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X-ray diffraction analysis of the inactivation of chymotrypsin by 3-benzyl-6-chloro-2-pyrone

Cite this: Biochemistry 1986, 25, 19, 5633–5638
Publication Date (Print):September 23, 1986
https://doi.org/10.1021/bi00367a043
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    Cited By

    This article is cited by 20 publications.

    1. Omri Segev,, Ishay Columbus,, Yacov Ashani, and, Yoram Cohen. Probing the Molecular Interaction of Chymotrypsin with Organophosphorus Compounds by 31P Diffusion NMR in Aqueous Solutions. The Journal of Organic Chemistry 2005, 70 (1) , 309-314. https://doi.org/10.1021/jo0485942
    2. In Taek Lim,, Samy O. Meroueh,, Mijoon Lee,, Mary Jane Heeg, and, Shahriar Mobashery. Strategy in Inhibition of Cathepsin B, A Target in Tumor Invasion and Metastasis. Journal of the American Chemical Society 2004, 126 (33) , 10271-10277. https://doi.org/10.1021/ja0489240
    3. Lizbeth Hedstrom. Serine Protease Mechanism and Specificity. Chemical Reviews 2002, 102 (12) , 4501-4524. https://doi.org/10.1021/cr000033x
    4. Lorraine M. Deck,, Miranda L. Baca,, Stephanie L. Salas,, Lucy A. Hunsaker, and, David L. Vander Jagt. 3-Alkyl-6-Chloro-2-pyrones:  Selective Inhibitors of Pancreatic Cholesterol Esterase. Journal of Medicinal Chemistry 1999, 42 (20) , 4250-4256. https://doi.org/10.1021/jm990309x
    5. Wei Huang, David M Booth, Matthew C Cane, Michael Chvanov, Muhammad A Javed, Victoria L Elliott, Jane A Armstrong, Hayley Dingsdale, Nicole Cash, Yan Li, William Greenhalf, Rajarshi Mukherjee, Bhupendra S Kaphalia, Mohammed Jaffar, Ole H Petersen, Alexei V Tepikin, Robert Sutton, David N Criddle. Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca 2+ -dependent mitochondrial dysfunction and acute pancreatitis. Gut 2014, 63 (8) , 1313-1324. https://doi.org/10.1136/gutjnl-2012-304058
    6. Can E. Ergenekan, Ming‐Liang Tan, Toshiko Ichiye. Effects of environment on the structure of Pyrococcus furiosus rubredoxin: A molecular dynamics study. Proteins: Structure, Function, and Bioinformatics 2005, 61 (4) , 823-828. https://doi.org/10.1002/prot.20685
    7. Mary Stoddard Hatch, William M Brown, Jason A Deck, Lucy A Hunsaker, Lorraine M Deck, David L Vander Jagt. Inhibition of yeast lipase (CRL1) and cholesterol esterase (CRL3) by 6-chloro-2-pyrones: comparison with porcine cholesterol esterase. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 2002, 1596 (2) , 381-391. https://doi.org/10.1016/S0167-4838(01)00304-1
    8. Usman Ghani, Kenneth K.S Ng, Atta-ur-Rahman, M.Iqbal Choudhary, Nisar Ullah, Michael N.G James. Crystal structure of γ-chymotrypsin in complex with 7-hydroxycoumarin 1 1Edited by I. A. Wilson. Journal of Molecular Biology 2001, 314 (3) , 519-525. https://doi.org/10.1006/jmbi.2001.5148
    9. Marina Gorrini, Anna Lupi, Simona Viglio, Franco Pamparana, Giuseppe Cetta, Paolo Iadarola, James C. Powers, Maurizio Luisetti. Inhibition of Human Neutrophil Elastase by Erythromycin and Flurythromycin, Two Macrolide Antibiotics. American Journal of Respiratory Cell and Molecular Biology 2001, 25 (4) , 492-499. https://doi.org/10.1165/ajrcmb.25.4.4552
    10. F. Björkling, A. Dahl, S. Patkar, M. Zundel. Inhibition of lipases by phosphonates. Bioorganic & Medicinal Chemistry 1994, 2 (7) , 697-705. https://doi.org/10.1016/0968-0896(94)85020-8
    11. Setsuko Nakagawa, Hsiang‐Ai Yu, Martin Karplus, Hideaki Urneyama. Active site dynamics of acyl‐chymotrypsin. Proteins: Structure, Function, and Bioinformatics 1993, 16 (2) , 172-194. https://doi.org/10.1002/prot.340160205
    12. R.F. Pratt. On the definition and classification of mechanism-based Enzyme Inhibitors. Bioorganic & Medicinal Chemistry Letters 1992, 2 (11) , 1323-1326. https://doi.org/10.1016/S0960-894X(00)80506-5
    13. . Can Laue catch Maxwell?: observation of short-lived species by Laue X-ray crystallography. Philosophical Transactions of the Royal Society of London. Series A: Physical and Engineering Sciences 1992, 273-284. https://doi.org/10.1098/rsta.1992.0066
    14. Dagmar Ringe, Gregory A. Petsko. Molecular metamorphosis. Nature 1991, 354 (6348) , 22-23. https://doi.org/10.1038/354022d0
    15. M. Harel, C.-T. Su, F. Frolow, Y. Ashani, I. Silman, J.L. Sussman. Refined crystal structures of “aged” and “non-aged” organophosphoryl conjugates of γ-chymotrypsin. Journal of Molecular Biology 1991, 221 (3) , 909-918. https://doi.org/10.1016/0022-2836(91)80183-U
    16. P E Reed, J A Katzenellenbogen. Proline-valine pseudo peptide enol lactones. Effective and selective inhibitors of chymotrypsin and human leukocyte elastase.. Journal of Biological Chemistry 1991, 266 (1) , 13-21. https://doi.org/10.1016/S0021-9258(18)52394-2
    17. Mark A. Ator, Paul R. Ortiz de Montellano. 5 Mechanism-Based (Suicide) Enzyme Inactivation. 1990, 213-282. https://doi.org/10.1016/S1874-6047(08)60198-5
    18. Hans-Ulrich Demuth. Recent Developments in Inhibiting Cysteine and Serine Proteases. Journal of Enzyme Inhibition 1990, 3 (4) , 249-278. https://doi.org/10.3109/14756369009030375
    19. R. Radhakrishnan, L.G. Presta, E.F. Meyer, Richard Wildonger. Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors. Journal of Molecular Biology 1987, 198 (3) , 417-424. https://doi.org/10.1016/0022-2836(87)90291-9
    20. Mary J. Bossard, Mark A. Levy, Ruth J. Mayer, Thomas D. Meek. Tenth Enzyme Mechanisms Conference. Bioorganic Chemistry 1987, 15 (3) , 303-327. https://doi.org/10.1016/0045-2068(87)90027-7