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Pd(II)-Catalyzed Amination of C−H Bonds Using Single-Electron or Two-electron Oxidants
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    Pd(II)-Catalyzed Amination of C−H Bonds Using Single-Electron or Two-electron Oxidants
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    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2009, 131, 31, 10806–10807
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    https://doi.org/10.1021/ja904709b
    Published July 16, 2009
    Copyright © 2009 American Chemical Society

    Abstract

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    Pd(II)-catalyzed intramolecular amination of arenes is developed using either a one- or two-electron oxidant. The reaction protocol tolerates a wide range of deactivating groups including acetyl, cyano, and nitro groups. This catalytic reaction allows expedient syntheses of broadly useful substituted indolines or indoles.

    Copyright © 2009 American Chemical Society

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    Experimental procedure and characterization of all new compounds. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Published July 16, 2009
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