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Highly Enantioselective Insertion of Carbenoids into N−H Bonds Catalyzed by Copper Complexes of Chiral Spiro Bisoxazolines
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    Highly Enantioselective Insertion of Carbenoids into N−H Bonds Catalyzed by Copper Complexes of Chiral Spiro Bisoxazolines
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    State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2007, 129, 18, 5834–5835
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    https://doi.org/10.1021/ja0711765
    Published April 12, 2007
    Copyright © 2007 American Chemical Society

    Abstract

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    A highly efficient copper-catalyzed asymmetric insertion of α-diazoesters into N−H bonds has been realized by using chiral spiro bisoxazoline ligands, affording α-amino acid derivatives in high yields with excellent enantioselectivities.

    Copyright © 2007 American Chemical Society

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