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Organometallic Cages as Vehicles for Intracellular Release of Photosensitizers

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Institut Universitaire de Pathologie, Centre Hospitalier Universitaire Vaudois, Bugnon 25, CH-1011 Lausanne, Switzerland
Institute of Chemistry, University of Neuchâtel, Avenue de Bellevaux 51, CH-2000 Neuchâtel, Switzerland
Cite this: J. Am. Chem. Soc. 2012, 134, 2, 754–757
Publication Date (Web):December 20, 2011
https://doi.org/10.1021/ja207784t
Copyright © 2011 American Chemical Society

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    Abstract

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    Water-soluble metalla-cages were used to deliver hydrophobic porphin molecules to cancer cells. After internalization, the photosensitizer was photoactivated, significantly increasing the cytotoxicity in cells. During the transport, the photosensitizer remains nonreactive to light, offering a new strategy to tackle overall photosensitization, a limitation often encountered in photodynamic therapy.

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    Experimental details, UV–vis spectra, and singlet oxygen quantum yields. This material is available free of charge via the Internet at http://pubs.acs.org.

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