Possible Inhibition of Atherosclerosis by a Flavonoid Isolated from Young Green Barley Leaves
- Takashi MiyakeTakashi MiyakeDepartment of Environmental Toxicology, University of California, Davis, CA 95616More by Takashi Miyake
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- Yashihide HagiwaraYashihide HagiwaraDepartment of Environmental Toxicology, University of California, Davis, CA 95616More by Yashihide Hagiwara
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- Hideaki HagiwaraHideaki HagiwaraHagiwara Institute of Health, 1173 Maruyama, Asazuma-cho, Kasai 679-01, JapanMore by Hideaki Hagiwara
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- Takayuki ShibamotoTakayuki ShibamotoDepartment of Environmental Toxicology, University of California, Davis, CA 95616More by Takayuki Shibamoto
Abstract
Young green barley leaves are known to possess potent pharmacological properties, including antioxidative, anti-inflammatory, antimutagenic, and antiallergic activities. In particular, an flavonoid, 2"-O-glycosylisovitexin (2"-O-GIV), isolated from an ethanol extract of young green barley leaves, possesses a strong inhibitory effect toward lipid peroxidation. 2"-O-GIV inhibited acetaldehyde formation from LDL by 76% at a level of 1 µmol/50 µg, whereas ferulic acid inhibited by 66% at the same level. In a case of a blood plasma system, 2"-O-GIV and probucol inhibited acetaldehyde formation by 89% and 94%, respectively, at a level of 3 µmol. 2"-O-GIV and vitamin C inhibited MDA formation by 54% and 32%, respectively, at a level of 0.1 µmol. A synergetic effect between 2"-O-GIV and vitamin C was observed.