ACS Publications. Most Trusted. Most Cited. Most Read
My Activity

Figure 1Loading Img

Triterpene Alcohol and Sterol Ferulates from Rice Bran and Their Anti-inflammatory Effects

View Author Information
College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan, College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan, Application Development Department, Yokogawa Analytical Systems Inc., 2-11-13 Nakacho, Musashino, Tokyo 101-0006, Japan, and Meikai University School of Dentistry, 1-1 Keyakidai, Sakado, Saitama 350-0283, Japan
Cite this: J. Agric. Food Chem. 2000, 48, 6, 2313–2319
Publication Date (Web):May 26, 2000
Copyright © 2000 American Chemical Society

    Article Views





    Read OnlinePDF (110 KB)


    Six novel feruloyl esters of triterpene alcohols and sterols, viz., two trans-ferulates, cycloeucalenol and 24-methylenecholesterol trans-ferulates, and four cis-ferulates, cycloartenol, 24-methyelenecycloartanol, 24-methylcholesterol, and sitosterol cis-ferulates, besides five known trans-ferulates, cycloartenol (CAR), 24-methylenecycloartanol (24-MCA), 24-methylcholesterol, sitosterol, and stigmastanol trans-ferulates, and one known cis-ferulate, stigmastanol cis-ferulate, were isolated from the methanol extract of edible rice bran. These and eight other synthetic trans- and cis-ferulates of triterpene alcohols and sterols, along with the corresponding free alcohols, were evaluated with respect to their anti-inflammatory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg per ear) in mice. All of the ferulates showed marked inhibitory activity, and their 50% inhibitory dose (ID50) was 0.1−0.8 mg per ear. On the other hand, whereas two free triterpene alcohols, CAR and 24-MCA, showed strong inhibition (ID50 0.2−0.3 mg/ear), eight free sterols examined showed weaker activity (ID50 0.7−2.7 mg/ear) than their corresponding ferulates.

    Keywords: Rice bran; trans- and cis-feruloyl esters; triterpene alcohol; sterol; antiedema; TPA-induced ear edema


     Author to whom correspondence should be addressed (fax +81-3-3293-7572; e-mail [email protected]).

     College of Science and Technology, Nihon University.

     College of Pharmacy, Nihon University.


     Yokogawa Analytical Systems Inc.

     Meikai University School of Dentistry.

    Cited By

    This article is cited by 245 publications.

    1. Sarah Schlag, Sören Götz, Felix Rüttler, Sandra M. Schmöckel, Walter Vetter. Quantitation of 20 Phytosterols in 34 Different Accessions of Quinoa (Chenopodium quinoa). Journal of Agricultural and Food Chemistry 2022, 70 (32) , 9856-9864.
    2. Pepijn Prinsen, Ana Gutiérrez, Craig B. Faulds, and José C. del Río . Comprehensive Study of Valuable Lipophilic Phytochemicals in Wheat Bran. Journal of Agricultural and Food Chemistry 2014, 62 (7) , 1664-1673.
    3. Mendel Friedman . Rice Brans, Rice Bran Oils, and Rice Hulls: Composition, Food and Industrial Uses, and Bioactivities in Humans, Animals, and Cells. Journal of Agricultural and Food Chemistry 2013, 61 (45) , 10626-10641.
    4. Martina Palomino-Schätzlein, Pablo V. Escrig, Herminio Boira, Jaime Primo, Antonio Pineda-Lucena, and Nuria Cabedo . Evaluation of Nonpolar Metabolites in Plant Extracts by 13C NMR Spectroscopy. Journal of Agricultural and Food Chemistry 2011, 59 (21) , 11407-11416.
    5. Yan-Ying Zhou, Shi-Hong Luo, Ting-Shuang Yi, Chun-Huan Li, Qian Luo, Juan Hua, Yan Liu, and Sheng-Hong Li . Secondary Metabolites from Glycine soja and Their Growth Inhibitory Effect against Spodoptera litura. Journal of Agricultural and Food Chemistry 2011, 59 (11) , 6004-6010.
    6. Ryousuke Ito, Kouya Mori, Ippei Hashimoto, Chiaki Nakano, Tsutomu Sato, and Tsutomu Hoshino . Triterpene Cyclases from Oryza sativa L.: Cycloartenol, Parkeol and Achilleol B Synthases. Organic Letters 2011, 13 (10) , 2678-2681.
    7. Tanja Nurmi, Anna-Maija Lampi, Laura Nyström, Milla Turunen and Vieno Piironen . Effects of Genotype and Environment on Steryl Ferulates in Wheat and Rye in the HEALTHGRAIN Diversity Screen. Journal of Agricultural and Food Chemistry 2010, 58 (17) , 9332-9340.
    8. Min-Hsiung Pan, Ching-Shu Lai, Slavik Dushenkov and Chi-Tang Ho . Modulation of Inflammatory Genes by Natural Dietary Bioactive Compounds. Journal of Agricultural and Food Chemistry 2009, 57 (11) , 4467-4477.
    9. Lúcia Oliveira, Carmen S. R. Freire, Armando J. D. Silvestre and Nereida Cordeiro . Lipophilic Extracts from Banana Fruit Residues: A Source of Valuable Phytosterols. Journal of Agricultural and Food Chemistry 2008, 56 (20) , 9520-9524.
    10. Ashwini Tilay, Mahesh Bule, Jyoti Kishenkumar and Uday Annapure. Preparation of Ferulic Acid from Agricultural Wastes: Its Improved Extraction and Purification. Journal of Agricultural and Food Chemistry 2008, 56 (17) , 7644-7648.
    11. Steven J. Britz,, P. V. V. Prasad,, Robert A. Moreau,, L. Hartwell Allen, Jr.,, Diane F. Kremer, and, Kenneth J. Boote. Influence of Growth Temperature on the Amounts of Tocopherols, Tocotrienols, and γ-Oryzanol in Brown Rice. Journal of Agricultural and Food Chemistry 2007, 55 (18) , 7559-7565.
    12. Shanggong Yu,, Zachary T. Nehus,, Thomas M. Badger, and, Nianbai Fang. Quantification of Vitamin E and γ-Oryzanol Components in Rice Germ and Bran. Journal of Agricultural and Food Chemistry 2007, 55 (18) , 7308-7313.
    13. Takashi Kikuchi,, Toshihiro Akihisa,, Harukuni Tokuda,, Motohiko Ukiya,, Kenji Watanabe, and, Hoyoku Nishino. Cancer Chemopreventive Effects of Cycloartane-Type and Related Triterpenoids in in Vitro and in Vivo Models. Journal of Natural Products 2007, 70 (6) , 918-922.
    14. Yanlan Bi,, Guolong Yang,, Hong Li,, Genwang Zhang, and, Zheng Guo. Characterization of the Chemical Composition of Lotus Plumule Oil. Journal of Agricultural and Food Chemistry 2006, 54 (20) , 7672-7677.
    15. Shanggong Yu,, Nianbai Fang,, Qinglin Li,, Jianxiang Zhang,, Hongfeng Luo,, Martin Ronis, and, Thomas M. Badger. In Vitro Actions on Human Cancer Cells and the Liquid Chromatography−Mass Spectrometry/Mass Spectrometry Fingerprint of Phytochemicals in Rice Protein Isolate. Journal of Agricultural and Food Chemistry 2006, 54 (12) , 4482-4492.
    16. Toshihiro Akihisa,, Kenji Watanabe,, Risa Yoneima,, Takashi Suzuki, and, Yumiko Kimura. Biotransformation of Cycloartane-Type Triterpenes by the Fungus Glomerella fusarioides. Journal of Natural Products 2006, 69 (4) , 604-607.
    17. Laura Nyström,, Marjukka Mäkinen,, Anna-Maija Lampi, and, Vieno Piironen. Antioxidant Activity of Steryl Ferulate Extracts from Rye and Wheat Bran. Journal of Agricultural and Food Chemistry 2005, 53 (7) , 2503-2510.
    18. Maria-Cruz Figueroa-Espinoza and, Pierre Villeneuve. Phenolic Acids Enzymatic Lipophilization. Journal of Agricultural and Food Chemistry 2005, 53 (8) , 2779-2787.
    19. Hong-Feng Luo,, Qinglin Li,, Shanggong Yu,, Thomas M. Badger, and, Nianbai Fang. Cytotoxic Hydroxylated Triterpene Alcohol Ferulates from Rice Bran. Journal of Natural Products 2005, 68 (1) , 94-97.
    20. Ronald A. Holser,, Georgia Bost, and, Maurits Van Boven. Phytosterol Composition of Hybrid Hibiscus Seed Oils. Journal of Agricultural and Food Chemistry 2004, 52 (9) , 2546-2548.
    21. Kenji Iwatsuki,, Toshihiro Akihisa,, Harukuni Tokuda,, Motohiko Ukiya,, Hiroshi Higashihara,, Teruo Mukainaka,, Masao Iizuka,, Yoshiharu Hayashi,, Yumiko Kimura, and, Hoyoku Nishino. Sterol Ferulates, Sterols, and 5-Alk(en)ylresorcinols from Wheat, Rye, and Corn Bran Oils and Their Inhibitory Effects on Epstein−Barr Virus Activation. Journal of Agricultural and Food Chemistry 2003, 51 (23) , 6683-6688.
    22. Nianbai Fang,, Shanggong Yu, and, Thomas M. Badger. Characterization of Triterpene Alcohol and Sterol Ferulates in Rice Bran Using LC-MS/MS. Journal of Agricultural and Food Chemistry 2003, 51 (11) , 3260-3267.
    23. Christianne E. C. Rodrigues,, Rosemar Antoniassi, and, Antonio J. A. Meirelles. Equilibrium Data for the System Rice Bran Oil + Fatty Acids + Ethanol + Water at 298.2 K. Journal of Chemical & Engineering Data 2003, 48 (2) , 367-373.
    24. Thomas H. J. Beveridge,, Thomas S. C. Li, and, John C. G. Drover. Phytosterol Content in American Ginseng Seed Oil. Journal of Agricultural and Food Chemistry 2002, 50 (4) , 744-750.
    25. Muhammad Zubair, Farooq Anwar, Insha Arshad, Shanza Malik, Muhammad Nadeem Zafar. Rice Nutraceuticals and Bioactive Compounds: Extraction, Characterization and Antioxidant Activity: A Review. Combinatorial Chemistry & High Throughput Screening 2023, 26 (15) , 2625-2643.
    26. D.S.U. Aluthge, K.K.D.S. Ranaweera, I.A.D.S.R. Gunathilake. The effect of stabilization heat treatment on rice bran quality parameters, including total phenolic content, gamma oryzanol content, antioxidant potential, oxidative stability and extraction yield during storage. Food Chemistry Advances 2023, 3 , 100531.
    27. Huiwen Zhou, Jinjin Zhang, Liping Bai, Jiayi Liu, Hongdi Li, Juan Hua, Shihong Luo. Chemical Structure Diversity and Extensive Biological Functions of Specialized Metabolites in Rice. International Journal of Molecular Sciences 2023, 24 (23) , 17053.
    28. Najmeh Davoodian, Ali Kadivar, Hossein Mehrban. Supplementation of media with gamma‐oryzanol as a novel antioxidant to overcome redox imbalance during bovine oocyte maturation in vitro. Reproduction in Domestic Animals 2023, 3
    29. Zhaoguo Liu, Xiaoxiao Liu, Zheng Ma, Tianzhu Guan. Phytosterols in rice bran and their health benefits. Frontiers in Nutrition 2023, 10
    30. Dmitry D. Evtyugin, Dmitry V. Evtuguin, Susana Casal, Maria Rosário Domingues. Advances and Challenges in Plant Sterol Research: Fundamentals, Analysis, Applications and Production. Molecules 2023, 28 (18) , 6526.
    31. Sadini Ekanayake, Chaminda Egodawatta, Renuka N. Attanayake, Dinum Perera. From salt pan to saucepan: Salicornia , a halophytic vegetable with an array of potential health benefits. Food Frontiers 2023, 4 (2) , 641-676.
    32. Mtabazi G. Sahini, Eric Mutegoa. Extraction, phytochemistry, nutritional, and therapeutical potentials of rice bran oil: A review. Phytomedicine Plus 2023, 3 (2) , 100453.
    33. Jason Ashworth. Anti-inflammatory Agent. 2023, 41-51.
    34. Salisa Chumsantea, Apiwat Jiruttisakul, Akkaradech Nakornsadet, Piraporn Sombutsuwan, Kornkanok Aryusuk. Simultaneous Determination of Vitamin E and γ-Oryzanol in Rice Bran Oil via HPSEC-PDA without Sample Pretreatment. Journal of Oleo Science 2023, 72 (7) , 655-665.
    35. T. Kalita, R. Sharma, S. Sengupta, D. Basumatari. Entomophagy practices in Bodoland Territorial Region, Assam: nutritional potential and implications for food security. Journal of Insects as Food and Feed 2022, 8 (12) , 1485-1500.
    36. Liangliang Xie, Tao Zhang, Emad Karrar, Liyou Zheng, Dan Xie, Jun Jin, Xingguo Wang, Qingzhe Jin. Purification, characterization, and cellular antioxidant activity of 4,4‐dimethylsterols and 4‐desmethylsterols. Journal of the American Oil Chemists' Society 2022, 99 (12) , 1165-1174.
    37. Mary Annilyn L. Villar, Mark Louis P. Vidallon, Evelyn B. Rodriguez. Nanostructured lipid carrier for bioactive rice bran gamma-oryzanol. Food Bioscience 2022, 50 , 102064.
    38. Sami Ali Aldhumri, Abeer Abu Zaid, Susu Alasfoury, Hamida Hamdi. Antimicrobial and Wound Healing Potentials of Some Cold Pressed Oils from Some Medicinal Plants from the Kingdom of Saudi Arabia. Journal of Biobased Materials and Bioenergy 2022, 16 (6) , 836-847.
    39. Swarnadip Ghosh, Haritha Bollinedi, S. Gopala Krishnan, Aditi Kundu, Anupama Singh, Prolay Kumar Bhowmick, Archana Singh, Mariappan Nagarajan, Kunnummal Kurungara Vinod, Ranjith Kumar Ellur, Ashok Kumar Singh. From farm to plate: Spatio-temporal characterization revealed compositional changes and reduced retention of γ-oryzanol upon processing in rice. Frontiers in Nutrition 2022, 9
    40. Ming-Der Wu, Ming-Jen Cheng. Undescribed Metabolites from an Actinobacteria Acrocarpospora punica and Their Anti-Inflammatory Activity. Molecules 2022, 27 (22) , 7982.
    41. Afifah Zahra Agista, Sharon Angela Tanuseputero, Takuya Koseki, Ardiansyah Ardiansyah, Slamet Budijanto, Halima Sultana, Yusuke Ohsaki, Chiu-Li Yeh, Suh-Ching Yang, Michio Komai, Hitoshi Shirakawa. Tryptamine, a Microbial Metabolite in Fermented Rice Bran Suppressed Lipopolysaccharide-Induced Inflammation in a Murine Macrophage Model. International Journal of Molecular Sciences 2022, 23 (19) , 11209.
    42. Abeer S. Alqurashi, Luluah M. Al Masoudi, Hamida Hamdi, Abeer Abu Zaid. Chemical Composition and Antioxidant, Antiviral, Antifungal, Antibacterial and Anticancer Potentials of Opuntia ficus-indica Seed Oil. Molecules 2022, 27 (17) , 5453.
    43. Emmanuel Kofi Kumatia, Frederick Ayertey, Regina Appiah-Opong, Ebenezer Ofori-Attah, Peter Bolah, Stephen Antwi, Alfred Ampomah Appiah, Augustine Ocloo. Effect of Anthonotha macrophyla (P. Beauv) leaf extract on carrageenan-induced paw oedema, oxidative stress makers and hyperalgesia in murine models. Advances in Traditional Medicine 2022, 22 (2) , 315-324.
    44. Mengjing Cong, Xiaoyan Pang, Kai Zhao, Yue Song, Yonghong Liu, Junfeng Wang. Deep-Sea Natural Products from Extreme Environments: Cold Seeps and Hydrothermal Vents. Marine Drugs 2022, 20 (6) , 404.
    45. Swarnima Dey, Alok Saxena, Yogesh Kumar, Tanushree Maity, Ayon Tarafdar, . Understanding the Antinutritional Factors and Bioactive Compounds of Kodo Millet (Paspalum scrobiculatum) and Little Millet (Panicum sumatrense). Journal of Food Quality 2022, 2022 , 1-19.
    46. Mario J. Rosado, Gisela Marques, Jorge Rencoret, Ana Gutiérrez, José C. del Río. Chemical Composition of Lipophilic Compounds From Rice (Oryza sativa) Straw: An Attractive Feedstock for Obtaining Valuable Phytochemicals. Frontiers in Plant Science 2022, 13
    47. S.-W. Hsiao, I-C. Kuo, C.-W. Su, Y.-H. Wang, H.-C. Mei, C.-K. Lee. Metabolite characterisation and profiling of Hermetia illucens L. larvae at various growth stages using Sesamum indicum residues as nutrient source. Journal of Insects as Food and Feed 2022, 8 (3) , 223-235.
    48. Michio Hashimoto, Shahdat Hossain, Kentaro Matsuzaki, Osamu Shido, Katsumi Yoshino. The journey from white rice to ultra-high hydrostatic pressurized brown rice: an excellent endeavor for ideal nutrition from staple food. Critical Reviews in Food Science and Nutrition 2022, 62 (6) , 1502-1520.
    49. Jasmeet Kour, Hitesh Chopra, Saba Bukhari, Renu Sharma, Rosy Bansal, Monika Hans, Dharmesh Chandra Saxena. Nutraceutical-A deep and profound concept. 2022, 1-28.
    50. Sahar A. Helmy, Saif El-Mofty, Amal M. El Gayar, Ibrahim M. El-Sherbiny, Yousra M. El-Far. Novel doxorubicin / folate-targeted trans-ferulic acid-loaded PLGA nanoparticles combination: In-vivo superiority over standard chemotherapeutic regimen for breast cancer treatment. Biomedicine & Pharmacotherapy 2022, 145 , 112376.
    51. Ranvijay Pratap Singh, Rohit Prakash, Astha Yadav, Asmita Singh, Priyanka Yadav, Sanjay Srivastava, Arun Sethi. Efficient Synthesis of Fluorinated Derivatives from Isolated 24-Ethyl cholest-5-en-3β-ol: Characterization, Quantum Chemical Calculations by DFT and Molecular Docking. Asian Journal of Chemistry 2022, 34 (11) , 2947-2954.
    52. Torit Bagchi, K. Chakraborty, A.N. Pattnaik, S. Sarkar, N. Basak, K. Chattopadhyay, P. Swain, S.K. Sahoo. Rice Bran Cake, a Novel Value Added Food Product:- Comparison with Market Available Cake with Respect to Sensory and Nutritional Qualities. SSRN Electronic Journal 2022, 53
    53. Mary Annilyn Lopez Villar, Mark Louis Vidallon, Evelyn Rodriguez. Nanostructured Lipid Carrier for Bioactive Rice Bran Gamma-Oryzanol. SSRN Electronic Journal 2022, 60
    54. Rehab F. Abdel-Rahman, Hany M. Fayed, Gihan F. Asaad, Hanan A. Ogaly, Alyaa F. Hessin, Abeer A. A. Salama, Sahar S. Abd El-Rahman, Mahmoud S. Arbid, Marawan Abd Elbaset Mohamed, . The involvement of TGF-β1 /FAK/α-SMA pathway in the antifibrotic impact of rice bran oil on thioacetamide-induced liver fibrosis in rats. PLOS ONE 2021, 16 (12) , e0260130.
    55. Chiao-Chih Huang, Tzu-Ching Lin, Chiung-Hui Liu, Hao-Chun Hu, Szu-Yin Yu, Shu-Jing Wu, Ming-Hong Yen, Yi-Hong Tsai, Fang-Rong Chang. Lipid Metabolism and its Mechanism Triggered by Supercritical CO2 Extract of Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) Bran in High-Fat Diet Induced Hyperlipidemic Hamsters. Frontiers in Pharmacology 2021, 12
    56. Walid Hamdy El-Tantawy. Nutrition in the management of type 2 diabetes mellitus: review. Archives of Physiology and Biochemistry 2021, 127 (6) , 509-526.
    57. Fernando Novillo, Estela Velasco-Barrios, Antonio Nieto-Camacho, Fabiola A. López-Huerta, Carlos A. Méndez Cuesta, María Teresa Ramírez-Apan, María Isabel Chávez, Esteban M. Martínez, Tzasna Hernández-Delgado, Francisco J. Espinosa-García, Guillermo Delgado. 3β-Palmitoyloxy-olean-12-ene analogs from Sapium lateriflorum (Euphorbiaceae): Their cytotoxic and anti-inflammatory properties and docking studies. Fitoterapia 2021, 155 , 105067.
    58. Daseul Kim, Ki-young Kim, . Hedera rhombea inhibits the biofilm formation of Candida, thereby increases the susceptibility to antifungal agent, and reduces infection. PLOS ONE 2021, 16 (10) , e0258108.
    59. Cong Liu, Xingjun Xi, Yuanyuan Liu, Yanzhen Lu, Fenfang Che, Yanxiang Gu, Yingchun Yu, Hao Li, Jiangang Liu, Yun Wei. Isolation of Four Major Compounds of γ-Oryzanol from Rice Bran Oil by Ionic Liquids Modified High-Speed Countercurrent Chromatography and Antimicrobial Activity and Neuroprotective Effect of Cycloartenyl Ferulate In Vitro. Chromatographia 2021, 84 (7) , 635-644.
    60. Lamesgen Yegrem, . Nutritional Composition, Antinutritional Factors, and Utilization Trends of Ethiopian Chickpea (Cicer arietinum L.). International Journal of Food Science 2021, 2021 , 1-10.
    61. Bing Li, Ru-Yue Wang, Ye Zhao, Yi-Fan Yu, Zhan-Xin Zhang, Fang-Di Hu, Kun Gao, Dong-Qing Fei. Triterpenoids with α-glucosidase inhibitory activities from the roots of Codonopsis pilosula var. modesta. Journal of Chemical Research 2021, 45 (5-6) , 635-638.
    62. Haritha Bollinedi, A. K. Singh, Neha Singh, Gopala Krishnan S, Prolay K. Bhowmick, Vinod K. K, Nagarajan M, Ellur R. K. Genetic and genomic approaches to address rapid rancidity of rice bran. Critical Reviews in Food Science and Nutrition 2021, 61 (1) , 75-84.
    63. Upasana Yadav, Shalini Arora, Isha Kaushik. Rice (Oryza sativa) Bran. 2021, 397-426.
    64. Muhammad Daniyal, Wei Wang. Molecular pharmacology of inflammation: Medicinal plants as antiinflammatory agents. 2021, 21-63.
    65. Senem Kamiloglu, Merve Tomas, Tugba Ozdal, Perihan Yolci-Omeroglu, Esra Capanoglu. Bioactive component analysis. 2021, 41-65.
    66. Jiaxin Xiao, Yifei Li, Bingbing Chen, Sijia Gong, Ziwei Li, Yingyi Ou, Zerui Ou, Ao Kang, Yingmin Jia, Anping Yang, Yong Cao, Jianyin Miao. Enzymatic preparation and antioxidative activity of hydrolysate from Rice bran protein. Journal of Food Measurement and Characterization 2020, 14 (6) , 3163-3174.
    67. Danh C. Vu, Trang H. D. Nguyen, Thi L. Ho. An overview of phytochemicals and potential health-promoting properties of black walnut. RSC Advances 2020, 10 (55) , 33378-33388.
    68. Dong Gu Lee, Ju Sung Lee, Kyung-Tack Kim, Sonia D. Jacinto, Sanghyun Lee. Analysis of terpenoids and steroids in the seeds of Panax ginseng. Horticulture, Environment, and Biotechnology 2020, 61 (3) , 609-613.
    69. Gebretsadkan Hintsa Tekulu, Teref Hiluf, Hailu Brhanu, Ephrem Mebrahtu Araya, Helen Bitew, Tesfay Haile. Anti-inflammatory and anti-nociceptive property of Capparis tomentosa Lam. root extracts. Journal of Ethnopharmacology 2020, 253 , 112654.
    70. Saikat Sen, Raja Chakraborty, Pratap Kalita. Rice - not just a staple food: A comprehensive review on its phytochemicals and therapeutic potential. Trends in Food Science & Technology 2020, 97 , 265-285.
    71. Tao Zhang, Ruijie Liu, Ming Chang, Qingzhe Jin, Hui Zhang, Xingguo Wang. Health benefits of 4,4-dimethyl phytosterols: an exploration beyond 4-desmethyl phytosterols. Food & Function 2020, 11 (1) , 93-110.
    72. Tara Chand Yadav, Naresh Kumar, Utkarsh Raj, Nidhi Goel, Pritish Kumar Vardawaj, Ramasare Prasad, Vikas Pruthi. Exploration of interaction mechanism of tyrosol as a potent anti-inflammatory agent. Journal of Biomolecular Structure and Dynamics 2020, 38 (2) , 382-397.
    73. Anirban Roy, Somnath Bhattacharyya. Breeding and QTL Mapping for γ-Oryzanol and Nutrition Content in Rice. 2020, 469-492.
    74. Marcelo Gomes de Gomes, Lucian Del Fabbro, André Rossito Goes, Leandro Cattelan Souza, Silvana Peterini Boeira, Sandra Elisa Haas, Robson Luiz Puntel, Cristiano Ricardo Jesse. Supplementation with gamma oryzanol ameliorates CCl4-induced hepatic fibrosis in mice. PharmaNutrition 2019, 10 , 100169.
    75. Ze‐Hua Guo, Richard P. Haslam, Louise V Michaelson, Edward C. Yeung, Shiu‐Cheung Lung, Johnathan A. Napier, Mee‐Len Chye. The overexpression of rice ACYL ‐ CoA ‐ BINDING PROTEIN 2 increases grain size and bran oil content in transgenic rice. The Plant Journal 2019, 100 (6) , 1132-1147.
    76. Lijuan Zhu, Siting Xiang, Zhaoping Ou, Chaoyang Ma, Xianglian Yi, Lin Huang, Yurong Ma, Zengenni Liang, Zhihang Yuan, Lixin Wen, Rongfang Li, Jing Wu, Zhuliang Tan, Jine Yi. Gamma-oryzanol prevents ethanol-induced liver injury by ameliorating oxidative stress and modulating apoptosis-related protein expression in mice. Journal of Functional Foods 2019, 62 , 103532.
    77. Bao Le, Pham Thi Ngoc Anh, Jung-Eun Kim, Jinhua Cheng, Seung Hwan Yang. Rice bran fermentation by lactic acid bacteria to enhance antioxidant activities and increase the ferulic acid, ρ-coumaric acid, and γ-oryzanol content. Journal of Applied Biological Chemistry 2019, 62 (3) , 257-264.
    78. Javed Sheikh, Ashutosh Agrawal, Harsh Garg, Aashi Agarwal, Prasun Mathur. Functionalization of Wool Fabric Using Pineapple Peel Extract (PPE) as a Natural Dye. AATCC Journal of Research 2019, 6 (5) , 16-20.
    79. Run-Yang Zhang, Hua-Min Liu, Yu-Xiang Ma, Xue-De Wang. Characterization of fragrant oil extracted from pepper seed during subcritical propane extraction. LWT 2019, 110 , 110-116.
    80. Dan Zhu, Laura Nyström. Phytosterols. 2019, 427-466.
    81. Ana Castanho, Manuela Lageiro, Ricardo C. Calhelha, Isabel C. F. R. Ferreira, Marina Sokovic, Luís M. Cunha, Carla Brites. Exploiting the bioactive properties of γ-oryzanol from bran of different exotic rice varieties. Food & Function 2019, 10 (5) , 2382-2389.
    82. Wakako Tsuzuki, Shiro Komba, Eiichi Kotake-Nara. Diversity in γ-oryzanol profiles of Japanese black-purple rice varieties. Journal of Food Science and Technology 2019, 56 (5) , 2778-2786.
    83. Takumi Kokumai, Junya Ito, Eri Kobayashi, Naoki Shimizu, Hiroyuki Hashimoto, Takahiro Eitsuka, Teruo Miyazawa, Kiyotaka Nakagawa. Comparison of Blood Profiles of γ-Oryzanol and Ferulic Acid in Rats after Oral Intake of γ-Oryzanol. Nutrients 2019, 11 (5) , 1174.
    84. Marcela Dendisová, Zuzana Němečková, Martin Člupek, Vadym Prokopec. EC-SERS study of phenolic acids sorption behavior on Au, Ag and Cu substrates – Effect of applied potential and metal used. Applied Surface Science 2019, 470 , 716-723.
    85. Arindam Barman, Chinky M. Marak, Rituparna Mitra Barman, Cheana S. Sangma. Nutraceutical Properties of Legume Seeds and Their Impact on Human Health. 2019
    86. Dongping He, Lingyi Liu. Analytical Aspects of Rice Bran Oil. 2019, 169-181.
    87. Danh C. Vu, Zhentian Lei, Lloyd W. Sumner, Mark V. Coggeshall, Chung-Ho Lin. Identification and quantification of phytosterols in black walnut kernels. Journal of Food Composition and Analysis 2019, 75 , 61-69.
    88. Niloufar Sharif, Mohammad-Taghi Golmakani, Mehrdad Niakousari, Seyed Hosseini, Behrouz Ghorani, Amparo Lopez-Rubio. Active Food Packaging Coatings Based on Hybrid Electrospun Gliadin Nanofibers Containing Ferulic Acid/Hydroxypropyl-Beta-Cyclodextrin Inclusion Complexes. Nanomaterials 2018, 8 (11) , 919.
    89. Koichi Misawa, Hiroko Jokura, Akira Shimotoyodome. Rice bran triterpenoids improve postprandial hyperglycemia in healthy male adults: a randomized, double-blind, placebo-controlled study. Food & Nutrition Research 2018, 62 (0)
    90. Uddin MS, Sahena Ferdosh, Md. Jahurul Haque Akanda, Kashif Ghafoor, Rukshana A.H., Md. Eaqub Ali, B. Y. Kamaruzzaman, Fauzi M. B., Hadijah S., Sharifudin Shaarani, Md. Zaidul Islam Sarker. Techniques for the extraction of phytosterols and their benefits in human health: a review. Separation Science and Technology 2018, 53 (14) , 2206-2223.
    91. Sara Martillanes, María Concepción Ayuso-Yuste, María Victoria Gil, Raquel Manzano-Durán, Jonathan Delgado-Adámez. Bioavailability, composition and functional characterization of extracts from Oryza sativa L. bran. Food Research International 2018, 111 , 299-305.
    92. Vladimiro Cardenia, Federica Sgarzi, Mara Mandrioli, Giovanni Tribuzio, Maria T. Rodriguez‐Estrada, Tullia Gallina Toschi. Durum Wheat Bran By‐Products: Oil and Phenolic Acids to be Valorized by Industrial Symbiosis. European Journal of Lipid Science and Technology 2018, 120 (8)
    93. Himanshi Tanwar, Shweta, Divya Singh, Shashi Bala Singh, Lilly Ganju. Anti-inflammatory activity of the functional groups present in Hippophae rhamnoides (Seabuckthorn) leaf extract. Inflammopharmacology 2018, 26 (1) , 291-301.
    94. Dong Gu Lee, Jaemin Lee, Kyung-Tack Kim, Sang-Won Lee, Young-Ock Kim, Ik-Hyun Cho, Hak-Jae Kim, Chun-Gun Park, Sanghyun Lee. High-performance liquid chromatography analysis of phytosterols in Panax ginseng root grown under different conditions. Journal of Ginseng Research 2018, 42 (1) , 16-20.
    95. Kittima Triratanasirichai, Manisha Singh, Anil Kumar Anal. Value‐Added By‐Products from Rice Processing Industries. 2017, 277-293.
    96. Muhammad Sohail, Allah Rakha, Masood Sadiq Butt, Muhammad Jawad Iqbal, Summer Rashid. Rice bran nutraceutics: A comprehensive review. Critical Reviews in Food Science and Nutrition 2017, 57 (17) , 3771-3780.
    97. Hui Teng, Lei Chen. α-Glucosidase and α-amylase inhibitors from seed oil: A review of liposoluble substance to treat diabetes. Critical Reviews in Food Science and Nutrition 2017, 57 (16) , 3438-3448.
    98. Xiao-Mei ZHUANG, Lin CHEN, Yan TAN, Hai-Ying YANG, Chuang LU, Yue GAO, Hua LI. Identification of human cytochrome P450 and UGT enzymes involved in the metabolism of ferulic acid, a major bioactive component in traditional Chinese medicines. Chinese Journal of Natural Medicines 2017, 15 (9) , 695-702.
    99. Soon Young Shin, Heon-Woong Kim, Hwan-Hee Jang, Yu-Jin Hwang, Jeong-Sook Choe, Jung-Bong Kim, Yoongho Lim, Young Han Lee. γ-Oryzanol suppresses COX-2 expression by inhibiting reactive oxygen species-mediated Erk1/2 and Egr-1 signaling in LPS-stimulated RAW264.7 macrophages. Biochemical and Biophysical Research Communications 2017, 491 (2) , 486-492.
    100. Soon Young Shin, Heon-Woong Kim, Hwan-Hee Jang, Yu-Jin Hwang, Jeong-Sook Choe, Yoongho Lim, Jung-Bong Kim, Young Han Lee. γ -Oryzanol-Rich Black Rice Bran Extract Enhances the Innate Immune Response. Journal of Medicinal Food 2017, 20 (9) , 855-863.
    Load more citations

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Your Mendeley pairing has expired. Please reconnect