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Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging

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† State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai 200050, P.R. China
‡ Institute of Radiation Medicine, Fudan University, 2094 Xie-Tu Road, Shanghai 200032, P.R. China
§ Department of Radiology, Shanghai Cancer Hospital, Fudan University, Shanghai 200032, P.R. China
[email protected]; [email protected]
Cite this: J. Am. Chem. Soc. 2013, 135, 17, 6494–6503
Publication Date (Web):April 10, 2013
https://doi.org/10.1021/ja312225b
Copyright © 2013 American Chemical Society
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Abstract

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Most hypoxic tumors are insensitive to radiation, which is a major obstacle in the development of conventional radiotherapy for tumor treatment. Some drugs, such as cisplatin (CDDP), have been extensively used both as an anticancer drug and clinically as a radiosensitizer to enhance radiotherapy. Herein, we develop rattle-structured multifunctional up-conversion core/porous silica shell nanotheranostics (UCSNs) for delivering CDDP to tumors for synergetic chemo-/radiotherapy by CDDP radiosensitization and magnetic/luminescent dual-mode imaging. UCSNs had a dynamic light scattering diameter of 79.1 nm and excellent water dispersity and stability. In vitro studies showed that CDDP loaded in UCSNs (UCSNs-CDDP) was more effective than free CDDP as a radiosensitizer. After injection, UCSNs-CDDP also demonstrated unambiguously enhanced radiotherapy efficacy in vivo. Our report aims at presenting a novel strategy in biomedical nanotechnology that allows simultaneous dual-mode imaging and localized therapy via synergetic chemo-/radiotherapy, which may achieve optimized therapeutic efficacy in cancer treatment.

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Synthetic procedures for Gd-UCNP, [email protected]1-SiO2, [email protected]1-SiO2@d2-SiO2, UCSNs, and FA-UCSNs, materials, characterizations, and other supplementary figures. This material is available free of charge via the Internet at http://pubs.acs.org.

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