ACS Publications. Most Trusted. Most Cited. Most Read
My Activity

Figure 1Loading Img

Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P-450 catalyzed reactions: a new method for the estimation of intrinsic isotope effects

Cite this: J. Am. Chem. Soc. 1986, 108, 22, 7074–7078
Publication Date (Print):October 1, 1986
    ACS Legacy Archive

    Article Views





    Other access options
    Supporting Info (1)»

    Note: In lieu of an abstract, this is the article's first page.

    Free first page

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.


    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    Supporting Information

    Terms & Conditions

    Electronic Supporting Information files are available without a subscription to ACS Web Editions. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting Information. Files available from the ACS website may be downloaded for personal use only. Users are not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information from the ACS website, either in whole or in part, in either machine-readable form or any other form without permission from the American Chemical Society. For permission to reproduce, republish and redistribute this material, requesters must process their own requests via the RightsLink permission system. Information about how to use the RightsLink permission system can be found at

    Cited By

    This article is cited by 88 publications.

    1. Yan Long, Shuo Zheng, Yuxin Feng, Zixuan Yang, Xinlei Xu, Heng Song. Kinetic Solvent Isotope Effect in P450-Mediated Cyclization in Indolactams: Evidence for Branched Reactions and Guide for Their Modulation in Heterocycle Chemoenzymatic Synthesis. ACS Catalysis 2022, 12 (16) , 9857-9863.
    2. Viktoria Steck, Joshua N. Kolev, Xinkun Ren, Rudi Fasan. Mechanism-Guided Design and Discovery of Efficient Cytochrome P450-Derived C–H Amination Biocatalysts. Journal of the American Chemical Society 2020, 142 (23) , 10343-10357.
    3. F. Peter Guengerich, Mostafa I. Fekry. Methylene Oxidation of Alkyl Sulfates by Cytochrome P450BM-3 and a Role for Conformational Selection in Substrate Recognition. ACS Catalysis 2020, 10 (9) , 5008-5022.
    4. Richiro Ushimaru, Mark W. Ruszczycky, Hung-wen Liu. Changes in Regioselectivity of H Atom Abstraction during the Hydroxylation and Cyclization Reactions Catalyzed by Hyoscyamine 6β-Hydroxylase. Journal of the American Chemical Society 2019, 141 (2) , 1062-1066.
    5. Li Chen, Nathchar Naowarojna, Bin Chen, Meiling Xu, Melissa Quill, Jiangyun Wang, Zixin Deng, Changming Zhao, Pinghua Liu. Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr). ACS Catalysis 2019, 9 (1) , 253-258.
    6. Li Chen, Nathchar Naowarojna, Heng Song, Shu Wang, Jiangyun Wang, Zixin Deng, Changming Zhao, Pinghua Liu. Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C–S Bond Formation. Journal of the American Chemical Society 2018, 140 (13) , 4604-4612.
    7. Rui Lai and Hui Li . Hydrogen Abstraction of Camphor Catalyzed by Cytochrome P450cam: A QM/MM Study. The Journal of Physical Chemistry B 2016, 120 (48) , 12312-12320.
    8. Spencer C. Peck, Jonathan R. Chekan, Emily C. Ulrich, Satish K. Nair, and Wilfred A. van der Donk . A Common Late-Stage Intermediate in Catalysis by 2-Hydroxyethyl-phosphonate Dioxygenase and Methylphosphonate Synthase. Journal of the American Chemical Society 2015, 137 (9) , 3217-3220.
    9. Veronica Gonzalez, Sabrina Touchet, Daniel J. Grundy, Juan A. Faraldos, and Rudolf K. Allemann . Evolutionary and Mechanistic Insights from the Reconstruction of α-Humulene Synthases from a Modern (+)-Germacrene A Synthase. Journal of the American Chemical Society 2014, 136 (41) , 14505-14512.
    10. Donghak Kim, Gun-Su Cha, Leslie D. Nagy, Chul-Ho Yun, and F. Peter Guengerich . Kinetic Analysis of Lauric Acid Hydroxylation by Human Cytochrome P450 4A11. Biochemistry 2014, 53 (39) , 6161-6172.
    11. W. Kurtis Childers and John P. Harrelson . Allosteric Modulation of Substrate Motion in Cytochrome P450 3A4-Mediated Xylene Oxidation. Biochemistry 2014, 53 (6) , 1018-1028.
    12. Harriet L. R. Cooper, Girish Mishra, Xiongyi Huang, Marilla Pender-Cudlip, Rachel N. Austin, John Shanklin, and John T. Groves . Parallel and Competitive Pathways for Substrate Desaturation, Hydroxylation, and Radical Rearrangement by the Non-heme Diiron Hydroxylase AlkB. Journal of the American Chemical Society 2012, 134 (50) , 20365-20375.
    13. Liansuo Zu, Meimei Xu, Michael W. Lodewyk, David E. Cane, Reuben J. Peters, and Dean J. Tantillo . Effect of Isotopically Sensitive Branching on Product Distribution for Pentalenene Synthase: Support for a Mechanism Predicted by Quantum Chemistry. Journal of the American Chemical Society 2012, 134 (28) , 11369-11371.
    14. Kevin Francis and Giovanni Gadda. Inflated Kinetic Isotope Effects in the Branched Mechanism of Neurospora crassa 2-Nitropropane Dioxygenase. Biochemistry 2009, 48 (11) , 2403-2410.
    15. Cyril Jacquot, Aaron T. Wecksler, Chris M. McGinley, Erika N. Segraves, Theodore R. Holman and Wilfred A. van der Donk. Isotope Sensitive Branching and Kinetic Isotope Effects in the Reaction of Deuterated Arachidonic Acids with Human 12- and 15-Lipoxygenases. Biochemistry 2008, 47 (27) , 7295-7303.
    16. John P. Harrelson, William M. Atkins and Sidney D. Nelson. Multiple-Ligand Binding in CYP2A6: Probing Mechanisms of Cytochrome P450 Cooperativity by Assessing Substrate Dynamics. Biochemistry 2008, 47 (9) , 2978-2988.
    17. Frédéric H. Vaillancourt,, Ellen Yeh,, David A. Vosburg,, Sylvie Garneau-Tsodikova, and, Christopher T. Walsh. Nature's Inventory of Halogenation Catalysts:  Oxidative Strategies Predominate. Chemical Reviews 2006, 106 (8) , 3364-3378.
    18. Charles W. Locuson, II,, Hisashi Suzuki,, Allan E. Rettie, and, Jeffrey P. Jones. Charge and Substituent Effects on Affinity and Metabolism of Benzbromarone-Based CYP2C19 Inhibitors. Journal of Medicinal Chemistry 2004, 47 (27) , 6768-6776.
    19. F. Peter Guengerich,, Joel A. Krauser, and, William W. Johnson. Rate-Limiting Steps in Oxidations Catalyzed by Rabbit Cytochrome P450 1A2. Biochemistry 2004, 43 (33) , 10775-10788.
    20. John R. Jalas and, Stephen S. Hecht. Synthesis of Stereospecifically Deuterated 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) Diastereomers and Metabolism by A/J Mouse Lung Microsomes and Cytochrome P450 2A5. Chemical Research in Toxicology 2003, 16 (6) , 782-793.
    21. John R. Jalas,, Edward J. McIntee,, Patrick M. J. Kenney,, Pramod Upadhyaya,, Lisa A. Peterson, and, Stephen S. Hecht. Stereospecific Deuterium Substitution Attenuates the Tumorigenicity and Metabolism of the Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chemical Research in Toxicology 2003, 16 (6) , 794-806.
    22. K. R. Korzekwa,, N. Krishnamachary,, M. Shou,, A. Ogai,, R. A. Parise,, A. E. Rettie,, F. J. Gonzalez, and, T. S. Tracy. Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models:  Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites. Biochemistry 1998, 37 (12) , 4137-4147.
    23. Gary L. Skiles and, Garold S. Yost. Mechanistic Studies on the Cytochrome P450-Catalyzed Dehydrogenation of 3-Methylindole. Chemical Research in Toxicology 1996, 9 (1) , 291-297.
    24. F. Peter Guengerich. Drug Metabolism: Cytochrome P450. 2022, 470-508.
    25. Ken Korzekwa. Enzyme Kinetics of Oxidative Metabolism—Cytochromes P450. 2021, 237-256.
    26. F. Peter Guengerich. Drug Metabolism: Cytochrome P450. 2021
    27. Heng Song, Nathchar Naowarojna, Ronghai Cheng, Juan Lopez, Pinghua Liu. Non-heme iron enzyme-catalyzed complex transformations. 2019, 1-61.
    28. Frederick P. Guengerich. Kinetic Deuterium Isotope Effects in Cytochrome P450 Reactions. 2017, 217-238.
    29. Maksim A. Fomich, Andrei V. Bekish, Dragoslav Vidovic, Connor R. Lamberson, Ivan L. Lysenko, Peter Lawrence, J. Thomas Brenna, Olga L. Sharko, Vadim V. Shmanai, Mikhail S. Shchepinov. Full Library of ( Bis– allyl)‐deuterated Arachidonic Acids: Synthesis and Analytical Verification. ChemistrySelect 2016, 1 (15) , 4758-4764.
    30. Francis K. Yoshimoto, Richard J. Auchus. The diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1). The Journal of Steroid Biochemistry and Molecular Biology 2015, 151 , 52-65.
    31. Abith Vattekkatte, Nathalie Gatto, Eva Schulze, Wolfgang Brandt, Wilhelm Boland. Inhibition of a multiproduct terpene synthase from Medicago truncatula by 3-bromoprenyl diphosphates. Organic & Biomolecular Chemistry 2015, 13 (16) , 4776-4784.
    32. John Eksterowicz, Dan A. Rock, Brooke M. Rock, Larry C. Wienkers, Robert S. Foti. Characterization of the Active Site Properties of CYP4F12. Drug Metabolism and Disposition 2014, 42 (10) , 1698-1707.
    33. Frederick Peter Guengerich. Experimental Approaches to Analysis of Reactions of Cytochrome P450 Enzymes. 2014, 199-220.
    34. F. Peter Guengerich. Mechanisms of Cytochrome P450‐Mediated Reactions. 2012, 1-23.
    35. Sebastian Peter, Matthias Kinne, Xiaoshi Wang, René Ullrich, Gernot Kayser, John T. Groves, Martin Hofrichter. Selective hydroxylation of alkanes by an extracellular fungal peroxygenase. The FEBS Journal 2011, 278 (19) , 3667-3675.
    36. Joshua Pearson, Upendra P. Dahal, Daniel Rock, Chi-Chi Peng, James O. Schenk, Carolyn Joswig-Jones, Jeffrey P. Jones. The kinetic mechanism for cytochrome P450 metabolism of Type II binding compounds: Evidence supporting direct reduction. Archives of Biochemistry and Biophysics 2011, 511 (1-2) , 69-79.
    37. Mieczysław Ziełiński, Marianna Kańska. Syntheses and Uses of Isotopically Labelled Compounds Containing C  C , C  O or C  N Groups. 2009
    38. Xinhao Zhang, Waltraud Zummack, Detlef Schröder, Frank A. Weinhold, Helmut Schwarz. Isotope‐Sensitive Degenerate [1,3]‐Hydrogen Migration versus Competitive Enol–Keto Tautomerization. Chemistry – A European Journal 2009, 15 (44) , 11815-11819.
    39. Jeffrey P. Jones. Metabolic Concerns in Drug Design. 2008, 1-24.
    40. W.F. Trager. Principles of Drug Metabolism 1: Redox Reactions. 2007, 87-132.
    41. John P. Harrelson, Kirk R. Henne, Darwin O.V. Alonso, Sidney D. Nelson. A comparison of substrate dynamics in human CYP2E1 and CYP2A6. Biochemical and Biophysical Research Communications 2007, 352 (4) , 843-849.
    43. Paul Fitzpatrick. Isotope Effects from Partitioning of Intermediates in Enzyme-Catalyzed Hydroxylation Reactions. 2005, 861-874.
    44. Peter Hlavica. Models and mechanisms of O‐O bond activation by cytochrome P450. European Journal of Biochemistry 2004, 271 (22) , 4335-4360.
    45. Kevin H. Mitchell, Corina E. Rogge, Todd Gierahn, Brian G. Fox. Insight into the mechanism of aromatic hydroxylation by toluene 4-monooxygenase by use of specifically deuterated toluene and p- xylene. Proceedings of the National Academy of Sciences 2003, 100 (7) , 3784-3789.
    46. Dan A Rock, Anthony E Boitano, Jan L Wahlstrom, Denise A Rock, Jeffrey P Jones. Use of Kinetic Isotope Effects to Delineate the Role of Phenylalanine 87 in P450BM-3. Bioorganic Chemistry 2002, 30 (2) , 107-118.
    47. Jeffrey P. Jones, Michael Mysinger, Kenneth Ray Korzekwa. Computational Models for Cytochrome P450: A Predictive Electronic Model for Aromatic Oxidation and Hydrogen Atom Abstraction. Drug Metabolism and Disposition 2002, 30 (1) , 7-12.
    48. Kenneth Korzekwa. In Vitro Enzyme Kinetics Applied to Drug-Metabolizing Enzymes. 2001, 33-54.
    49. LeeAnn Higgins, Kenneth R. Korzekwa, Streedhara Rao, Magong Shou, Jeffrey P. Jones. An Assessment of the Reaction Energetics for Cytochrome P450-Mediated Reactions. Archives of Biochemistry and Biophysics 2001, 385 (1) , 220-230.
    50. Michael L. Schrag, Larry C. Wienkers. Triazolam Substrate Inhibition. 2001, 347-350.
    51. David C Williams, Brian J Carroll, Qingwu Jin, Christopher D Rithner, Steven R Lenger, Heinz G Floss, Robert M Coates, Robert M Williams, Rodney Croteau. Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase. Chemistry & Biology 2000, 7 (12) , 969-977.
    52. David C Williams, Mark R Wildung, Alan Qingwu Jin, Dolan Dalal, John S Oliver, Robert M Coates, Rodney Croteau. Heterologous Expression and Characterization of a “Pseudomature” Form of Taxadiene Synthase Involved in Paclitaxel (Taxol) Biosynthesis and Evaluation of a Potential Intermediate and Inhibitors of the Multistep Diterpene Cyclization Reaction. Archives of Biochemistry and Biophysics 2000, 379 (1) , 137-146.
    54. Mitchell L. Wise, Rodney Croteau. Monoterpene Biosynthesis. 1999, 97-153.
    55. Kelly A Regal, William N Howald, Raimund M Peter, Carlos A Gartner, Kent L Kunze, Sidney D Nelson. Subnanomolar quantification of caffeine's in vitro metabolites by stable isotope dilution gas chromatography–mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 1998, 708 (1-2) , 75-85.
    56. Xiangming Guan, Michael B Fisher, Dieter H Lang, Yi-Min Zheng, Dennis R Koop, Allan E Rettie. Cytochrome P450-dependent desaturation of lauric acid: isoform selectivity and mechanism of formation of 11-dodecenoic acid. Chemico-Biological Interactions 1998, 110 (1-2) , 103-121.
    57. Sason Shaik, Michael Filatov, Detlef Schröder, Helmut Schwarz. Electronic Structure Makes a Difference: Cytochrome P-450 Mediated Hydroxylations of Hydrocarbons as a Two-State Reactivity Paradigm. Chemistry - A European Journal 1998, 4 (2) , 193-199.<193::AID-CHEM193>3.0.CO;2-Q
    58. Christopher L. Steele, John Crock, Jörg Bohlmann, Rodney Croteau. Sesquiterpene Synthases from Grand Fir (Abies grandis). Journal of Biological Chemistry 1998, 273 (4) , 2078-2089.
    59. L. Chastine Bell, F. Peter Guengerich. Oxidation Kinetics of Ethanol by Human Cytochrome P450 2E1. Journal of Biological Chemistry 1997, 272 (47) , 29643-29651.
    60. Thomas R. Browne. Chapter 2 Isotope effect: Implications for pharmaceutical investigations. 1997, 13-18.
    61. Wolf-Dietrich Woggon. Cytochrome P450: Significance, reaction mechanisms and active site analogues. 1996, 39-96.
    62. Kenneth R. Korzekwa, James Grogan, Steven DeVito, Jeffrey P. Jones. Electronic Models for Cytochrome P450 Oxidations. 1996, 361-369.
    63. Norbert Raabe, Sigurd Karraß, Helmut Schwarz. Ligand‐Induced Directionality Shift in the Fe + ‐Mediated Dehydrogenation of 1,8‐Diphenyloctane. Chemische Berichte 1995, 128 (6) , 649-650.
    64. Paul R. Ortiz de Montellano. Oxygen Activation and Reactivity. 1995, 245-303.
    65. Kenneth r. Korzekwa, James r. Gillette, William f. Trager. Isotope Effect Studies on the Cytochrome P450 Enzymes. Drug Metabolism Reviews 1995, 27 (1-2) , 45-59.
    66. Norbert Raabe, Sigurd Karraß, Helmut Schwarz. Fe(I)‐Mediated Regio‐ and Stereoselective CC/CH Bond Activation of Internal Methylene Groups of α,ω‐Diphenylalkanes. Chemische Berichte 1994, 127 (1) , 261-265.
    67. Katrin Seemeyer, Tilmann Prüsse, Helmut Schwarz. Definitive Proof for the Operation of Isotopically Sensitive Branching (‘Metabolic Switching’) in Fe I ‐Mediated CH Bond Activation in the Gas Phase Short Communication. Helvetica Chimica Acta 1993, 76 (4) , 1632-1635.
    68. F. Peter Guengerich, Timothy L. Macdonald. SEQUENTIAL ELECTRON TRANSFER REACTIONS CATALYZED BY CYTOCHROME P-450 ENZYMES. 1993, 191-241.
    69. Patrick S. Callery, Babu Subramanyam, Zhi-Min Yuan, Sovitj Pou, Linda A. Geelhaar, Kevin A. Reynolds. Isotopically sensitive regioselectivity in the oxidative deamination of a homologous series of diamines catalyzed by diamine oxidase. Chemico-Biological Interactions 1992, 85 (1) , 15-26.
    70. Detlef Schröder, Helena Florencio, Waltraud Zummack, Helmut Schwarz. Highly Selective Benzylic CH Bond Activation of Toluene 1 by ‘Bare’ FeO + in the Gas Phase. Short communication. Helvetica Chimica Acta 1992, 75 (6) , 1792-1797.
    71. S. D. Nelson, R. H. McClanahan, D. Thomassen, W. Perry Gordon, N. Knebel. Investigations of mechanisms of reactive metabolite formation from (R)-(+)-pulegone. Xenobiotica 1992, 22 (9-10) , 1157-1164.
    72. Tilmann Prüsse, Andreas Fiedler, Helmut Schwarz. Regioselectivity, Stereoselectivity, and Isotopically Sensitive Branching in the Fe(I)‐Mediated Dehydrogenation of Octane‐1,8‐diol in the Gas Phase. Helvetica Chimica Acta 1991, 74 (5) , 1127-1134.
    73. Kurt Wagschal, Thomas J. Savage, Rodney Croteau. Isotopically sensitive branching as a tool for evaluating multiple product formation by monoterpene cyclases. Tetrahedron 1991, 47 (31) , 5933-5944.
    74. Ronald E. White. The involvement of free radicals in the mechanisms of monooxygenases. Pharmacology & Therapeutics 1991, 49 (1-2) , 21-42.
    75. L R Hall, R P Hanzlik. Kinetic deuterium isotope effects on the N-demethylation of tertiary amides by cytochrome P-450.. Journal of Biological Chemistry 1990, 265 (21) , 12349-12355.
    76. Kenneth Korzekwa, William N. Howald, William F. Trager. The use of Brauman's least squares approach for the quantification of deuterated chlorophenols. Biological Mass Spectrometry 1990, 19 (4) , 211-217.
    77. F. Peter Guengerich. Enzymatic Oxidation of Xenobiotic Chemical. Critical Reviews in Biochemistry and Molecular Biology 1990, 25 (2) , 97-153.
    78. Kah-Hiing John Ling, Robert P. Hanzlik. Deuterium isotope effects on toluene metabolism. Product release as a rate-limiting step in cytochrome P-450 catalysis. Biochemical and Biophysical Research Communications 1989, 160 (2) , 844-849.
    79. C A CaJacob, W K Chan, E Shephard, P R Ortiz de Montellano. The catalytic site of rat hepatic lauric acid omega-hydroxylase. Protein versus prosthetic heme alkylation in the omega-hydroxylation of acetylenic fatty acids.. Journal of Biological Chemistry 1988, 263 (35) , 18640-18649.
    80. A W Wood, D C Swinney, P E Thomas, D E Ryan, P F Hall, W Levin, W A Garland. Mechanism of androstenedione formation from testosterone and epitestosterone catalyzed by purified cytochrome P-450b.. Journal of Biological Chemistry 1988, 263 (33) , 17322-17332.
    81. Erik J. Søderlund, Gunnar Brunborg, James G. Omichinski, Jørn A. Holme, Jon E. Dahl, Sidney D. Nelson, Erik Dybing. Testicular necrosis and DNA damage caused by deuterated and methylated analogs of 1,2-dibromo-3-chloropropane in the rat. Toxicology and Applied Pharmacology 1988, 94 (3) , 437-447.
    82. F P Guengerich, L A Peterson, R H Böcker. Cytochrome P-450-catalyzed hydroxylation and carboxylic acid ester cleavage of Hantzsch pyridine esters.. Journal of Biological Chemistry 1988, 263 (17) , 8176-8183.
    83. Erik J. Sederlund, James G. Omichinski, Jon E. Dahl, Sidney D. Nelson, Erik Dybing. Nephrotoxicity of Selectively Deuterated and Methylated Analogues of Tris‐BP and Bis‐BP in the Rat. Pharmacology & Toxicology 1988, 62 (3) , 142-149.
    84. James G. Omichinski, Erik J. Soderlund, Erik Dybing, Paul G. Pearson, Sidney D. Nelson. Detection and mechanism of formation of the potent direct-acting mutagen 2-bromoacrolein from 1,2-dibromo-3-chloropropane. Toxicology and Applied Pharmacology 1988, 92 (2) , 286-294.
    85. Dale B. Hales, Bert Ho, John A. Thompson. Inter- and intramolecular deuterium isotope effects on the cytochrome P-450-catalyzed oxidative dehalogenation of 1,1,2,2-tetrachloroethane. Biochemical and Biophysical Research Communications 1987, 149 (2) , 319-325.
    86. James G. Omichinski, Gunnar Brunborg, Erik J. Søderlund, Jon E. Dahl, James A. Bausano, Jørn A. Holme, Sidney D. Nelson, Erik Dybing. Renal necrosis and DNA damage caused by selectively deuterated and methylated analogs of 1,2-dibromo-3-chloropropane in the rat. Toxicology and Applied Pharmacology 1987, 91 (3) , 358-370.
    87. Gerald T. Miwa, Anthony Y. H. Lu. Kinetic isotope effects and ‘metabolic switching’ in cytochrome P450‐catalyzed reactions. BioEssays 1987, 7 (5) , 215-219.
    88. J. P. JONES, K. R. KORZEKWA, A. E. RETTIE, W. F. TRAGER. ChemInform Abstract: Isotopically Sensitive Branching and Its Effect on the Observed Intramolecular Isotope Effects in Cytochrome P‐450 Catalyzed Reactions: A New Method for the Estimation of Intrinsic Isotope Effects.. ChemInform 1987, 18 (12)

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Your Mendeley pairing has expired. Please reconnect