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Binding Forces Associated with Staphylococcus aureus Biofilms on Medical Implants

  • Ruchirej Yongsunthon
    Ruchirej Yongsunthon
    The Ohio State University, 125 South Oval Mall, 275 Mendenhall Laboratory, Columbus, OH 43210
  • Vance G. Fowler, Jr.
    Vance G. Fowler, Jr.
    Duke University Medical Center, Box 3824, Durham, NC 27710
  • , and 
  • Steven K. Lower
    Steven K. Lower
    The Ohio State University, 125 South Oval Mall, 275 Mendenhall Laboratory, Columbus, OH 43210
DOI: 10.1021/bk-2008-0984.ch011
    Publication Date (Print):May 30, 2008
    Copyright © 2008 American Chemical Society.
    Microbial Surfaces
    Chapter 11pp 189-197
    ACS Symposium SeriesVol. 984
    ISBN13: 9780841274303eISBN: 9780841221277

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    Abstract

    Staphylococcus aureus is one of the most frequently isolated bacteria from infected medical implants. S. aureus has the capacity to adhere to the surface of an implant where it forms a biofilm. We used atomic force microscopy to probe binding forces between a fibronectin-coated tip and isolates of S. aureus, which were obtained from either patients with infected prostheses or healthy humans. A unique force-signature was observed for binding events between the tip and the cells. There is a statistically significant difference in the binding force-signature observed for S. aureus isolated from the infected vs. healthy populations. This observation suggests a fundamental correlation between nanometer scale binding forces and the clinical outcome of patients with implanted medical devices.

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