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Cobalt-Catalyzed Regioselective Dehydrohalogenation of Alkyl Halides with Dimethylphenylsilylmethylmagnesium Chloride

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    Cobalt-Catalyzed Regioselective Dehydrohalogenation of Alkyl Halides with Dimethylphenylsilylmethylmagnesium Chloride
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    Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
    [email protected]; [email protected]
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2008, 130, 34, 11276–11277
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    https://doi.org/10.1021/ja804277x
    Published July 31, 2008
    Copyright © 2008 American Chemical Society
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    Abstract

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    Cobalt-catalyzed reactions of haloalkanes with dimethylphenylsilylmethylmagnesium chloride result in highly regioselective dehydrohalogenation. The reaction does not follow the conventional E2 elimination mechanism but includes β-hydride elimination from the corresponding alkylcobalt intermediate. The interesting reaction mechanism of the cobalt-catalyzed dehydrohalogenation offered unique transformations that are otherwise difficult to attain.

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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2008, 130, 34, 11276–11277
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ja804277x
    Published July 31, 2008
    Copyright © 2008 American Chemical Society
    Request reuse permissions

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