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Pd(II)-Catalyzed Amination of C−H Bonds Using Single-Electron or Two-electron Oxidants

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Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037
Cite this: J. Am. Chem. Soc. 2009, 131, 31, 10806–10807
Publication Date (Web):July 16, 2009
Copyright © 2009 American Chemical Society

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    Pd(II)-catalyzed intramolecular amination of arenes is developed using either a one- or two-electron oxidant. The reaction protocol tolerates a wide range of deactivating groups including acetyl, cyano, and nitro groups. This catalytic reaction allows expedient syntheses of broadly useful substituted indolines or indoles.

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