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Dual-Thermoresponsive Phase Behavior of Blood Compatible Zwitterionic Copolymers Containing Nonionic Poly(N-isopropyl acrylamide)

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R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Jhong-Li, Taoyuan 320, Taiwan, Department of Chemical and Materials Engineering, National Central University, Jhong-Li, Taoyuan 320, Taiwan, and Research Center for Applied Sciences, Academia Sinica 128 Sec. 2, Academia Road, Nankang, Taipei 11529, Taiwan
* To whom correspondence should be addressed. E-mail: [email protected]
†Chung Yuan Christian University.
‡National Central University.
§Research Center for Applied Sciences.
Cite this: Biomacromolecules 2009, 10, 8, 2092–2100
Publication Date (Web):July 2, 2009
https://doi.org/10.1021/bm900208u
Copyright © 2009 American Chemical Society
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Abstract

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Thermoresponsive statistical copolymers of zwitterionic sulfobetaine methacrylate (SBMA) and nonionic N-isopropylacrylamide (NIPAAm) were prepared with an average molecular weight of about 6.0 kDa via homogeneous free radical copolymerization. The aqueous solution properties of poly(SBMA-co-NIPAAm) were measured using a UV−visible spectrophotometer. The copolymers exhibited controllable lower and upper critical solution temperatures in aqueous solution and showed stimuli-responsive phase transition in the presence of salts. Regulated zwitterionic and nonionic molar mass ratios led to poly(SBMA-co-NIPAAm) copolymers having double-critical solution temperatures, where the water-insoluble polymer microdomains are generated by the zwitterionic copolymer region of polySBMA or nonionic copolymer region of polyNIPAAm depending on temperature. A high content of the nonionic polyNIPAAm in poly(SBMA-co-NIPAAm) exhibits nonionic aggregation at high temperatures due to the desolvation of polyNIPAAm, whereas relatively low content of polyNIPAAm in poly(SBMA-co-NIPAAm) exhibits zwitterionic aggregation at low temperatures due to the desolvation of polySBMA. Plasma protein adsorption on the surface coated with poly(SBMA-co-NIPAAm) was measured with a surface plasmon resonance (SPR) sensor. The copolymers containing polySBMA above 29 mol % showed extremely low protein adsorption and high anticoagulant activity in human blood plasma. The tunable and switchable thermoresponsive phase behavior of poly(SBMA-co-NIPAAm), as well as its high plasma protein adsorption resistance and anticoagulant activity, suggests a potential for blood-contacting applications.

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  2. Min Liu, Xiangyu Zhang, Hongshuang Guo, Yingnan Zhu, Chiyu Wen, Xiaojie Sui, Jing Yang, Lei Zhang. Dimethyl Sulfoxide-Free Cryopreservation of Chondrocytes Based on Zwitterionic Molecule and Polymers. Biomacromolecules 2019, 20 (10) , 3980-3988. https://doi.org/10.1021/acs.biomac.9b01024
  3. Chuanzhuang Zhao, Louis Dolmans, X. X. Zhu. Thermoresponsive Behavior of Poly(acrylic acid-co-acrylonitrile) with a UCST. Macromolecules 2019, 52 (12) , 4441-4446. https://doi.org/10.1021/acs.macromol.9b00794
  4. Antoine Venault, Yung Chang. Designs of Zwitterionic Interfaces and Membranes. Langmuir 2019, 35 (5) , 1714-1726. https://doi.org/10.1021/acs.langmuir.8b00562
  5. Seungjoo Yi, Won Kyu Lee, Ji-Ho Park, Jae-Seung Lee, Ji-Hun Seo. One-Pot Synthesis of a Zwitterionic Small Molecule Bearing Disulfide Moiety for Antibiofouling Macro- and Nanoscale Gold Surfaces. Langmuir 2019, 35 (5) , 1768-1777. https://doi.org/10.1021/acs.langmuir.8b01532
  6. Martin Danko, Zuzana Kroneková, Miroslav Mrlik, Josef Osicka, Ammar bin Yousaf, Andrea Mihálová, Jan Tkac, Peter Kasak. Sulfobetaines Meet Carboxybetaines: Modulation of Thermo- and Ion-Responsivity, Water Structure, Mechanical Properties, and Cell Adhesion. Langmuir 2019, 35 (5) , 1391-1403. https://doi.org/10.1021/acs.langmuir.8b01592
  7. Chungjung Chou, Sioujyuan Syu, Jen-Hsuan Chang, Pierre Aimar, Yung Chang. Bioinspired Pseudozwitterionic Hydrogels with Bioactive Enzyme Immobilization via pH-Responsive Regulation. Langmuir 2019, 35 (5) , 1909-1918. https://doi.org/10.1021/acs.langmuir.8b02483
  8. Yajnaseni Biswas and Tarun K. Mandal . Structural Variation in Homopolymers Bearing Zwitterionic and Ionic Liquid Pendants for Achieving Tunable Multi-Stimuli Responsiveness and Hierarchical Nanoaggregates. Macromolecules 2017, 50 (24) , 9807-9820. https://doi.org/10.1021/acs.macromol.7b02106
  9. Ying-Nien Chou, Antoine Venault, Chia-Ho Cho, Mei-Chan Sin, Lu-Chen Yeh, Jheng-Fong Jhong, Arunachalam Chinnathambi, Yu Chang, and Yung Chang . Epoxylated Zwitterionic Triblock Copolymers Grafted onto Metallic Surfaces for General Biofouling Mitigation. Langmuir 2017, 33 (38) , 9822-9835. https://doi.org/10.1021/acs.langmuir.7b02164
  10. Hui Sun, Xiaolu Chen, Xia Han, and Honglai Liu . Dual Thermoresponsive Aggregation of Schizophrenic PDMAEMA-b-PSBMA Copolymer with an Unrepeatable pH Response and a Recycled CO2/N2 Response. Langmuir 2017, 33 (10) , 2646-2654. https://doi.org/10.1021/acs.langmuir.7b00065
  11. Dianyu Dong, Junjie Li, Man Cui, Jinmei Wang, Yuhang Zhou, Liu Luo, Yufei Wei, Lei Ye, Hong Sun, and Fanglian Yao . In Situ “Clickable” Zwitterionic Starch-Based Hydrogel for 3D Cell Encapsulation. ACS Applied Materials & Interfaces 2016, 8 (7) , 4442-4455. https://doi.org/10.1021/acsami.5b12141
  12. Hu Zhang, Shengwei Guo, Weizheng Fan, and Yue Zhao . Ultrasensitive pH-Induced Water Solubility Switch Using UCST Polymers. Macromolecules 2016, 49 (4) , 1424-1433. https://doi.org/10.1021/acs.macromol.5b02522
  13. Yicheng Zhu, Rhiannon Batchelor, Andrew B. Lowe, and Peter J. Roth . Design of Thermoresponsive Polymers with Aqueous LCST, UCST, or Both: Modification of a Reactive Poly(2-vinyl-4,4-dimethylazlactone) Scaffold. Macromolecules 2016, 49 (2) , 672-680. https://doi.org/10.1021/acs.macromol.5b02056
  14. Tanmoy Maji, Sanjib Banerjee, Yajnaseni Biswas, and Tarun K. Mandal . Dual-Stimuli-Responsive l-Serine-Based Zwitterionic UCST-Type Polymer with Tunable Thermosensitivity. Macromolecules 2015, 48 (14) , 4957-4966. https://doi.org/10.1021/acs.macromol.5b01099
  15. Hu Zhang, Xia Tong, and Yue Zhao . Diverse Thermoresponsive Behaviors of Uncharged UCST Block Copolymer Micelles in Physiological Medium. Langmuir 2014, 30 (38) , 11433-11441. https://doi.org/10.1021/la5026334
  16. Wetra Yandi, Sophie Mieszkin, Pierre Martin-Tanchereau, Maureen E. Callow, James A. Callow, Lyndsey Tyson, Bo Liedberg, and Thomas Ederth . Hydration and Chain Entanglement Determines the Optimum Thickness of Poly(HEMA-co-PEG10MA) Brushes for Effective Resistance to Settlement and Adhesion of Marine Fouling Organisms. ACS Applied Materials & Interfaces 2014, 6 (14) , 11448-11458. https://doi.org/10.1021/am502084x
  17. Yu-Ju Shih, Yung Chang, Damien Quemener, Hui-Shan Yang, Jheng-Fong Jhong, Feng-Ming Ho, Akon Higuchi, and Yu Chang . Hemocompatibility of Polyampholyte Copolymers with Well-Defined Charge Bias in Human Blood. Langmuir 2014, 30 (22) , 6489-6496. https://doi.org/10.1021/la5015779
  18. Peter A. Woodfield, Yicheng Zhu, Yiwen Pei, and Peter J. Roth . Hydrophobically Modified Sulfobetaine Copolymers with Tunable Aqueous UCST through Postpolymerization Modification of Poly(pentafluorophenyl acrylate). Macromolecules 2014, 47 (2) , 750-762. https://doi.org/10.1021/ma402391a
  19. Nien-Jung Lin, Hui-Shan Yang, Yung Chang, Kuo-Lun Tung, Wei-Hao Chen, Hui-Wen Cheng, Sheng-Wen Hsiao, Pierre Aimar, Kazuo Yamamoto, and Juin-Yih Lai . Surface Self-Assembled PEGylation of Fluoro-Based PVDF Membranes via Hydrophobic-Driven Copolymer Anchoring for Ultra-Stable Biofouling Resistance. Langmuir 2013, 29 (32) , 10183-10193. https://doi.org/10.1021/la401336y
  20. Miao Tian, Jinmei Wang, Ershuai Zhang, Junjie Li, Cuimi Duan, and Fanglian Yao . Synthesis of Agarose-graft-poly[3-dimethyl (methacryloyloxyethyl) ammonium propanesulfonate] Zwitterionic Graft Copolymers via ATRP and Their Thermally-Induced Aggregation Behavior in Aqueous Media. Langmuir 2013, 29 (25) , 8076-8085. https://doi.org/10.1021/la4007668
  21. Tao Wang, Xiaowen Wang, Yunchao Long, Guangming Liu, and Guangzhao Zhang . Ion-Specific Conformational Behavior of Polyzwitterionic Brushes: Exploiting It for Protein Adsorption/Desorption Control. Langmuir 2013, 29 (22) , 6588-6596. https://doi.org/10.1021/la401069y
  22. Yu-Ju Shih, Yung Chang, Andre Deratani, and Damien Quemener . “Schizophrenic” Hemocompatible Copolymers via Switchable Thermoresponsive Transition of Nonionic/Zwitterionic Block Self-Assembly in Human Blood. Biomacromolecules 2012, 13 (9) , 2849-2858. https://doi.org/10.1021/bm3008764
  23. Peter J. Roth, Thomas P. Davis, and Andrew B. Lowe . Comparison between the LCST and UCST Transitions of Double Thermoresponsive Diblock Copolymers: Insights into the Behavior of POEGMA in Alcohols. Macromolecules 2012, 45 (7) , 3221-3230. https://doi.org/10.1021/ma300374y
  24. Yu Chang, Yung Chang, Akon Higuchi, Yu-Ju Shih, Pei-Tsz Li, Wen-Yih Chen, Eing-Mei Tsai, and Ging-Ho Hsiue . Bioadhesive Control of Plasma Proteins and Blood Cells from Umbilical Cord Blood onto the Interface Grafted with Zwitterionic Polymer Brushes. Langmuir 2012, 28 (9) , 4309-4317. https://doi.org/10.1021/la203504h
  25. Ai T. Nguyen, Jacob Baggerman, Jos M. J. Paulusse, Han Zuilhof, and Cees J. M. van Rijn . Bioconjugation of Protein-Repellent Zwitterionic Polymer Brushes Grafted from Silicon Nitride. Langmuir 2012, 28 (1) , 604-610. https://doi.org/10.1021/la2031363
  26. Zhixin Dong, Jun Mao, Muquan Yang, Dapeng Wang, Shuqin Bo, and Xiangling Ji . Phase Behavior of Poly(sulfobetaine methacrylate)-Grafted Silica Nanoparticles and Their Stability in Protein Solutions. Langmuir 2011, 27 (24) , 15282-15291. https://doi.org/10.1021/la2038558
  27. Ryan Longenecker, Tingting Mu, Mark Hanna, Nicholas A. D. Burke, and Harald D. H. Stöver . Thermally Responsive 2-Hydroxyethyl Methacrylate Polymers: Soluble–Insoluble and Soluble–Insoluble–Soluble Transitions. Macromolecules 2011, 44 (22) , 8962-8971. https://doi.org/10.1021/ma201528r
  28. Yung Chang, Wan-Ju Chang, Yu-Ju Shih, Ta-Chin Wei, and Ging-Ho Hsiue . Zwitterionic Sulfobetaine-Grafted Poly(vinylidene fluoride) Membrane with Highly Effective Blood Compatibility via Atmospheric Plasma-Induced Surface Copolymerization. ACS Applied Materials & Interfaces 2011, 3 (4) , 1228-1237. https://doi.org/10.1021/am200055k
  29. Ai T. Nguyen, Jacob Baggerman, Jos M. J. Paulusse, Cees J. M. van Rijn, and Han Zuilhof . Stable Protein-Repellent Zwitterionic Polymer Brushes Grafted from Silicon Nitride. Langmuir 2011, 27 (6) , 2587-2594. https://doi.org/10.1021/la104657c
  30. Gang Wu, Si-Chong Chen, Qi Zhan, and Yu-Zhong Wang . Well-Defined Amphiphilic Biodegradable Comb-Like Graft Copolymers: Their Unique Architecture-Determined LCST and UCST Thermoresponsivity. Macromolecules 2011, 44 (4) , 999-1008. https://doi.org/10.1021/ma102588k
  31. Jennifer Y. Kelly, Julie N. L. Albert, John A. Howarter, Shuhui Kang, Christopher M. Stafford, Thomas H. Epps, III, and Michael J. Fasolka . Investigation of Thermally Responsive Block Copolymer Thin Film Morphologies Using Gradients. ACS Applied Materials & Interfaces 2010, 2 (11) , 3241-3248. https://doi.org/10.1021/am100695m
  32. Yu-Ju Shih and Yung Chang. Tunable Blood Compatibility of Polysulfobetaine from Controllable Molecular-Weight Dependence of Zwitterionic Nonfouling Nature in Aqueous Solution. Langmuir 2010, 26 (22) , 17286-17294. https://doi.org/10.1021/la103186y
  33. Yung Chang, Wetra Yandi, Wen-Yih Chen, Yu-Ju Shih, Chang-Chung Yang, Yu Chang, Qing-Dong Ling and Akon Higuchi . Tunable Bioadhesive Copolymer Hydrogels of Thermoresponsive Poly(N-isopropyl acrylamide) Containing Zwitterionic Polysulfobetaine. Biomacromolecules 2010, 11 (4) , 1101-1110. https://doi.org/10.1021/bm100093g
  34. Fu-Sheng Du, Xiao-Nan Huang, Guang-Tao Chen, Shrong-Shi Lin, Dehai Liang and Zi-Chen Li. Aqueous Solution Properties of the Acid-Labile Thermoresponsive Poly(meth)acrylamides with Pendent Cyclic Orthoester Groups. Macromolecules 2010, 43 (5) , 2474-2483. https://doi.org/10.1021/ma902227g
  35. Yung Chang, Shih-Hung Shu, Yu-Ju Shih, Chih-Wei Chu, Ruoh-Chyu Ruaan and Wen-Yih Chen . Hemocompatible Mixed-Charge Copolymer Brushes of Pseudozwitterionic Surfaces Resistant to Nonspecific Plasma Protein Fouling. Langmuir 2010, 26 (5) , 3522-3530. https://doi.org/10.1021/la903172j
  36. Palash Banerjee, Somdeb Jana, Tarun K. Mandal. Coulomb interaction-driven UCST in poly(ionic liquid) random copolymers. European Polymer Journal 2020, 133 , 109747. https://doi.org/10.1016/j.eurpolymj.2020.109747
  37. Hye In Cho, Seungjoo Yi, Jiseong Hwang, Ji-Hun Seo, Jae-Seung Lee. Roles of Zwitterionic Charges in Polymers on Synthesis of Ag Seeds with Anisotropic Growth Properties. Journal of Industrial and Engineering Chemistry 2020, https://doi.org/10.1016/j.jiec.2020.05.008
  38. Ángela A. Beltrán-Osuna, José L. Gómez-Ribelles, Jairo E. Perilla. Temperature and pH responsive behavior of antifouling zwitterionic mesoporous silica nanoparticles. Journal of Applied Physics 2020, 127 (13) , 135106. https://doi.org/10.1063/1.5140707
  39. Yuanfeng Wang, Xin Liang, He Zhu, John H. Xin, Qi Zhang, Shiping Zhu. Reversible Water Transportation Diode: Temperature‐Adaptive Smart Janus Textile for Moisture/Thermal Management. Advanced Functional Materials 2020, 30 (6) , 1907851. https://doi.org/10.1002/adfm.201907851
  40. Somnath Bhattacharjee, Derek S. Frank, Jayme Cannon, James R. Baker. Thermosensitivity studies of hyperbranched dendrimers and branched polymer with terminal N-isopropylamide. European Polymer Journal 2020, 124 , 109464. https://doi.org/10.1016/j.eurpolymj.2019.109464
  41. Satoshi Yamamoto, Satomi Takao, Shinji Muraishi, Cheng Xu, Minoru Taya. Synthesis of Fe70Pd30 nanoparticles and their surface modification by zwitterionic linker. Materials Chemistry and Physics 2019, 234 , 237-244. https://doi.org/10.1016/j.matchemphys.2019.05.011
  42. Hui Liu, Zhengfeng Ma, Wufang Yang, Xiaowei Pei, Feng Zhou. Facile preparation of structured zwitterionic polymer substrate via sub-surface initiated atom transfer radical polymerization and its synergistic marine antifouling investigation. European Polymer Journal 2019, 112 , 146-152. https://doi.org/10.1016/j.eurpolymj.2018.07.025
  43. Chuanzhuang Zhao, Zhiyuan Ma, X.X. Zhu. Rational design of thermoresponsive polymers in aqueous solutions: A thermodynamics map. Progress in Polymer Science 2019, 90 , 269-291. https://doi.org/10.1016/j.progpolymsci.2019.01.001
  44. Dominic Büning, Franka Ennen-Roth, Sarah Verena Walter, Tobias Hennecke, Mathias Ulbricht. Potassium-sensitive poly( N -isopropylacrylamide)-based hydrogels for sensor applications. Polymer Chemistry 2018, 9 (26) , 3600-3614. https://doi.org/10.1039/C8PY00490K
  45. Minjie Li, Xiongliang He, Ying Ling, Haoyu Tang. Dual thermoresponsive homopolypeptide with LCST-type linkages and UCST-type pendants: Synthesis, characterization, and thermoresponsive properties. Polymer 2017, 132 , 264-272. https://doi.org/10.1016/j.polymer.2017.11.016
  46. Robin Rajan, Kazuaki Matsumura. Tunable Dual-Thermoresponsive Core-Shell Nanogels Exhibiting UCST and LCST Behavior. Macromolecular Rapid Communications 2017, 38 (22) , 1700478. https://doi.org/10.1002/marc.201700478
  47. Jingfeng Yu, Yudong Liu, Sanan Song, Ge Gao, Fengqi Liu. Phase behavior of a high-concentration sulfobetaine zwitterionic polymer solution. Polymer Journal 2017, 49 (11) , 767-774. https://doi.org/10.1038/pj.2017.51
  48. A. Kristen Means, Daniel A. Ehrhardt, Lauren V. Whitney, Melissa A. Grunlan. Thermoresponsive Double Network Hydrogels with Exceptional Compressive Mechanical Properties. Macromolecular Rapid Communications 2017, 38 (20) , 1700351. https://doi.org/10.1002/marc.201700351
  49. Vinod B. Damodaran, Victoria Leszczak, Melissa M. Reynolds, Ketul C. Popat. Zwitterionic Polymeric Materials. 2017,,, 1661-1672. https://doi.org/10.1081/E-EBPPC-120050037
  50. Antoine Venault, Ko-Jen Hsu, Lu-Chen Yeh, Arunachalam Chinnathambi, Hsin-Tsung Ho, Yung Chang. Surface charge-bias impact of amine-contained pseudozwitterionic biointerfaces on the human blood compatibility. Colloids and Surfaces B: Biointerfaces 2017, 151 , 372-383. https://doi.org/10.1016/j.colsurfb.2016.12.040
  51. Yajnaseni Biswas, Somdeb Jana, Madhab Dule, Tarun K. Mandal. Responsive Polymer Nanostructures. 2017,,, 173-304. https://doi.org/10.1007/978-3-319-57003-7_6
  52. Aijing Lu, Chenglong Li, Zhengzhong Wu, Xianglin Luo. The interaction between poly(ε-caprolactone) copolymers containing sulfobetaines and proteins. Colloid and Polymer Science 2016, 294 (12) , 1887-1899. https://doi.org/10.1007/s00396-016-3942-3
  53. Yohei Kotsuchibashi, Mitsuhiro Ebara, Takao Aoyagi, Ravin Narain. Recent Advances in Dual Temperature Responsive Block Copolymers and Their Potential as Biomedical Applications. Polymers 2016, 8 (11) , 380. https://doi.org/10.3390/polym8110380
  54. Ruey-Yug Tsay, Toyoko Imae. Development of Nonfouling Biomaterials. 2016,,, 145-160. https://doi.org/10.1002/9781119075691.ch11
  55. Ying-Nien Chou, Ten-Chin Wen, Yung Chang. Zwitterionic surface grafting of epoxylated sulfobetaine copolymers for the development of stealth biomaterial interfaces. Acta Biomaterialia 2016, 40 , 78-91. https://doi.org/10.1016/j.actbio.2016.03.046
  56. Wetra Yandi, Sophie Mieszkin, Alessio di Fino, Pierre Martin-Tanchereau, Maureen E. Callow, James A. Callow, Lyndsey Tyson, Anthony S. Clare, Thomas Ederth. Charged hydrophilic polymer brushes and their relevance for understanding marine biofouling. Biofouling 2016, 32 (6) , 609-625. https://doi.org/10.1080/08927014.2016.1170816
  57. Jingfeng Yu, Zhiying Li, Xiaoli Liu, Sanan Song, Ge Gao, Qing Zhang, Fengqi Liu. Molecular size and morphology of single chains of poly(sulfobetaine methacrylate). Chemical Research in Chinese Universities 2016, 32 (3) , 499-504. https://doi.org/10.1007/s40242-016-5419-9
  58. Jin-Ge Tong, Zhong-Yu Wei, Hao-Lin Yang, Zhen-Yu Yang, Yu Chen. Study on the phase transition behaviors of thermoresponsive hyperbranched polyampholytes in water. Polymer 2016, 84 , 107-116. https://doi.org/10.1016/j.polymer.2015.12.049
  59. Vinod B. Damodaran, Victoria Leszczak, Melissa M. Reynolds, Ketul C. Popat. Zwitterionic Polymeric Materials. 2016,,, 8299-8310. https://doi.org/10.1081/E-EBPP-120050037
  60. Sabrina Nehache, Chin-Cheng Yeh, Mona Semsarilar, André Deratani, Yung Chang, Damien Quemener. Anti-Bioadhesive Coating Based on Easy to Make Pseudozwitterionic RAFT Block Copolymers for Blood-Contacting Applications. Macromolecular Bioscience 2016, 16 (1) , 57-62. https://doi.org/10.1002/mabi.201500185
  61. Emma R. L. Brisson, Zeyun Xiao, Lucas Levin, George V. Franks, Luke A. Connal. Facile synthesis of histidine functional poly(N-isopropylacrylamide): zwitterionic and temperature responsive materials. Polymer Chemistry 2016, 7 (10) , 1945-1952. https://doi.org/10.1039/C5PY01915J
  62. Amélie Augé, Yue Zhao. What determines the volume transition temperature of UCST acrylamide–acrylonitrile hydrogels?. RSC Advances 2016, 6 (74) , 70616-70623. https://doi.org/10.1039/C6RA12720G
  63. Wenjun Zhan, Xiujuan Shi, Qian Yu, Zhonglin Lyu, Limin Cao, Hui Du, Qi Liu, Xin Wang, Gaojian Chen, Dan Li, John L. Brash, Hong Chen. Bioinspired Blood Compatible Surface Having Combined Fibrinolytic and Vascular Endothelium-Like Properties via a Sequential Coimmobilization Strategy. Advanced Functional Materials 2015, 25 (32) , 5206-5213. https://doi.org/10.1002/adfm.201501642
  64. Qilu Zhang, Filippo Tosi, Sibel Üǧdüler, Samarendra Maji, Richard Hoogenboom. Tuning the LCST and UCST Thermoresponsive Behavior of Poly( N,N -dimethylaminoethyl methacrylate) by Electrostatic Interactions with Trivalent Metal Hexacyano Anions and Copolymerization. Macromolecular Rapid Communications 2015, 36 (7) , 633-639. https://doi.org/10.1002/marc.201400550
  65. Qian Ye, Feng Zhou. Antifouling Surfaces Based on Polymer Brushes. 2015,,, 55-81. https://doi.org/10.1007/978-3-662-45204-2_3
  66. Ya Zhao, Tao Bai, Qing Shao, Shaoyi Jiang, Amy Q. Shen. Thermoresponsive self-assembled NiPAm-zwitterion copolymers. Polymer Chemistry 2015, 6 (7) , 1066-1077. https://doi.org/10.1039/C4PY01553C
  67. Christophe Blaszykowski, Sonia Sheikh, Michael Thompson. A survey of state-of-the-art surface chemistries to minimize fouling from human and animal biofluids. Biomaterials Science 2015, 3 (10) , 1335-1370. https://doi.org/10.1039/C5BM00085H
  68. Boguang Yang, Changyong Wang, Yabin Zhang, Lei Ye, Yufeng Qian, Yao Shu, Jinmei Wang, Junjie Li, Fanglian Yao. A thermoresponsive poly(N-vinylcaprolactam-co-sulfobetaine methacrylate) zwitterionic hydrogel exhibiting switchable anti-biofouling and cytocompatibility. Polymer Chemistry 2015, 6 (18) , 3431-3442. https://doi.org/10.1039/C5PY00123D
  69. Kay E. B. Doncom, Nicholas J. Warren, Steven P. Armes. Polysulfobetaine-based diblock copolymer nano-objects via polymerization-induced self-assembly. Polymer Chemistry 2015, 6 (41) , 7264-7273. https://doi.org/10.1039/C5PY00396B
  70. Xiaolu Chen, Hui Sun, Jian Xu, Xia Han, Honglai Liu, Ying Hu. pH-modulated double LCST behaviors with diverse aggregation processes of random-copolymer grafted silica nanoparticles in aqueous solution. RSC Advances 2015, 5 (105) , 86584-86592. https://doi.org/10.1039/C5RA13557E
  71. Jheng-Fong Jhong, Mei-Chan Sin, Hsiao-Han Kung, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Yung Chang. Hemocompatibility of pseudozwitterionic polymer brushes with a systematic well-defined charge-bias control. Journal of Biomaterials Science, Polymer Edition 2014, 25 (14-15) , 1558-1572. https://doi.org/10.1080/09205063.2014.921754
  72. Xiaojie Lin, Kazuhiko Ishihara. Water-soluble polymers bearing phosphorylcholine group and other zwitterionic groups for carrying DNA derivatives. Journal of Biomaterials Science, Polymer Edition 2014, 25 (14-15) , 1461-1478. https://doi.org/10.1080/09205063.2014.934319
  73. Ching-Yi Chen, Hsiang-Ling Wang. Dual Thermo- and pH-Responsive Zwitterionic Sulfobataine Copolymers for Oral Delivery System. Macromolecular Rapid Communications 2014, 35 (17) , 1534-1540. https://doi.org/10.1002/marc.201400161
  74. Mei-Chan Sin, Sheng-Han Chen, Yung Chang. Hemocompatibility of zwitterionic interfaces and membranes. Polymer Journal 2014, 46 (8) , 436-443. https://doi.org/10.1038/pj.2014.46
  75. M. Luisa Lopez-Donaire, J. Paul Santerre. Surface modifying oligomers used to functionalize polymeric surfaces: Consideration of blood contact applications. Journal of Applied Polymer Science 2014, 131 (14) , n/a-n/a. https://doi.org/10.1002/app.40328
  76. Francis O. Obiweluozor, Amin GhavamiNejad, Saud Hashmi, Mohammad Vatankhah-Varnoosfaderani, Florian J. Stadler. A NIPAM-Zwitterion Copolymer: Rheological Interpretation of the Specific Ion Effect on the LCST. Macromolecular Chemistry and Physics 2014, 215 (11) , 1077-1091. https://doi.org/10.1002/macp.201300778
  77. Yan-Ling Luo, Xiao-Li Yang, Feng Xu, Ya-Shao Chen, Bin Zhang. Thermosensitive PNIPAM-b-HTPB block copolymer micelles: Molecular architectures and camptothecin drug release. Colloids and Surfaces B: Biointerfaces 2014, 114 , 150-157. https://doi.org/10.1016/j.colsurfb.2013.09.043
  78. Zhixin Dong, Jun Mao, Dapeng Wang, Muquan Yang, Weicai Wang, Shuqin Bo, Xiangling Ji. Tunable Dual-Thermoresponsive Phase Behavior of Zwitterionic Polysulfobetaine Copolymers Containing Poly( N,N -dimethylaminoethyl methacrylate)-Grafted Silica Nanoparticles in Aqueous Solution. Macromolecular Chemistry and Physics 2014, 215 (1) , 111-120. https://doi.org/10.1002/macp.201300552
  79. Yu-Ju Shih, Ching-Wei Tsai, Lemmuel L. Tayo, Yung Chang. Zwitterionic Nanocarriers for Gene Delivery. 2014,,, 35-53. https://doi.org/10.1007/978-94-017-8896-0_3
  80. Lutz Tauhardt, David Pretzel, Kristian Kempe, Michael Gottschaldt, Dirk Pohlers, Ulrich S. Schubert. Zwitterionic poly(2-oxazoline)s as promising candidates for blood contacting applications. Polym. Chem. 2014, 5 (19) , 5751-5764. https://doi.org/10.1039/C4PY00434E
  81. Qun Zhang, Xinde Tang, Tieshi Wang, Faqi Yu, Wenjuan Guo, Meishan Pei. Thermo-sensitive zwitterionic block copolymers via ATRP. RSC Adv. 2014, 4 (46) , 24240-24247. https://doi.org/10.1039/C4RA00971A
  82. Xiaoli Liu, Lin Yuan, Dan Li, Zengchao Tang, Yanwei Wang, Gaojian Chen, Hong Chen, John L. Brash. Blood compatible materials: state of the art. J. Mater. Chem. B 2014, 2 (35) , 5718-5738. https://doi.org/10.1039/C4TB00881B
  83. Yi-Fan Zhao, Li-Ping Zhu, Zhuan Yi, Bao-Ku Zhu, You-Yi Xu. Improving the hydrophilicity and fouling-resistance of polysulfone ultrafiltration membranes via surface zwitterionicalization mediated by polysulfone-based triblock copolymer additive. Journal of Membrane Science 2013, 440 , 40-47. https://doi.org/10.1016/j.memsci.2013.03.064
  84. Yan-Ling Luo, Xiao-Li Yang, Feng Xu, Ya-Shao Chen, Zhuo-Ma Ren-Ting. Thermosensitive self-assembly micelles from A 2 BA 2 -type poly( N -isopropyl acrylamide) 2 - b -Poly(lactic acid)- b -Poly( N -isopropyl acrylamide) 2 four-armed star block copolymers and their applications as drug carriers. Journal of Applied Polymer Science 2013, 28 , n/a-n/a. https://doi.org/10.1002/app.39530
  85. Jinyan Ning, Kazuomi Kubota, Guang Li, Kazutoshi Haraguchi. Characteristics of zwitterionic sulfobetaine acrylamide polymer and the hydrogels prepared by free-radical polymerization and effects of physical and chemical crosslinks on the UCST. Reactive and Functional Polymers 2013, 73 (7) , 969-978. https://doi.org/10.1016/j.reactfunctpolym.2012.11.005
  86. Xia Han, Xuxia Zhang, Quanyi Yin, Jun Hu, Honglai Liu, Ying Hu. Thermoresponsive Diblock Copolymer with Tunable Soluble-Insoluble and Soluble-Insoluble-Soluble Transitions. Macromolecular Rapid Communications 2013, 34 (7) , 574-580. https://doi.org/10.1002/marc.201200785
  87. Bomi Kim, Hye Soo Lee, Jaeyun Kim, Shin-Hyun Kim. Microfluidic fabrication of photo-responsive hydrogel capsules. Chemical Communications 2013, 49 (18) , 1865. https://doi.org/10.1039/c3cc37719a
  88. Jiaming Zhuang, Mallory R. Gordon, Judy Ventura, Longyu Li, S. Thayumanavan. Multi-stimuli responsive macromolecules and their assemblies. Chemical Society Reviews 2013, 42 (17) , 7421. https://doi.org/10.1039/c3cs60094g
  89. Jan Seuring, Seema Agarwal. Polymers with Upper Critical Solution Temperature in Aqueous Solution. Macromolecular Rapid Communications 2012, 33 (22) , 1898-1920. https://doi.org/10.1002/marc.201200433
  90. Chang Liu, Vittoria Balsamo, Dali Sun, Melodie Naja, Xuemei Wang, Barry Rosen, Chen-Zhong Li. A 3D localized surface plasmon resonance biosensor for the study of trivalent arsenic binding to the ArsA ATPase. Biosensors and Bioelectronics 2012, 38 (1) , 19-26. https://doi.org/10.1016/j.bios.2012.04.026
  91. Yen-Che Chiang, Yung Chang, Ching-Jong Chuang, Ruoh-Chyu Ruaan. A facile zwitterionization in the interfacial modification of low bio-fouling nanofiltration membranes. Journal of Membrane Science 2012, 389 , 76-82. https://doi.org/10.1016/j.memsci.2011.10.017
  92. Alexandra Muñoz-Bonilla, Marta Fernández-García. Polymeric materials with antimicrobial activity. Progress in Polymer Science 2012, 37 (2) , 281-339. https://doi.org/10.1016/j.progpolymsci.2011.08.005
  93. Hyo Jung Moon, Du Young Ko, Min Hee Park, Min Kyung Joo, Byeongmoon Jeong. Temperature-responsive compounds as in situ gelling biomedical materials. Chemical Society Reviews 2012, 41 (14) , 4860. https://doi.org/10.1039/c2cs35078e
  94. Christophe Blaszykowski, Sonia Sheikh, Michael Thompson. Surface chemistry to minimize fouling from blood-based fluids. Chemical Society Reviews 2012, 41 (17) , 5599. https://doi.org/10.1039/c2cs35170f
  95. Peter J. Roth, Thomas P. Davis, Andrew B. Lowe. UCST-driven self-assembly and crosslinking of diblock copolymer micelles. Polymer Chemistry 2012, 3 (8) , 2228. https://doi.org/10.1039/c2py20204b
  96. Yi Wen Pei, Jadranka Travas-Sejdic, David E. Williams. Synthesis and Characterization of Polysulfobetaines and their Random Copolymers. Materials Science Forum 2011, 700 , 219-222. https://doi.org/10.4028/www.scientific.net/MSF.700.219
  97. Myoung-Hwa Cha, Jiyeon Choi, Bo Gyu Choi, Kwideok Park, Ik Hwan Kim, Byeongmoon Jeong, Dong Keun Han. Synthesis and characterization of novel thermo-responsive F68 block copolymers with cell-adhesive RGD peptide. Journal of Colloid and Interface Science 2011, 360 (1) , 78-85. https://doi.org/10.1016/j.jcis.2011.04.041
  98. Min Ji Hwang, Min Kyung Joo, Bo Gyu Choi, Min Hee Park, Ian W. Hamley, Byeongmoon Jeong. Multiple Sol-Gel Transitions of PEG-PCL-PEG Triblock Copolymer Aqueous Solution. Macromolecular Rapid Communications 2010, 31 (23) , 2064-2069. https://doi.org/10.1002/marc.201000403
  99. . LIQUID-LIQUID EQUILIBRIUM (LLE) DATA OF POLYMER SOLUTIONS. 2010,,, 111-258. https://doi.org/10.1201/b10820-4

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