Exploration of Oxidative Stress and Inflammatory Markers in Relation to Urinary Phthalate Metabolites: NHANES 1999–2006
Abstract

Phthalate exposure has been associated with a wide range of adverse health outcomes in limited epidemiologic studies, and inflammation and oxidative stress have been hypothesized as potential mechanisms involved. In the present study we investigated associations between urinary concentrations of phthalate metabolites and potential blood markers of oxidative stress (bilirubin) and inflammation (alkaline phosphatase [ALP], absolute neutrophil count [ANC], ferritin [adjusted for iron status], and fibrinogen), using data from 10,026 participants in the National Health and Nutrition Examination Survey (NHANES) recruited between 1999 and 2006. After adjustment for covariates we found that bilirubin was inversely associated with several phthalate metabolites (all p-values <0.0001), including the metabolites of di-2-ethylhexyl phthalate (DEHP) and dibutyl phthalate (DBP), in addition to monobenzyl phthalate (MBzP) and mono-(3-carboxypropyl) phthalate (MCPP). Since bilirubin is a potent antioxidant these relationships suggest that phthalates may be associated with increased oxidative stress. Many of the same metabolites were also significantly and positively related with ANC, ALP, and ferritin, suggesting phthalates may be associated with increased inflammation. These markers may be useful in other studies of low-dose exposure to environmental contaminants.
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- Kelly K. Ferguson, David E. Cantonwine, Luis O. Rivera-González, Rita Loch-Caruso, Bhramar Mukherjee, Liza V. Anzalota Del Toro, Braulio Jiménez-Vélez, Antonia M. Calafat, Xiaoyun Ye, Akram N. Alshawabkeh, José F. Cordero, and John D. Meeker . Urinary Phthalate Metabolite Associations with Biomarkers of Inflammation and Oxidative Stress Across Pregnancy in Puerto Rico. Environmental Science & Technology 2014, 48
(12)
, 7018-7025. https://doi.org/10.1021/es502076j
- Jeanne M. Hankett, William R. Collin, and Zhan Chen . Molecular Structural Changes of Plasticized PVC after UV Light Exposure. The Journal of Physical Chemistry B 2013, 117
(50)
, 16336-16344. https://doi.org/10.1021/jp409254y
- Qiong Huang, Jinfa Wan, Wenbin Nan, Siqi Li, Baimei He, Zhenyu Peng. Association between manganese exposure in heavy metals mixtures and the prevalence of sarcopenia in US adults from NHANES 2011–2018. Journal of Hazardous Materials 2024, 464 , 133005. https://doi.org/10.1016/j.jhazmat.2023.133005
- Shihao Jin, Shanshan Cui, Xiaoyu Mu, Zhao Liu, Yu Han, Tingkai Cui, Wenjuan Xiong, Wei Xi, Xin Zhang. Exposure to phthalates and their alternatives in relation to biomarkers of inflammation and oxidative stress in adults: evidence from NHANES 2017–2018. Environmental Science and Pollution Research 2023, 108 https://doi.org/10.1007/s11356-023-30924-8
- Ren Zhou, Lei Zhang, Yu Sun, Jia Yan, Hong Jiang. Association of urinary bisphenols with oxidative stress and inflammatory markers and their role in obesity. Ecotoxicology and Environmental Safety 2023, 266 , 115546. https://doi.org/10.1016/j.ecoenv.2023.115546
- Jiran Shen, Yue Wang, Sijing Zhou, Min Tang, Min Li, Rui Han, Guanghe Fei, Ran Wang. Association between urinary phthalate metabolites and chronic obstructive pulmonary disease incidence in US adults: results from NHANES 2007–2018. Environmental Science and Pollution Research 2023, 30
(52)
, 113026-113038. https://doi.org/10.1007/s11356-023-30334-w
- Ekramy Mahmoud Elmorsy, Ayat Al-Ghafari, Huda Al Doghaither. Role of mitochondrial disruption and oxidative stress in plasticizer phthalate-induced cytotoxicity to human bone osteoblasts. Toxicology Research 2023, 12
(5)
, 765-774. https://doi.org/10.1093/toxres/tfad065
- Yuting Chen, Jiran Shen, Ye Wu, Lanlan Fang, Shanshan Xu, Yongzhen Peng, Faming Pan. Associations between urinary phthalate metabolite concentrations and rheumatoid arthritis in the U.S. adult population. Chemosphere 2023, 337 , 139382. https://doi.org/10.1016/j.chemosphere.2023.139382
- Xianwei Guo, Dongdong Zhao, Jia Meng, Wenjing Hu, Birong Wu, Xingyue Wang, Wenqi Su, Muzi Meng, Guangbo Qu, Yehuan Sun. Association of a mixture of phthalates and phenols with frailty among middle-aged and older adults: A population-based cross-sectional study. Chemosphere 2023, 336 , 139144. https://doi.org/10.1016/j.chemosphere.2023.139144
- Lu Han, Qi Wang. Association between brominated flame retardants exposure and markers of oxidative stress in US adults: An analysis based on the National Health and Nutrition Examination Survey 2007–2016. Ecotoxicology and Environmental Safety 2023, 263 , 115253. https://doi.org/10.1016/j.ecoenv.2023.115253
- Aldo Mileo, Teresa Chianese, Gianluca Fasciolo, Paola Venditti, Anna Capaldo, Luigi Rosati, Maria De Falco. Effects of Dibutylphthalate and Steroid Hormone Mixture on Human Prostate Cells. International Journal of Molecular Sciences 2023, 24
(18)
, 14341. https://doi.org/10.3390/ijms241814341
- Xiaodong Zang, Wengang Qin, Yingying Xiong, Anlan Xu, Hesuyuan Huang, Tao Fang, Xiaowei Zang, Mingwu Chen. Using three statistical methods to analyze the association between aldehyde exposure and markers of inflammation and oxidative stress. Environmental Science and Pollution Research 2023, 30
(32)
, 79437-79450. https://doi.org/10.1007/s11356-023-27717-4
- Huan Liu, Linjing Xu, Lizi Zhou, Wenna Han, Zhongyi Li, Chunhong Liu. DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway. Food and Chemical Toxicology 2023, 176 , 113782. https://doi.org/10.1016/j.fct.2023.113782
- Amanda C. Wylie, Sarah J. Short. Environmental Toxicants and the Developing Brain. Biological Psychiatry 2023, 93
(10)
, 921-933. https://doi.org/10.1016/j.biopsych.2023.01.007
- Marissa Chan, Emma V. Preston, Victoria Fruh, Marlee R. Quinn, Michele R. Hacker, Blair J. Wylie, Karen O'Brien, Paige L. Williams, Russ Hauser, Tamarra James-Todd, Shruthi Mahalingaiah. Use of personal care products during pregnancy and birth outcomes – A pilot study. Environmental Research 2023, 225 , 115583. https://doi.org/10.1016/j.envres.2023.115583
- Xiaolu Zhou, Shuo Gao, Mengjie Yue, Shuyun Zhu, Qian Liu, Xian-En Zhao. Recent advances in analytical methods of oxidative stress biomarkers induced by environmental pollutant exposure. TrAC Trends in Analytical Chemistry 2023, 160 , 116978. https://doi.org/10.1016/j.trac.2023.116978
- Bo Qian, Zhao-xuan Zheng, Lei Yang, Cheng-qiang Wang, Yu-Chun Lin, Zhong-Ning Lin. Prenatal exposure to phthalates and polybrominated diphenyl ethers on neonatal health: A birth cohort study in Guangxi, China. Environmental Research 2023, 216 , 114571. https://doi.org/10.1016/j.envres.2022.114571
- Ruoru Yang, Jianheng Zheng, Jin Qin, Shaojie Liu, Xinyuan Liu, Yiying Gu, Shuyu Yang, Jun Du, Shuguang Li, Bo Chen, Ruihua Dong. Dibutyl phthalate affects insulin synthesis and secretion by regulating the mitochondrial apoptotic pathway and oxidative stress in rat insulinoma cells. Ecotoxicology and Environmental Safety 2023, 249 , 114396. https://doi.org/10.1016/j.ecoenv.2022.114396
- Nina Z. Heilmann, Katherine W. Reeves, Susan E. Hankinson. Phthalates and bone mineral density: a systematic review. Environmental Health 2022, 21
(1)
https://doi.org/10.1186/s12940-022-00920-5
- Zeng-Jin Wen, Zhong-Yu Wang, Yin-Feng Zhang. Adverse cardiovascular effects and potential molecular mechanisms of DEHP and its metabolites—A review. Science of The Total Environment 2022, 847 , 157443. https://doi.org/10.1016/j.scitotenv.2022.157443
- Ryan S. Babadi, Anne M. Riederer, Paul D. Sampson, Sheela Sathyanarayana, Terrance J. Kavanagh, Jennifer E. Krenz, Syam S. Andra, Seunghee Kim-Schulze, Karen L. Jansen, Elizabeth Torres, Adriana Perez, Lisa R. Younglove, Maria I. Tchong-French, Catherine J. Karr. Associations between repeated measures of urinary phthalate metabolites and biomarkers of oxidative stress in a rural agricultural cohort of children with asthma. Science of The Total Environment 2022, 848 , 157493. https://doi.org/10.1016/j.scitotenv.2022.157493
- Alexandre M. B. Cavalca, Ariana M. Aquino, Francielle C. Mosele, Luis A. Justulin, Flávia K. Delella, Jodi A. Flaws, Wellerson R. Scarano. Effects of a phthalate metabolite mixture on both normal and tumoral human prostate cells. Environmental Toxicology 2022, 37
(10)
, 2566-2578. https://doi.org/10.1002/tox.23619
- Angel D. Davalos, Lidia Mínguez-Alarcón, Thomas J. van t’ Erve, Alexander P. Keil, Paige L. Williams, John D. Meeker, Ginger L. Milne, Shanshan Zhao, Russ Hauser, Kelly K. Ferguson. Associations between mixtures of urinary phthalate metabolite concentrations and oxidative stress biomarkers among couples undergoing fertility treatment. Environmental Research 2022, 212 , 113342. https://doi.org/10.1016/j.envres.2022.113342
- Chuang Zhang, Weirui Ren, Meng Li, Wenbo Wang, Chi Sun, Lin Liu, Yanbin Fang, Lin Liu, Xiaofeng Yang, Xiangjian Zhang, Suolin Li. Association Between the Children's Dietary Inflammatory Index (C-DII) and Markers of Inflammation and Oxidative Stress Among Children and Adolescents: NHANES 2015-2018. Frontiers in Nutrition 2022, 9 https://doi.org/10.3389/fnut.2022.894966
- Conghua Bai, Linlin Liu, Shuang Chen, Lei Zhao, Huihua Yang, Wenting Guo, Meng Li, Miao Liu, Xuefeng Lai, Xiaomin Zhang, Liangle Yang. Urinary phthalate metabolites and arterial stiffness: A panel study. Environmental Research 2022, 207 , 112657. https://doi.org/10.1016/j.envres.2021.112657
- Carla Giovana Basso, Anderson Tadeu de Araújo-Ramos, Anderson Joel Martino-Andrade. Exposure to phthalates and female reproductive health: A literature review. Reproductive Toxicology 2022, 109 , 61-79. https://doi.org/10.1016/j.reprotox.2022.02.006
- Shiting Xiang, Jie Dong, Xun Li, Chao Li. Urine Phthalate Levels and Liver Function in US Adolescents: Analyses of NHANES 2007–2016. Frontiers in Public Health 2022, 10 https://doi.org/10.3389/fpubh.2022.843971
- Gabriela Vieyra, Susan E. Hankinson, Youssef Oulhote, Laura Vandenberg, Lesley Tinker, JoAnn E. Manson, Aladdin H. Shadyab, RB Wallace, Chrisa Arcan, JC Chen, Katherine W. Reeves. Dietary Patterns and Urinary Phthalate Exposure Among Postmenopausal Women of the Women's Health Initiative. SSRN Electronic Journal 2022, 7 https://doi.org/10.2139/ssrn.4129831
- Jonathan Boss, Alexander Rix, Yin‐Hsiu Chen, Naveen N. Narisetty, Zhenke Wu, Kelly K. Ferguson, Thomas F. McElrath, John D. Meeker, Bhramar Mukherjee. A hierarchical integrative group least absolute shrinkage and selection operator for analyzing environmental mixtures. Environmetrics 2021, 32
(8)
https://doi.org/10.1002/env.2698
- Vincent Bessonneau, Roy R. Gerona, Jessica Trowbridge, Rachel Grashow, Thomas Lin, Heather Buren, Rachel Morello-Frosch, Ruthann A. Rudel. Gaussian graphical modeling of the serum exposome and metabolome reveals interactions between environmental chemicals and endogenous metabolites. Scientific Reports 2021, 11
(1)
https://doi.org/10.1038/s41598-021-87070-9
- Emma V. Preston, Victoria Fruh, Marlee R. Quinn, Michele R. Hacker, Blair J. Wylie, Karen O’Brien, Shruthi Mahalingaiah, Tamarra James-Todd. Endocrine disrupting chemical-associated hair product use during pregnancy and gestational age at delivery: a pilot study. Environmental Health 2021, 20
(1)
https://doi.org/10.1186/s12940-021-00772-5
- Ching-Way Chen, Shu-Yu Tang, Jin-Shiang Hwang, Chang-Chuan Chan, Cheng-Chih Hsu, Chien-Yu Lin, Ta-Chen Su. Association between Levels of Urine Di-(2-ethylhexyl)phthalate Metabolites and Heart Rate Variability in Young Adults. Toxics 2021, 9
(12)
, 351. https://doi.org/10.3390/toxics9120351
- Olufemi I. Oluranti, Babatunde A. Alabi, Olugbenga S. Michael, Alaba O. Ojo, Bosede P. Fatokun. Rutin prevents cardiac oxidative stress and inflammation induced by bisphenol A and dibutyl phthalate exposure via NRF-2/NF-κB pathway. Life Sciences 2021, 284 , 119878. https://doi.org/10.1016/j.lfs.2021.119878
- Linling Yu, Meng Yang, Man Cheng, Lieyang Fan, Xing Wang, Tao Xu, Bin Wang, Weihong Chen. Associations between urinary phthalate metabolite concentrations and markers of liver injury in the US adult population. Environment International 2021, 155 , 106608. https://doi.org/10.1016/j.envint.2021.106608
- Lars Kaiser, Isabel Quint, René Csuk, Manfred Jung, Hans-Peter Deigner. Lineage-Selective Disturbance of Early Human Hematopoietic Progenitor Cell Differentiation by the Commonly Used Plasticizer Di-2-ethylhexyl Phthalate via Reactive Oxygen Species: Fatty Acid Oxidation Makes the Difference. Cells 2021, 10
(10)
, 2703. https://doi.org/10.3390/cells10102703
- Amber L. Cathey, Jarrod L. Eaton, Pahriya Ashrap, Deborah J. Watkins, Zaira Y. Rosario, Carmen Vélez Vega, Akram N. Alshawabkeh, José F. Cordero, Bhramar Mukherjee, John D. Meeker. Individual and joint effects of phthalate metabolites on biomarkers of oxidative stress among pregnant women in Puerto Rico. Environment International 2021, 154 , 106565. https://doi.org/10.1016/j.envint.2021.106565
- Jiayao Fan, Shaofang Cai, Shuai Mi, Hanzhu Chen, Dingwan Chen, Chunhong Fan, Lingling Sun, Yingjun Li. Association of urinary phthalate metabolites with osteoarthritis in American adults: Results from the national health and nutrition examination survey 2003–2014. Chemosphere 2021, 268 , 128807. https://doi.org/10.1016/j.chemosphere.2020.128807
- Yuan Cui, Xintong Zhang, Kai Yin, Xue Qi, Yue Zhang, Jinxi Zhang, Shu Li, Hongjin Lin. Dibutyl phthalate-induced oxidative stress, inflammation and apoptosis in grass carp hepatocytes and the therapeutic use of taxifolin. Science of The Total Environment 2021, 764 , 142880. https://doi.org/10.1016/j.scitotenv.2020.142880
- Lingling Sun, Jiayao Fan, Guangzhong Song, Shaofang Cai, Chunhong Fan, Yaohong Zhong, Yingjun Li. Exposure to phthalates is associated with grip strength in US adults. Ecotoxicology and Environmental Safety 2021, 209 , 111787. https://doi.org/10.1016/j.ecoenv.2020.111787
- Po-Ching Chu, Charlene Wu, Ta-Chen Su. Association between Urinary Phthalate Metabolites and Markers of Endothelial Dysfunction in Adolescents and Young Adults. Toxics 2021, 9
(2)
, 33. https://doi.org/10.3390/toxics9020033
- Chia-Fang Wu, Chao A. Hsiung, Hui-Ju Tsai, Ching-Mei Cheng, Bai-Hsiun Chen, Chiung-Wen Hu, Yeou-Lih Huang, Ming-Tsang Wu. Decreased levels of urinary di-2-ethylhexyl phthalate (DEHP) metabolites and biomarkers of oxidative stress in children exposed to DEHP-tainted foods in Taiwan in 2011: A 44-month follow-up. Environmental Pollution 2020, 266 , 115204. https://doi.org/10.1016/j.envpol.2020.115204
- Jian-Qing Wang, Ya-Bin Hu, Hui Gao, Jie Sheng, Kun Huang, Yun-Wei Zhang, Lei-Jing Mao, Shan-Shan Zhou, Xiu-Xiu Cai, Liang-Jian Zhang, Su-Fang Wang, Jia-Hu Hao, Li-Qi Yang, Fang-Biao Tao. Sex-specific difference in placental inflammatory transcriptional biomarkers of maternal phthalate exposure: a prospective cohort study. Journal of Exposure Science & Environmental Epidemiology 2020, 30
(5)
, 835-844. https://doi.org/10.1038/s41370-020-0200-z
- Weixiang Wu, Chuangyan Wu, Cunwei Ji, Fuqiang Diao, Jinglun Peng, Dan Luo, Xiaoping Mu, Xiaolin Ruan. Association between phthalate exposure and asthma risk: A meta-analysis of observational studies. International Journal of Hygiene and Environmental Health 2020, 228 , 113539. https://doi.org/10.1016/j.ijheh.2020.113539
- Sunny O. Abarikwu, Godwin Simple, Chimezie Samuel Onuoha. Morphometric Evaluation of the Seminiferous Tubules and the Antioxidant Protective Effects of Gallic Acid and Quercetin in the Testis and Liver of Butyl Phthalate Treated Rats. Indian Journal of Clinical Biochemistry 2020, 35
(1)
, 20-31. https://doi.org/10.1007/s12291-018-0788-0
- Helen B. Chin, Anne Marie Jukic, Allen J. Wilcox, Clarice R. Weinberg, Kelly K. Ferguson, Antonia M. Calafat, D. Robert McConnaughey, Donna D. Baird. Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation. Environmental Health 2019, 18
(1)
https://doi.org/10.1186/s12940-019-0522-2
- A. Hartwig, . Benzyl butyl phthalate [MAK Value Documentation, 2018]. 2019, 1802-1874. https://doi.org/10.1002/3527600418.mb8568e6519
- Yoonjeong Choi, Sun Ju Lee, Jooeun Jeon, Keum Ji Jung, Sun Ha Jee. Inverse associations of bisphenol A and phthalate metabolites with serum bilirubin levels in Korean population. Environmental Science and Pollution Research 2019, 26
(26)
, 26685-26695. https://doi.org/10.1007/s11356-019-05205-y
- Tarek Atia, Sahar Abdel-Gawad. Pulmonary toxicity induced by exposure to phthalates, an experimental study. Inhalation Toxicology 2019, 31
(9-10)
, 376-383. https://doi.org/10.1080/08958378.2019.1695025
- Lulu Song, Bingqing Liu, Mingyang Wu, Lina Zhang, Lulin Wang, Bin Zhang, Chao Xiong, Yuanyuan Li, Zhongqiang Cao, Youjie Wang, Shunqing Xu. Prenatal Exposure to Phthalates and Newborn Telomere Length: A Birth Cohort Study in Wuhan, China. Environmental Health Perspectives 2019, 127
(8)
https://doi.org/10.1289/EHP4492
- Ta-Chen Su, Juey-Jen Hwang, Chien-Wen Sun, Shu-Li Wang. Urinary phthalate metabolites, coronary heart disease, and atherothrombotic markers. Ecotoxicology and Environmental Safety 2019, 173 , 37-44. https://doi.org/10.1016/j.ecoenv.2019.02.021
- Marina R. Sweeney, Keri G. O’Leary, Zsuzsanna Jeney, Megan C. Braunlin, Herman J. Gibb. Systematic review and quality ranking of studies of two phthalate metabolites and anogenital distance, bone health, inflammation, and oxidative stress. Critical Reviews in Toxicology 2019, 49
(4)
, 281-301. https://doi.org/10.1080/10408444.2019.1605332
- Inae Lee, Raid Alakeel, Sungmin Kim, Yazeed A. Al-Sheikh, Hazem Al-Mandeel, Abdullah A. Alyousef, Younglim Kho, Kyungho Choi. Urinary phthalate metabolites among children in Saudi Arabia: Occurrences, risks, and their association with oxidative stress markers. Science of The Total Environment 2019, 654 , 1350-1357. https://doi.org/10.1016/j.scitotenv.2018.11.025
- Helen B. Chin, Anne Marie Jukic, Allen J. Wilcox, Clarice R. Weinberg, Kelly K. Ferguson, Antonia M. Calafat, D. Robert McConnaughey, Donna D. Baird. Association of urinary concentrations of phthalate metabolites and bisphenol A with early pregnancy endpoints. Environmental Research 2019, 168 , 254-260. https://doi.org/10.1016/j.envres.2018.09.037
- Young-Min Kim, Jihyun Kim, Hae-Kwan Cheong, Byoung-Hak Jeon, Kangmo Ahn, . Exposure to phthalates aggravates pulmonary function and airway inflammation in asthmatic children. PLOS ONE 2018, 13
(12)
, e0208553. https://doi.org/10.1371/journal.pone.0208553
- Kimberly Berger, Brenda Eskenazi, John Balmes, Nina Holland, Antonia M. Calafat, Kim G. Harley. Associations between prenatal maternal urinary concentrations of personal care product chemical biomarkers and childhood respiratory and allergic outcomes in the CHAMACOS study. Environment International 2018, 121 , 538-549. https://doi.org/10.1016/j.envint.2018.09.027
- Hyeong-Moo Shin, Rebecca J. Schmidt, Daniel Tancredi, Jacqueline Barkoski, Sally Ozonoff, Deborah H. Bennett, Irva Hertz-Picciotto. Prenatal exposure to phthalates and autism spectrum disorder in the MARBLES study. Environmental Health 2018, 17
(1)
https://doi.org/10.1186/s12940-018-0428-4
- Alanna V. Rigobon, Thirumagal Kanagasabai, Valerie H. Taylor. Obesity moderates the complex relationships between inflammation, oxidative stress, sleep quality and depressive symptoms. BMC Obesity 2018, 5
(1)
https://doi.org/10.1186/s40608-018-0208-2
- Michael Zhou, Breanna Ford, Douglas Lee, Gwen Tindula, Karen Huen, Vy Tran, Asa Bradman, Robert Gunier, Brenda Eskenazi, Daniel K. Nomura, Nina Holland. Metabolomic Markers of Phthalate Exposure in Plasma and Urine of Pregnant Women. Frontiers in Public Health 2018, 6 https://doi.org/10.3389/fpubh.2018.00298
- A. Hartwig, . Benzylbutylphthalat [MAK Value Documentation in German language, 2018]. 2018, 1195-1271. https://doi.org/10.1002/3527600418.mb8568d0065
- Sunyeong Cha, Kayeon Jung, Min Young Lee, Yeon Jeong Hwang, Eunhyeok Yang, Sung-Ho Lee, Hyo-il Jung, Yong-Pil Cheon. Nonmonotonic Effects of Chronic Low-Dose Di(2-ethylhexyl) Phthalate
on Gonadal Weight and Reproductive. Development & Reproduction 2018, 22
(1)
, 85-94. https://doi.org/10.12717/DR.2018.22.1.085
- Darla R. Shores, Allen D. Everett. Children as Biomarker Orphans: Progress in the Field of Pediatric Biomarkers. The Journal of Pediatrics 2018, 193 , 14-20.e31. https://doi.org/10.1016/j.jpeds.2017.08.077
- José F. Cordero, John D. Meeker, Rita Loch-Caruso, Roger Giese, Ingrid Padilla, Dorothy Vesper, David Kaeli, Thomas Sheahan, Phil Brown, Carmen M. Vélez-Vega, Akram N. Alshawabkeh. Team Science Applied to Environmental Health Research: Karst Hydrogeology and Preterm Birth in Puerto Rico. 2018, 17-25. https://doi.org/10.1007/978-3-319-51070-5_3
- Yishuang Duan, Lei Wang, Liping Han, Bin Wang, Hongwen Sun, Liming Chen, Lingyan Zhu, Yi Luo. Exposure to phthalates in patients with diabetes and its association with oxidative stress, adiponectin, and inflammatory cytokines. Environment International 2017, 109 , 53-63. https://doi.org/10.1016/j.envint.2017.09.002
- Rafael Jaimes, Adam Swiercz, Meredith Sherman, Narine Muselimyan, Paul J. Marvar, Nikki Gillum Posnack. Plastics and cardiovascular health: phthalates may disrupt heart rate variability and cardiovascular reactivity. American Journal of Physiology-Heart and Circulatory Physiology 2017, 313
(5)
, H1044-H1053. https://doi.org/10.1152/ajpheart.00364.2017
- Mohammad Rahbar, Hanes Swingle, MacKinsey Christian, Manouchehr Hessabi, MinJae Lee, Meagan Pitcher, Sean Campbell, Amy Mitchell, Ryan Krone, Katherine Loveland, Donald Patterson Jr.. Environmental Exposure to Dioxins, Dibenzofurans, Bisphenol A, and Phthalates in Children with and without Autism Spectrum Disorder Living near the Gulf of Mexico. International Journal of Environmental Research and Public Health 2017, 14
(11)
, 1425. https://doi.org/10.3390/ijerph14111425
- Peter Y. Bai, Gary Wittert, Anne W. Taylor, Sean A. Martin, Robert W. Milne, Alicia J. Jenkins, Andrzej S. Januszewski, Zumin Shi. The association between total phthalate concentration and non-communicable diseases and chronic inflammation in South Australian urban dwelling men. Environmental Research 2017, 158 , 366-372. https://doi.org/10.1016/j.envres.2017.06.021
- Chien-Yu Lin, Pau-Chung Chen, Chia-Jung Hsieh, Chao-Yu Chen, Anren Hu, Fung-Chang Sung, Hui-Ling Lee, Ta-Chen Su. Positive Association between Urinary Concentration of Phthalate Metabolites and Oxidation of DNA and Lipid in Adolescents and Young Adults. Scientific Reports 2017, 7
(1)
https://doi.org/10.1038/srep44318
- Bruno A. Rocha, Alexandros G. Asimakopoulos, Fernando Barbosa, Kurunthachalam Kannan. Urinary concentrations of 25 phthalate metabolites in Brazilian children and their association with oxidative DNA damage. Science of The Total Environment 2017, 586 , 152-162. https://doi.org/10.1016/j.scitotenv.2017.01.193
- Johnathan R. Nuttall. The plausibility of maternal toxicant exposure and nutritional status as contributing factors to the risk of autism spectrum disorders. Nutritional Neuroscience 2017, 20
(4)
, 209-218. https://doi.org/10.1080/1028415X.2015.1103437
- Nina Holland. Future of environmental research in the age of epigenomics and exposomics. Reviews on Environmental Health 2017, 32
(1-2)
, 45-54. https://doi.org/10.1515/reveh-2016-0032
- Cheng-bin Gong, Xiao-xiao Ou, Song Liu, Yong-lei Jin, Hai-rong Huang, Qian Tang, Michael Hon-Wah Lam, Cheuk-fai Chow, Qian Tang. A molecular imprinting-based multifunctional chemosensor for phthalate esters. Dyes and Pigments 2017, 137 , 499-506. https://doi.org/10.1016/j.dyepig.2016.10.047
- Haotian Wu, Alexandra Olmsted, David E. Cantonwine, Shahin Shahsavari, Tayyab Rahil, Cynthia Sites, J. Richard Pilsner. Urinary phthalate and phthalate alternative metabolites and isoprostane among couples undergoing fertility treatment. Environmental Research 2017, 153 , 1-7. https://doi.org/10.1016/j.envres.2016.11.003
- Ye Yuan, John D. Meeker, Kelly K. Ferguson. Serum polybrominated diphenyl ether (PBDE) concentrations in relation to biomarkers of oxidative stress and inflammation: The National Health and Nutrition Examination Survey 2003–2004. Science of The Total Environment 2017, 575 , 400-405. https://doi.org/10.1016/j.scitotenv.2016.10.028
- Lusine Yaghjyan, Gabriela L. Ghita, Marilyn Dumont-Driscoll, Richard A. Yost, Su-Hsin Chang. Maternal exposure to di-2-ethylhexylphthalate and adverse delivery outcomes: A systematic review. Reproductive Toxicology 2016, 65 , 76-86. https://doi.org/10.1016/j.reprotox.2016.07.002
- Gerard M.H. Swaen, Miriam J.E. Urlings, Maurice P. Zeegers. Outcome reporting bias in observational epidemiology studies on phthalates. Annals of Epidemiology 2016, 26
(8)
, 597-599.e4. https://doi.org/10.1016/j.annepidem.2016.07.001
- Chien-Yu Lin, Chia-Jung Hsieh, Shyh-Chyi Lo, Pau-Chung Chen, Pao-Ling Torng, Anren Hu, Fung-Chang Sung, Ta-Chen Su. Positive association between concentration of phthalate metabolites in urine and microparticles in adolescents and young adults. Environment International 2016, 92-93 , 157-164. https://doi.org/10.1016/j.envint.2016.04.006
- Anne Marie Jukic, Antonia M. Calafat, D. Robert McConnaughey, Matthew P. Longnecker, Jane A. Hoppin, Clarice R. Weinberg, Allen J. Wilcox, Donna D. Baird, Antonia M. Calafat, D. Robert McConnaughey, Matthew P. Longnecker, Jane A. Hoppin, Clarice R. Weinberg, Allen J. Wilcox, Donna D. Baird. Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss. Environmental Health Perspectives 2016, 124
(3)
, 321-328. https://doi.org/10.1289/ehp.1408164
- Nina Holland, Karen Huen, Vy Tran, Kelly Street, Brian Nguyen, Asa Bradman, Brenda Eskenazi. Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in a Mexican-American Cohort: Variability in Early and Late Pregnancy. Toxics 2016, 4
(1)
, 7. https://doi.org/10.3390/toxics4010007
- Jonatan Axelsson, Lars Rylander, Anna Rignell-Hydbom, Bo A.G. Jönsson, Christian H. Lindh, Aleksander Giwercman. Phthalate exposure and reproductive parameters in young men from the general Swedish population. Environment International 2015, 85 , 54-60. https://doi.org/10.1016/j.envint.2015.07.005
- Yitao Pan, Jun Jing, Fengshou Dong, Qi Yao, Wei Zhang, Hongxia Zhang, Bing Yao, Jiayin Dai. Association between phthalate metabolites and biomarkers of reproductive function in 1066 Chinese men of reproductive age. Journal of Hazardous Materials 2015, 300 , 729-736. https://doi.org/10.1016/j.jhazmat.2015.08.011
- Thu Quach, Julie Von Behren, Debbie Goldberg, Michael Layefsky, Peggy Reynolds. Adverse birth outcomes and maternal complications in licensed cosmetologists and manicurists in California. International Archives of Occupational and Environmental Health 2015, 88
(7)
, 823-833. https://doi.org/10.1007/s00420-014-1011-0
- Kelly K. Ferguson, Thomas F. McElrath, Bhramar Mukherjee, Rita Loch-Caruso, John D. Meeker, . Associations between Maternal Biomarkers of Phthalate Exposure and Inflammation Using Repeated Measurements across Pregnancy. PLOS ONE 2015, 10
(8)
, e0135601. https://doi.org/10.1371/journal.pone.0135601
- Daniel B. Martinez-Arguelles, Vassilios Papadopoulos. Mechanisms Mediating Environmental Chemical-Induced Endocrine Disruption in the Adrenal Gland. Frontiers in Endocrinology 2015, 6 https://doi.org/10.3389/fendo.2015.00029
- Caroline Carrico, Chris Gennings, David C. Wheeler, Pam Factor-Litvak. Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting. Journal of Agricultural, Biological, and Environmental Statistics 2015, 20
(1)
, 100-120. https://doi.org/10.1007/s13253-014-0180-3
- Xia Sun, Yi Lin, Qiansheng Huang, Junpeng Shi, Ling Qiu, Mei Kang, Yajie Chen, Chao Fang, Ting Ye, Sijun Dong. Di(2‐ethylhexyl) phthalate‐induced apoptosis in rat
INS
‐1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection. Journal of Cellular and Molecular Medicine 2015, 19
(3)
, 581-594. https://doi.org/10.1111/jcmm.12409
- Kelly K. Ferguson, Thomas F. McElrath, Yin-Hsiu Chen, Bhramar Mukherjee, John D. Meeker. Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in Pregnant Women: A Repeated Measures Analysis. Environmental Health Perspectives 2015, 123
(3)
, 210-216. https://doi.org/10.1289/ehp.1307996
- Robin M. Whyatt, Matthew S. Perzanowski, Allan C. Just, Andrew G. Rundle, Kathleen M. Donohue, Antonia M. Calafat, Lori A. Hoepner, Frederica P. Perera, Rachel L. Miller. Asthma in Inner-City Children at 5–11 Years of Age and Prenatal Exposure to Phthalates: The Columbia Center for Children’s Environmental Health Cohort. Environmental Health Perspectives 2014, 122
(10)
, 1141-1146. https://doi.org/10.1289/ehp.1307670
- Liang Liu, Piao Xu, Guangming Zeng, Danlian Huang, Meihua Zhao, Cui Lai, Ming Chen, Ningjie Li, Chao Huang, Cong Wang, Min Cheng, Xiaoxiao He, Mingyong Lai, Yibin He. Inherent antioxidant activity and high yield production of antioxidants in Phanerochaete chrysosporium. Biochemical Engineering Journal 2014, 90 , 245-254. https://doi.org/10.1016/j.bej.2014.06.014
- Kelly K. Ferguson, Thomas F. McElrath, Yi-An Ko, Bhramar Mukherjee, John D. Meeker. Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth. Environment International 2014, 70 , 118-124. https://doi.org/10.1016/j.envint.2014.05.016
- Jeanne M. Hankett, Alexander Welle, Joerg Lahann, Zhan Chen. Evaluating UV/H
2
O
2
exposure as a DEHP degradation treatment for plasticized PVC. Journal of Applied Polymer Science 2014, 131
(16)
https://doi.org/10.1002/app.40649
- Michelle L. North, Tim K. Takaro, Miriam L. Diamond, Anne K. Ellis. Effects of phthalates on the development and expression of allergic disease and asthma. Annals of Allergy, Asthma & Immunology 2014, 112
(6)
, 496-502. https://doi.org/10.1016/j.anai.2014.03.013
- Justin A. Colacino, Anna E. Arthur, Kelly K. Ferguson, Laura S. Rozek. Dietary antioxidant and anti-inflammatory intake modifies the effect of cadmium exposure on markers of systemic inflammation and oxidative stress. Environmental Research 2014, 131 , 6-12. https://doi.org/10.1016/j.envres.2014.02.003
- Virginie Cuvillier-Hot, Karine Salin, Séverine Devers, Aurélie Tasiemski, Pauline Schaffner, Raphaël Boulay, Sylvain Billiard, Alain Lenoir. Impact of ecological doses of the most widespread phthalate on a terrestrial species, the ant Lasius niger. Environmental Research 2014, 131 , 104-110. https://doi.org/10.1016/j.envres.2014.03.016
- Sunmi Kim, Sungeun Kang, Gowoon Lee, Saeram Lee, Areum Jo, Kyunghee Kwak, Dohyung Kim, Dohyun Koh, Young Lim Kho, Sungkyoon Kim, Kyungho Choi. Urinary phthalate metabolites among elementary school children of Korea: Sources, risks, and their association with oxidative stress marker. Science of The Total Environment 2014, 472 , 49-55. https://doi.org/10.1016/j.scitotenv.2013.10.118
- Kelly K. Ferguson, Thomas F. McElrath, John D. Meeker. Environmental Phthalate Exposure and Preterm Birth. JAMA Pediatrics 2014, 168
(1)
, 61. https://doi.org/10.1001/jamapediatrics.2013.3699
- Zhichao Sun, Yebin Tao, Shi Li, Kelly K Ferguson, John D Meeker, Sung Kyun Park, Stuart A Batterman, Bhramar Mukherjee. Statistical strategies for constructing health risk models with multiple pollutants and their interactions: possible choices and comparisons. Environmental Health 2013, 12
(1)
https://doi.org/10.1186/1476-069X-12-85
- Martha M. Téllez-Rojo, Alejandra Cantoral, David E. Cantonwine, Lourdes Schnaas, Karen Peterson, Howard Hu, John D. Meeker. Prenatal urinary phthalate metabolites levels and neurodevelopment in children at two and three years of age. Science of The Total Environment 2013, 461-462 , 386-390. https://doi.org/10.1016/j.scitotenv.2013.05.021
- Lauren M. Tetz, Adrienne A. Cheng, Cassandra S. Korte, Roger W. Giese, Poguang Wang, Craig Harris, John D. Meeker, Rita Loch-Caruso. Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro. Toxicology and Applied Pharmacology 2013, 268
(1)
, 47-54. https://doi.org/10.1016/j.taap.2013.01.020
- Ying Guo, Kurunthachalam Kannan. Challenges encountered in the analysis of phthalate esters in foodstuffs and other biological matrices. Analytical and Bioanalytical Chemistry 2012, 404
(9)
, 2539-2554. https://doi.org/10.1007/s00216-012-5999-2