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2-Ethylhexyl Tetrabromobenzoate and Bis(2-ethylhexyl) Tetrabromophthalate Flame Retardants in the Great Lakes Atmosphere
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    2-Ethylhexyl Tetrabromobenzoate and Bis(2-ethylhexyl) Tetrabromophthalate Flame Retardants in the Great Lakes Atmosphere
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    School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana 47405, United States
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    Environmental Science & Technology

    Cite this: Environ. Sci. Technol. 2012, 46, 1, 204–208
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    https://doi.org/10.1021/es203251f
    Published November 30, 2011
    Copyright © 2011 American Chemical Society

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    Two relatively new flame retardants, 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) and bis(2-ethylhexyl)-tetrabromophthalate (TBPH), were identified and quantitated in gas and particle-phase air samples collected from six sites near the shores of the Great Lakes. TBB and TBPH were detected in more than half of the samples collected from 2008 to 2010. Urban areas, such as Chicago and Cleveland, showed the highest concentrations (0.36–290 pg/m3), while remote areas, such as Eagle Harbor and Sleeping Bear Dunes, exhibited the lowest levels (0.050–32 pg/m3). The atmospheric concentrations of TBB and TBPH increased rapidly and significantly over this time period, perhaps indicating that these compounds are replacing the polybrominated diphenyl ethers (PBDEs), which have been removed or soon will be removed from the marketplace.

    Copyright © 2011 American Chemical Society

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    2. Staci L. Capozzi, Daniel C. Lehman, Marta Venier. Disentangling Source Profiles and Time Trends of Halogenated Flame Retardants in the Great Lakes. Environmental Science & Technology 2023, 57 (3) , 1309-1319. https://doi.org/10.1021/acs.est.2c06610
    3. Ping Xiong, Xueting Yan, Qingqing Zhu, Guangbo Qu, Jianbo Shi, Chunyang Liao, Guibin Jiang. A Review of Environmental Occurrence, Fate, and Toxicity of Novel Brominated Flame Retardants. Environmental Science & Technology 2019, 53 (23) , 13551-13569. https://doi.org/10.1021/acs.est.9b03159
    4. Fang Tao, Ulla Sellström, Cynthia A. de Wit. Organohalogenated Flame Retardants and Organophosphate Esters in Office Air and Dust from Sweden. Environmental Science & Technology 2019, 53 (4) , 2124-2133. https://doi.org/10.1021/acs.est.8b05269
    5. Ling-Chuan Guo, Shangxia Pan, Shengbing Yu, Tao Liu, Jianpeng Xiao, Binghui Zhu, Yabin Qu, Weixiong Huang, Min Li, Xing Li, Weilin Zeng, Shannon Rutherford, Lifeng Lin, Yonghui Zhang, Wenjun Ma. Human Sex Hormone Disrupting Effects of New Flame Retardants and Their Interactions with Polychlorinated Biphenyls, Polybrominated Diphenyl Ethers, a Case Study in South China. Environmental Science & Technology 2018, 52 (23) , 13935-13941. https://doi.org/10.1021/acs.est.8b01540
    6. Hillary Marler, Douglas H. Adams, Yan Wu, Clayton K. Nielsen, Li Shen, Eric J. Reiner, Da Chen. Maternal Transfer of Flame Retardants in Sharks from the Western North Atlantic Ocean. Environmental Science & Technology 2018, 52 (22) , 12978-12986. https://doi.org/10.1021/acs.est.8b01613
    7. Zhiyuan Ma, Hui Peng, Yaru Jin, Xianming Zhang, Xianyi Xie, Kang Jian, Hongling Liu, Guanyong Su, Song Tang, Hongxia Yu. Multigenerational Effects and Demographic Responses of Zebrafish (Danio rerio) Exposed to Organo-Bromine Compounds. Environmental Science & Technology 2018, 52 (15) , 8764-8773. https://doi.org/10.1021/acs.est.8b00569
    8. Katrin Vorkamp, Knud Falk, Søren Møller, Frank F. Rigét, and Peter B. Sørensen . Regulated and Unregulated Halogenated Flame Retardants in Peregrine Falcon Eggs from Greenland. Environmental Science & Technology 2018, 52 (2) , 474-483. https://doi.org/10.1021/acs.est.7b04866
    9. Šimon Vojta, Lisa Melymuk, and Jana Klánová . Changes in Flame Retardant and Legacy Contaminant Concentrations in Indoor Air during Building Construction, Furnishing, and Use. Environmental Science & Technology 2017, 51 (20) , 11891-11899. https://doi.org/10.1021/acs.est.7b03245
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    16. Marta Venier, Amina Salamova, and Ronald A. Hites . Halogenated Flame Retardants in the Great Lakes Environment. Accounts of Chemical Research 2015, 48 (7) , 1853-1861. https://doi.org/10.1021/acs.accounts.5b00180
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    54. Xianming Zhang, Matthew Robson, Karl Jobst, Miren Pena-Abaurrea, Alina Muscalu, Sri Chaudhuri, Chris Marvin, Ian D. Brindle, Eric J. Reiner, Paul Helm. Halogenated organic contaminants of concern in urban-influenced waters of Lake Ontario, Canada: Passive sampling with targeted and non-targeted screening. Environmental Pollution 2020, 264 , 114733. https://doi.org/10.1016/j.envpol.2020.114733
    55. Sagi Enicole A. Gillera, William P. Marinello, Brian M. Horman, Allison L. Phillips, Matthew T. Ruis, Heather M. Stapleton, David M. Reif, Heather B. Patisaul. Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles. Neurotoxicology and Teratology 2020, 79 , 106840. https://doi.org/10.1016/j.ntt.2019.106840
    56. Dong Niu, Yanling Qiu, Xinyu Du, Li Li, Yihui Zhou, Daqiang Yin, Zhifen Lin, Ling Chen, Zhiliang Zhu, Jianfu Zhao, Åke Bergman. Novel brominated flame retardants in house dust from Shanghai, China: levels, temporal variation, and human exposure. Environmental Sciences Europe 2019, 31 (1) https://doi.org/10.1186/s12302-019-0189-x
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    60. Shuqin Tang, Hongli Tan, Xiaotu Liu, Da Chen. Legacy and alternative flame retardants in house dust and hand wipes from South China. Science of The Total Environment 2019, 656 , 1-8. https://doi.org/10.1016/j.scitotenv.2018.11.369
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    66. Ling-Chuan Guo, Jianpeng Xiao, Yonghui Zhang, Shengbing Yu, Hualiang Lin, Guangning Su, Tao Liu, Xing Li, Shaomin Lv, Shannon Rutherford, Wenjun Ma. Association between serum polybrominated diphenyl ethers, new flame retardants and thyroid hormone levels for school students near a petrochemical complex, South China. Chemosphere 2018, 202 , 476-482. https://doi.org/10.1016/j.chemosphere.2018.03.120
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    70. Ishwar Chandra Yadav, Ningombam Linthoingmabi Devi, Jun Li, Gan Zhang. Occurrence and source apportionment of halogenated flame retardants in the indoor air of Nepalese cities: Implication on human health. Atmospheric Environment 2017, 161 , 122-131. https://doi.org/10.1016/j.atmosenv.2017.04.031
    71. Maeva Giraudo, Mélanie Douville, Robert J. Letcher, Magali Houde. Effects of food-borne exposure of juvenile rainbow trout (Oncorhynchus mykiss) to emerging brominated flame retardants 1,2-bis(2,4,6-tribromophenoxy)ethane and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate. Aquatic Toxicology 2017, 186 , 40-49. https://doi.org/10.1016/j.aquatox.2017.02.023
    72. Qilu Li, Kong Yang, Kechang Li, Xin Liu, Duohong Chen, Jun Li, Gan Zhang. New halogenated flame retardants in the atmosphere of nine urban areas in China: Pollution characteristics, source analysis and variation trends. Environmental Pollution 2017, 224 , 679-688. https://doi.org/10.1016/j.envpol.2017.02.052
    73. Jiehong Guo, Marta Venier, Amina Salamova, Ronald A. Hites. Bioaccumulation of Dechloranes, organophosphate esters, and other flame retardants in Great Lakes fish. Science of The Total Environment 2017, 583 , 1-9. https://doi.org/10.1016/j.scitotenv.2016.11.063
    74. Mary S. Wolff, Jessie P. Buckley, Stephanie M. Engel, Rob S. McConnell, Dana B. Barr. Emerging exposures of developmental toxicants. Current Opinion in Pediatrics 2017, 29 (2) , 218-224. https://doi.org/10.1097/MOP.0000000000000455
    75. Gabriel A. Knudsen, J. Michael Sanders, Linda S. Birnbaum. Disposition of the emerging brominated flame retardant, bis(2-ethylhexyl) tetrabromophthalate, in female Sprague Dawley rats: effects of dose, route and repeated administration. Xenobiotica 2017, 47 (3) , 245-254. https://doi.org/10.1080/00498254.2016.1174793
    76. Yan Wang, Xiaowei Wu, Hongxia Zhao, Qing Xie, Minmin Hou, Qiaonan Zhang, Juan Du, Jingwen Chen. Characterization of PBDEs and novel brominated flame retardants in seawater near a coastal mariculture area of the Bohai Sea, China. Science of The Total Environment 2017, 580 , 1446-1452. https://doi.org/10.1016/j.scitotenv.2016.12.114
    77. Xiangzi Jin, Sunggyu Lee, Yunsun Jeong, Jae-Pyoung Yu, Woon Kee Baek, Kyung-Hoon Shin, Kurunthachalam Kannan, Hyo-Bang Moon. Species-specific accumulation of polybrominated diphenyl ethers (PBDEs) and other emerging flame retardants in several species of birds from Korea. Environmental Pollution 2016, 219 , 191-200. https://doi.org/10.1016/j.envpol.2016.10.040
    78. Gabriel A. Knudsen, Michael F. Hughes, J. Michael Sanders, Samantha M. Hall, Linda S. Birnbaum. Estimation of human percutaneous bioavailability for two novel brominated flame retardants, 2-ethylhexyl 2,3,4,5-tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP). Toxicology and Applied Pharmacology 2016, 311 , 117-127. https://doi.org/10.1016/j.taap.2016.10.005
    79. Ivana Klopčič, Darja Gramec Skledar, Lucija Peterlin Mašič, Marija Sollner Dolenc. Comparison of in vitro hormone activities of novel flame retardants TBB, TBPH and their metabolites TBBA and TBMEPH using reporter gene assays. Chemosphere 2016, 160 , 244-251. https://doi.org/10.1016/j.chemosphere.2016.06.091
    80. Sum Chi Lee, Ed Sverko, Tom Harner, Karla Pozo, Enzo Barresi, JoAnne Schachtschneider, Donna Zaruk, Maryl DeJong, Julie Narayan. Retrospective analysis of “new” flame retardants in the global atmosphere under the GAPS Network. Environmental Pollution 2016, 217 , 62-69. https://doi.org/10.1016/j.envpol.2016.01.080
    81. Marta Venier, Ondřej Audy, Šimon Vojta, Jitka Bečanová, Kevin Romanak, Lisa Melymuk, Martina Krátká, Petr Kukučka, Joseph Okeme, Amandeep Saini, Miriam L. Diamond, Jana Klánová. Brominated flame retardants in the indoor environment — Comparative study of indoor contamination from three countries. Environment International 2016, 94 , 150-160. https://doi.org/10.1016/j.envint.2016.04.029
    82. Darja Gramec Skledar, Tihomir Tomašič, Adriana Carino, Eleonora Distrutti, Stefano Fiorucci, Lucija Peterlin Mašič. New brominated flame retardants and their metabolites as activators of the pregnane X receptor. Toxicology Letters 2016, 259 , 116-123. https://doi.org/10.1016/j.toxlet.2016.08.005
    83. Crystal Usenko, Erika Abel, Aaron Hopkins, Gerardo Martinez, Jonathan Tijerina, Molly Kudela, Nick Norris, Lana Joudeh, Erica Bruce. Evaluation of Common Use Brominated Flame Retardant (BFR) Toxicity Using a Zebrafish Embryo Model. Toxics 2016, 4 (3) , 21. https://doi.org/10.3390/toxics4030021
    84. Liang-Ying Liu, Amina Salamova, Marta Venier, Ronald A. Hites. Trends in the levels of halogenated flame retardants in the Great Lakes atmosphere over the period 2005–2013. Environment International 2016, 92-93 , 442-449. https://doi.org/10.1016/j.envint.2016.04.025
    85. Margaret Widelka, Michael J. Lydy, Yan Wu, Da Chen. Statewide surveillance of halogenated flame retardants in fish in Illinois, USA. Environmental Pollution 2016, 214 , 627-634. https://doi.org/10.1016/j.envpol.2016.04.063
    86. Shaorui Wang, Yan Wang, Chunling Luo, Jun Li, Hua Yin, Gan Zhang. Plant selective uptake of halogenated flame retardants at an e-waste recycling site in southern China. Environmental Pollution 2016, 214 , 705-712. https://doi.org/10.1016/j.envpol.2016.04.071
    87. Wen-Long Li, Li-Yan Liu, Zi-Feng Zhang, Wei-Wei Song, Chun-Yan Huo, Li-Na Qiao, Wan-Li Ma, Yi-Fan Li. Brominated flame retardants in the surrounding soil of two manufacturing plants in China: Occurrence, composition profiles and spatial distribution. Environmental Pollution 2016, 213 , 1-7. https://doi.org/10.1016/j.envpol.2016.01.092
    88. Paola Gramatica, Stefano Cassani, Alessandro Sangion. Are some “safer alternatives” hazardous as PBTs? The case study of new flame retardants. Journal of Hazardous Materials 2016, 306 , 237-246. https://doi.org/10.1016/j.jhazmat.2015.12.017
    89. Golnoush Abbasi, Amandeep Saini, Emma Goosey, Miriam L. Diamond. Product screening for sources of halogenated flame retardants in Canadian house and office dust. Science of The Total Environment 2016, 545-546 , 299-307. https://doi.org/10.1016/j.scitotenv.2015.12.028
    90. H. Fromme, G. Becher, B. Hilger, W. Völkel. Brominated flame retardants – Exposure and risk assessment for the general population. International Journal of Hygiene and Environmental Health 2016, 219 (1) , 1-23. https://doi.org/10.1016/j.ijheh.2015.08.004
    91. Wen-Long Li, Li-Yan Liu, Wei-Wei Song, Zi-Feng Zhang, Li-Na Qiao, Wan-Li Ma, Yi-Fan Li. Five-year trends of selected halogenated flame retardants in the atmosphere of Northeast China. Science of The Total Environment 2016, 539 , 286-293. https://doi.org/10.1016/j.scitotenv.2015.09.001
    92. J.M. Bailey, E.D. Levin. Neurotoxicity of FireMaster 550® in zebrafish (Danio rerio): Chronic developmental and acute adolescent exposures. Neurotoxicology and Teratology 2015, 52 , 210-219. https://doi.org/10.1016/j.ntt.2015.07.001
    93. Nanshan Zhang, Jialong Shen, Melissa A. Pasquinelli, David Hinks, Alan E. Tonelli. Formation and characterization of an inclusion complex of triphenyl phosphate and β-cyclodextrin and its use as a flame retardant for polyethylene terephthalate. Polymer Degradation and Stability 2015, 120 , 244-250. https://doi.org/10.1016/j.polymdegradstab.2015.07.014
    94. Lisa Melymuk, Emma Goosey, Nicole Riddell, Miriam L. Diamond. Interlaboratory study of novel halogenated flame retardants: INTERFLAB. Analytical and Bioanalytical Chemistry 2015, 407 (22) , 6759-6769. https://doi.org/10.1007/s00216-015-8843-7
    95. . Subnational and private sector PBT policies. 2015, 203-238. https://doi.org/10.1201/b18757-7
    96. Da Chen, Robert C. Hale, Robert J. Letcher. Photochemical and microbial transformation of emerging flame retardants: Cause for concern?. Environmental Toxicology and Chemistry 2015, 34 (4) , 687-699. https://doi.org/10.1002/etc.2858
    97. Alissa Cordner, Phil Brown. A multisector alliance approach to environmental social movements: flame retardants and chemical reform in the United States. Environmental Sociology 2015, 1 (1) , 69-79. https://doi.org/10.1080/23251042.2015.1016685
    98. David M.V. Saunders, Michelle Podaima, Garry Codling, John. P. Giesy, Steve Wiseman. A mixture of the novel brominated flame retardants TBPH and TBB affects fecundity and transcript profiles of the HPGL-axis in Japanese medaka. Aquatic Toxicology 2015, 158 , 14-21. https://doi.org/10.1016/j.aquatox.2014.10.019
    99. Mahiba Shoeib, Lutz Ahrens, Liisa Jantunen, Tom Harner. Concentrations in air of organobromine, organochlorine and organophosphate flame retardants in Toronto, Canada. Atmospheric Environment 2014, 99 , 140-147. https://doi.org/10.1016/j.atmosenv.2014.09.040
    100. Hong Qi, Wen-Long Li, Li-Yan Liu, Zi-Feng Zhang, Ning-Zheng Zhu, Wei-Wei Song, Wan-Li Ma, Yi-Fan Li. Levels, distribution and human exposure of new non-BDE brominated flame retardants in the indoor dust of China. Environmental Pollution 2014, 195 , 1-8. https://doi.org/10.1016/j.envpol.2014.08.008
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    Cite this: Environ. Sci. Technol. 2012, 46, 1, 204–208
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    Published November 30, 2011
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