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Kinetics of cytochrome P-450 reduction: evidence for faster reduction of the high-spin ferric state

Cite this: Biochemistry 1985, 24, 19, 5130–5136
Publication Date (Print):September 1, 1985
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    Cited By

    This article is cited by 40 publications.

    1. Donovan C. Haines, Amita Hegde, Baozhi Chen, Weiqiang Zhao, Muralidhar Bondlela, John M. Humphreys, David A. Mullin, Diana R. Tomchick, Mischa Machius, and Julian A. Peterson . A Single Active-Site Mutation of P450BM-3 Dramatically Enhances Substrate Binding and Rate of Product Formation. Biochemistry 2011, 50 (39) , 8333-8341.
    2. Abhishek Dey, Yonging Jiang, Paul Ortiz de Montellano, Keith O. Hodgson, Britt Hedman and Edward I. Solomon . S K-edge XAS and DFT Calculations on Cytochrome P450: Covalent and Ionic Contributions to the Cysteine-Fe Bond and Their Contribution to Reactivity. Journal of the American Chemical Society 2009, 131 (22) , 7869-7878.
    3. Sibylle Brenner,, Sam Hay,, Hazel M. Girvan,, Andrew W. Munro, and, Nigel S. Scrutton. Conformational Dynamics of the Cytochrome P450 BM3/N-Palmitoylglycine Complex:  The Proposed “Proximal−Distal” Transition Probed by Temperature-Jump Spectroscopy. The Journal of Physical Chemistry B 2007, 111 (27) , 7879-7886.
    4. F. Peter Guengerich, Clayton J. Wilkey, Thanh T.N. Phan. Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes. Journal of Biological Chemistry 2019, 294 (28) , 10928-10941.
    5. D. R. Davydov. Molecular organization of the microsomal oxidative system: a new connotation for an old term. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 2016, 10 (1) , 10-21.
    6. D.R. Davydov. Molecular organization of the microsomal oxidative system: a new connotation for an old term. Biomeditsinskaya Khimiya 2015, 61 (2) , 176-187.
    7. Dmitri R. Davydov, Nadezhda Y. Davydova, Elena V. Sineva, James R. Halpert. Interactions among Cytochromes P450 in Microsomal Membranes. Journal of Biological Chemistry 2015, 290 (6) , 3850-3864.
    8. Ilia G. Denisov, Stephen G. Sligar. Activation of Molecular Oxygen in Cytochromes P450. 2015, 69-109.
    9. Dmitri R. Davydov, Elena V. Sineva, Nadezhda Y. Davydova, Douglas H. Bartlett, James R. Halpert. CYP261 enzymes from deep sea bacteria: A clue to conformational heterogeneity in cytochromes P450. Biotechnology and Applied Biochemistry 2013, 60 (1) , 30-40.
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    11. Harshica Fernando, Jessica A. O. Rumfeldt, Nadezhda Y. Davydova, James R. Halpert, Dmitri R. Davydov. Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity. Xenobiotica 2011, 41 (4) , 281-289.
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    13. Dmitri R. Davydov, Elena V. Sineva, Srinivas Sistla, Nadezhda Y. Davydova, Daniel J. Frank, Stephen G. Sligar, James R. Halpert. Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: The effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium. Biochimica et Biophysica Acta (BBA) - Bioenergetics 2010, 1797 (3) , 378-390.
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    15. Harshica Fernando, James R. Halpert, Dmitri R. Davydov. Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein. Archives of Biochemistry and Biophysics 2008, 471 (1) , 20-31.
    16. Lian Wei, Charles W. Locuson, Timothy S. Tracy. Polymorphic Variants of CYP2C9: Mechanisms Involved in Reduced Catalytic Activity. Molecular Pharmacology 2007, 72 (5) , 1280-1288.
    17. James R Reed, Paul F Hollenberg. New perspectives on the conformational equilibrium regulating multi-phasic reduction of cytochrome P450 2B4 by cytochrome P450 reductase. Journal of Inorganic Biochemistry 2003, 97 (3) , 276-286.
    18. Peter Hlavica, David F. V. Lewis. Allosteric phenomena in cytochrome P450‐catalyzed monooxygenations. European Journal of Biochemistry 2001, 268 (18) , 4817-4832.
    19. John D. Lipscomb, Sang‐Kyu Lee, Jeremy C. Nesheim, Yi Jin, Bradley J. Wallar, Xiao‐Yun Zhang. Intermediates in the reaction cycle of methane monooxygenase: structure and chemistry. 1999, 323-339.
    20. Yuri D. Ivanov, Irina P. Kanaeva, Vadim Yu. Kuznetsov, Michael Lehnerer, Johannes Schulze, Peter Hlavica, Alexander I. Archakov. The Optical Biosensor Studies on the Role of Hydrophobic Tails of NADPH-Cytochrome P450 Reductase and Cytochromes P450 2B4 and b5 upon Productive Complex Formation within a Monomeric Reconstituted System. Archives of Biochemistry and Biophysics 1999, 362 (1) , 87-93.
    21. Alexander I. Archakov, Yuri D. Ivanov. The Optical Biosensor Study of Protein-Protein Interactions within Cytochromes P450 Containing Monooxygenase Systems. 1998, 173-194.
    22. John B. Schenkman, Ingela Jansson. Introduction to Cytochrome P450. 1995, 1-19.
    23. R. Bernhardt. Cytochrome P450: Structure, function, and generation of reactive oxygen species. 1995, 137-221.
    24. Arnold R. Goeptar, Heleen Scheerens, Nico P. E. Vermeulen. Oxygen and Xenobiotic Reductase Activities of Cytochrome P450. Critical Reviews in Toxicology 1995, 25 (1) , 25-65.
    25. A.I. Voznesensky, J.B. Schenkman. Quantitative analyses of electrostatic interactions between NADPH-cytochrome P450 reductase and cytochrome P450 enzymes.. Journal of Biological Chemistry 1994, 269 (22) , 15724-15731.
    26. H. Rein, C. Jung. Metabolic Reactions: Mechanisms of Substrate Oxygenation. 1993, 105-122.
    27. Shakunthala Narasimhulu. On the Model Controversy for Substrate-Induced Spin-State Transition in Cytochrome P450: (A New Perspective). Endocrine Research 1993, 19 (4) , 223-258.
    28. Dmitri R. Davydov, Tatyana V. Knyushko, Gaston Hui Bon Hoa. High pressure induced inactivation of ferrous cytochrome P-450 LM2 (11B4) CO complex: Evidence for the presence of two conformers in the oligomer. Biochemical and Biophysical Research Communications 1992, 188 (1) , 216-221.
    29. Paavo Honkakoski, Annika Linnala-Kankkunen, Sergei A. Usanov, Matti A. Lang. Highly homologous cytochromes P-450 and b5: a model to study protein-protein interactions in a reconstituted monooxygenase system. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1992, 1122 (1) , 6-14.
    30. Charles S. Eyer, Wayne L. Backes. Relationship between the rate of reductase-cytochrome P450 complex formation and the rate of first electron transfer. Archives of Biochemistry and Biophysics 1992, 293 (2) , 231-240.
    31. Yoshiaki Omata, Fred K. Friedman. A fluorescence study the interactions of benzo[a]pyrene, cytochrome P450c and NADPH-cytochrome P450 reductase. Biochemical Pharmacology 1991, 42 (1) , 97-101.
    32. John B. Schenkman. Functional Aspects of Protein-Protein Interactions of Cytochrome P450 Cytochrome b5 and Cytochrome P450 Reductase. 1991, 185-198.
    33. Ronald E. White. The involvement of free radicals in the mechanisms of monooxygenases. Pharmacology & Therapeutics 1991, 49 (1-2) , 21-42.
    34. Duane L. Crankshaw, Richard R. Erickson, Jordan L. Holtzman. Effect of phenobarbital induction, charcoal treatment and storage on the spectral binding characteristics and NADPH-cytochrome P-450 reductase activity of hepatic microsomes. Biochemical Pharmacology 1990, 39 (2) , 393-396.
    35. W L Backes, C S Eyer. Cytochrome P-450 LM2 Reduction. Journal of Biological Chemistry 1989, 264 (11) , 6252-6259.
    36. W L Backes, C E Reker-Backes. The effect of NADPH concentration on the reduction of cytochrome P-450 LM2.. Journal of Biological Chemistry 1988, 263 (1) , 247-253.
    37. O. Bangcharoenpaurpong, P. M. Champion, Susan A. Martinis, Stephen G. Sligar. Investigations of the resonance Raman excitation profiles of cytochrome P 450cam. The Journal of Chemical Physics 1987, 87 (8) , 4273-4284.
    38. A Parkinson, P E Thomas, D E Ryan, L D Gorsky, J E Shively, J M Sayer, D M Jerina, W Levin. Mechanism of inactivation of rat liver microsomal cytochrome P-450c by 2-bromo-4'-nitroacetophenone.. Journal of Biological Chemistry 1986, 261 (25) , 11487-11495.
    39. Stephen L. Mayo, Walther R. Ellis, Robert J. Crutchley, Harry B. Gray. Long-Range Electron Transfer in Heme Proteins. Science 1986, 233 (4767) , 948-952.
    40. Ronald E. White, Mary-Beth McCarthy. Active site mechanics of liver microsomal cytochrome P-450. Archives of Biochemistry and Biophysics 1986, 246 (1) , 19-32.

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