Figueroa, Tomás A. Santa-Coloma. Intracellular Chloride Concentration Changes Modulate IL-1β Expression and Secretion in Human Bronchial Epithelial Cultured Cells. Journal of Cellular Biochemistry 2017, 118 (8) , 2131-2140. https://doi.org/10.1002/jcb.25850
    53. Isabella Salzer, Fatma Asli Erdem, Wei‐Qiang Chen, Seok Heo, Xaver Koenig, Klaus W. Schicker, Helmut Kubista, Gert Lubec, Stefan Boehm, Jae‐Won Yang. Phosphorylation regulates the sensitivity of voltage‐gated Kv7.2 channels towards phosphatidylinositol‐4,5‐bisphosphate. The Journal of Physiology 2017, 595 (3) , 759-776. https://doi.org/10.1113/JP273274
    54. Daniel M. Czyż, Neeta Jain-Gupta, Howard A. Shuman, Sean Crosson. A dual-targeting approach to inhibit Brucella abortus replication in human cells. Scientific Reports 2016, 6 (1) https://doi.org/10.1038/srep35835
    55. Raymond M. Sturgeon, Neil S. Magoski. Diacylglycerol‐mediated regulation of Aplysia bag cell neuron excitability requires protein kinase C. The Journal of Physiology 2016, 594 (19) , 5573-5592. https://doi.org/10.1113/JP272152
    56. Alexander J. M. Disney, Barrie Kellam, Lodewijk V. Dekker. Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications. ChemMedChem 2016, 11 (9) , 972-979. https://doi.org/10.1002/cmdc.201500589
    57. Xiufen Liu, Fabian Müller, Alan S. Wayne, Ira Pastan. Protein Kinase Inhibitor H89 Enhances the Activity of Pseudomonas Exotoxin A–Based Immunotoxins. Molecular Cancer Therapeutics 2016, 15 (5) , 1053-1062. https://doi.org/10.1158/1535-7163.MCT-15-0828
    58. Valjean R. Bacot-Davis, Angelia V. Bassenden, Albert M. Berghuis. Drug-target networks in aminoglycoside resistance: hierarchy of priority in structural drug design. MedChemComm 2016, 7 (1) , 103-113. https://doi.org/10.1039/C5MD00384A
    59. Lisa M. Pham, Luis Carvalho, Scott Schaus, Eric D. Kolaczyk. Perturbation Detection Through Modeling of Gene Expression on a Latent Biological Pathway Network: A Bayesian Hierarchical Approach. Journal of the American Statistical Association 2016, 111 (513) , 73-92. https://doi.org/10.1080/01621459.2015.1110523
    60. Patricia Pablos, Aitziber Mendiguren, Joseba Pineda. Contribution of nitric oxide-dependent guanylate cyclase and reactive oxygen species signaling pathways to desensitization of μ-opioid receptors in the rat locus coeruleus. Neuropharmacology 2015, 99 , 422-431. https://doi.org/10.1016/j.neuropharm.2015.08.004
    61. Kelsey Barcomb, Dayton J. Goodell, Don B. Arnold, K. Ulrich Bayer. Live imaging of endogenous Ca 2+ /calmodulin-dependent protein kinase II in neurons reveals that ischemia-related aggregation does not require kinase activity. Journal of Neurochemistry 2015, 135 (4) , 666-673. https://doi.org/10.1111/jnc.13263
    62. Cheryl H Arrowsmith, James E Audia, Christopher Austin, Jonathan Baell, Jonathan Bennett, Julian Blagg, Chas Bountra, Paul E Brennan, Peter J Brown, Mark E Bunnage, Carolyn Buser-Doepner, Robert M Campbell, Adrian J Carter, Philip Cohen, Robert A Copeland, Ben Cravatt, Jayme L Dahlin, Dashyant Dhanak, Aled M Edwards, Mathias Frederiksen, Stephen V Frye, Nathanael Gray, Charles E Grimshaw, David Hepworth, Trevor Howe, Kilian V M Huber, Jian Jin, Stefan Knapp, Joanne D Kotz, Ryan G Kruger, Derek Lowe, Mary M Mader, Brian Marsden, Anke Mueller-Fahrnow, Susanne Müller, Ronan C O'Hagan, John P Overington, Dafydd R Owen, Saul H Rosenberg, Ruth Ross, Bryan Roth, Matthieu Schapira, Stuart L Schreiber, Brian Shoichet, Michael Sundström, Giulio Superti-Furga, Jack Taunton, Leticia Toledo-Sherman, Chris Walpole, Michael A Walters, Timothy M Willson, Paul Workman, Robert N Young, William J Zuercher. The promise and peril of chemical probes. Nature Chemical Biology 2015, 11 (8) , 536-541. https://doi.org/10.1038/nchembio.1867
    63. Doriano Fabbro, Sandra W Cowan‐Jacob, Henrik Moebitz. Ten things you should know about protein kinases: IUPHAR R eview 14. British Journal of Pharmacology 2015, 172 (11) , 2675-2700. https://doi.org/10.1111/bph.13096
    64. Stefan Gross, Rami Rahal, Nicolas Stransky, Christoph Lengauer, Klaus P. Hoeflich. Targeting cancer with kinase inhibitors. Journal of Clinical Investigation 2015, 125 (5) , 1780-1789. https://doi.org/10.1172/JCI76094
    65. Marion Cortier, Rahamata Boina-Ali, Cindy Racoeur, Catherine Paul, Eric Solary, Jean-François Jeannin, Ali Bettaieb. H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway. Oncotarget 2015, 6 (9) , 6877-6886. https://doi.org/10.18632/oncotarget.3124
    66. Valeria Capurro, Ambra Gianotti, Emanuela Caci, Roberto Ravazzolo, Luis J.V. Galietta, Olga Zegarra-Moran. Functional analysis of acid-activated Cl− channels: Properties and mechanisms of regulation. Biochimica et Biophysica Acta (BBA) - Biomembranes 2015, 1848 (1) , 105-114. https://doi.org/10.1016/j.bbamem.2014.10.008
    67. Juhyun Song, So Yeong Cheon, Won Taek Lee, Kyung Ah Park, Jong Eun Lee. PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury. Neural Plasticity 2015, 2015 , 1-13. https://doi.org/10.1155/2015/374520
    68. Eileen J. Kennedy, John D. Scott. Selective Disruption of the AKAP Signaling Complexes. 2015, 137-150. https://doi.org/10.1007/978-1-4939-2537-7_11
    69. Maté Biro, Marcia A Munoz, Wolfgang Weninger. Targeting R ho‐ GTP ases in immune cell migration and inflammation. British Journal of Pharmacology 2014, 171 (24) , 5491-5506. https://doi.org/10.1111/bph.12658
    70. Y. Yu, N.P. Boyer, C. Zhang. Three structurally similar odorants trigger distinct signaling pathways in a mouse olfactory neuron. Neuroscience 2014, 275 , 194-210. https://doi.org/10.1016/j.neuroscience.2014.05.063
    71. Tomoyuki Isobe, Ken Mizuno, Yoshio Kaneko, Masayuki Ohta, Takashi Koide, Sohei Tanabe. Effects of K-115, a Rho-Kinase Inhibitor, on Aqueous Humor Dynamics in Rabbits. Current Eye Research 2014, 39 (8) , 813-822. https://doi.org/10.3109/02713683.2013.874444
    72. Daniel G. Cordek, Tayler J. Croom-Perez, Jungwook Hwang, Michele R.S. Hargittai, Chennareddy V. Subba-Reddy, Qingxia Han, Maria Fernanda Lodeiro, Gang Ning, Thomas S. McCrory, Jamie J. Arnold, Hasan Koc, Brett D. Lindenbach, Scott A. Showalter, Craig E. Cameron. Expanding the Proteome of an RNA Virus by Phosphorylation of an Intrinsically Disordered Viral Protein. Journal of Biological Chemistry 2014, 289 (35) , 24397-24416. https://doi.org/10.1074/jbc.M114.589911
    73. Seyedeh Y. Seyedi, Forouz Salehi, Borna Payandemehr, Sara Hossein, Mahshid S. Hosseini‐Zare, Ehsan Nassireslami, Behnoosh B. Yazdi, Mohammad Sharifzadeh. Dual effect of cAMP agonist on ameliorative function of PKA inhibitor in morphine‐dependent mice. Fundamental & Clinical Pharmacology 2014, 28 (4) , 445-454. https://doi.org/10.1111/fcp.12045
    74. Anne Marie E. Smith, John D. Brennan. Simultaneous Inhibition Assay for Human and Microbial Kinases via MALDI‐MS/MS. ChemBioChem 2014, 15 (4) , 587-594. https://doi.org/10.1002/cbic.201300739
    75. Satoru Ito. Role of RhoA/Rho-kinase and Calcium Sensitivity in Airway Smooth Muscle Functions. 2014, 285-307. https://doi.org/10.1007/978-3-319-01312-1_15
    76. Kelsey Barcomb, Steven J. Coultrap, K. Ulrich Bayer. Enzymatic Activity of CaMKII Is Not Required for Its Interaction with the Glutamate Receptor Subunit GluN2B. Molecular Pharmacology 2013, 84 (6) , 834-843. https://doi.org/10.1124/mol.113.089045
    77. Liliana Moreira, Isabel Araújo, Tito Costa, Ana Correia-Branco, Ana Faria, Fátima Martel, Elisa Keating. Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism. Experimental Cell Research 2013, 319 (12) , 1784-1795. https://doi.org/10.1016/j.yexcr.2013.05.001
    78. Wouter G. van Doorn, Fisun G. Çelikel, Caroline Pak, Harmannus Harkema. Delay of Iris flower senescence by cytokinins and jasmonates. Physiologia Plantarum 2013, 148 (1) , 105-120. https://doi.org/10.1111/j.1399-3054.2012.01690.x
    79. S.L. Hyzy, R. Olivares-Navarrete, D.L. Hutton, C. Tan, B.D. Boyan, Z. Schwartz. Microstructured titanium regulates interleukin production by osteoblasts, an effect modulated by exogenous BMP-2. Acta Biomaterialia 2013, 9 (3) , 5821-5829. https://doi.org/10.1016/j.actbio.2012.10.030
    80. Loek T. M. van Wandelen, Jeroen van Ameijde, Ahmed S. A. Mady, Angelique E. M. Wammes, Alois Bode, Alex J. Poot, Rob Ruijtenbeek, Rob M. J. Liskamp. Directed Modulation of Protein Kinase C Isozyme Selectivity with Bisubstrate‐Based Inhibitors. ChemMedChem 2012, 7 (12) , 2113-2121. https://doi.org/10.1002/cmdc.201200349
    81. Laurie Ludgate, Xiaojun Ning, David H. Nguyen, Christina Adams, Laura Mentzer, Jianming Hu. Cyclin-Dependent Kinase 2 Phosphorylates S/T-P Sites in the Hepadnavirus Core Protein C-Terminal Domain and Is Incorporated into Viral Capsids. Journal of Virology 2012, 86 (22) , 12237-12250. https://doi.org/10.1128/JVI.01218-12
    82. Pedro Gonçalves, Telmo Catarino, Inês Gregório, Fátima Martel. Inhibition of butyrate uptake by the primary bile salt chenodeoxycholic acid in intestinal epithelial cells. Journal of Cellular Biochemistry 2012, 113 (9) , 2937-2947. https://doi.org/10.1002/jcb.24172
    83. Alexander Pflug, Kenneth A. Johnson, Richard A. Engh. Anomalous dispersion analysis of inhibitor flexibility: a case study of the kinase inhibitor H-89. Acta Crystallographica Section F Structural Biology and Crystallization Communications 2012, 68 (8) , 873-877. https://doi.org/10.1107/S1744309112028655
    84. Cristhiaan D. Ochoa, Mikhail Alexeyev, Viktoriya Pastukh, Ron Balczon, Troy Stevens. Pseudomonas aeruginosa Exotoxin Y Is a Promiscuous Cyclase That Increases Endothelial Tau Phosphorylation and Permeability. Journal of Biological Chemistry 2012, 287 (30) , 25407-25418. https://doi.org/10.1074/jbc.M111.301440
    85. M Althaus, KD Urness, WG Clauss, DL Baines, M Fronius. The gasotransmitter hydrogen sulphide decreases Na + transport across pulmonary epithelial cells. British Journal of Pharmacology 2012, 166 (6) , 1946-1963. https://doi.org/10.1111/j.1476-5381.2012.01909.x
    86. Darja Lavogina, Katrin Kalind, Jevgenia Bredihhina, Madis Hurt, Angela Vaasa, Marje Kasari, Erki Enkvist, Gerda Raidaru, Asko Uri. Conjugates of 5-isoquinolinesulfonylamides and oligo-d-arginine possess high affinity and selectivity towards Rho kinase (ROCK). Bioorganic & Medicinal Chemistry Letters 2012, 22 (10) , 3425-3430. https://doi.org/10.1016/j.bmcl.2012.03.101
    87. Carlos A. Jiménez‐Rivera, Johnny Figueroa, Rafael Vázquez‐Torres, María E. Vélez‐Hernandez, David Schwarz, María C. Velásquez‐Martinez, Francisco Arencibia‐Albite. Presynaptic inhibition of glutamate transmission by α2 receptors in the VTA. European Journal of Neuroscience 2012, 35 (9) , 1406-1415. https://doi.org/10.1111/j.1460-9568.2012.08029.x
    88. Yasuhiro Ishimaru, Shin Hamamoto, Nobuyuki Uozumi, Minoru Ueda. Regulatory Mechanism of Plant Nyctinastic Movement: An Ion Channel-Related Plant Behavior. 2012, 125-142. https://doi.org/10.1007/978-3-642-29110-4_5
    89. Kapil Bhalla, Celalettin Ustun, Warren Fiskus. Chronic Myeloid Leukemia. 2012, 277-314. https://doi.org/10.1007/978-94-007-5028-9_13
    90. Calvin K. Y. Chan, Judith Mak, Yuansheung Gao, Ricky Y. K. Man, Paul M. Vanhoutte. Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries. American Journal of Physiology-Heart and Circulatory Physiology 2011, 301 (6) , H2313-H2321. https://doi.org/10.1152/ajpheart.00258.2011
    91. Kenneth J Mandell, Matthew R Kudelka, Barbara Wirostko. Rho kinase inhibitors for treatment of glaucoma. Expert Review of Ophthalmology 2011, 6 (6) , 611-622. https://doi.org/10.1586/eop.11.65
    92. Mahshid Sadat Hosseini-Zare, Forouz Salehi, Seyedeh Yalda Seyedi, Kian Azami, Tahereh Ghadiri, Mohammad Mobasseri, Shervin Gholizadeh, Cordian Beyer, Mohammad Sharifzadeh. Effects of pentoxifylline and H-89 on epileptogenic activity of bucladesine in pentylenetetrazol-treated mice. European Journal of Pharmacology 2011, 670 (2-3) , 464-470. https://doi.org/10.1016/j.ejphar.2011.09.026
    93. Giri K Chandaka, Isabella Salzer, Helmut Drobny, Stefan Boehm, Klaus W Schicker. Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y1 receptors. British Journal of Pharmacology 2011, 164 (5) , 1522-1533. https://doi.org/10.1111/j.1476-5381.2011.01466.x
    94. Elizabeth R. Sharlow, Gabriela Mustata Wilson, David Close, Stephanie Leimgruber, Manuj Tandon, Robyn B. Reed, Tong Ying Shun, Q. Jane Wang, Peter Wipf, John S. Lazo, . Discovery of Diverse Small Molecule Chemotypes with Cell-Based PKD1 Inhibitory Activity. PLoS ONE 2011, 6 (10) , e25134. https://doi.org/10.1371/journal.pone.0025134
    95. Desiree H. Fong, Bing Xiong, Jiyoung Hwang, Albert M. Berghuis, . Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor. PLoS ONE 2011, 6 (5) , e19589. https://doi.org/10.1371/journal.pone.0019589
    96. Ken-Ichi Miyamoto, Kohsei Inoko, Kyoko Ikeda, Shinya Wakusawa, Shinji Kajita, Takaaki Hasegawa, Kenzo Takagi, Masao Koyama. Effect of Staurosporine Derivatives on Protein Kinase Activity and Vinblastine Accumulation in Mouse Leukaemia P388/ADR Cells. Journal of Pharmacy and Pharmacology 2011, 45 (1) , 43-47. https://doi.org/10.1111/j.2042-7158.1993.tb03677.x
    97. S Mudassar, K I Andrabi, M Khullar, N K Ganguly, B N S Walia. Effect of exogenous copper on lipid peroxidation in rat hepatocytes. Possible involvement of protein kinase C. Journal of Pharmacy and Pharmacology 2011, 44 (7) , 609-611. https://doi.org/10.1111/j.2042-7158.1992.tb05475.x
    98. Shigeo Nakamura, Shinya Wakusawa, Kazuo Tajima, Ken-Ichi Miyamoto, Masatoshi Hagiwara, Hiroyoshi Hidaka. Effects of Isoquinolinesulphonamide Compounds on Multidrug-resistant P388 Cells. Journal of Pharmacy and Pharmacology 2011, 45 (4) , 268-273. https://doi.org/10.1111/j.2042-7158.1993.tb05551.x
    99. Araceli Encabo, Mercedes Ferrer, Jesús Marín, Concepción Peiró, Juliana Redondo, Ma Rosa De Sagarrat, Gloria Balfagón. Phorbol Dibutyrate Induces Contractions in Bovine Cerebral Arteries by an Extracellular Calcium-independent Mechanism. Journal of Pharmacy and Pharmacology 2011, 45 (4) , 274-279. https://doi.org/10.1111/j.2042-7158.1993.tb05552.x
    100. Tsukasa Matsumoto, Haruki Yamada. Regulation of Immune Complexes Binding of Macrophages by Pectic Polysaccharide from Bupleurum falcatum L.: Pharmacological Evidence for the Requirement of Intracellular Calcium/Calmodulin on Fc Receptor Up-regulation by Bupleuran 2IIb. Journal of Pharmacy and Pharmacology 2011, 47 (2) , 152-156. https://doi.org/10.1111/j.2042-7158.1995.tb05769.x
    Load more citations

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect