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Mechanism of inactivation of human leukocyte elastase by a chloromethyl ketone: kinetic and solvent isotope effect studies

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Download Hi-Res ImageDownload to MS-PowerPointCite This:Biochemistry 1986, 25, 19, 5414-5419
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    Mechanism of inactivation of human leukocyte elastase by a chloromethyl ketone: kinetic and solvent isotope effect studies
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    Biochemistry

    Cite this: Biochemistry 1986, 25, 19, 5414–5419
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    https://doi.org/10.1021/bi00367a011
    Published September 23, 1986
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    19. Haridas Rode, Stefanie Koerbe, Anita Besch, Karen Methling, Jutta Loose, Hans-Hartwig Otto. Synthesis and in vitro evaluation of pseudosaccharinamine derivatives as potential elastase inhibitors. Bioorganic & Medicinal Chemistry 2006, 14 (8) , 2789-2798. https://doi.org/10.1016/j.bmc.2005.11.057
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    26. Dexter B. Northrop. Uses of Isotope Effects in the Study of Enzymes. Methods 2001, 24 (2) , 117-124. https://doi.org/10.1006/meth.2001.1173
    27. Dexter B. Northrop, Yong-Kweon Cho. Effects of High Pressure on Solvent Isotope Effects of Yeast Alcohol Dehydrogenase. Biophysical Journal 2000, 79 (3) , 1621-1628. https://doi.org/10.1016/S0006-3495(00)76412-5
    28. J. VINCENT EDWARDS, ALVIN F BOPP, SARAH BATISTE, ABUL J ULLAH, I. KELMAN COHEN, ROBERT F DIEGELMANN, STEVEN J MONTANTE. Inhibition of elastase by a synthetic cotton‐bound serine protease inhibitor: in vitro kinetics and inhibitor release. Wound Repair and Regeneration 1999, 7 (2) , 106-118. https://doi.org/10.1046/j.1524-475X.1999.00106.x
    29. Carlton C. Barnett, Ernest E. Moore, Gary W. Mierau, David A. Partrick, Walter L. Biffl, David J. Elzi, Christopher C. Silliman. ICAM-1-CD18 interaction mediates neutrophil cytotoxicity through protease release. American Journal of Physiology-Cell Physiology 1998, 274 (6) , C1634-C1644. https://doi.org/10.1152/ajpcell.1998.274.6.C1634
    30. Tsuyoshi Ohba, Jun Wakayama, Eitatsu Ikeda, Hisashi Takei. Studies on irreversible inhibition of serine proteases by α-sulfonyloxyketone derivatives. Bioorganic & Medicinal Chemistry Letters 1996, 6 (10) , 1127-1132. https://doi.org/10.1016/0960-894X(96)00178-3
    31. Krzysztof Rakowski, Piotr Paneth. Isotope effects on binding. Journal of Molecular Structure 1996, 378 (1) , 35-43. https://doi.org/10.1016/0022-2860(95)09146-7
    32. Hans Früh, Georgios Kostoulas, Beat A. Michel, Antonio Baici. Human Myeloblastin (Leukocyte Proteinase 3): Reactions with Substrates, Inactivators and Activators in Comparison with Leukocyte Elastase. Biological Chemistry Hoppe-Seyler 1996, 377 (9) , 579-586. https://doi.org/10.1515/bchm3.1996.377.9.579
    33. Peter J. Lenting, Hans ter Maat, Patrick P.F.M. Clijsters, Marie-José S.H. Donath, Jan A. van Mourik, Koen Mertens. Cleavage at Arginine 145 in Human Blood Coagulation Factor IX Converts the Zymogen into a Factor VIII Binding Enzyme. Journal of Biological Chemistry 1995, 270 (25) , 14884-14890. https://doi.org/10.1074/jbc.270.25.14884
    34. Philip D. Edwards, Peter R. Bernstein. Synthetic Inhibitors of Elastase. Medicinal Research Reviews 1994, 14 (2) , 127-194. https://doi.org/10.1002/med.2610140202
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    37. B.G. Green, H. Weston, B.M. Ashe, J. Doherty, P. Finke, W. Hagmann, M. Lark, J. Mao, A. Maycock, V. Moore, R. Mumford, S. Shah, L. Walakovits, W.B. Knight. PMN elastases: A comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors. Archives of Biochemistry and Biophysics 1991, 286 (1) , 284-292. https://doi.org/10.1016/0003-9861(91)90042-H
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    42. R. J. Bonney, B. Ashe, A. Maycock, P. Dellea, K. Hand, D. Osinga, D. Fletcher, R. Mumford, P. Davies, D. Frankenfield, T. Nolan, L. Schaeffer, W. Hagmann, P. Finke, S. Shah, C. Dorn, J. Doherty. Pharmacological profile of the substituted beta‐lactam L‐659,286: A member of a new class of human PMN elastase inhibitors. Journal of Cellular Biochemistry 1989, 39 (1) , 47-53. https://doi.org/10.1002/jcb.240390106
    43. Wei An-Zhi, Irmgard Mayr, Wolfram Bode. The refined 2.3 Å crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor. FEBS Letters 1988, 234 (2) , 367-373. https://doi.org/10.1016/0014-5793(88)80118-2
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    47. Richard B. Silverman. The Potential Use of Mechanism-Based Enzyme Inactivators in Medicine. Journal of Enzyme Inhibition 1988, 2 (2) , 73-90. https://doi.org/10.3109/14756368809040714
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    Biochemistry

    Cite this: Biochemistry 1986, 25, 19, 5414–5419
    Click to copy citationCitation copied!
    https://doi.org/10.1021/bi00367a011
    Published September 23, 1986
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