Polyvalent Nucleic Acid NanostructuresClick to copy article linkArticle link copied!
Abstract

Polyvalent oligonucleotide–nanoparticle conjugates possess several unique emergent properties, including enhanced cellular uptake, high antisense bioactivity, and nuclease resistance, which hypothetically originate from the dense packing and orientation of oligonucleotides on the surface of the nanoparticle. In this Communication, we describe a new class of polyvalent nucleic acid nanostructures (PNANs), which are comprised of only cross-linked and oriented nucleic acids. We demonstrate that these particles are capable of effecting high cellular uptake and gene regulation without the need of a cationic polymer co-carrier. The PNANs also exhibit cooperative binding behavior and nuclease resistance properties.
Cited By
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by ACS Publications if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
This article is cited by 163 publications.
- Amy E. Laturski, Maria T. Dulay, Jillian L. Perry, Joseph M. DeSimone. Transfection via RNA-Based Nanoparticles: Comparing Encapsulation vs Adsorption Approaches of RNA Incorporation. Bioconjugate Chemistry 2025, 36
(3)
, 367-376. https://doi.org/10.1021/acs.bioconjchem.5c00028
- James A. R. Tilden, Evan A. Doud, Hayden R. Montgomery, Heather D. Maynard, Alexander M. Spokoyny. Organometallic Chemistry Tools for Building Biologically Relevant Nanoscale Systems. Journal of the American Chemical Society 2024, 146
(44)
, 29989-30003. https://doi.org/10.1021/jacs.4c07110
- Congli Wang, Suting Chen, Hongqian Chu, Haoran Qi, Xia Yu, Hairong Huang. A Facile Metal-Coordinated Spherical Nucleic Acid Nanoplatform for Enhanced Biological Applications by Avoiding Thiol Interference. ACS Applied Nano Materials 2024, 7
(18)
, 22304-22312. https://doi.org/10.1021/acsanm.4c04811
- Ina F. de la Fuente, Shraddha S. Sawant, Kiang W. Kho, Nirod K. Sarangi, Rachelle C. Canete, Suman Pal, Lisa H. Liang, Tia E. Keyes, Jessica L. Rouge. Determining the Role of Surfactant on the Cytosolic Delivery of DNA Cross-Linked Micelles. ACS Applied Materials & Interfaces 2024, 16
(33)
, 43400-43415. https://doi.org/10.1021/acsami.4c09894
- Chad A. Mirkin, Sarah Hurst Petrosko. Inspired Beyond Nature: Three Decades of Spherical Nucleic Acids and Colloidal Crystal Engineering with DNA. ACS Nano 2023, 17
(17)
, 16291-16307. https://doi.org/10.1021/acsnano.3c06564
- Maria-Eleni Kyriazi, Afaf H. El-Sagheer, Igor L. Medintz, Tom Brown, Antonios G. Kanaras. An Investigation into the Resistance of Spherical Nucleic Acids against DNA Enzymatic Degradation. Bioconjugate Chemistry 2022, 33
(1)
, 219-225. https://doi.org/10.1021/acs.bioconjchem.1c00540
- Vijay Gulumkar, Ville Tähtinen, Aliaa Ali, Jani Rahkila, Juan José Valle-Delgado, Antti Äärelä, Monika Österberg, Marjo Yliperttula, Pasi Virta. Synthesis of an Azide- and Tetrazine-Functionalized [60]Fullerene and Its Controlled Decoration with Biomolecules. ACS Omega 2022, 7
(1)
, 1329-1336. https://doi.org/10.1021/acsomega.1c05955
- Sarah Hurst Petrosko, Benjamin D. Coleman, Riki J. Drout, Jonathan D. Schultz, Chad A. Mirkin. Spherical Nucleic Acids: Integrating Nanotechnology Concepts into General Chemistry Curricula. Journal of Chemical Education 2021, 98
(10)
, 3090-3099. https://doi.org/10.1021/acs.jchemed.1c00441
- Wuliang Zhang, Cassandra E. Callmann, Chad A. Mirkin. Controlling the Biological Fate of Liposomal Spherical Nucleic Acids Using Tunable Polyethylene Glycol Shells. ACS Applied Materials & Interfaces 2021, 13
(39)
, 46325-46333. https://doi.org/10.1021/acsami.1c12852
- Vijay Gulumkar, Antti Äärelä, Olli Moisio, Jani Rahkila, Ville Tähtinen, Laura Leimu, Niko Korsoff, Heidi Korhonen, Päivi Poijärvi-Virta, Satu Mikkola, Victor Nesati, Elina Vuorimaa-Laukkanen, Tapani Viitala, Marjo Yliperttula, Anne Roivainen, Pasi Virta. Controlled Monofunctionalization of Molecular Spherical Nucleic Acids on a Buckminster Fullerene Core. Bioconjugate Chemistry 2021, 32
(6)
, 1130-1138. https://doi.org/10.1021/acs.bioconjchem.1c00187
- Jiawei Liu, Jingtao Huang, Wenxin Niu, Chaoliang Tan, Hua Zhang. Unconventional-Phase Crystalline Materials Constructed from Multiscale Building Blocks. Chemical Reviews 2021, 121
(10)
, 5830-5888. https://doi.org/10.1021/acs.chemrev.0c01047
- Ran Liu, Songbai Zhang, Ting-Ting Zheng, Yan-Ru Chen, Jing-Ting Wu, Zai-Sheng Wu. Intracellular Nonenzymatic In Situ Growth of Three-Dimensional DNA Nanostructures for Imaging Specific Biomolecules in Living Cells. ACS Nano 2020, 14
(8)
, 9572-9584. https://doi.org/10.1021/acsnano.9b09995
- Caroline D. Kusmierz, Katherine E. Bujold, Cassandra E. Callmann, Chad A. Mirkin. Defining the Design Parameters for in Vivo Enzyme Delivery Through Protein Spherical Nucleic Acids. ACS Central Science 2020, 6
(5)
, 815-822. https://doi.org/10.1021/acscentsci.0c00313
- Chang Xue, Songbai Zhang, Congcong Li, Xin Yu, Changhe Ouyang, Yi Lu, Zai-Sheng Wu. Y-Shaped Backbone-Rigidified Triangular DNA Scaffold-Directed Stepwise Movement of a DNAzyme Walker for Sensitive MicroRNA Imaging within Living Cells. Analytical Chemistry 2019, 91
(24)
, 15678-15685. https://doi.org/10.1021/acs.analchem.9b03784
- Kurinji Krishnamoorthy, Sumit Kewalramani, Ali Ehlen, Liane M. Moreau, Chad A. Mirkin, Monica Olvera de la Cruz, Michael J. Bedzyk. Enzymatic Degradation of DNA Probed by In Situ X-ray Scattering. ACS Nano 2019, 13
(10)
, 11382-11391. https://doi.org/10.1021/acsnano.9b04752
- Wataru Asahi, Ryohsuke Kurihara, Kotaro Takeyama, Yui Umehara, Yu Kimura, Teruyuki Kondo, Kazuhito Tanabe. Aggregate Formation of BODIPY-Tethered Oligonucleotides That Led to Efficient Intracellular Penetration and Gene Regulation. ACS Applied Bio Materials 2019, 2
(10)
, 4456-4463. https://doi.org/10.1021/acsabm.9b00631
- Yudie Sun, Qiwei Wang, Lan Mi, Lin Shi, Tao Li. Target-Induced Payload Amplification for Spherical Nucleic Acid Enzyme (SNAzyme)-Catalyzed Electrochemiluminescence Detection of Circulating microRNAs. Analytical Chemistry 2019, 91
(20)
, 12948-12953. https://doi.org/10.1021/acs.analchem.9b03001
- Congcong Li, Chang Xue, Jue Wang, Mengxue Luo, Zhifa Shen, Zai-Sheng Wu. Oriented Tetrahedron-Mediated Protection of Catalytic DNA Molecular-Scale Detector against in Vivo Degradation for Intracellular miRNA Detection. Analytical Chemistry 2019, 91
(18)
, 11529-11536. https://doi.org/10.1021/acs.analchem.9b00860
- Xue Hu, Guoliang Ke, Lu Liu, Xiaoyi Fu, Gezhi Kong, Mengyi Xiong, Mei Chen, Xiao-Bing Zhang. Valency-Controlled Molecular Spherical Nucleic Acids with Tunable Biosensing Performances. Analytical Chemistry 2019, 91
(17)
, 11374-11379. https://doi.org/10.1021/acs.analchem.9b02614
- Gyeong-Hwan Kim, Jeong-Wook Oh, Mouhong Lin, Han Choe, Jinsoo Oh, Jung-Hoon Lee, Hohsuk Noh, Jwa-Min Nam. Statistical Modeling of Ligand-Mediated Multimeric Nanoparticle Assembly. The Journal of Physical Chemistry C 2019, 123
(34)
, 21195-21206. https://doi.org/10.1021/acs.jpcc.9b03108
- Roger
M. Pallares, Priscilla Choo, Lisa E. Cole, Chad A. Mirkin, Andrew Lee, Teri W. Odom. Manipulating Immune Activation of Macrophages by Tuning the Oligonucleotide Composition of Gold Nanoparticles. Bioconjugate Chemistry 2019, 30
(7)
, 2032-2037. https://doi.org/10.1021/acs.bioconjchem.9b00316
- Maria Moros, Maria-Eleni Kyriazi, Afaf H. El-Sagheer, Tom Brown, Claudia Tortiglione, Antonios G. Kanaras. DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals. ACS Applied Materials & Interfaces 2019, 11
(15)
, 13905-13911. https://doi.org/10.1021/acsami.8b17846
- Jennifer
R. Ferrer, Jason A. Wertheim, Chad A. Mirkin. Dual Toll-Like Receptor Targeting Liposomal Spherical Nucleic Acids. Bioconjugate Chemistry 2019, 30
(3)
, 944-951. https://doi.org/10.1021/acs.bioconjchem.9b00047
- Yudie Sun, Lin Shi, Qiwei Wang, Lan Mi, Tao Li. Spherical Nucleic Acid Enzyme (SNAzyme) Boosted Chemiluminescence miRNA Imaging Using a Smartphone. Analytical Chemistry 2019, 91
(5)
, 3652-3658. https://doi.org/10.1021/acs.analchem.8b05696
- Munira
F. Fouz, Sourav K. Dey, Kosuke Mukumoto, Krzysztof Matyjaszewski, Bruce A. Armitage, Subha R. Das. Accessibility of Densely Localized DNA on Soft Polymer Nanoparticles. Langmuir 2018, 34
(49)
, 14731-14737. https://doi.org/10.1021/acs.langmuir.8b02038
- Na Li, Mei-Hao Xiang, Jin-Wen Liu, Hao Tang, Jian-Hui Jiang. DNA Polymer Nanoparticles Programmed via Supersandwich Hybridization for Imaging and Therapy of Cancer Cells. Analytical Chemistry 2018, 90
(21)
, 12951-12958. https://doi.org/10.1021/acs.analchem.8b03253
- Renpeng Gu, Thomas Oweida, Yaroslava G. Yingling, Ashutosh Chilkoti, Stefan Zauscher. Enzymatic Synthesis of Nucleobase-Modified Single-Stranded DNA Offers Tunable Resistance to Nuclease Degradation. Biomacromolecules 2018, 19
(8)
, 3525-3535. https://doi.org/10.1021/acs.biomac.8b00816
- Zhiqing Zhang, Shuzhen Liu, Ting Zhou, Hongzhi Zhang, Fang Wang, Guodong Zhang, Xiufeng Wang, Tingting Liu. Salt-Induced Assembly Transformation of DNA–AuNP Conjugates Based on RCA Origami: From Linear Arrays to Nanorings. Langmuir 2018, 34
(30)
, 8904-8909. https://doi.org/10.1021/acs.langmuir.8b01505
- Resham J. Banga, Brian Meckes, Suguna P. Narayan, Anthony J. Sprangers, SonBinh T. Nguyen, and Chad A. Mirkin . Cross-Linked Micellar Spherical Nucleic Acids from Thermoresponsive Templates. Journal of the American Chemical Society 2017, 139
(12)
, 4278-4281. https://doi.org/10.1021/jacs.6b13359
- Xuyu Tan, Xueguang Lu, Fei Jia, Xiaofan Liu, Yehui Sun, Jessica K. Logan, and Ke Zhang . Blurring the Role of Oligonucleotides: Spherical Nucleic Acids as a Drug Delivery Vehicle. Journal of the American Chemical Society 2016, 138
(34)
, 10834-10837. https://doi.org/10.1021/jacs.6b07554
- Qingjie Luo, Zheng Shi, Yitao Zhang, Xi-Jun Chen, Seo-Yeon Han, Tobias Baumgart, David M. Chenoweth, and So-Jung Park . DNA Island Formation on Binary Block Copolymer Vesicles. Journal of the American Chemical Society 2016, 138
(32)
, 10157-10162. https://doi.org/10.1021/jacs.6b04076
- Andrea S. Carlini, Lisa Adamiak, and Nathan C. Gianneschi . Biosynthetic Polymers as Functional Materials. Macromolecules 2016, 49
(12)
, 4379-4394. https://doi.org/10.1021/acs.macromol.6b00439
- Laura Purdie, Cameron Alexander, Sebastian G. Spain, and Johannes P. Magnusson . Influence of Polymer Size on Uptake and Cytotoxicity of Doxorubicin-Loaded DNA–PEG Conjugates. Bioconjugate Chemistry 2016, 27
(5)
, 1244-1252. https://doi.org/10.1021/acs.bioconjchem.6b00085
- Ryan V. Thaner, Ibrahim Eryazici, Robert J. Macfarlane, Keith A. Brown, Byeongdu Lee, SonBinh T. Nguyen, and Chad A. Mirkin . The Significance of Multivalent Bonding Motifs and “Bond Order” in DNA-Directed Nanoparticle Crystallization. Journal of the American Chemical Society 2016, 138
(19)
, 6119-6122. https://doi.org/10.1021/jacs.6b02479
- Jeffrey D. Brodin, Anthony J. Sprangers, Janet R. McMillan, and Chad A. Mirkin . DNA-Mediated Cellular Delivery of Functional Enzymes. Journal of the American Chemical Society 2015, 137
(47)
, 14838-14841. https://doi.org/10.1021/jacs.5b09711
- Xueguang Lu, Thanh-Huyen Tran, Fei Jia, Xuyu Tan, Sage Davis, Swathi Krishnan, Mansoor M. Amiji, and Ke Zhang . Providing Oligonucleotides with Steric Selectivity by Brush-Polymer-Assisted Compaction. Journal of the American Chemical Society 2015, 137
(39)
, 12466-12469. https://doi.org/10.1021/jacs.5b08069
- Jessica L. Rouge, Timothy L. Sita, Liangliang Hao, Fotini M. Kouri, William E. Briley, Alexander H. Stegh, and Chad A. Mirkin . Ribozyme–Spherical Nucleic Acids. Journal of the American Chemical Society 2015, 137
(33)
, 10528-10531. https://doi.org/10.1021/jacs.5b07104
- Xuyu Tan, Ben B. Li, Xueguang Lu, Fei Jia, Clarissa Santori, Priyanka Menon, Hui Li, Bohan Zhang, Jean J. Zhao, and Ke Zhang . Light-Triggered, Self-Immolative Nucleic Acid-Drug Nanostructures. Journal of the American Chemical Society 2015, 137
(19)
, 6112-6115. https://doi.org/10.1021/jacs.5b00795
- Yilei Wu, Rufei Shi, Yi-Lin Wu, James M. Holcroft, Zhichang Liu, Marco Frasconi, Michael R. Wasielewski, Hui Li, and J. Fraser Stoddart . Complexation of Polyoxometalates with Cyclodextrins. Journal of the American Chemical Society 2015, 137
(12)
, 4111-4118. https://doi.org/10.1021/ja511713c
- Jinhwan Kim, Yeong Mi Lee, Youngnam Kang, and Won Jong Kim . Tumor-Homing, Size-Tunable Clustered Nanoparticles for Anticancer Therapeutics. ACS Nano 2014, 8
(9)
, 9358-9367. https://doi.org/10.1021/nn503349g
- Resham J. Banga, Natalia Chernyak, Suguna P. Narayan, SonBinh T. Nguyen, and Chad A. Mirkin . Liposomal Spherical Nucleic Acids. Journal of the American Chemical Society 2014, 136
(28)
, 9866-9869. https://doi.org/10.1021/ja504845f
- Xiaochen A. Wu, Chung Hang J. Choi, Chuan Zhang, Liangliang Hao, and Chad A. Mirkin . Intracellular Fate of Spherical Nucleic Acid Nanoparticle Conjugates. Journal of the American Chemical Society 2014, 136
(21)
, 7726-7733. https://doi.org/10.1021/ja503010a
- William Morris, William E. Briley, Evelyn Auyeung, Maria D. Cabezas, and Chad A. Mirkin . Nucleic Acid–Metal Organic Framework (MOF) Nanoparticle Conjugates. Journal of the American Chemical Society 2014, 136
(20)
, 7261-7264. https://doi.org/10.1021/ja503215w
- Duncan Hieu M. Dam, Raymond C. Lee, and Teri W. Odom . Improved in Vitro Efficacy of Gold Nanoconstructs by Increased Loading of G-quadruplex Aptamer. Nano Letters 2014, 14
(5)
, 2843-2848. https://doi.org/10.1021/nl500844m
- Phapanin Charoenphol and Harry Bermudez . Aptamer-Targeted DNA Nanostructures for Therapeutic Delivery. Molecular Pharmaceutics 2014, 11
(5)
, 1721-1725. https://doi.org/10.1021/mp500047b
- Wen-Bin Zhang, Xinfei Yu, Chien-Lung Wang, Hao-Jan Sun, I-Fan Hsieh, Yiwen Li, Xue-Hui Dong, Kan Yue, Ryan Van Horn, and Stephen Z. D. Cheng . Molecular Nanoparticles Are Unique Elements for Macromolecular Science: From “Nanoatoms” to Giant Molecules. Macromolecules 2014, 47
(4)
, 1221-1239. https://doi.org/10.1021/ma401724p
- Sumit Kewalramani, Jos W. Zwanikken, Robert J. Macfarlane, Cheuk-Yui Leung, Monica Olvera de la Cruz, Chad A. Mirkin, and Michael J. Bedzyk . Counterion Distribution Surrounding Spherical Nucleic Acid–Au Nanoparticle Conjugates Probed by Small-Angle X-ray Scattering. ACS Nano 2013, 7
(12)
, 11301-11309. https://doi.org/10.1021/nn405109z
- Cuichen Wu, Da Han, Tao Chen, Lu Peng, Guizhi Zhu, Mingxu You, Liping Qiu, Kwame Sefah, Xiaobing Zhang, and Weihong Tan . Building a Multifunctional Aptamer-Based DNA Nanoassembly for Targeted Cancer Therapy. Journal of the American Chemical Society 2013, 135
(49)
, 18644-18650. https://doi.org/10.1021/ja4094617
- Stefan Howorka . DNA Nanoarchitectonics: Assembled DNA at Interfaces. Langmuir 2013, 29
(24)
, 7344-7353. https://doi.org/10.1021/la3045785
- Samuel E. Lohse, Jonathan R. Eller, Sean T. Sivapalan, Michael R. Plews, and Catherine J. Murphy . A Simple Millifluidic Benchtop Reactor System for the High-Throughput Synthesis and Functionalization of Gold Nanoparticles with Different Sizes and Shapes. ACS Nano 2013, 7
(5)
, 4135-4150. https://doi.org/10.1021/nn4005022
- Ke Zhang, Liangliang Hao, Sarah J. Hurst, and Chad A. Mirkin . Antibody-Linked Spherical Nucleic Acids for Cellular Targeting. Journal of the American Chemical Society 2012, 134
(40)
, 16488-16491. https://doi.org/10.1021/ja306854d
- Kazuhito Tanabe, Takumi Asada, Takeo Ito, and Sei-ichi Nishimoto . Radiolytic Reduction Characteristics of Drug-Encapsulating DNA Aggregates Possessing Disulfide Bond. Bioconjugate Chemistry 2012, 23
(9)
, 1909-1914. https://doi.org/10.1021/bc3002985
- Kaylie L. Young, Alexander W. Scott, Liangliang Hao, Sarah E. Mirkin, Guoliang Liu, and Chad A. Mirkin . Hollow Spherical Nucleic Acids for Intracellular Gene Regulation Based upon Biocompatible Silica Shells. Nano Letters 2012, 12
(7)
, 3867-3871. https://doi.org/10.1021/nl3020846
- Stuart S. Dunn, Shaomin Tian, Steven Blake, Jin Wang, Ashley L. Galloway, Andrew Murphy, Patrick D. Pohlhaus, Jason P. Rolland, Mary E. Napier, and Joseph M. DeSimone . Reductively Responsive siRNA-Conjugated Hydrogel Nanoparticles for Gene Silencing. Journal of the American Chemical Society 2012, 134
(17)
, 7423-7430. https://doi.org/10.1021/ja300174v
- Graham D. Hamblin, Karina M. M. Carneiro, Johans F. Fakhoury, Katherine E. Bujold, and Hanadi F. Sleiman . Rolling Circle Amplification-Templated DNA Nanotubes Show Increased Stability and Cell Penetration Ability. Journal of the American Chemical Society 2012, 134
(6)
, 2888-2891. https://doi.org/10.1021/ja2107492
- Joshua I. Cutler, Evelyn Auyeung, and Chad A. Mirkin . Spherical Nucleic Acids. Journal of the American Chemical Society 2012, 134
(3)
, 1376-1391. https://doi.org/10.1021/ja209351u
- Andrea J. Luthi, Heng Zhang, Dongwoo Kim, David A. Giljohann, Chad A. Mirkin, and C. Shad Thaxton . Tailoring of Biomimetic High-Density Lipoprotein Nanostructures Changes Cholesterol Binding and Efflux. ACS Nano 2012, 6
(1)
, 276-285. https://doi.org/10.1021/nn2035457
- Mingchao Jiang, Luanfeng Liao, Jinyan Zhang, Xiaojie Wei, Cui-Yun Yu, Hua Wei. Peptide core spherical nucleic acids circumvent tumor immunosuppression via supplementing methionine for enhanced photodynamic/gene immune/therapy of hepatocellular carcinoma. Journal of Colloid and Interface Science 2025, 682 , 653-670. https://doi.org/10.1016/j.jcis.2024.11.146
- Haoqi Yang, Huimin Niu, Chenxiao Zhao, Shusheng Zhang, Shujuan Sun, Pengfei Shi. A rolling circle amplification-based DNAzyme walker against intracellular degradation for imaging tumor cells' microRNA. Chemical Communications 2024, 61
(2)
, 294-297. https://doi.org/10.1039/D4CC05440G
- Haoqi Yang, Ziyong Wu, Shujuan Sun, Shusheng Zhang, Pengfei Shi. A DNA nanowire based-DNAzyme walker for amplified imaging of microRNA in tumor cells. Journal of Materials Chemistry B 2024, 12
(44)
, 11381-11388. https://doi.org/10.1039/D4TB01703J
- Zi Ye, Wenjing Liao, Zhaojia Deng, Lingfeng Wang, Bei Wen, Dapeng Zhang, Hailin Wang, Wenjing Xie, Hanyong Peng. Fast-track synthesis of DNA-functionalized gold nanoparticles for biosensing applications. TrAC Trends in Analytical Chemistry 2024, 175 , 117724. https://doi.org/10.1016/j.trac.2024.117724
- Ming-Chao Jiang, Zhou-Long Fang, Jin-Yan Zhang, Wei Ma, Luan-Feng Liao, Cui-Yun Yu, Hua Wei. A fully biodegradable spherical nucleic acid nanoplatform for self-codelivery of doxorubicin and miR122 for innate and adaptive immunity activation. Acta Biomaterialia 2024, 180 , 407-422. https://doi.org/10.1016/j.actbio.2024.04.013
- Jingting Wu, Xiaoqi Zheng, Wenqing Lin, Linhuan Chen, Zai‐Sheng Wu. Persistent Targeting DNA Nanocarrier Made of 3D Structural Unit Assembled from Only One Basic Multi‐Palindromic Oligonucleotide for Precise Gene Cancer Therapy. Advanced Healthcare Materials 2024, 13
(11)
https://doi.org/10.1002/adhm.202303865
- Tharun K. Kotammagari, Lange Yakubu Saleh, Tuomas Lönnberg. Organometallic modification confers oligonucleotides new functionalities. Chemical Communications 2024, 60
(23)
, 3118-3128. https://doi.org/10.1039/D4CC00305E
- Zhi-Guo Lu, Jie Shen, Jun Yang, Jing-Wen Wang, Rui-Chen Zhao, Tian-Lu Zhang, Jing Guo, Xin Zhang. Nucleic acid drug vectors for diagnosis and treatment of brain diseases. Signal Transduction and Targeted Therapy 2023, 8
(1)
https://doi.org/10.1038/s41392-022-01298-z
- Meredith A. Davis, Ezra Cho, Michelle H. Teplensky. Harnessing biomaterial architecture to drive anticancer innate immunity. Journal of Materials Chemistry B 2023, 11
(46)
, 10982-11005. https://doi.org/10.1039/D3TB01677C
- Abu Baker, Jochen Lorch, David VanderWeele, Bin Zhang. Smart Nanocarriers for the Targeted Delivery of Therapeutic Nucleic Acid for Cancer Immunotherapy. Pharmaceutics 2023, 15
(6)
, 1743. https://doi.org/10.3390/pharmaceutics15061743
- Antonio Garcia-Guerra, Ruth Ellerington, Jens Gaitzsch, Jonathan Bath, Mahnseok Kye, Miguel A. Varela, Giuseppe Battaglia, Matthew J. A. Wood, Raquel Manzano, Carlo Rinaldi, Andrew J. Turberfield. A modular RNA delivery system comprising spherical nucleic acids built on endosome-escaping polymeric nanoparticles. Nanoscale Advances 2023, 5
(11)
, 2941-2949. https://doi.org/10.1039/D2NA00846G
- Saeed Anwar, Farin Mir, Toshifumi Yokota. Enhancing the Effectiveness of Oligonucleotide Therapeutics Using Cell-Penetrating Peptide Conjugation, Chemical Modification, and Carrier-Based Delivery Strategies. Pharmaceutics 2023, 15
(4)
, 1130. https://doi.org/10.3390/pharmaceutics15041130
- Chenghong Zhu, Weishan Wang, Yan Wang, Yan Zhang, Jinbo Li. Dendronized DNA Chimeras Harness Scavenger Receptors To Degrade Cell Membrane Proteins. Angewandte Chemie 2023, 135
(13)
https://doi.org/10.1002/ange.202300694
- Chenghong Zhu, Weishan Wang, Yan Wang, Yan Zhang, Jinbo Li. Dendronized DNA Chimeras Harness Scavenger Receptors To Degrade Cell Membrane Proteins. Angewandte Chemie International Edition 2023, 62
(13)
https://doi.org/10.1002/anie.202300694
- Robert J. Mosley, Brendan Rucci, Mark E. Byrne. Recent advancements in design of nucleic acid nanocarriers for controlled drug delivery. Journal of Materials Chemistry B 2023, 11
(10)
, 2078-2094. https://doi.org/10.1039/D2TB02325C
- Yang Fang, Ke Zhang. Cationic vs. non-cationic polymeric vectors for nucleic acid delivery. 2023, 574-589. https://doi.org/10.1016/B978-0-12-822425-0.00024-5
- Ali A. Rabaan, Rehab Bukhamsin, Hajir AlSaihati, Saleh A. Alshamrani, Jehad AlSihati, Hani M. Al-Afghani, Roua A. Alsubki, Abdulmonem A. Abuzaid, Saleh Al-Abdulhadi, Yahya Aldawood, Abdulmonem A. Alsaleh, Yousef N. Alhashem, Jenan A. Almatouq, Talha Bin Emran, Shamsah H. Al-Ahmed, Firzan Nainu, Ranjan K. Mohapatra. Recent Trends and Developments in Multifunctional Nanoparticles for Cancer Theranostics. Molecules 2022, 27
(24)
, 8659. https://doi.org/10.3390/molecules27248659
- Debalina Bhattacharya. Static DNA Nanostructures and Their Applications. 2022, 245-267. https://doi.org/10.1002/9781119857747.ch8
- Afreen Sultana, Mina Zare, Vinoy Thomas, T.S. Sampath Kumar, Seeram Ramakrishna. Nano-based drug delivery systems: Conventional drug delivery routes, recent developments and future prospects. Medicine in Drug Discovery 2022, 15 , 100134. https://doi.org/10.1016/j.medidd.2022.100134
- Yan-Ru Chen, Shujuan Sun, Hongwei Yin, Weijun Wang, Ran Liu, Huo Xu, Ya Yang, Zai-Sheng Wu. Tumor-targeting [2]catenane-based grid-patterned periodic DNA monolayer array for
in vivo
theranostic application. Journal of Materials Chemistry B 2022, 10
(12)
, 1969-1979. https://doi.org/10.1039/D1TB01978C
- Yangmeihui Song, Wenyu Song, Xiaoli Lan, Weibo Cai, Dawei Jiang. Spherical nucleic acids: Organized nucleotide aggregates as versatile nanomedicine. Aggregate 2022, 3
(1)
https://doi.org/10.1002/agt2.120
- T. Jiang, M. Zheng, Bingyang Shi. Preparation and Evaluation of siRNAsome as siRNA and Drug Delivery System. 2022, 523-542. https://doi.org/10.1007/978-981-16-5419-0_28
- Lei Wu, Wenhui Zhou, Lihua Lin, Anhong Chen, Jing Feng, Xiangmeng Qu, Hongbo Zhang, Jun Yue. Delivery of therapeutic oligonucleotides in nanoscale. Bioactive Materials 2022, 7 , 292-323. https://doi.org/10.1016/j.bioactmat.2021.05.038
- Fatma Demir Duman, Sophia S. Boyadjieva, Margarita Štrimaite, Rachel Foulkes, Gareth R. Williams, Ross S. Forgan. Inorganic Materials in Drug Delivery. 2021, 14-126. https://doi.org/10.1039/9781788019293-00014
- Tong Jiang, Yonghan Qiao, Weimin Ruan, Dongya Zhang, Qingshan Yang, Guoying Wang, Qunzhi Chen, Fengping Zhu, Jinlong Yin, Yan Zou, Rongjun Qian, Meng Zheng, Bingyang Shi. Cation‐Free siRNA Micelles as Effective Drug Delivery Platform and Potent RNAi Nanomedicines for Glioblastoma Therapy. Advanced Materials 2021, 33
(45)
https://doi.org/10.1002/adma.202104779
- Chan-Jin Kim, Ga-Hyun Kim, Eun Hye Jeong, Hyukjin Lee, So-Jung Park. The core composition of DNA block copolymer micelles dictates DNA hybridization properties, nuclease stabilities, and cellular uptake efficiencies. Nanoscale 2021, 13
(32)
, 13758-13763. https://doi.org/10.1039/D1NR00756D
- Ina F. de la Fuente, Shraddha S. Sawant, Mark Q. Tolentino, Patrick M. Corrigan, Jessica L. Rouge. Viral Mimicry as a Design Template for Nucleic Acid Nanocarriers. Frontiers in Chemistry 2021, 9 https://doi.org/10.3389/fchem.2021.613209
- Eli Sutter, Bo Zhang, Peter Sutter. Single-strand DNA-nanorod conjugates – tunable anisotropic colloids for on-demand self-assembly. Journal of Colloid and Interface Science 2021, 586 , 847-854. https://doi.org/10.1016/j.jcis.2020.11.009
- Xiangang Huang, Nicholas Thomas Blum, Jing Lin, Jinjun Shi, Chuan Zhang, Peng Huang. Chemotherapeutic drug–DNA hybrid nanostructures for anti-tumor therapy. Materials Horizons 2021, 8
(1)
, 78-101. https://doi.org/10.1039/D0MH00715C
- T. Jiang, M. Zheng, B. Y. Shi. Preparation and Evaluation of siRNAsome as siRNA and Drug Delivery System. 2021, 1-20. https://doi.org/10.1007/978-981-33-6198-0_28-1
- Fay Nicolson, Akbar Ali, Moritz F. Kircher, Suchetan Pal. DNA Nanostructures and DNA‐Functionalized Nanoparticles for Cancer Theranostics. Advanced Science 2020, 7
(23)
https://doi.org/10.1002/advs.202001669
- Qiuyang Sun, Yu Han, Yuming Yang, Jesús M. de la Fuente, Daxiang Cui, Xiaoqiang Wang. Application of DNA nanostructures in cancer therapy. Applied Materials Today 2020, 21 , 100861. https://doi.org/10.1016/j.apmt.2020.100861
- Thomas R. Holmes, Amy S. Paller. Gene Regulation Using Spherical Nucleic Acids to Treat Skin Disorders. Pharmaceuticals 2020, 13
(11)
, 360. https://doi.org/10.3390/ph13110360
- Chang Xue, Songbai Zhang, Xin Yu, Shuyao Hu, Yi Lu, Zai‐Sheng Wu. Periodically Ordered, Nuclease‐Resistant DNA Nanowires Decorated with Cell‐Specific Aptamers as Selective Theranostic Agents. Angewandte Chemie 2020, 132
(40)
, 17693-17700. https://doi.org/10.1002/ange.202004805
- Chang Xue, Songbai Zhang, Xin Yu, Shuyao Hu, Yi Lu, Zai‐Sheng Wu. Periodically Ordered, Nuclease‐Resistant DNA Nanowires Decorated with Cell‐Specific Aptamers as Selective Theranostic Agents. Angewandte Chemie International Edition 2020, 59
(40)
, 17540-17547. https://doi.org/10.1002/anie.202004805
- Reina Kainuma, Yuto Motohashi, Tatsuya Nishihara, Ryohsuke Kurihara, Kazuhito Tanabe. Modulation of cell membrane functionalization with aggregates of oligodeoxynucleotides containing alkyl chain-modified uridines. Organic & Biomolecular Chemistry 2020, 18
(28)
, 5406-5413. https://doi.org/10.1039/D0OB00943A
- Xuyu Tan, Fei Jia, Ping Wang, Ke Zhang. Nucleic acid-based drug delivery strategies. Journal of Controlled Release 2020, 323 , 240-252. https://doi.org/10.1016/j.jconrel.2020.03.040
- Sotaro Misu, Ryohsuke Kurihara, Reina Kainuma, Ryugai Sato, Tatsuya Nishihara, Kazuhito Tanabe. Hybridizing Oligonucleotides with Hydrophobic Peptide Nucleic Acids Assists Their Cellular Uptake through Aggregate Formation. ChemBioChem 2020, 21
(8)
, 1140-1143. https://doi.org/10.1002/cbic.201900607
- Stephanie Hwu, Manon Garzuel, Csaba Forró, Stephan J. Ihle, Andreas M. Reichmuth, Fiodar Kurdzesau, János Vörös. An analytical method to control the surface density and stability of DNA-gold nanoparticles for an optimized biosensor. Colloids and Surfaces B: Biointerfaces 2020, 187 , 110650. https://doi.org/10.1016/j.colsurfb.2019.110650
- Gokay Yamankurt, Robert J. Stawicki, Diana M. Posadas, Joseph Q. Nguyen, Richard W. Carthew, Chad A. Mirkin. The effector mechanism of siRNA spherical nucleic acids. Proceedings of the National Academy of Sciences 2020, 117
(3)
, 1312-1320. https://doi.org/10.1073/pnas.1915907117
- Shahid S. Siddiqui, Mashael Saeed Al-Qahtani, Faisal Ahmed Khalil Al Allaf, Loganathan Sivakumar, Zeba Kidwai Siddiqui. Application of Nanomaterials in Cancer Diagnosis, Drug Delivery, and Therapy. 2020, 147-171. https://doi.org/10.1007/978-981-15-4802-4_8
- Anna Graczyk, Roza Pawlowska, Dominika Jedrzejczyk, Arkadiusz Chworos. Gold Nanoparticles in Conjunction with Nucleic Acids as a Modern Molecular System for Cellular Delivery. Molecules 2020, 25
(1)
, 204. https://doi.org/10.3390/molecules25010204
- Ahad Mokhtarzadeh, Hassan Vahidnezhad, Leila Youssefian, Jafar Mosafer, Behzad Baradaran, Jouni Uitto. Applications of Spherical Nucleic Acid Nanoparticles as Delivery Systems. Trends in Molecular Medicine 2019, 25
(12)
, 1066-1079. https://doi.org/10.1016/j.molmed.2019.08.012
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.