A Graphical Journey of Innovative Organic Architectures That Have Improved Our LivesClick to copy article linkArticle link copied!
Abstract
A new free graphical teaching tool that highlights the beautiful organic architectures of the top selling pharmaceuticals is detailed on two posters. In addition to the multitude of teaching and data-mining opportunities these posters offer, they were also created to emphasize the central role organic chemists play in the development of new therapeutics.
Cited By
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by ACS Publications if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
This article is cited by 931 publications.
- Sergio Sisti, Fabio Ioele, Filippo Scarchilli, Simona Laparelli, Marco Galeotti, Omid Hosseinzadeh, Zhehan Jia, Gino A. DiLabio, Michela Salamone, Massimo Bietti. Hydrogen Atom Transfer-Based C(sp3)–H Bond Oxygenation of Lactams and Cycloalkenes: The Influence of Ring Size on Reactivity and Site Selectivity. The Journal of Organic Chemistry 2025, 90
(15)
, 5195-5205. https://doi.org/10.1021/acs.joc.5c00092
- Jiahao Wu, Xiangwen Tan, Wanqing Wu, Huanfeng Jiang. Easily Handled NaBArF4 Catalyzed Selective Electrophilic Deuteration Method for C(sp2)–H Bond of Aryl Amines. The Journal of Organic Chemistry 2025, 90
(15)
, 5161-5170. https://doi.org/10.1021/acs.joc.5c00066
- Cunzhi Chen, Youwei Chen, Hongguang Du, Jiaxi Xu, Zhanhui Yang. Enantioselective and Regiodivergent Skeletal Transformations of 1,2,3-Thiadiazoles to Alkylidene Dihydrothiophenes. Organic Letters 2025, Article ASAP.
- Weimei Zeng, Chengyi Peng, Youai Qiu. Electrochemical Benzylic C–H Carboxylation. Journal of the American Chemical Society 2025, Article ASAP.
- Shu-Kui Guo, Yu-Han Zhang, Fan Yang, Xiao-De An, Yao-Bin Shen, Jian Xiao, Bin Qiu. Synthesis of All Ring Sizes of Medium-Sized Heterocycles Bridged Biaryls via VQM-Enabled Diversity-Oriented Synthetic Strategy. Organic Letters 2025, 27
(13)
, 3237-3241. https://doi.org/10.1021/acs.orglett.5c00531
- Joseph P. Milton, Dorota Gryko. Photochemical Functionalization of 4-Diazoisoquinoline-1,3(2H,4H)-diones and Their 1-Sulfoxide Analogues. ACS Organic & Inorganic Au 2025, Article ASAP.
- Huamin Wang, Wenjing Niu, Min Wei, Ying Xiao, Ying-Wu Lin. Direct Access to CF3-Containing 4H-1,3-Oxazines and 2-Aminopyrimidines Via a [4 + 2] Annulation Using In Situ Generated Carbodiimide Anions. Organic Letters 2025, 27
(11)
, 2721-2727. https://doi.org/10.1021/acs.orglett.5c00494
- Jiemin Ma, Yuhua Zhong, Hu Cai, Wentao Xu. Photocatalytic α-C(sp3)–H Arylation/Heteroarylation of Amines Enabled by Pyrylium Salt. The Journal of Organic Chemistry 2025, 90
(11)
, 4080-4089. https://doi.org/10.1021/acs.joc.5c00090
- Kumari Swati Sharma, Nagender Thadem, Ganesh Pandey. Visible-Light-Induced Secondary Benzylic C(sp3)–H Functionalization for Nucleophilic Substitution: An Intermolecular C–X (C–N, C–C, and C–Br) Bond Forming Reaction. The Journal of Organic Chemistry 2025, 90
(9)
, 3384-3390. https://doi.org/10.1021/acs.joc.4c03052
- Zihang Yin, Yanwei Cao, Jiaojiao Zhao, Long Pan, Tingting Wang, Xianjie Fang, Lin He. Confined Ru Nanoclusters for the Low-Temperature Cyclization of Diamines to Piperidines/Pyridines. ACS Catalysis 2025, 15
(5)
, 3711-3721. https://doi.org/10.1021/acscatal.4c07429
- Miguel Bernús, Gonzalo D. Núñez, Will C. Hartley, Marc Guasch, Jordi Mestre, Maria Besora, Jorge J. Carbó, Omar Boutureira. Impact of Fluorine Pattern on Lipophilicity and Acid–Base Properties of 2-(Thiofluoroalkyl)pyridines: Insights from Experiments and Statistical Modeling. Journal of Medicinal Chemistry 2025, 68
(4)
, 4787-4800. https://doi.org/10.1021/acs.jmedchem.4c03045
- Binbin Chen, Jiahui Huang, Yingchun Liu, Lirong Yang, Qi Wang, Haoran Yu. Computational Study on the Catalytic Mechanism of UstD Catalyzing the Synthesis of γ-Hydroxy-α-Amino Acids. Journal of Chemical Information and Modeling 2025, 65
(4)
, 2026-2037. https://doi.org/10.1021/acs.jcim.4c01998
- Joseph Hatton, David R. Stuart. Synthesis of N-Aryl Carbamates from Aryl(TMP)iodonium Salts via C–N Coupling. Organic Letters 2025, 27
(5)
, 1130-1135. https://doi.org/10.1021/acs.orglett.4c04582
- Subham Das, Amit Dhibar, Basudev Sahoo. Strategic Synthesis of Sulfinamides as Versatile S(IV) Intermediates. ACS Organic & Inorganic Au 2025, 5
(1)
, 1-12. https://doi.org/10.1021/acsorginorgau.4c00078
- Oliver D. Jackson, Albert Reyes, Collin D. Stein, Nathaniel G. Larson, Calvin T. Andrews, Sharon R. Neufeldt. C2-Selective Palladium-Catalyzed C–S Cross-Coupling of 2,4-Dihalopyrimidines. Journal of the American Chemical Society 2025, 147
(4)
, 3017-3022. https://doi.org/10.1021/jacs.4c17020
- Maria Logotheti, Susanne Gehres, Alexandre S. França, Uwe T. Bornscheuer, Rodrigo O. M. A. de Souza, Matthias Höhne. Combining Photochemical Oxyfunctionalization and Enzymatic Catalysis for the Synthesis of Chiral Pyrrolidines and Azepanes. The Journal of Organic Chemistry 2025, 90
(2)
, 1036-1043. https://doi.org/10.1021/acs.joc.4c02228
- Jun Zhang, Xiaodong Zeng, Huixue Chen, Qian Yun, Wenya Tian, Yeqing Du, Zhi Lin, Chun Lei, Zixin Deng, Xudong Qu. Site-Specific Introduction of Sulfoxides and Sulfones into Polyketide Scaffolds through a Relayed Chemo-Biosynthetic Strategy. ACS Catalysis 2025, 15
(2)
, 889-894. https://doi.org/10.1021/acscatal.4c05446
- Renato Olarte Hernandez, Armand Soldera, Benoît Champagne. Vibronic Structure of the UV/Visible Absorption Spectra of Phenol and Phenolate: A Hybrid Density Functional Theory─Doktorov’s Quantum Algorithm Approach. The Journal of Physical Chemistry A 2025, 129
(1)
, 396-406. https://doi.org/10.1021/acs.jpca.4c06960
- Jin-Ping Wang, Tao Liu, Yichen Wu, Peng Wang. Pd-Catalyzed Migratory 1,1-Cycloannulation Reaction of Alkenes. Journal of the American Chemical Society 2025, 147
(1)
, 69-77. https://doi.org/10.1021/jacs.4c14153
- Ewald P. J. Jongkind, Jack Domenech, Arthur Govers, Marcel van den Broek, Jean-Marc Daran, Gideon Grogan, Caroline E. Paul. Discovery and Synthetic Applications of a NAD(P)H-Dependent Reductive Aminase from Rhodococcus erythropolis. ACS Catalysis 2025, 15
(1)
, 211-219. https://doi.org/10.1021/acscatal.4c04935
- Shuyang Liu, Ziyu Gan, Min Jiang, Qian Liao, Yusheng Lu, Hongyao Wang, Zhiyan Xue, Ziyang Chen, Yongqiang Zhang, Xiaobo Yang, Chunying Duan, Yunhe Jin. Selective Arene Photonitration via Iron-Complex β-Homolysis. JACS Au 2024, 4
(12)
, 4899-4909. https://doi.org/10.1021/jacsau.4c00880
- Joyann S. Donaldson, Matthew Del Bel, John Braganza, Sujin Cho-Schultz, Mingying He, Bryan Li, Congjun Liu, Jean Matthews, Sajiv K. Nair, Martha Ornelas, Feng Shi, Chengfu Xie, Qing Zhang, Ru Zhou. Synthesis of Fused Bicyclic [1,2,4]-Triazoles from Amino Acids. The Journal of Organic Chemistry 2024, 89
(24)
, 18122-18130. https://doi.org/10.1021/acs.joc.4c01945
- Hang Zhou, Xin-Yu Pang, Xiaojiang Xie, David Lee Phillips, Han-Yuan Gong, Jonathan L. Sessler, Wei Jiang. Amide-Based Naphthotubes as Biomimetic Receptors for Acetal Protection and Other Substrates in Water via Noncovalent Interactions. Journal of the American Chemical Society 2024, 146
(50)
, 34842-34851. https://doi.org/10.1021/jacs.4c13907
- Jiayang Wang, Yun Wang, Wenjing Lin, Anyi Yang, Ying Wang, Jingran Wang, Haizhen Zheng, Haixia Ge. Photoredox-Catalyzed C–H Methylation of N-Heteroarenes Enabled by N,N-Dimethylethanolamine. The Journal of Organic Chemistry 2024, 89
(23)
, 17482-17487. https://doi.org/10.1021/acs.joc.4c02223
- Hua Tu, Xi Deng, Hongyi Li, Yangjing Xu, Jing Chen, Xiaofeng Zhang, Weiping Su. Efficient Construction of β-Arylethylamines via Selective C(sp3)-H Arylation of Aliphatic Amines. ACS Catalysis 2024, 14
(23)
, 17535-17546. https://doi.org/10.1021/acscatal.4c04805
- Yu-Shen Zhu, Ya-Lin Guo, Ying-Ying Zhu, Bo Su. Enantioselective 1,4-Borylamination via Copper-Catalyzed Cascade Hydroborylation and Hydroamination of Arylidenecyclopropanes. Journal of the American Chemical Society 2024, 146
(47)
, 32283-32291. https://doi.org/10.1021/jacs.4c12852
- Sophia M. Baldassarre, Heidi S. Sato, Adam P. Louise, Layna L. Summer, Benjamin P. Wilson, Brett N. Hemric. Three-Component 1,2-Dioxygenation of 1,3-Dienes Using Carboxylic Acids and TEMPO. The Journal of Organic Chemistry 2024, 89
(22)
, 16865-16872. https://doi.org/10.1021/acs.joc.4c02244
- Vinh T. Nguyen, R. Noah Sladek, Yihan Cao, Nattamai Bhuvanesh, Jia Zhou, Oleg V. Ozerov. C–H Activation of Pyridines by Boryl Pincer Complexes: Elucidation of Boryl-Directed C–H Oxidative Addition to Ir and Discovery of Transition Metal-Assisted Reductive Elimination from Boron at Rh. Journal of the American Chemical Society 2024, 146
(45)
, 31281-31294. https://doi.org/10.1021/jacs.4c12143
- Kacey G. Ortiz, Andrew T. Brusoe, Jason An, Eugene Chong, Lifen Wu. Green Synthesis of Morpholines via Selective Monoalkylation of Amines. Journal of the American Chemical Society 2024, 146
(43)
, 29847-29856. https://doi.org/10.1021/jacs.4c11708
- Erin E. Plasek, Roman G. Belli, Douglas M. Kavaguti, Courtney C. Roberts. Bidentate Phosphine Ligand Impacts on Previously Inaccessible Five-Membered N-Heteroaryne Formation and Functionalization. Organometallics 2024, 43
(20)
, 2637-2642. https://doi.org/10.1021/acs.organomet.4c00257
- Koustav Pal, Debabrata Das, Krishna Gopal Ghosh, Devarajulu Sureshkumar. Visible-Light Driven Synthesis of Vinyl Amines without Photocatalyst. The Journal of Organic Chemistry 2024, 89
(20)
, 15317-15324. https://doi.org/10.1021/acs.joc.4c01624
- Shu-Zhen Zheng, Eman Fayad, Najla A. Alshaye, Hua-Li Qin. Stereo- and Regioselective Installation of Vinyl Sulfonyl Fluoride onto Indoles without Transition-Metal Catalyst. The Journal of Organic Chemistry 2024, 89
(19)
, 14564-14570. https://doi.org/10.1021/acs.joc.4c01689
- Fei Xiao, Tai-Ping Zhou, Sheng Dong, Tong Li, Cai-Hong Yun, Yingang Feng, Qiu Cui, Kui Hong, Binju Wang, Wenli Li. Molecular Basis for the P450-Catalyzed sp3 C–N Glycosidic Bond Formation in Staurosporine Biosynthesis. ACS Catalysis 2024, 14
(19)
, 14274-14284. https://doi.org/10.1021/acscatal.4c03875
- Chengxi Zhang, Xianqing Wu, Jingping Qu, Yifeng Chen. A General Enantioselective α-Alkyl Amino Acid Derivatives Synthesis Enabled by Cobalt-Catalyzed Reductive Addition. Journal of the American Chemical Society 2024, 146
(38)
, 25918-25926. https://doi.org/10.1021/jacs.4c09556
- Joshua T. Gavin, Lars W. Anderson, Courtney C. Roberts. Aryne Aminohalogenation Using Protic Amines Enabled by Halogen Transfer. Organic Letters 2024, 26
(36)
, 7530-7534. https://doi.org/10.1021/acs.orglett.4c02407
- Ye Liu, Yu Chen, Yu-Jie Zhao, Guo-Qing Zhang, Yongxiang Zheng, Peiyuan Yu, Peng Chen, Zhi-Jun Jia. Iron-Catalyzed Primary Amination of C(sp3)–H Bonds. Journal of the American Chemical Society 2024, 146
(36)
, 24863-24870. https://doi.org/10.1021/jacs.4c05407
- Rajender Nallagonda, Rachel Quan, Lauren Grant, Christine Jorge, Shiuhang Yip, Dauh-Rurng Wu, T. G. Murali Dhar, James Kempson, Arvind Mathur, Martins S. Oderinde. Unveiling the Stereoselectivity Aspects of Metallaphotoredox Decarboxylative Arylation. ACS Catalysis 2024, 14
(17)
, 13439-13450. https://doi.org/10.1021/acscatal.4c03818
- Uttam Dhawa, Lara Lavrencic, Xile Hu. Nickel-Catalyzed Enantio- and Diastereoselective Synthesis of Fluorine-Containing Vicinal Stereogenic Centers. ACS Central Science 2024, 10
(8)
, 1657-1666. https://doi.org/10.1021/acscentsci.4c00819
- Chiwon Hwang, Yunhui Jang, Yongsuk Jung, Jaeyoon Seo, Kwangmin Shin, Seung Hwan Cho. Diverse Synthesis of (Thio)ethers and (Thio)esters Using Halodiborylmethane as a Transformable C1 Building Block. Organic Letters 2024, 26
(33)
, 7010-7014. https://doi.org/10.1021/acs.orglett.4c02510
- Someshwar B. Kale, Tejaswini A. Patil, Utpal Das. Rongalite as a C1 Source: Sulfonylmethylation of Indoles with Aryl/Alkyl Hydrazides and Sulfinates. The Journal of Organic Chemistry 2024, 89
(16)
, 11347-11352. https://doi.org/10.1021/acs.joc.4c01012
- Zhenhua Zhang, Lorenzo Poletti, Daniele Leonori. A Radical Strategy for the Alkylation of Amides with Alkyl Halides by Merging Boryl Radical-Mediated Halogen-Atom Transfer and Copper Catalysis. Journal of the American Chemical Society 2024, 146
(32)
, 22424-22430. https://doi.org/10.1021/jacs.4c05487
- Nadia Hirbawi, Ethan T. A. Raffman, James R. Pedroarena, Tristan M. McGinnis, Elizabeth R. Jarvo. Sacrificial Anode-Free Electrochemical Cross-Electrophile Coupling of 1,3-Diol Derivatives to Form Aliphatic and Aryl Cyclopropanes. Organic Letters 2024, 26
(31)
, 6556-6561. https://doi.org/10.1021/acs.orglett.4c02022
- Christopher M. Marshall, John G. Federice, Chloe N. Bell, Philip B. Cox, Jon T. Njardarson. An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023). Journal of Medicinal Chemistry 2024, 67
(14)
, 11622-11655. https://doi.org/10.1021/acs.jmedchem.4c01122
- Tao Zeng, Zhehao Jin, Shuangjia Zheng, Tao Yu, Ruibo Wu. Developing BioNavi for Hybrid Retrosynthesis Planning. JACS Au 2024, 4
(7)
, 2492-2502. https://doi.org/10.1021/jacsau.4c00228
- Nathan March, Bradley J. Paul-Gorsline. Mechanistic Studies of Imidazole Autocatalysis in 1,1′-Thiocarbonyldiimidazole-Mediated Couplings of Aniline. Organic Process Research & Development 2024, 28
(7)
, 2488-2498. https://doi.org/10.1021/acs.oprd.4c00098
- Charles P. Mikan, Joseph O. Watson, Ryan Walton, Paul G. Waddell, Jonathan P. Knowles. Stereoselective Access to Diverse Alkaloid-Like Scaffolds via an Oxidation/Double-Mannich Reaction Sequence. Organic Letters 2024, 26
(26)
, 5549-5553. https://doi.org/10.1021/acs.orglett.4c01924
- Yixiang Shi, Yin Yuan, Jianhui Li, Junfeng Yang, Junliang Zhang. Catalytic Asymmetric Synthesis of Sulfinamides via Cu-Catalyzed Asymmetric Addition of Aryl Boroxines to Sulfinylamines. Journal of the American Chemical Society 2024, 146
(26)
, 17580-17586. https://doi.org/10.1021/jacs.4c03473
- Dayu Tian, Guang Chen, Xiaocheng Wang, Hai-Jun Zhang. Modular Access to Functionalized Oxetanes as Benzoyl Bioisosteres. Journal of the American Chemical Society 2024, 146
(26)
, 18011-18018. https://doi.org/10.1021/jacs.4c04504
- Zhen Zhang, Yuanli Li, Huannan Wang, Wei Xu, Chunying Wang, Huabin Ma, Fang Zhong, Jiazhi Ou, Zhuhua Luo, Hai-Bin Luo, Zhongbin Cheng. Ergone Derivatives from the Deep-Sea-Derived Fungus Aspergillus terreus YPGA10 and 25,28-Dihydroxyergone-Induced Apoptosis in Human Colon Cancer SW620 Cells. Journal of Natural Products 2024, 87
(6)
, 1563-1573. https://doi.org/10.1021/acs.jnatprod.4c00154
- Jianxin Zhang, Bowen Lei, Mingrui Qin, Tao Lei, Ge Yang, Junjie Liu, Qianhui Liu, Da-Jin Yang, Shu-Feng Song, Yudong Yang. Regioselective N-Trideuteromethylation of Tautomeric Polyaza Heterocycles. The Journal of Organic Chemistry 2024, 89
(11)
, 7780-7789. https://doi.org/10.1021/acs.joc.4c00448
- Robert E. Wiley, Martin Holan, Wan Shin Kim, Khoa D. Nguyen, Xingzhong Zeng, Mariusz Krawiec, Andrew T. Brusoe. Regioselective Syntheses of 2,3,5-Trisubstituted Pyridines via 5-Chloro-3-fluoro-2-(methylsulfonyl)pyridine. The Journal of Organic Chemistry 2024, 89
(11)
, 8299-8304. https://doi.org/10.1021/acs.joc.4c00753
- Matthew R. Lasky, En-Chih Liu, Matthew S. Remy, Melanie S. Sanford. Visible-Light Photocatalytic C–H Amination of Arenes Utilizing Acridine–Lewis Acid Complexes. Journal of the American Chemical Society 2024, 146
(21)
, 14799-14806. https://doi.org/10.1021/jacs.4c02991
- Xiang Yi, Florian Kleinbeck, Charlene Ching, Lorita Boghospor, Sandy Gomes, Oscar Alvizo, Thomas Allmendinger, Jason Fell, Nandhitha Subramanian, Michelle Li, Ravi Garcia, James Riggins, David Entwistle, Yvonne Richter, Daniel Gschwend, Liam Lauener, Thomas S. Peat, Hélène Lebhar, Thierry Schlama, Thomas Ruch. Enhancing the Imine Reductase Activity of a Promiscuous Glucose Dehydrogenase for Scalable Manufacturing of a Chiral Neprilysin Inhibitor Precursor. ACS Catalysis 2024, 14
(9)
, 7087-7096. https://doi.org/10.1021/acscatal.3c05615
- Xuemei Li, Rui Zhang, Jianjiong Li, Na Liu, Xi Chen, Yiyin Liu, Gang Zhao, Kai Ding, Peiyuan Yao, Jinhui Feng, Qiaqing Wu, Dunming Zhu, Yanhe Ma. Chemo-Enzymatic Strategy for the Efficient Synthesis of Steroidal Drugs with 10α-Methyl Group and a Side Chain at C17-Position from Biorenewable Phytosterols. JACS Au 2024, 4
(4)
, 1356-1364. https://doi.org/10.1021/jacsau.3c00688
- Suman Ghosh, Mainak Koner, Anusree A. Kunhiraman, Mahiuddin Baidya. Free Amine-Directed Redox Neutral Ruthenium(II) Catalysis toward Regioselective Synthesis of Heterobiaryls. Organic Letters 2024, 26
(15)
, 2987-2992. https://doi.org/10.1021/acs.orglett.4c00568
- Remkes A. Scheele, Yanik Weber, Friederike E. H. Nintzel, Michael Herger, Tomasz S. Kaminski, Florian Hollfelder. Ultrahigh Throughput Evolution of Tryptophan Synthase in Droplets via an Aptamer Sensor. ACS Catalysis 2024, 14
(8)
, 6259-6271. https://doi.org/10.1021/acscatal.4c00230
- Xiaoyan Jia, Gui-Lin Hao, Mengxia Feng, Huanfeng Jiang, Shou-Guo Wang, Liangbin Huang. Rh(III)-Catalyzed Diastereo- and Enantioselective Regiodivergent (Hetero)Arylamidation of (Homo)Allylic Sulfides. Journal of the American Chemical Society 2024, 146
(14)
, 9768-9778. https://doi.org/10.1021/jacs.3c14041
- Cameron B. Berlin, Eesha Sharma, Marisa C. Kozlowski. Quantification of Hydrogen-Bond-Donating Ability of Biologically Relevant Compounds. The Journal of Organic Chemistry 2024, 89
(7)
, 4684-4690. https://doi.org/10.1021/acs.joc.3c02939
- Lele Wang, Zhongxian Li, Yang Zhou, Jun Zhu. Nickel-Catalyzed Deoxygenative Amidation of Alcohols with Carbamoyl Chlorides. Organic Letters 2024, 26
(11)
, 2297-2302. https://doi.org/10.1021/acs.orglett.4c00519
- Shouliang Yang, Fen Wang, Stephanie Scales, Michelle Tran-Dubé, Madeline Berry, Haiwei Xu, Feng Tang, Liangliang Xue, Zhongwei Ma, Bryan Li, Indrawan McAlpine. A Disconnection for Rapid Access to Heterocyclic Benzylic Amines with Fully Substituted α-Carbons. The Journal of Organic Chemistry 2024, 89
(6)
, 3926-3930. https://doi.org/10.1021/acs.joc.3c02748
- Dattatraya H. Dethe, Amar Uike, Nagabhushana C. Beeralingappa. Ru(II)-Catalyzed Deoxygenative Formal [3 + 1 + 2] Benzannulation of Allyl Alcohols and Acetylenediesters via C–H Activation and Selective Carbon–Carbon Triple Bond Cleavage. Organic Letters 2024, 26
(10)
, 2013-2017. https://doi.org/10.1021/acs.orglett.4c00060
- Lukas Lückemeier, Thijs De Vos, Lisa Schlichter, Christian Gutheil, Constantin G. Daniliuc, Frank Glorius. Chemoselective Heterogeneous Hydrogenation of Sulfur Containing Quinolines under Mild Conditions. Journal of the American Chemical Society 2024, 146
(9)
, 5864-5871. https://doi.org/10.1021/jacs.3c11163
- Jiawei Sun, Hirofumi Endo, Megan A. Emmanuel, Martins S. Oderinde, Yu Kawamata, Phil S. Baran. Simplified Modular Access to Enantiopure 1,2-Aminoalcohols via Ni-Electrocatalytic Decarboxylative Arylation. Journal of the American Chemical Society 2024, 146
(9)
, 6209-6216. https://doi.org/10.1021/jacs.3c14119
- Sojung F. Kim, Henrik Schwarz, Justin Jurczyk, Bailey R. Nebgen, Hailey Hendricks, Hojoon Park, Andrew Radosevich, Michael W. Zuerch, Kaid Harper, Michaelyn C. Lux, Charles S. Yeung, Richmond Sarpong. Mechanistic Investigation, Wavelength-Dependent Reactivity, and Expanded Reactivity of N–Aryl Azacycle Photomediated Ring Contractions. Journal of the American Chemical Society 2024, 146
(8)
, 5580-5596. https://doi.org/10.1021/jacs.3c13982
- Carole Duboc, Sabine L. Flitsch. Drug Discovery and Development. JACS Au 2024, 4
(2)
, 276-278. https://doi.org/10.1021/jacsau.4c00111
- Nengneng Zhou, Fangli Zhao, Lei Wang, Xiang Gao, Xiaowei Zhao, Man Zhang. Visible-Light-Induced Regioselective Cascade Radical Cyclization of α-Bromocarbonyls: Access to Benzazepine Derivatives. The Journal of Organic Chemistry 2024, 89
(4)
, 2238-2246. https://doi.org/10.1021/acs.joc.3c02184
- Kosuke Yamamoto, Kohei Torigoe, Masami Kuriyama, Yosuke Demizu, Osamu Onomura. (3+2) Cycloaddition of Heteroaromatic N-Ylides with Sulfenes. Organic Letters 2024, 26
(4)
, 798-803. https://doi.org/10.1021/acs.orglett.3c03878
- Tian-Bao Zhang, Fang Wang, Jun-Yao Ouyang, Zhen-Wei Luo, Jing-Hao Qin, Jin-Heng Li, Xuan-Hui Ouyang. Aryldiazonium-Salt-Triggered Carboxylative Azotization of Pyrroles or Indoles with Polyhalomethanes via Halogen-Atom Transfer (XAT). Organic Letters 2024, 26
(2)
, 461-466. https://doi.org/10.1021/acs.orglett.3c03701
- Yutao Shi, Jinhuan Nie, Zhijie Wu, Xiaochen Ji, Huawen Huang. Photoredox Enabled Defluorinative Benzylation of Trifluoromethyl Alkenes with Alkylarenes. Organic Letters 2024, 26
(1)
, 100-105. https://doi.org/10.1021/acs.orglett.3c03713
- Lilian Geniller, Marc Taillefer, Florian Jaroschik, Alexis Prieto. Photocatalyzed Amination of Alkyl Halides to Access Primary Amines. The Journal of Organic Chemistry 2024, 89
(1)
, 656-664. https://doi.org/10.1021/acs.joc.3c02431
- Bowen Zhang, Frederik R. Erb, Aristidis Vasilopoulos, Eric A. Voight, Erik J. Alexanian. General Synthesis of N-Alkylindoles from N,N-Dialkylanilines via [4 + 1] Annulative Double C–H Functionalization. Journal of the American Chemical Society 2023, 145
(49)
, 26540-26544. https://doi.org/10.1021/jacs.3c10751
- Claire A. Herbert, Elizabeth R. Jarvo. Nickel-Catalyzed Stereoselective Coupling Reactions of Benzylic and Alkyl Alcohol Derivatives. Accounts of Chemical Research 2023, 56
(22)
, 3313-3324. https://doi.org/10.1021/acs.accounts.3c00547
- Shi-Hao Deng, Shi-Yi Zhao, Yi-Yun Huang, Meng-Ran Chang, Zhi-Bing Dong. Glyoxylic Acid Monohydrate-Promoted Formation of the C–SO2 Bond Starting from Maleimides/Quinones and Sodium Sulfinates. The Journal of Organic Chemistry 2023, 88
(22)
, 15925-15936. https://doi.org/10.1021/acs.joc.3c02113
- Huaipu Yan, Yonghong Liu, Xiao Feng, Lei Shi. Hantzsch Esters Enabled [2π+2σ] Cycloadditions of Bicyclo [1.1.0] butanes and Alkenes under Photo Conditions. Organic Letters 2023, 25
(45)
, 8116-8120. https://doi.org/10.1021/acs.orglett.3c03222
- Julia R. Dorsheimer, Tomislav Rovis. Late-Stage Isotopic Exchange of Primary Amines. Journal of the American Chemical Society 2023, 145
(44)
, 24367-24374. https://doi.org/10.1021/jacs.3c09442
- Subrata K. Ghosh, Lizhe He, Zilu Tang, Robert J. Comito. Selective and Functional-Group-Tolerant Photoalkylation of Imines by Energy-Transfer Photocatalysis. The Journal of Organic Chemistry 2023, 88
(21)
, 15209-15217. https://doi.org/10.1021/acs.joc.3c01722
- Deepan Chowdhury, Suman Ghosh, K.S.S.V. Prasad Reddy, Sharma S.R.K.C. Yamijala, Mahiuddin Baidya. Cobalt(III)-Catalyzed Free-Amine-Directed Site-Selective Allylation in 2-Aminobiaryls with Vinyl Cyclopropanes. ACS Catalysis 2023, 13
(19)
, 12543-12552. https://doi.org/10.1021/acscatal.3c03112
- Kyohei Yonekura, Mari Murooka, Kohei Aoki, Eiji Shirakawa. Electrochemical Direct α-Arylation of Alkylamines with Sulfonylarenes. Organic Letters 2023, 25
(36)
, 6682-6687. https://doi.org/10.1021/acs.orglett.3c02535
- Elliot Davenport, Daniela E. Negru, Geoff Badman, David M. Lindsay, William J. Kerr. Robust and General Late-Stage Methylation of Aryl Chlorides: Application to Isotopic Labeling of Drug-like Scaffolds. ACS Catalysis 2023, 13
(17)
, 11541-11547. https://doi.org/10.1021/acscatal.3c02761
- Ganesh Chandra Upreti, Tavinder Singh, Divakar Chaudhary, Anand Singh. Cascade Cyclizations Triggered by Photochemically Generated Carbamoyl Radicals Derived from Alkyl Amines. The Journal of Organic Chemistry 2023, 88
(16)
, 11801-11808. https://doi.org/10.1021/acs.joc.3c01090
- Jing Ren, Kaiyun Liu, Ning Wang, Xiangxiang Kong, Jinlong Li, Kaizhi Li. Copper-Catalyzed 1,2-Difunctionalization Trifluoromethylamidation of Alkynes Assisted by a Coordinating Group. ACS Catalysis 2023, 13
(16)
, 11001-11011. https://doi.org/10.1021/acscatal.3c02662
- Weiyang Guan, Yejin Chang, Song Lin. Electrochemically Driven Deoxygenative Borylation of Alcohols and Carbonyl Compounds. Journal of the American Chemical Society 2023, 145
(31)
, 16966-16972. https://doi.org/10.1021/jacs.3c03418
- Colin A. Gould, Andria L. Pace, David. W. C. MacMillan. Rapid and Modular Access to Quaternary Carbons from Tertiary Alcohols via Bimolecular Homolytic Substitution. Journal of the American Chemical Society 2023, 145
(30)
, 16330-16336. https://doi.org/10.1021/jacs.3c05405
- Dylan M. Lynch, Mark D. Nolan, Conor Williams, Leendert Van Dalsen, Susannah H. Calvert, Fabrice Dénès, Cristina Trujillo, Eoin M. Scanlan. Traceless Thioacid-Mediated Radical Cyclization of 1,6-Dienes. The Journal of Organic Chemistry 2023, 88
(14)
, 10020-10026. https://doi.org/10.1021/acs.joc.3c00824
- Roman V. Larkovich, Victoria E. Shambalova, Savva A. Ponomarev, Alexander S. Aldoshin, Konstantin A. Lyssenko, Mikhail S. Nechaev, Valentine G. Nenajdenko. Barton–Zard Reaction of β-Fluoro-β-nitrostyrenes─a Selective Route to Functionalized 4-Fluoropyrroles. The Journal of Organic Chemistry 2023, 88
(14)
, 10122-10136. https://doi.org/10.1021/acs.joc.3c00935
- Dingding Xia, Rongkai Wu, Jinxin Wang, Xinyu Han, Yanchuan Li, Qiannan Li, Xin Luan, Xin Hong, Yu Zhang, Wei-Dong Zhang. Visible-Light-Mediated Energy Transfer Enables Cyclopropanes Bearing Contiguous All-Carbon Quaternary Centers. ACS Catalysis 2023, 13
(14)
, 9806-9816. https://doi.org/10.1021/acscatal.3c02350
- Yiwen Xu, Qiang Li, Runyou Ye, Buyi Xu, Xiangge Zhou. Electrochemical Oxidative C–H Amination through a Ritter-Type Reaction. The Journal of Organic Chemistry 2023, 88
(13)
, 9518-9522. https://doi.org/10.1021/acs.joc.3c00609
- Pawan Kumar, Archana Rai, Manish Kumar, Gamidi Rama Krishna, Utpal Das. Radical Cascade Cyclization of Unactivated Alkene-Tethered Indoles with Aryldiazonium Salt and Sodium Metabisulfite to Access Azo- and Sulfonylated-2,3-Dihyro-1H-pyrrolo[1,2-a]indoles. The Journal of Organic Chemistry 2023, 88
(13)
, 9123-9129. https://doi.org/10.1021/acs.joc.3c00759
- Lilian Geniller, Marc Taillefer, Florian Jaroschik, Alexis Prieto. Photo-Induced Formal Trifluoropropanation of Organic Halides. ACS Catalysis 2023, 13
(13)
, 8624-8630. https://doi.org/10.1021/acscatal.3c02087
- Rong-Gui Hu, Yueqian Sang, Fang-Fang Tan, Yuan-Li Sun, Xiao-Song Xue, Yang Li. Photoredox and Vanadate Cocatalyzed Hydrolysis of Aryl Ethers at Ambient Temperature. ACS Catalysis 2023, 13
(13)
, 9264-9273. https://doi.org/10.1021/acscatal.3c02301
- Yuan Cai, Sagnik Chatterjee, Tobias Ritter. Photoinduced Copper-Catalyzed Late-Stage Azidoarylation of Alkenes via Arylthianthrenium Salts. Journal of the American Chemical Society 2023, 145
(25)
, 13542-13548. https://doi.org/10.1021/jacs.3c04016
- Hongtao Zhao, Jonas Brånalt, Matthew Perry, Christian Tyrchan. The Role of Allylic Strain for Conformational Control in Medicinal Chemistry. Journal of Medicinal Chemistry 2023, 66
(12)
, 7730-7755. https://doi.org/10.1021/acs.jmedchem.3c00446
- Keri A. Steiniger, Matthew C. Lamb, Tristan H. Lambert. Cross-Coupling of Amines via Photocatalytic Denitrogenation of In Situ Generated Diazenes. Journal of the American Chemical Society 2023, 145
(21)
, 11524-11529. https://doi.org/10.1021/jacs.3c03634
- I. N. Chaithanya Kiran, Ramagonolla Kranthikumar. Nickel-Catalyzed Deaminative Ketone Synthesis: Coupling of Alkylpyridinium Salts with Thiopyridine Esters via C–N Bond Activation. Organic Letters 2023, 25
(20)
, 3623-3627. https://doi.org/10.1021/acs.orglett.3c00943
- Qiao-Lin Wang, Huawen Huang, Mengqi Zhu, Tianci Xu, Guojiang Mao, Guo-Jun Deng. Visible-Light-Induced Stoichiometric Coupling of Alkylarenes and Trifluoromethyl Ketones. Organic Letters 2023, 25
(20)
, 3800-3805. https://doi.org/10.1021/acs.orglett.3c01307
- Priyabrata Biswal, M. Siva Subramani, Shaikh Samser, Vadapalli Chandrasekhar, Krishnan Venkatasubbaiah. Ligand-Controlled Ruthenium-Catalyzed Borrowing-Hydrogen and Interrupted-Borrowing-Hydrogen Methodologies: Functionalization of Ketones Using Methanol as a C1 Source. The Journal of Organic Chemistry 2023, 88
(8)
, 5135-5146. https://doi.org/10.1021/acs.joc.2c00653
- William L. Lyon, David W. C. MacMillan. Expedient Access to Underexplored Chemical Space: Deoxygenative C(sp3)–C(sp3) Cross-Coupling. Journal of the American Chemical Society 2023, 145
(14)
, 7736-7742. https://doi.org/10.1021/jacs.3c01488
- Jiajun Zhang, Xiao-Feng Wu. Palladium-Catalyzed Carbonylative Synthesis of Diaryl Ketones from Arenes and Arylboronic Acids through C(sp2)–H Thianthrenation. Organic Letters 2023, 25
(12)
, 2162-2166. https://doi.org/10.1021/acs.orglett.3c00792
- Dieter Ruijten, Thomas Narmon, Korneel Van Aelst, Hanne De Weer, Robbe van der Zweep, Tessy Hendrickx, Claude Poleunis, Lingfeng Li, Kevin M. Van Geem, Damien P. Debecker, Bert F. Sels. Tertiary Amines from RCF Lignin Mono- and Dimers: Catalytic N-Functionalized Antioxidants from Wood. ACS Sustainable Chemistry & Engineering 2023, 11
(12)
, 4776-4788. https://doi.org/10.1021/acssuschemeng.2c07343
- Lang Liu, Changting Wen, Guojin Sun, Yao Li, Jun Zhang, Zhe Zhang, Zesi Wang, Mengyao She, Ping Liu, Shengyong Zhang, Jianli Li. Multisite-Sequential Cyclization To Construct 1,2,4-Triazole-Based N-Fused Heterocyclics. Organic Letters 2023, 25
(9)
, 1530-1535. https://doi.org/10.1021/acs.orglett.3c00322
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.