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Nucleic Acid Nanocapsules for Enzyme-Triggered Drug Release
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    Nucleic Acid Nanocapsules for Enzyme-Triggered Drug Release
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    Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States
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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2017, 139, 18, 6278–6281
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    https://doi.org/10.1021/jacs.6b13087
    Published April 25, 2017
    Copyright © 2017 American Chemical Society

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    Herein we describe a nucleic acid functionalized nanocapsule in which nucleic acid ligands are assembled and disassembled in the presence of enzymes. The particles are fully degradable in response to esterases due to an embedded ester cross-linker in the particle’s core. During synthesis the nanocapsules can be loaded with hydrophobic small molecules and post self-assembly undergo covalent cross-linking using copper catalyzed click chemistry. They can then be functionalized with thiolated DNA through stepwise thiolyne chemistry using UV light irradiation. Additionally, the capsule is compatible with enzyme mediated functionalization of a therapeutic mRNA-cleaving DNAzyme at the particle’s surface. The resulting particle is highly stable, monodisperse in size, and maximizes the therapeutic potential of both the particles interior and exterior.

    Copyright © 2017 American Chemical Society

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    Journal of the American Chemical Society

    Cite this: J. Am. Chem. Soc. 2017, 139, 18, 6278–6281
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jacs.6b13087
    Published April 25, 2017
    Copyright © 2017 American Chemical Society

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