Binding Forces Associated with Staphylococcus aureus Biofilms on Medical Implants
- Ruchirej YongsunthonRuchirej YongsunthonThe Ohio State University, 125 South Oval Mall, 275 Mendenhall Laboratory, Columbus, OH 43210More by Ruchirej Yongsunthon
- Vance G. Fowler, Jr.Vance G. Fowler, Jr.Duke University Medical Center, Box 3824, Durham, NC 27710More by Vance G. Fowler, Jr.
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- Steven K. LowerSteven K. LowerThe Ohio State University, 125 South Oval Mall, 275 Mendenhall Laboratory, Columbus, OH 43210More by Steven K. Lower
Staphylococcus aureus is one of the most frequently isolated bacteria from infected medical implants. S. aureus has the capacity to adhere to the surface of an implant where it forms a biofilm. We used atomic force microscopy to probe binding forces between a fibronectin-coated tip and isolates of S. aureus, which were obtained from either patients with infected prostheses or healthy humans. A unique force-signature was observed for binding events between the tip and the cells. There is a statistically significant difference in the binding force-signature observed for S. aureus isolated from the infected vs. healthy populations. This observation suggests a fundamental correlation between nanometer scale binding forces and the clinical outcome of patients with implanted medical devices.
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