Convenient method for stepwise synthesis of oligothymidylate derivatives in large-scale quantities

Robert L. Letsinger, and Kelvin K. Ogilvie

J. Am. Chem. Soc., 1967, 89 (18), pp 4801–4803

DOI: 10.1021/ja00994a048

Publication Date: August 1967

Cite this:J. Am. Chem. Soc. 89, 18, 4801-4803

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Article

Convenient method for stepwise synthesis of oligothymidylate derivatives in large-scale quantities

Matrix Isolation Infrared and DFT Study of the Trimethyl Phosphite–Hydrogen Chloride Interaction: Hydrogen Bonding versus Nucleophilic Substitution

Proton-Block Strategy for the Synthesis of Oligodeoxynucleotides without Base Protection, Capping Reaction, and P−N Bond Cleavage Reaction

Matrix Assisted Synthetic Transformations: A Mosaic of Diverse Contributions. II. The Pattern Is Completed

Analysis of Double-Stranded Oligonucleotides by Electrospray Mass Spectrometry

Nucleotide synthesis. III. Nucleotide synthesis. Derivatives of thymidine containing m- and p-haloacetamidophenyl phosphate groups

Nuclear magnetic resonance chemical shifts of cyclopropane HCH in unsubstituted bicyclo[X.1.0]alkanes as a function of ring size

N6'-di-O-substituted deoxyadenosine

Synthesis of deoxyguanylyldeoxyguanosine on an insoluble polymer support

Preparation and study of some 1-norbornenyl and norbornenyl-1-carbinyl derivatives

Hot Start PCR with heat-activatable primers: a novel approach for improved PCR performance

Oligo- and poly-nucleotides: 50 years of chemical synthesis

Transformation of Dinucleoside S-Aryl Phosphorothioates into the Corresponding O-Alkyl Phosphates by Use of Tributyltin Alkoxides.

Simplified Liquid-Phase Preparation of Four Decadeoxyribonucleotides and their Preliminary Spectroscopic Characterization

Nucleotide. XIV. Substituierte ?-Phenyl�thyl-Gruppen. Neue Schutzgruppen f�r Oligonucleotid-Synthesen nach dem Phosphors�uretriester-Verfahren

Nucleotide. XV. Synthese und Eigenschaften von 2?-O-t-Butyldimethylsilyl-5?-O-monomethoxytritylribonucleosid-3?-phosphotriestern, Ausgangssubstanzen f�r Oligonucleotid-Synthesen

Nucleotide, XI. Synthese und Eigenschaften von Dinucleosidmonophosphaten mit Thymidin und 1-(2′-Desoxy-β-D-ribofuranosyl)lumazinen als Bausteine

Nucleotide. X. Synthese und Eigenschaften von Dinucleosidmonophosphaten mit 2?-Desoxyadenosin und 1-(2?-Desoxy-?-D-ribofuranosyl)-lumazinen als Bausteine

Nucleotide. IX. Synthese und Eigenschaften von 1-(2?-Desoxy-D-ribofuranosyl)-lumazin-3?-monophosphaten

Nucleotide, II. Über die Verseifung von Dinucleosidmonophosphorsäurephenylester und die Isomerisierung der Internucleotid-Bindung

Nucleotide, I. Synthese und Eigenschaften von Thymidylyl-(3′ → 3′)-, -(3′ → 5′)- und -(5′ → 5′)-thymidin

Nucleoside und Nucleotide. Teil 3. �ber die Polykondensation von Thymidin-3?-phosphat nach der Triestermethode

Nucleosides and Nucleotides as Potential Therapeutic Agents

Nucleoside und Nucleotide als mögliche Therapeutika

Synthese von Oligodesoxynucleotiden über Phosphorsäuretriester

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