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Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework-Hybridization Approach for Biomedicine

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† State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China
‡ Nanomaterials Center, School of Chemical Engineering and Australia Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland 4072, Australia
§ Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, P. R. China
[email protected]
[email protected]
[email protected]
Cite this: J. Am. Chem. Soc. 2014, 136, 46, 16326–16334
Publication Date (Web):October 24, 2014
https://doi.org/10.1021/ja508721y
Copyright © 2014 American Chemical Society
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Abstract

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Chemical construction of molecularly organic–inorganic hybrid hollow mesoporous organosilica nanoparticles (HMONs) with silsesquioxane framework is expected to substantially improve their therapeutic performance and enhance the biological effects beneficial for biomedicine. In this work, we report on a simple, controllable, and versatile chemical homology principle to synthesize multiple-hybridized HMONs with varied functional organic groups homogeneously incorporated into the framework (up to quintuple hybridizations). As a paradigm, the hybridization of physiologically active thioether groups with triple distinctive disulfide bonds can endow HMONs with unique intrinsic reducing/acidic- and external high intensity focused ultrasound (HIFU)-responsive drug-releasing performances, improved biological effects (e.g., lowered hemolytic effect and improved histocompatibility), and enhanced ultrasonography behavior. The doxorubicin-loaded HMONs with concurrent thioether and phenylene hybridization exhibit drastically enhanced therapeutic efficiency against cancer growth and metastasis, as demonstrated both in vitro and in vivo.

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Experimental section, additional characterization data of multiple-hybridized HMONs, and in vitro biological effects/therapeutic outcome. This material is available free of charge via the Internet at http://pubs.acs.org.

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