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Highly efficient, practical approach to natural taxol

Cite this: J. Am. Chem. Soc. 1988, 110, 17, 5917–5919
Publication Date (Print):August 1, 1988
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    70. S. Karuppusamy, T. Pullaiah. Botany of paclitaxel producing plants. 2022, 155-170.
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    74. Marit A C Vermunt, Andries M Bergman, Eric van der Putten, Jos H Beijnen. The Intravenous to Oral Switch of Taxanes: Strategies and Current Clinical Developments. Future Oncology 2021, 17 (11) , 1379-1399.
    75. Oliver Plettenburg. Drug Discovery in Academia. 2021, 1-46.
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    78. Da-Cheng Hao. Mining chemodiversity from biodiversity of Taxus plants: chemistry and chemical biology. 2021, 53-88.
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    82. Sameh S.M. Soliman, Manish N. Raizada. Sites of biosynthesis and storage of Taxol in Taxus media (Rehder) plants: Mechanism of accumulation. Phytochemistry 2020, 175 , 112369.
    83. Sean A. Sullivan, Irosha N. Nawarathne, Kevin D. Walker. CoA recycling by a benzoate coenzyme A ligase in cascade reactions with aroyltransferases to biocatalyze paclitaxel analogs. Archives of Biochemistry and Biophysics 2020, 683 , 108276.
    84. Baoyu Xue, Junhong Zhao, Yange Fan, Shipeng Chen, Wenfeng Li, Jin Chen, Zheng Li, Hongxing Wang, Hongjun Kong. Synthesis of Taxol and Docetaxel by Using 10‐Deacetyl‐7‐xylosyltaxanes. Chemistry & Biodiversity 2020, 17 (2)
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    86. Kuntal Das, P. E. Rajasekharan. Drugs From Threatened Medicinal Plants. 2020, 347-366.
    87. N. Z. Mamadalieva, N. A. Mamedov. Taxus brevifolia a High-Value Medicinal Plant, as a Source of Taxol. 2020, 201-218.
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    89. . Renewable Feedstocks. 2019, 208-236.
    90. Pradeep Kumar, Balwant Singh, Vikram Thakur, Abhishek Thakur, Nandita Thakur, Deepak Pandey, Duni Chand. Hyper-production of taxol from Aspergillus fumigatus, an endophytic fungus isolated from Taxus sp. of the Northern Himalayan region. Biotechnology Reports 2019, 24 , e00395.
    91. Linyan Zhu, Liqun Chen. Progress in research on paclitaxel and tumor immunotherapy. Cellular & Molecular Biology Letters 2019, 24 (1)
    92. . Total Synthesis: Some Elements to Contemplate. 2019, 1-19.
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    97. Anna Lichota, Krzysztof Gwozdzinski. Anticancer Activity of Natural Compounds from Plant and Marine Environment. International Journal of Molecular Sciences 2018, 19 (11) , 3533.
    98. Pei‐Qiang Huang. Introduction. 2018, 1-25.
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