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Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine

  • Jiayu Ren
    Jiayu Ren
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China
    University of Chinese Academy of Sciences, Beijing 100049, China
    More by Jiayu Ren
  • Nicholas Andrikopoulos
    Nicholas Andrikopoulos
    Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia
  • Kelly Velonia
    Kelly Velonia
    Department of Materials Science and Technology, University of Crete, Heraklion 70013, Greece
  • Huayuan Tang
    Huayuan Tang
    Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States
    More by Huayuan Tang
  • Rong Cai
    Rong Cai
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China
    More by Rong Cai
  • Feng Ding
    Feng Ding
    Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States
    More by Feng Ding
  • Pu Chun Ke
    Pu Chun Ke
    Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia
    Nanomedicine Center, The GBA National Institute for Nanotechnology Innovation, 136 Kaiyuan Avenue, Guangzhou 510700, China
    More by Pu Chun Ke
  • , and 
  • Chunying Chen*
    Chunying Chen
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China
    University of Chinese Academy of Sciences, Beijing 100049, China
    Nanomedicine Center, The GBA National Institute for Nanotechnology Innovation, 136 Kaiyuan Avenue, Guangzhou 510700, China
    *[email protected]
Cite this: J. Am. Chem. Soc. 2022, 144, 21, 9184–9205
Publication Date (Web):May 10, 2022
https://doi.org/10.1021/jacs.2c02277
Copyright © 2022 American Chemical Society

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    Abstract

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    An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous collection of biomolecular species by nanoparticles in living systems. The protein corona is dynamic in composition and may entail improved water suspendability and compromised delivery and targeting to the nanoparticles. How much of this nonspecific protein ensemble is determined by the chemistry of the nanoparticle core and its surface functionalization, and how much of this entity is dictated by the biological environments that vary spatiotemporally in vivo? How do we “live with” and exploit the protein corona without significantly sacrificing the efficacy of nanomedicines in diagnosing and curing human diseases? This article discusses the chemical and biophysical signatures of the protein corona and ponders challenges ahead for the field of nanomedicine.

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