Creatine Synthesis: An Undergraduate Organic Chemistry Laboratory ExperimentClick to copy article linkArticle link copied!
Abstract
Students in introductory chemistry classes typically appreciate seeing the connection between course content and the "real world". For this reason, we have developed a synthesis of creatine monohydrate—a popular supplement used in sports requiring short bursts of energy—for introductory organic chemistry laboratory courses. Creatine monohydrate is easily synthesized from N-methylglycine (sarcosine) and cyanamide in the presence of salt and base. The crude product is purified by recrystallization and analyzed by thin-layer chromatography, melting point, and nuclear magnetic resonance spectroscopy. This synthesis illustrates the electrophilic nature of nitriles, as well as the nucleophilic nature of amines.
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