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Properties of hydroxylase systems in the human fetal liver active on free and sulfoconjugated steroids

Cite this: Biochemistry 1975, 14, 2, 429–437
Publication Date (Print):January 28, 1975
https://doi.org/10.1021/bi00673a033
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    Cited By

    This article is cited by 38 publications.

    1. Sofia Christakoudi, David A. Cowan, Norman F. Taylor. Steroids excreted in urine by neonates with 21-hydroxylase deficiency. 3. Characterization, using GC–MS and GC–MS/MS, of androstanes and androstenes. Steroids 2012, 77 (13) , 1487-1501. https://doi.org/10.1016/j.steroids.2012.08.012
    2. M. HILL, A. PAŘÍZEK, R. KANCHEVA, J. E. JIRÁSEK. Reduced Progesterone Metabolites in Human Late Pregnancy. Physiological Research 2011, , 225-241. https://doi.org/10.33549/physiolres.932077
    3. Martin Hill, Antonín Pařízek, David Cibula, Radmila Kancheva, Jan Evangelista Jirásek, Marie Jirkovská, Marta Velíková, Jana Kubátová, Michaela Klímková, Andrea Pašková, Zdeněk Žižka, Lyudmila Kancheva, Hana Kazihnitková, Ludmila Zamrazilová, Luboslav Stárka. Steroid metabolome in fetal and maternal body fluids in human late pregnancy. The Journal of Steroid Biochemistry and Molecular Biology 2010, 122 (4) , 114-132. https://doi.org/10.1016/j.jsbmb.2010.05.007
    4. Brian W. Ogilvie, Donglu Zhang, Wenying Li, A. David Rodrigues, Amy E. Gipson, Jeff Holsapple, Paul Toren, Andrew Parkinson. GLUCURONIDATION CONVERTS GEMFIBROZIL TO A POTENT, METABOLISM-DEPENDENT INHIBITOR OF CYP2C8: IMPLICATIONS FOR DRUG-DRUG INTERACTIONS. Drug Metabolism and Disposition 2006, 34 (1) , 191-197. https://doi.org/10.1124/dmd.105.007633
    5. Joel A. Krauser, Markus Voehler, Li‐Hong Tseng, Alexandre B. Schefer, Markus Godejohann, F. Peter Guengerich. Testosterone 1β‐hydroxylation by human cytochrome P450 3A4. European Journal of Biochemistry 2004, 271 (19) , 3962-3969. https://doi.org/10.1111/j.1432-1033.2004.04339.x
    6. R. MORFIN, P. LAFAYE, A. C. COTILLON, F. NATO, V. CHMIELEWSKI, D. POMPON. 7α‐Hydroxy‐Dehydroepiandrosterone and Immune Response. Annals of the New York Academy of Sciences 2000, 917 (1) , 971-982. https://doi.org/10.1111/j.1749-6632.2000.tb05464.x
    7. Pierre Lafaye, Valérie Chmielewski, Farida Nato, Jean-Claude Mazié, Robert Morfin. The 7α-hydroxysteroids produced in human tonsils enhance the immune response to tetanus toxoid and Bordetella pertussis antigens. Biochimica et Biophysica Acta (BBA) - General Subjects 1999, 1472 (1-2) , 222-231. https://doi.org/10.1016/S0304-4165(99)00124-5
    8. J.-L.J. Gachancard-Bouya, R.-J. Bègue. Urinary steroids from a newborn human infant. Identification of 2α-hydroxy-4-pregnene-3,20-dione, 3β,15β-dihydroxy-5-pregnen-20-one and 3β,15α-dihydroxy-5-pregnen-20-one. The Journal of Steroid Biochemistry and Molecular Biology 1994, 49 (2-3) , 213-226. https://doi.org/10.1016/0960-0760(94)90013-2
    9. Mitsukazu Kitada, Tetsuya Kamataki. Cytochrome P450 in Human Fetal Liver: Significance and Fetal-Specific Expresson. Drug Metabolism Reviews 1994, 26 (1-2) , 305-323. https://doi.org/10.3109/03602539409029800
    10. Robert Masse, Danielle Goudreault. Studies on anabolic steroids—11. 18-hydroxylated metabolites of mesterolone, methenolone and stenbolone: New steroids isolated from human urine. The Journal of Steroid Biochemistry and Molecular Biology 1992, 42 (3-4) , 399-410. https://doi.org/10.1016/0960-0760(92)90145-9
    11. R.A. Anderson, T.A. Baillie, M. Axelson, T. Cronholm, K. Sjövall, J. Sjövall. Stable isotope studies on steroid metabolism and kinetics: sulfates of 3α-hydroxy-5α-pregnane derivatives in human pregnancy. Steroids 1990, 55 (10) , 443-457. https://doi.org/10.1016/0039-128X(90)90013-2
    12. J Gustafsson. Bile acid biosynthesis during development: hydroxylation of C27-sterols in human fetal liver.. Journal of Lipid Research 1988, 27 (8) , 801-806. https://doi.org/10.1016/S0022-2275(20)38786-1
    13. G T Emmons, J St Pyrek, R Dam, M Martin, K Kudo, G J Schroepfer. 5 alpha-cholest-8(14)-en-3 beta-ol-15-one, a potent regulator of cholesterol metabolism: occurrence in rat skin.. Journal of Lipid Research 1988, 29 (8) , 1039-1054. https://doi.org/10.1016/S0022-2275(20)38468-6
    14. M Kitada, T Kamataki, K Itahashi, T Rikihisa, Y Kanakubo. P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate.. Journal of Biological Chemistry 1987, 262 (28) , 13534-13537. https://doi.org/10.1016/S0021-9258(19)76460-6
    15. Cedric H.L. Shackleton, Janos Homoki, Norman F. Taylor. A paradox: Elevated 21-hydroxypregnenolone production in newborns with 21-hydroxylase deficiency. Steroids 1987, 49 (4-5) , 295-311. https://doi.org/10.1016/0039-128X(87)90006-7
    16. Mitsukazu Kitada, Tetsuya Kamataki, Koshiro Itahashi, Tadaaki Rikihisa, Yoshio Kanakubo. Significance of cytochrome P-450 (P-450 HFLa) of human fetal livers in the steroid and drug oxidations. Biochemical Pharmacology 1987, 36 (4) , 453-456. https://doi.org/10.1016/0006-2952(87)90350-9
    17. R. Cantineau, P. Kremers, J. De Graeve, J.E. Gielen, R. Lambotte. 15- and 16-hydroxylations of androgens and estrogens in the human fetal liver: A critical step in estetrol biosynthesis. Journal of Steroid Biochemistry 1985, 22 (2) , 195-201. https://doi.org/10.1016/0022-4731(85)90112-8
    18. Agneta Blanck, Anders Rane, Rune Toftgård, Jan-Åke Gustafsson. Biotransformation of benzo[a]pyrene and 7-ethoxyresorufin and heme-staining proteins in microsomes from human fetal liver and placenta. Biochemical Pharmacology 1983, 32 (10) , 1547-1552. https://doi.org/10.1016/0006-2952(83)90325-8
    19. K Carlström, D N Kirk, J Sjövall. Microbial synthesis of 1 beta- and 15 beta-hydroxylated bile acids.. Journal of Lipid Research 1981, 22 (8) , 1225-1234. https://doi.org/10.1016/S0022-2275(20)37315-6
    20. Gerard J. Mulder, Ina C. M. Halsema, Henk Koster, John H. N. Meerman, K. Sandy Pang. Selective Inhibition of Sulfation in Vivo. 1981, 86-97. https://doi.org/10.1007/978-1-349-06118-1_7
    21. T.A. Baillie, T. Curstedt, K. Sjövall, J. Sjövall. Production rates and metabolism of sulphates of 3β-hydroxy-5α-pregnane derivatives in pregnant women. Journal of Steroid Biochemistry 1980, 13 (12) , 1473-1486. https://doi.org/10.1016/0022-4731(80)90062-X
    22. Olavi Pelkonen. Biotransformation of xenobiotics in the fetus. Pharmacology & Therapeutics 1980, 10 (2) , 261-281. https://doi.org/10.1016/0163-7258(80)90083-2
    23. R.J. Begue, M. Moriniere, P. Padieu. Urinary excretion of 5β-pregnane-3α,6α,20α-triol in human gestation. Journal of Steroid Biochemistry 1978, 9 (8) , 779-784. https://doi.org/10.1016/0022-4731(78)90200-5
    24. Y. Sorgue, L. Miravet. Chromatographic separation of vitamin D3 sulfate and vitamin D3. Steroids 1978, 31 (5) , 653-660. https://doi.org/10.1016/S0039-128X(78)80005-1
    25. Matsui Michio, Hakozaki Misako. Disulphates of 16-oxygenated ketonic c19 steroids as biliary metabolites of androsterone sulphate in female rats. Steroids 1978, 31 (2) , 219-226. https://doi.org/10.1016/0039-128X(78)90114-9
    26. T. A. Baillie, R. A. Anderson, M. Axelson, K. Sjövall, J. Sjövall. Pathways of steroid metabolism in vivo studied by deuterium labeling techniques. 1978, 177-188. https://doi.org/10.1007/978-1-349-03328-7_16
    27. Jan-Åke Gustafsson. [40] Steroid hydroxylations catalyzed by cytochrome P-450. 1978, 377-388. https://doi.org/10.1016/S0076-6879(78)52042-9
    28. N. F. Taylor, C. H. L. Shackleton. 15α-Hydroxyoestriol and other Polar Oestrogens in Pregnancy Monitoring. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 1978, 15 (1-6) , 1-11. https://doi.org/10.1177/000456327801500101
    29. Olavi Pelkonen. Differential Inhibition of Aryl Hydrocarbon Hydroxylase in Human Foetal Liver, Adrenal Gland and Placenta*. Acta Pharmacologica et Toxicologica 1977, 41 (4) , 306-316. https://doi.org/10.1111/j.1600-0773.1977.tb02670.x
    30. J. Montelius, J.-Å. Gustafsson, M. Ingelman-Sundberg, J. Rydström. Binding and hydroxylation of sulfoconjugated steroids in adrenal cortex mitochondria. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1977, 488 (3) , 502-511. https://doi.org/10.1016/0005-2760(77)90208-9
    31. P.R.C. Harvey, R. Hobkirk. The metabolism of estrone and estradiol-17β and their 3-sulfates by female guinea pig liver microsomes. Steroids 1977, 30 (1) , 115-128. https://doi.org/10.1016/0039-128X(77)90142-8
    32. Anders Berg, Kjell Carlström, Magnus Ingelman-Sundberg, Joseph Rafter, Jan-Åke Gustafsson. STUDIES ON A CYTOCHROME P-450-DEPENDENT HYDROXYLASE SYSTEM ACTIVE ON STEROIDS IN Bacillus megaterium. 1977, 377-384. https://doi.org/10.1016/B978-0-08-021523-5.50054-7
    33. JOHN B. WATKINS, JAY A. PERMAN. Bile Acid Metabolism in Infants and Children. Clinics in Gastroenterology 1977, 6 (1) , 201-218. https://doi.org/10.1016/S0300-5089(21)00393-X
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    36. T.A. Baillie, R.A. Anderson, K. Sjövall, J. Sjövall. Identification and quantitation of 16α-hydroxy c21 steroid sulphates in plasma from pregnant women. Journal of Steroid Biochemistry 1976, 7 (3) , 203-209. https://doi.org/10.1016/0022-4731(76)90203-X
    37. Thomas A. Baillie, Jan Sjövall, Kerstin Sjövall. Origin of 5α‐pregnane‐3α,20α,21‐triol 3‐sulphate in pregnant women. FEBS Letters 1975, 60 (1) , 145-148. https://doi.org/10.1016/0014-5793(75)80438-8
    38. Thomas A. Baillie, Håkan Eriksson. Role of the site of sulpho‐conjugation on the formation of hydroxylated corticosterone metabolites in the rat. FEBS Letters 1975, 58 (1-2) , 170-174. https://doi.org/10.1016/0014-5793(75)80251-1