Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect
ACS Publications. Most Trusted. Most Cited. Most Read
Storage of Hydrogen Spin Polarization in Long-Lived 13C2 Singlet Order and Implications for Hyperpolarized Magnetic Resonance Imaging

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2013, 135, 26, 9632-9635
    Communication

    Storage of Hydrogen Spin Polarization in Long-Lived 13C2 Singlet Order and Implications for Hyperpolarized Magnetic Resonance Imaging
    Click to copy article linkArticle link copied!

    View Author Information
    Department of Chemistry, Duke University, Durham, North Carolina 27708, United States
    [email protected]
    Other Access OptionsSupporting Information (1)

    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2013, 135, 26, 9632–9635
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ja404936p
    Published June 20, 2013
    Copyright © 2013 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    Hyperpolarized magnetic resonance imaging (MRI) is a powerful technique enabling real-time monitoring of metabolites at concentration levels not accessible by standard MRI techniques. A considerable challenge this technique faces is the T1 decay of the hyperpolarization upon injection into the system under study. Here we show that AnA′nXX′ spin systems such as 13C2-1,2-diphenylacetylene (13C2-DPA) sustain long-lived polarization for both 13C and 1H spins with decay constants of almost 4.5 min at high magnetic fields of up to 16.44 T without spin-locking; the T1 of proton polarization is only 3.8 s. Therefore, storage of the proton polarization in a 13C2-singlet state causes a 69-fold extension of the spin lifetime. Notably, this extension is demonstrated with proton-only pulse sequences, which can be readily implemented on standard clinical scanners.

    Copyright © 2013 American Chemical Society

    Subjects

    what are subjects

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Supporting Information

    Click to copy section linkSection link copied!

    Detailed pulse sequence parameters, synthetic routes, sample 13C spectra, and description of the simulation methods. This material is available free of charge via the Internet at http://pubs.acs.org

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    Click to copy section linkSection link copied!

    This article is cited by 67 publications.

    1. Nadiya Iqbal, Drew O. Brittin, Praveen J. Daluwathumullagamage, Md Shahabuddin Alam, Ishani M. Senanayake, A. Tobi Gafar, Zahid Siraj, Anthony Petrilla, Margaret Pugh, Brockton Tonazzi, Sudarshan Ragunathan, Megan E. Poorman, Laura Sacolick, Thomas Theis, Matthew S. Rosen, Eduard Y. Chekmenev, Boyd M. Goodson. Toward Next-Generation Molecular Imaging with a Clinical Low-Field (0.064 T) Point-of-Care MRI Scanner. Analytical Chemistry 2024, 96 (25) , 10348-10355. https://doi.org/10.1021/acs.analchem.4c01299
    2. Iuliia Mandzhieva, Isaiah Adelabu, Eduard Y. Chekmenev, Thomas Theis. Proton-Only Sensing of Hyperpolarized [1,2-13C2]Pyruvate. ACS Sensors 2022, 7 (12) , 3773-3781. https://doi.org/10.1021/acssensors.2c01608
    3. Zijian Zhou, Jin Yu, Johannes F. P. Colell, Raul Laasner, Angus Logan, Danila A. Barskiy, Roman V. Shchepin, Eduard Y. Chekmenev, Volker Blum, Warren S. Warren, and Thomas Theis . Long-Lived 13C2 Nuclear Spin States Hyperpolarized by Parahydrogen in Reversible Exchange at Microtesla Fields. The Journal of Physical Chemistry Letters 2017, 8 (13) , 3008-3014. https://doi.org/10.1021/acs.jpclett.7b00987
    4. Danila A. Barskiy, Kirill V. Kovtunov, Evgeny Y. Gerasimov, M. Anthony Phipps, Oleg G. Salnikov, Aaron M. Coffey, Larisa M. Kovtunova, Igor P. Prosvirin, Valerii I. Bukhtiyarov, Igor V. Koptyug, Eduard Y. Chekmenev. 2D Mapping of NMR Signal Enhancement and Relaxation for Heterogeneously Hyperpolarized Propane Gas. The Journal of Physical Chemistry C 2017, 121 (18) , 10038-10046. https://doi.org/10.1021/acs.jpcc.7b02506
    5. Milton L. Truong, Thomas Theis, Aaron M. Coffey, Roman V. Shchepin, Kevin W. Waddell, Fan Shi, Boyd M. Goodson, Warren S. Warren, and Eduard Y. Chekmenev . 15N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH. The Journal of Physical Chemistry C 2015, 119 (16) , 8786-8797. https://doi.org/10.1021/acs.jpcc.5b01799
    6. Michael J. Burns, Peter J. Rayner, Gary G. R. Green, Louise A. R. Highton, Ryan E. Mewis, and Simon B. Duckett . Improving the Hyperpolarization of 31P Nuclei by Synthetic Design. The Journal of Physical Chemistry B 2015, 119 (15) , 5020-5027. https://doi.org/10.1021/acs.jpcb.5b00686
    7. Ryan E. Mewis, Richard A. Green, Martin C. R. Cockett, Michael J. Cowley, Simon B. Duckett, Gary G. R. Green, Richard O. John, Peter J. Rayner, and David C. Williamson . Strategies for the Hyperpolarization of Acetonitrile and Related Ligands by SABRE. The Journal of Physical Chemistry B 2015, 119 (4) , 1416-1424. https://doi.org/10.1021/jp511492q
    8. Kevin Claytor, Thomas Theis, Yesu Feng, Jin Yu, David Gooden, and Warren S. Warren . Accessing Long-Lived Disconnected Spin-1/2 Eigenstates through Spins > 1/2. Journal of the American Chemical Society 2014, 136 (43) , 15118-15121. https://doi.org/10.1021/ja505792j
    9. Basile Vuichoud, Jonas Milani, Aurélien Bornet, Roberto Melzi, Sami Jannin, and Geoffrey Bodenhausen . Hyperpolarization of Deuterated Metabolites via Remote Cross-Polarization and Dissolution Dynamic Nuclear Polarization. The Journal of Physical Chemistry B 2014, 118 (5) , 1411-1415. https://doi.org/10.1021/jp4118776
    10. Benno Meier, Jean-Nicolas Dumez, Gabriele Stevanato, Joseph T. Hill-Cousins, Soumya Singha Roy, Pär Håkansson, Salvatore Mamone, Richard C. D. Brown, Giuseppe Pileio, and Malcolm H. Levitt . Long-Lived Nuclear Spin States in Methyl Groups and Quantum-Rotor-Induced Polarization. Journal of the American Chemical Society 2013, 135 (50) , 18746-18749. https://doi.org/10.1021/ja410432f
    11. Eul Hyun Suh, Roozbeh Eskandari, Mai T. Huynh, Gaurav Sharma, Chalermchai Khemtong, Olivier Ouari, Zoltan Kovacs. Hyperpolarized tracer design, synthesis, and characterization. 2024, 1-156. https://doi.org/10.1016/B978-0-323-91842-8.00006-9
    12. Thomas B. R. Robertson, Rose C. Bannister, Topaz A. A. Cartlidge, Thimo Hugger, Sebastien Breham, Klaus Zick, Frank Engelke, Sam Thompson, Giuseppe Pileio. A dual-core NMR system for field-cycling singlet assisted diffusion NMR. Frontiers in Chemistry 2023, 11 https://doi.org/10.3389/fchem.2023.1229586
    13. Aiky Razanahoera, Anna Sonnefeld, Geoffrey Bodenhausen, Kirill Sheberstov. Paramagnetic relaxivity of delocalized long-lived states of protons in chains of CH 2 groups. Magnetic Resonance 2023, 4 (1) , 47-56. https://doi.org/10.5194/mr-4-47-2023
    14. Anna Sonnefeld, Aiky Razanahoera, Philippe Pelupessy, Geoffrey Bodenhausen, Kirill Sheberstov. Long-lived states of methylene protons in achiral molecules. Science Advances 2022, 8 (48) https://doi.org/10.1126/sciadv.ade2113
    15. Anna Sonnefeld, Geoffrey Bodenhausen, Kirill Sheberstov. Polychromatic Excitation of Delocalized Long-Lived Proton Spin States in Aliphatic Chains. Physical Review Letters 2022, 129 (18) https://doi.org/10.1103/PhysRevLett.129.183203
    16. Shengjun Yang, Philip Saul, Salvatore Mamone, Lukas Kaltschnee, Stefan Glöggler. Bimodal Fluorescence/Magnetic Resonance Molecular Probes with Extended Spin Lifetimes. Chemistry – A European Journal 2022, 28 (8) https://doi.org/10.1002/chem.202104158
    17. Stephen J. DeVience, Ronald L. Walsworth, Matthew S. Rosen. NMR of 31P nuclear spin singlet states in organic diphosphates. Journal of Magnetic Resonance 2021, 333 , 107101. https://doi.org/10.1016/j.jmr.2021.107101
    18. Philip Saul, Shengjun Yang, Salvatore Mamone, Felipe Opazo, Andreas Meyer, Silvio O. Rizzoli, Stefan Glöggler. Exotic nuclear spin behavior in dendritic macromolecules. Physical Chemistry Chemical Physics 2021, 23 (46) , 26349-26355. https://doi.org/10.1039/D1CP04483D
    19. Christian Bengs, Laurynas Dagys, Gamal A. I. Moustafa, James W. Whipham, Mohamed Sabba, Alexey S. Kiryutin, Konstantin L. Ivanov, Malcolm H. Levitt. Nuclear singlet relaxation by chemical exchange. The Journal of Chemical Physics 2021, 155 (12) https://doi.org/10.1063/5.0066182
    20. Yohei Kondo, Hiroshi Nonaka, Yoichi Takakusagi, Shinsuke Sando. Entwicklung molekularer Sonden für die hyperpolarisierte NMR‐Bildgebung im biologischen Bereich. Angewandte Chemie 2021, 133 (27) , 14904-14925. https://doi.org/10.1002/ange.201915718
    21. Yohei Kondo, Hiroshi Nonaka, Yoichi Takakusagi, Shinsuke Sando. Design of Nuclear Magnetic Resonance Molecular Probes for Hyperpolarized Bioimaging. Angewandte Chemie International Edition 2021, 60 (27) , 14779-14799. https://doi.org/10.1002/anie.201915718
    22. Giulia Melchiorre, Ciara Nelder, Lynda J. Brown, Jean-Nicolas Dumez, Giuseppe Pileio. Single-scan measurements of nuclear spin singlet order decay rates. Physical Chemistry Chemical Physics 2021, 23 (16) , 9851-9859. https://doi.org/10.1039/D1CP00807B
    23. Aliki Moysiadi, Francesco Giustiniano, Andrew M. R. Hall, Topaz A. A. Cartlidge, Lynda J. Brown, Giuseppe Pileio. Nuclear Spin Relaxation of Longitudinal and Singlet Order in Liquid-CO2 Solutions. Frontiers in Chemistry 2021, 9 https://doi.org/10.3389/fchem.2021.668044
    24. Jean-Nicolas Dumez. Perspective on long-lived nuclear spin states. Molecular Physics 2020, 118 (6) https://doi.org/10.1080/00268976.2019.1644382
    25. Bogdan A. Rodin, Kirill F. Sheberstov, Alexey S. Kiryutin, Lynda J. Brown, Richard C. D. Brown, Mohamed Sabba, Malcolm H. Levitt, Alexandra V. Yurkovskaya, Konstantin L. Ivanov. Fast destruction of singlet order in NMR experiments. The Journal of Chemical Physics 2019, 151 (23) https://doi.org/10.1063/1.5131730
    26. Kirill F. Sheberstov, Hans-Martin Vieth, Herbert Zimmermann, Bogdan A. Rodin, Konstantin L. Ivanov, Alexey S. Kiryutin, Alexandra V. Yurkovskaya. Generating and sustaining long-lived spin states in 15N,15N′-azobenzene. Scientific Reports 2019, 9 (1) https://doi.org/10.1038/s41598-019-56734-y
    27. Jaspal Singh, Eul Hyun Suh, Gaurav Sharma, Chalermchai Khemtong, A. Dean Sherry, Zoltan Kovacs. Probing carbohydrate metabolism using hyperpolarized 13 C‐labeled molecules. NMR in Biomedicine 2019, 32 (10) https://doi.org/10.1002/nbm.4018
    28. Bryan Erriah, Stuart J. Elliott. Experimental evidence for the role of paramagnetic oxygen concentration on the decay of long-lived nuclear spin order. RSC Advances 2019, 9 (40) , 23418-23424. https://doi.org/10.1039/C9RA03748A
    29. Stuart J. Elliott, Pavel Kadeřávek, Lynda J. Brown, Mohamed Sabba, Stefan Glöggler, Daniel J. O'Leary, Richard C. D. Brown, Fabien Ferrage, Malcolm H. Levitt. Field-cycling long-lived-state NMR of 15 N 2 spin pairs. Molecular Physics 2019, 117 (7-8) , 861-867. https://doi.org/10.1080/00268976.2018.1543906
    30. Stuart J. Elliott, Gabriele Stevanato. Homonuclear ADAPT: A general preparation route to long-lived nuclear singlet order. Journal of Magnetic Resonance 2019, 301 , 49-55. https://doi.org/10.1016/j.jmr.2019.02.005
    31. Shengjun Yang, Jeffrey McCormick, Salvatore Mamone, Louis‐S. Bouchard, Stefan Glöggler. Nuclear Spin Singlet States in Photoactive Molecules: From Fluorescence/NMR Bimodality to a Bimolecular Switch for Spin Singlet States. Angewandte Chemie 2019, 131 (9) , 2905-2909. https://doi.org/10.1002/ange.201814198
    32. Shengjun Yang, Jeffrey McCormick, Salvatore Mamone, Louis‐S. Bouchard, Stefan Glöggler. Nuclear Spin Singlet States in Photoactive Molecules: From Fluorescence/NMR Bimodality to a Bimolecular Switch for Spin Singlet States. Angewandte Chemie International Edition 2019, 58 (9) , 2879-2883. https://doi.org/10.1002/anie.201814198
    33. S. J. Elliott, C. Bengs, L. J. Brown, J. T. Hill-Cousins, D. J. O’Leary, G. Pileio, M. H. Levitt. Nuclear singlet relaxation by scalar relaxation of the second kind in the slow-fluctuation regime. The Journal of Chemical Physics 2019, 150 (6) https://doi.org/10.1063/1.5074199
    34. Boris Kharkov, Xueyou Duan, Emily S. Tovar, James W. Canary, Alexej Jerschow. Singlet excitation in the intermediate magnetic equivalence regime and field-dependent study of singlet–triplet leakage. Physical Chemistry Chemical Physics 2019, 21 (5) , 2595-2600. https://doi.org/10.1039/C8CP06883F
    35. Philip Saul, Salvatore Mamone, Stefan Glöggler. Nuclear singlet multimers (NUSIMERs) with long-lived singlet states. Chemical Science 2019, 10 (2) , 413-417. https://doi.org/10.1039/C8SC02831A
    36. Bogdan A. Rodin, Alexey S. Kiryutin, Alexandra V. Yurkovskaya, Konstantin L. Ivanov, Satoru Yamamoto, Kazunobu Sato, Takeji Takui. Using optimal control methods with constraints to generate singlet states in NMR. Journal of Magnetic Resonance 2018, 291 , 14-22. https://doi.org/10.1016/j.jmr.2018.03.005
    37. Stuart J. Elliott, Benno Meier, Basile Vuichoud, Gabriele Stevanato, Lynda J. Brown, Javier Alonso-Valdesueiro, Lyndon Emsley, Sami Jannin, Malcolm H. Levitt. Hyperpolarized long-lived nuclear spin states in monodeuterated methyl groups. Physical Chemistry Chemical Physics 2018, 20 (15) , 9755-9759. https://doi.org/10.1039/C8CP00253C
    38. Salvatore Mamone, Stefan Glöggler. Nuclear spin singlet states as magnetic on/off probes in self-assembling systems. Physical Chemistry Chemical Physics 2018, 20 (35) , 22463-22467. https://doi.org/10.1039/C8CP04448A
    39. Deepak Khurana, T.S. Mahesh. Bang-bang optimal control of large spin systems: Enhancement of 13C–13C singlet-order at natural abundance. Journal of Magnetic Resonance 2017, 284 , 8-14. https://doi.org/10.1016/j.jmr.2017.09.006
    40. Kun Shen, Angus W. J. Logan, Johannes F. P. Colell, Junu Bae, Gerardo X. Ortiz, Thomas Theis, Warren S. Warren, Steven J. Malcolmson, Qiu Wang. Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization. Angewandte Chemie 2017, 129 (40) , 12280-12284. https://doi.org/10.1002/ange.201704970
    41. Kun Shen, Angus W. J. Logan, Johannes F. P. Colell, Junu Bae, Gerardo X. Ortiz, Thomas Theis, Warren S. Warren, Steven J. Malcolmson, Qiu Wang. Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization. Angewandte Chemie International Edition 2017, 56 (40) , 12112-12116. https://doi.org/10.1002/anie.201704970
    42. Eleonora Cavallari, Carla Carrera, Francesca Reineri. ParaHydrogen Hyperpolarized Substrates for Molecular Imaging Studies. Israel Journal of Chemistry 2017, 57 (9) , 833-842. https://doi.org/10.1002/ijch.201700030
    43. Aaron M. Coffey, Matthew A. Feldman, Roman V. Shchepin, Danila A. Barskiy, Milton L. Truong, Wellington Pham, Eduard Y. Chekmenev. High-resolution hyperpolarized in vivo metabolic 13C spectroscopy at low magnetic field (48.7 mT) following murine tail-vein injection. Journal of Magnetic Resonance 2017, 281 , 246-252. https://doi.org/10.1016/j.jmr.2017.06.009
    44. Giuseppe Pileio. Singlet NMR methodology in two-spin-1/2 systems. Progress in Nuclear Magnetic Resonance Spectroscopy 2017, 98-99 , 1-19. https://doi.org/10.1016/j.pnmrs.2016.11.002
    45. James Eills, Gabriele Stevanato, Christian Bengs, Stefan Glöggler, Stuart J. Elliott, Javier Alonso-Valdesueiro, Giuseppe Pileio, Malcolm H. Levitt. Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems. Journal of Magnetic Resonance 2017, 274 , 163-172. https://doi.org/10.1016/j.jmr.2016.11.010
    46. Stefan Glöggler, Stuart J. Elliott, Gabriele Stevanato, Richard C. D. Brown, Malcolm H. Levitt. Versatile magnetic resonance singlet tags compatible with biological conditions. RSC Advances 2017, 7 (55) , 34574-34578. https://doi.org/10.1039/C7RA05196D
    47. Andrey N. Pravdivtsev, Alexey S. Kiryutin, Alexandra V. Yurkovskaya, Hans-Martin Vieth, Konstantin L. Ivanov. Robust conversion of singlet spin order in coupled spin-1/2 pairs by adiabatically ramped RF-fields. Journal of Magnetic Resonance 2016, 273 , 56-64. https://doi.org/10.1016/j.jmr.2016.10.003
    48. Dennis Kurzbach, Emmanuelle M. M. Weber, Aditya Jhajharia, Samuel F. Cousin, Aude Sadet, Sina Marhabaie, Estel Canet, Nicolas Birlirakis, Jonas Milani, Sami Jannin, Dmitry Eshchenko, Alia Hassan, Roberto Melzi, Stephan Luetolf, Marco Sacher, Marc Rossire, James Kempf, Joost A. B. Lohman, Matthias Weller, Geoffrey Bodenhausen, Daniel Abergel. Dissolution dynamic nuclear polarization of deuterated molecules enhanced by cross-polarization. The Journal of Chemical Physics 2016, 145 (19) https://doi.org/10.1063/1.4967402
    49. Stuart J. Elliott, Lynda J. Brown, Jean-Nicolas Dumez, Malcolm H. Levitt. Long-lived nuclear spin states in rapidly rotating CH 2 D groups. Journal of Magnetic Resonance 2016, 272 , 87-90. https://doi.org/10.1016/j.jmr.2016.09.009
    50. Yuning Zhang, Xueyou Duan, Pei Che Soon, Vladimír Sychrovský, James W. Canary, Alexej Jerschow. Limits in Proton Nuclear Singlet‐State Lifetimes Measured with para ‐Hydrogen‐Induced Polarization. ChemPhysChem 2016, 17 (19) , 2967-2971. https://doi.org/10.1002/cphc.201600663
    51. Rajat K. Ghosh, Nicholas N. Kuzma, Stephen J. Kadlecek, Rahim R. Rizi. Versatile pulse sequence device to conserve hyperpolarization for NMR and MRI studies. Magnetic Resonance in Medicine 2016, 75 (4) , 1822-1830. https://doi.org/10.1002/mrm.25679
    52. Qianni Guo, Qingbin Zeng, Weiping Jiang, Xiaoxiao Zhang, Qing Luo, Xu Zhang, Louis‐S. Bouchard, Maili Liu, Xin Zhou. A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized 129 Xe Molecular Clamp Probe. Chemistry – A European Journal 2016, 22 (12) , 3967-3970. https://doi.org/10.1002/chem.201600193
    53. He Deng, Jianping Zhong, Weiwei Ruan, Xian Chen, Xianping Sun, Chaohui Ye, Maili Liu, Xin Zhou. Constant-variable flip angles for hyperpolarized media MRI. Journal of Magnetic Resonance 2016, 263 , 92-100. https://doi.org/10.1016/j.jmr.2015.12.022
    54. Zijian Zhou, Kevin Claytor, Warren S. Warren, Thomas Theis. Accessing long lived 1H states via 2H couplings. Journal of Magnetic Resonance 2016, 263 , 108-115. https://doi.org/10.1016/j.jmr.2015.12.020
    55. Yesu Feng, Jeremy W. Gordon, Peter J. Shin, Cornelius von Morze, Michael Lustig, Peder E.Z. Larson, Michael A. Ohliger, Lucas Carvajal, James Tropp, John M. Pauly, Daniel B. Vigneron. Development and testing of hyperpolarized 13C MR calibrationless parallel imaging. Journal of Magnetic Resonance 2016, 262 , 1-7. https://doi.org/10.1016/j.jmr.2015.10.018
    56. Stephen J. DeVience, Ronald L. Walsworth, Matthew S. Rosen. Probing scalar coupling differences via long-lived singlet states. Journal of Magnetic Resonance 2016, 262 , 42-49. https://doi.org/10.1016/j.jmr.2015.12.003
    57. Dirk Graafen, María Belén Franzoni, Laura M. Schreiber, Hans W. Spiess, Kerstin Münnemann. Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system. Journal of Magnetic Resonance 2016, 262 , 68-72. https://doi.org/10.1016/j.jmr.2015.12.006
    58. Stuart J. Elliott, Lynda J. Brown, Jean-Nicolas Dumez, Malcolm H. Levitt. Long-lived nuclear spin states in monodeuterated methyl groups. Physical Chemistry Chemical Physics 2016, 18 (27) , 17965-17972. https://doi.org/10.1039/C6CP03619H
    59. Alexey S. Kiryutin, Herbert Zimmermann, Alexandra V. Yurkovskaya, Hans-Martin Vieth, Konstantin L. Ivanov. Long-lived spin states as a source of contrast in magnetic resonance spectroscopy and imaging. Journal of Magnetic Resonance 2015, 261 , 64-72. https://doi.org/10.1016/j.jmr.2015.10.004
    60. Frédéric A. Perras, David L. Bryce. Revisiting the Concept of Equivalence in Solid-State NMR. 2015, 561-574. https://doi.org/10.1002/9780470034590.emrstm1469
    61. Maninder Singh, Narayanan D. Kurur. An improved method for the measurement of lifetimes of long-lived coherences in NMR. RSC Advances 2015, 5 (11) , 8236-8238. https://doi.org/10.1039/C4RA10535D
    62. Yesu Feng, Thomas Theis, Tung-Lin Wu, Kevin Claytor, Warren S. Warren. Long-lived polarization protected by symmetry. The Journal of Chemical Physics 2014, 141 (13) https://doi.org/10.1063/1.4896895
    63. Yuning Zhang, Pei Che Soon, Alexej Jerschow, James W. Canary. Long‐Lived 1 H Nuclear Spin Singlet in Dimethyl Maleate Revealed by Addition of Thiols. Angewandte Chemie 2014, 126 (13) , 3464-3467. https://doi.org/10.1002/ange.201310284
    64. Yuning Zhang, Pei Che Soon, Alexej Jerschow, James W. Canary. Long‐Lived 1 H Nuclear Spin Singlet in Dimethyl Maleate Revealed by Addition of Thiols. Angewandte Chemie International Edition 2014, 53 (13) , 3396-3399. https://doi.org/10.1002/anie.201310284
    65. Kevin Claytor, Thomas Theis, Yesu Feng, Warren Warren. Measuring long-lived 13C2 state lifetimes at natural abundance. Journal of Magnetic Resonance 2014, 239 , 81-86. https://doi.org/10.1016/j.jmr.2013.12.009
    66. T. Theis, Y. Feng, T. Wu, W. S. Warren. Composite and shaped pulses for efficient and robust pumping of disconnected eigenstates in magnetic resonance. The Journal of Chemical Physics 2014, 140 (1) https://doi.org/10.1063/1.4851337
    67. Dirk Graafen, Sandro Ebert, Oliver Neudert, Lisandro Buljubasich, María Belén Franzoni, Jan Falk Dechent, Kerstin Münnemann. 1H NMR Spectroscopy and MR Imaging with Hyperpolarised Substances. 2014, 167-215. https://doi.org/10.1016/B978-0-12-800184-4.00004-7
    Download PDF
    Go to Journal of the American Chemical Society
    Get e-Alerts
    Get e-Alerts

    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2013, 135, 26, 9632–9635
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ja404936p
    Published June 20, 2013
    Copyright © 2013 American Chemical Society
    Request reuse permissions

    Article Views

    1464

    Altmetric

    -

    Citations

    67
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.