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The Determination of Enzyme Dissociation Constants

Cite this: J. Am. Chem. Soc. 1934, 56, 3, 658–666
Publication Date (Print):March 1, 1934
https://doi.org/10.1021/ja01318a036
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    100. Stephen L. Bearne . Illustrating Enzyme Inhibition Using Gibbs Energy Profiles. Journal of Chemical Education 2012, 89 (6) , 732-737. https://doi.org/10.1021/ed200395n
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