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Synthesis of Spiro Diphosphines and Their Application in Asymmetric Hydrogenation of Ketones
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    Synthesis of Spiro Diphosphines and Their Application in Asymmetric Hydrogenation of Ketones
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    State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2003, 125, 15, 4404–4405
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    https://doi.org/10.1021/ja029907i
    Published March 21, 2003
    Copyright © 2003 American Chemical Society

    Abstract

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    Synthesis of chiral diphosphine ligands containing a spiro scaffold was described. The ruthenium complexes of these spiro ligands were found to have extremely high activities (S/C up to 100 000) and enantioselectivities (ee up to 99.5%) in the asymmetric hydrogenation of aromatic, heteroaromatic, and α,β-unsaturated ketones.

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    Preparations and properties of compounds 26 and 7, procedures for asymmetric hydrogenation of ketones, GC behavior of chiral alcohols (PDF). This material is available free of charge via the Internet at http://pubs.acs.org.

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