ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
CONTENT TYPES

Figure 1Loading Img

Effect of Sesame Seeds Rich in Sesamin and Sesamolin on Fatty Acid Oxidation in Rat Liver

View Author Information
National Food Research Institute, Ministry of Agriculture Forestry and Fisheries, 2-1-2 Kannondai, Tsukuba 305-8642, Japan; National Agriculture Research Center, Ministry of Agriculture Forestry and Fisheries, 2-1-2 Kannondai, Tsukuba 305-8666, Japan; and Chugoku National Agriculture Experimental Station, Ministry of Agriculture Forestry and Fisheries, Nishifukatsu 6-12-1, Fukuyama 721-8514, Japan
Cite this: J. Agric. Food Chem. 2001, 49, 5, 2647–2651
Publication Date (Web):April 6, 2001
https://doi.org/10.1021/jf001362t
Copyright © 2001 American Chemical Society

    Article Views

    1097

    Altmetric

    -

    Citations

    LEARN ABOUT THESE METRICS
    Other access options

    Abstract

    Activities of enzymes involved in hepatic fatty acid oxidation and synthesis among rats fed sesame (Sesamum indicum L.) differing in lignan content (sesamin and sesamolin) were compared. Sesame seeds rich in lignans from two lines, 0730 and 0732, lines established in this laborary, and those from a conventional cultivar (Masekin) were employed. Seeds from the 0730 and 0732 lines contained sesamin and sesamolin at amounts twice those from Masekin. Sesame seeds were added at levels of 200 g/kg to the experimental diets. Sesame increased both the hepatic mitochondrial and the peroxisomal fatty acid oxidation rate. Increases were greater with sesame rich in lignans than with Maskin. Noticeably, peroxisomal activity levels were >3 times higher in rats fed diets containing sesame seeds from the 0730 and 0732 lines than in those fed a control diet without sesame. The diet containing Masekin seed caused only a 50% increase in the value, however. Diets containing seeds from the 0730 and 0732 lines, compared to the control and Masekin diets, also significantly increased the activity of hepatic fatty acid oxidation enzymes including acyl-CoA oxidase, carnitine palmitoyltranferase, 3-hydroxyacyl-CoA dehydrogenase, and 3-ketoacyl-CoA thiolase. In contrast, diets containing sesame lowered the activity of enzymes involved in fatty acid synthesis including fatty acid synthase, glucose-6-phosphate dehydrogenase, ATP-citrate lyase, and pyruvate kinase. No significant differences in enzyme activities were, however, seen among diets containing sesame from Masekin cultivar and lines 0730 and 0732. Serum triacylglycerol concentrations were lower in rats fed diets containing sesame from lines 0730 and 0732 than in those fed the control or Masekin diet. It is apparent that sesame rich in lignans more profoundly affects hepatic fatty acid oxidation and serum triacylglycerol levels. Therefore, consumption of sesame rich in lignans results in physiological activity to alter lipid metabolism in a potentially beneficial manner.

    Keywords: Sesame; lignans; hepatic fatty acid oxidation; serum lipids; rat

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

     National Agriculture Research Center.

     Chugoku National Agriculture Experimental Station.

    §

     National Food Research Institute.

    *

     Corresponding author (telephone 81-298-38-8083; fax 81-298-38-7996; e-mail [email protected]).

    Cited By

    This article is cited by 82 publications.

    1. Yang Yang, Jing Yu, Jiayao Huo, Yaping Yan. Sesamolin Attenuates Kidney Injury, Intestinal Barrier Dysfunction, and Gut Microbiota Imbalance in High-Fat and High-Fructose Diet-Fed Mice. Journal of Agricultural and Food Chemistry 2023, 71 (3) , 1562-1576. https://doi.org/10.1021/acs.jafc.2c07084
    2. Yang Yang, Jingjing Wang, Yongmin Zhang, Jing Li, Wenji Sun. Black Sesame Seeds Ethanol Extract Ameliorates Hepatic Lipid Accumulation, Oxidative Stress, and Insulin Resistance in Fructose-Induced Nonalcoholic Fatty Liver Disease. Journal of Agricultural and Food Chemistry 2018, 66 (40) , 10458-10469. https://doi.org/10.1021/acs.jafc.8b04210
    3. Honoo Satake, Eiichiro Ono, and Jun Murata . Recent Advances in the Metabolic Engineering of Lignan Biosynthesis Pathways for the Production of Transgenic Plant-Based Foods and Supplements. Journal of Agricultural and Food Chemistry 2013, 61 (48) , 11721-11729. https://doi.org/10.1021/jf4007104
    4. Pubali Dhar,, Krishna Chattopadhya,, Debashis Bhattacharyya,, Arundhati Biswas,, Biswajit Roy, and, Santinath Ghosh. Ameliorative Influence of Sesame Lignans on Lipid Profile and Lipid Peroxidation in Induced Diabetic Rats. Journal of Agricultural and Food Chemistry 2007, 55 (14) , 5875-5880. https://doi.org/10.1021/jf063721b
    5. Chia-Pu Lee and, Gow-Chin Yen. Antioxidant Activity and Bioactive Compounds of Tea Seed (Camellia oleifera Abel.) Oil. Journal of Agricultural and Food Chemistry 2006, 54 (3) , 779-784. https://doi.org/10.1021/jf052325a
    6. Rabia Batool, Tahira Batool, Fakhr Un Nisa, Farwa Khalid, Zahra Asghar. Ethnobotanical, Pharmacological, and Therapeutic Importance of Sesame Seeds Along With Their Role in the Biogenic Synthesis of Important Chemicals. 2024, 241-273. https://doi.org/10.4018/979-8-3693-1986-4.ch009
    7. Mahdi Vajdi, Hooria Seyedhosseini-Ghaheh, Shirin Hassanizadeh, Negar Mostafavi, Mahsa Khajeh, Fatemeh Pourteymour Fard Tabrizi, Gholamreza Askari. Effect of sesame supplementation on body composition and lipid profile in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. Nutrition, Metabolism and Cardiovascular Diseases 2024, 34 (4) , 838-849. https://doi.org/10.1016/j.numecd.2024.01.020
    8. Erik Samyr Correia Alves, Polrat Wilairatana, Maria Joseane Macedo da Cruz, Laize Aparecida Nunes Lopes Campos, Metton Ribeiro Lopes e Silva, Daniel Sampaio Alves, Isaac Moura Araújo, Francisco Antonio Vieira dos Santos, Pablo Antonio Maia de Farias, Eliane Maria Gonçalves Moreira de Vasconcelos, Abolghasem Siyadatpanah, Henrique Douglas Melo Coutinho, Fernando Gomes Figueredo. Bioactivities and ethnopharmacology of Sesamum indicum L seed oil. LWT 2023, 185 , 115120. https://doi.org/10.1016/j.lwt.2023.115120
    9. Elham Hadipour, Seyed Ahmad Emami, Niloufar Tayarani‐Najaran, Zahra Tayarani‐Najaran. Effects of sesame ( Sesamum indicum L.) and bioactive compounds (sesamin and sesamolin) on inflammation and atherosclerosis: A review. Food Science & Nutrition 2023, 11 (7) , 3729-3757. https://doi.org/10.1002/fsn3.3407
    10. Panpan Wei, Fenglan Zhao, Zhen Wang, Qibao Wang, Xiaoyun Chai, Guige Hou, Qingguo Meng. Sesame (Sesamum indicum L.): A Comprehensive Review of Nutritional Value, Phytochemical Composition, Health Benefits, Development of Food, and Industrial Applications. Nutrients 2022, 14 (19) , 4079. https://doi.org/10.3390/nu14194079
    11. Waseem Khalid, Muhammad Sajid Arshad, Muhammad Modassar Ali Nawaz Ranjha, Maria Barbara Różańska, Shafeeqa Irfan, Bakhtawar Shafique, Muhammad Abdul Rahim, Muhammad Zubair Khalid, Gholamreza Abdi, Przemysław Łukasz Kowalczewski. Functional constituents of plant-based foods boost immunity against acute and chronic disorders. Open Life Sciences 2022, 17 (1) , 1075-1093. https://doi.org/10.1515/biol-2022-0104
    12. Shuqi He, Zixiao Xiong, Lanxin Li, Yanbo Wang, Chong Wang, Baodong Zheng, Hongliang Zeng, Yi Zhang. Lotus seed resistant starch ameliorates high-fat diet induced hyperlipidemia by fatty acid degradation and glycerolipid metabolism pathways in mouse liver. International Journal of Biological Macromolecules 2022, 215 , 79-91. https://doi.org/10.1016/j.ijbiomac.2022.06.077
    13. Muinat M. Adeyanju, Idris A. Saheed, Oluwaseun I. Oyelekan, Taiwo A. Dele-Osibanjo, Ayodeji A. Adelegan, Adekunle J. Raimi, Samuel O. Olalekan, Olugbenga S. Alabi, Khadijat M. Alli. Sesamum indicum diet prevents hyperlipidemia in experimental rats. Food Chemistry: Molecular Sciences 2022, 4 , 100092. https://doi.org/10.1016/j.fochms.2022.100092
    14. Kunjumon Dayana, Megaravalli R Manasa. Anti-Inflammatory Activity of Sesamum Indicum L. Seed Extracts in Experimental Animal Models. Biomedical and Pharmacology Journal 2022, 15 (1) , 255-260. https://doi.org/10.13005/bpj/2361
    15. Yiting Sun, Jingyi Ren, Siqi Zhu, Zhenao Zhang, Zihao Guo, Jiaqi An, Bowen Yin, Yuxia Ma. The Effects of Sesamin Supplementation on Obesity, Blood Pressure, and Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in Endocrinology 2022, 13 https://doi.org/10.3389/fendo.2022.842152
    16. Jorge Simón, María Casado-Andrés, Naroa Goikoetxea-Usandizaga, Marina Serrano-Maciá, María Luz Martínez-Chantar. Nutraceutical Properties of Polyphenols against Liver Diseases. Nutrients 2020, 12 (11) , 3517. https://doi.org/10.3390/nu12113517
    17. Amin F. Majdalawieh, Sarah Dalibalta, Sarah M. Yousef. Effects of sesamin on fatty acid and cholesterol metabolism, macrophage cholesterol homeostasis and serum lipid profile: A comprehensive review. European Journal of Pharmacology 2020, 885 , 173417. https://doi.org/10.1016/j.ejphar.2020.173417
    18. M. Bonesi, A. M. Saab, M. C. Tenuta, M. Leporini, M. J. Saab, M. R. Loizzo, R. Tundis. Screening of traditional Lebanese medicinal plants as antioxidants and inhibitors of key enzymes linked to type 2 diabetes. Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology 2020, 154 (5) , 656-662. https://doi.org/10.1080/11263504.2019.1674400
    19. Marzieh Mokhber, Seyyed Ali Keshavarz, Farzad Shidfar, Abbas Hadji Akhundi, Hamidreza Pouraliakbar, Zahra Nazem Bokaee, Kamal Azam, Masoumeh Jabbarifakher, Feridoun Noohi. WITHDRAWN ARTICLE: Effect of Sesame Lignan Supplementation on Carotid Intima-Media Thickness, Serum Lipid Profile, Serum VEGF, VCAM-1, ICAM-1 and vWF Levels in Cardiovascular Disease Patients. International Journal of Endocrinology and Metabolism 2020, 19 (1) https://doi.org/10.5812/ijem.82984
    20. . Studies on trait association and path co-efficient analysis of sesame (Sesamum sp.) for quantitative traits and oil quality parameters. ELECTRONIC JOURNAL OF PLANT BREEDING 2020, 18-24. https://doi.org/10.37992/2020.1101.004
    21. Lucy Sun Hwang, Min‐Hsiung Lee, Nan‐Wei Su. Sesame Oil. 2020, 1-39. https://doi.org/10.1002/047167849X.bio031.pub2
    22. Seung-Hwa Baek, Myung-Gyun Kang, Daeui Park. Inhibitory Effect of Sesamolin on Melanogenesis in B16F10 Cells Determined by In Vitro and Molecular Docking Analyses. Current Pharmaceutical Biotechnology 2020, 21 (2) , 169-178. https://doi.org/10.2174/1389201020666191011151123
    23. Ayesha Mushtaq, Muhammad Asif Hanif, Muhammad Adnan Ayub, Ijaz Ahmad Bhatti, Muhammad Idrees Jilani. Sesame. 2020, 601-615. https://doi.org/10.1016/B978-0-08-102659-5.00044-6
    24. Yihang Zhao, Qianxu Wang, Mengzhen Jia, Shangchen Fu, Junru Pan, Chuanqi Chu, Xiaoning Liu, Xuebo Liu, Zhigang Liu. (+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation. The Journal of Nutritional Biochemistry 2019, 64 , 61-71. https://doi.org/10.1016/j.jnutbio.2018.10.006
    25. Niti Pathak, Asani Bhaduri, Ashwani K. Rai. Sesame: Bioactive Compounds and Health Benefits. 2019, 181-200. https://doi.org/10.1007/978-3-319-78030-6_59
    26. Xin Guo, Tao Zhang, Longkai Shi, Mengyue Gong, Jun Jin, Yu Zhang, Ruijie Liu, Ming Chang, Qingzhe Jin, Xingguo Wang. The relationship between lipid phytochemicals, obesity and its related chronic diseases. Food & Function 2018, 9 (12) , 6048-6062. https://doi.org/10.1039/C8FO01026A
    27. Yumiko Nakatani, Yukie Yaguchi, Tomomi Komura, Masakazu Nakadai, Kenji Terao, Eriko Kage-Nakadai, Yoshikazu Nishikawa. Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans. European Journal of Nutrition 2018, 57 (3) , 1137-1146. https://doi.org/10.1007/s00394-017-1396-0
    28. Carolina Alves Cardoso, Gláucia Maria Moraes de Oliveira, Luciana de Almeida Vittori Gouveia, Annie Seixas Bello Moreira, Glorimar Rosa. The effect of dietary intake of sesame ( Sesamumindicum L .) derivatives related to the lipid profile and blood pressure: A systematic review. Critical Reviews in Food Science and Nutrition 2018, 58 (1) , 116-125. https://doi.org/10.1080/10408398.2015.1137858
    29. Niti Pathak, Asani Bhaduri, Ashwani K Rai. Sesame: Bioactive Compounds and Health Benefits. 2018, 1-20. https://doi.org/10.1007/978-3-319-54528-8_59-1
    30. Mijeong Kim, Minji Woo, Jeong Sook Noh, Eunok Choe, Yeong Ok Song. Sesame oil lignans inhibit hepatic endoplasmic reticulum stress and apoptosis in high-fat diet-fed mice. Journal of Functional Foods 2017, 37 , 658-665. https://doi.org/10.1016/j.jff.2017.08.036
    31. S. Gharby, H. Harhar, Z. Bouzoubaa, A. Asdadi, A. El Yadini, Z. Charrouf. Chemical characterization and oxidative stability of seeds and oil of sesame grown in Morocco. Journal of the Saudi Society of Agricultural Sciences 2017, 16 (2) , 105-111. https://doi.org/10.1016/j.jssas.2015.03.004
    32. Honoo Satake, Tomotsugu Koyama, Erika Matsumoto, Kinuyo Morimoto, Eiichiro Ono, Jun Murata. Metabolic Engineering of Lignan Biosynthesis Pathways for the Production of Transgenic Plant-Based Foods. 2017, 373-398. https://doi.org/10.1007/978-3-319-28669-3_11
    33. Honoo Satake, Akira Shiraishi, Tomotsugu Koyama, Erika Matsumoto, Kinuyo Morimoto, Sedigheh E. Bahabadi, Eiichiro Ono, Jun Murata. Lignan Biosynthesis for Food Bioengineering. 2017, 351-379. https://doi.org/10.1016/B978-0-12-811372-1.00012-9
    34. Vahid Rezaeipour, Alireza Barsalani, Rohullah Abdullahpour. Effects of phytase supplementation on growth performance, jejunum morphology, liver health, and serum metabolites of Japanese quails fed sesame (Sesamum indicum) meal-based diets containing graded levels of protein. Tropical Animal Health and Production 2016, 48 (6) , 1141-1146. https://doi.org/10.1007/s11250-016-1066-x
    35. Saman Khalesi, Ernesta Paukste, Elham Nikbakht, Hossein Khosravi-Boroujeni. Sesame fractions and lipid profiles: a systematic review and meta-analysis of controlled trials. British Journal of Nutrition 2016, 115 (5) , 764-773. https://doi.org/10.1017/S0007114515005012
    36. Honoo Satake, Tomotsugu Koyama, Erika Matsumoto, Kinuyo Morimoto, Eiichiro Ono, Jun Murata. Metabolic Engineering of Lignan Biosynthesis Pathways for the Production of Transgenic Plant-Based Foods. 2016, 1-26. https://doi.org/10.1007/978-3-319-27490-4_11-1
    37. Jun Murata, Erika Matsumoto, Kinuyo Morimoto, Tomotsugu Koyama, Honoo Satake, . Generation of Triple-Transgenic Forsythia Cell Cultures as a Platform for the Efficient, Stable, and Sustainable Production of Lignans. PLOS ONE 2015, 10 (12) , e0144519. https://doi.org/10.1371/journal.pone.0144519
    38. Yun Hee Kim, Hye Lim Lee. Therapeutic Effects of Sesamum Indicum Extracts on Atopic Dermatitis-Like Skin Lesions of NC/Nga Mouce. The Journal of Korean Oriental Pediatrics 2015, 29 (4) , 39-66. https://doi.org/10.7778/jpkm.2015.29.4.039
    39. Mohammad Ali Nasseri, Saeideh Sharifi Bigy, Ali Allahresani, Mohammad Malekaneh. Assessment of Antioxidant Activity, Chemical Characterization and Evaluation of Fatty Acid Compositions of Scorzonera Paradoxa Fisch and C. A. Mey. Jundishapur Journal of Natural Pharmaceutical Products 2015, 10 (4) https://doi.org/10.17795/jjnpp-19781
    40. Vasundhra Shukla, Prameela Kandra. Development, physico-chemical and sensory evaluation of natural nutra candy. Journal of Food Science and Technology 2015, 52 (11) , 7535-7539. https://doi.org/10.1007/s13197-015-1810-7
    41. N. Pathak, A. Bhaduri, K.V. Bhat, A.K. Rai, . Tracking sesamin synthase gene expression through seed maturity in wild and cultivated sesame species – a domestication footprint. Plant Biology 2015, 17 (5) , 1039-1046. https://doi.org/10.1111/plb.12327
    42. Honoo Satake, Tomotsugu Koyama, Sedigheh Bahabadi, Erika Matsumoto, Eiichiro Ono, Jun Murata. Essences in Metabolic Engineering of Lignan Biosynthesis. Metabolites 2015, 5 (2) , 270-290. https://doi.org/10.3390/metabo5020270
    43. Takashi Ide, Ayana Azechi, Sayaka Kitade, Yoko Kunimatsu, Natsuko Suzuki, Chihiro Nakajima, Naoki Ogata. Comparative Effects of Sesame Seeds Differing in Lignan Contents and Composition on Fatty Acid Oxidation in Rat Liver. Journal of Oleo Science 2015, 64 (2) , 211-222. https://doi.org/10.5650/jos.ess14182
    44. Yun Sik Nam, Kown-Chul Noh, Eun Joo Roh, Gyochang Keum, Yeonhee Lee, Kang-Bong Lee. Determination of Edible Vegetable Oil Adulterants in Sesame Oil Using 1 H Nuclear Magnetic Resonance Spectroscopy. Analytical Letters 2014, 47 (7) , 1190-1200. https://doi.org/10.1080/00032719.2013.865199
    45. Peraphan Pothacharoen, Sumet Najarus, Jongkolnee Settakorn, Shuji Mizumoto, Kazuyuki Sugahara, Prachya Kongtawelert. Effects of sesamin on the biosynthesis of chondroitin sulfate proteoglycans in human articular chondrocytes in primary culture. Glycoconjugate Journal 2014, 31 (3) , 221-230. https://doi.org/10.1007/s10719-013-9514-6
    46. N.E. Mohamed, M.M. Wakwak. Effect of sesame seeds or oil supplementation to the feed on some physiological parameters in Japanese Quail. Journal of Radiation Research and Applied Sciences 2014, 7 (1) , 101-109. https://doi.org/10.1016/j.jrras.2013.12.003
    47. Danijela Ristic-Medic, Gordana Perunicic-Pekovic, Zorica Rasic-Milutinovic, Marija Takic, Tamara Popovic, Aleksandra Arsic, Marija Glibetic. Effects of Dietary Milled Seed Mixture on Fatty Acid Status and Inflammatory Markers in Patients on Hemodialysis. The Scientific World Journal 2014, 2014 , 1-9. https://doi.org/10.1155/2014/563576
    48. Jia-Le Song, Jung-Ho Choi, Jae-Hoon Seo, Jeung-Ha Kil, Kun-Young Park. Antioxidative effects of fermented sesame sauce against hydrogen peroxide-induced oxidative damage in LLC-PK1 porcine renal tubule cells. Nutrition Research and Practice 2014, 8 (2) , 138. https://doi.org/10.4162/nrp.2014.8.2.138
    49. AnnaLotta Schiller Vestergren, Sofia Trattner, Jinfeng Pan, Pernilla Johnsson, Afaf Kamal-Eldin, Eva Brännäs, Ali A. Moazzami, Jana Pickova. The effect of combining linseed oil and sesamin on the fatty acid composition in white muscle and on expression of lipid-related genes in white muscle and liver of rainbow trout (Oncorhynchus mykiss). Aquaculture International 2013, 21 (4) , 843-859. https://doi.org/10.1007/s10499-012-9511-y
    50. Kequan Zhou, Yuting Zhou, Y. Martin Lo. Refining Food Processing By‐Products for Value‐Added Functional Ingredients. 2013, 441-448. https://doi.org/10.1002/9781118642047.ch24
    51. Nitesh Kumar, Jayesh Mudgal, Vipan K. Parihar, Pawan G. Nayak, N. Gopalan Kutty, C. Mallikarjuna Rao. Sesamol Treatment Reduces Plasma Cholesterol and Triacylglycerol Levels in Mouse Models of Acute and Chronic Hyperlipidemia. Lipids 2013, 48 (6) , 633-638. https://doi.org/10.1007/s11745-013-3778-2
    52. V. Aparna, K. V. Dileep, C. Sadasivan, M. Haridas. Computational and thermodynamic analyses of the phospholipase A2 inhibition by erucic acid and linoleic acid. Medicinal Chemistry Research 2013, 22 (3) , 1102-1106. https://doi.org/10.1007/s00044-012-0114-y
    53. Sedigheh Asgary, Mahmoud Rafieian-Kopaei, Somayeh Najafi, Esfandiar Heidarian, Amirhossein Sahebkar. Antihyperlipidemic Effects of Sesamum indicum L. in Rabbits Fed a High-Fat Diet. The Scientific World Journal 2013, 2013 , 1-5. https://doi.org/10.1155/2013/365892
    54. Ramez Alhazzaa, Andrew R. Bridle, Chris G. Carter, Peter D. Nichols. Sesamin modulation of lipid class and fatty acid profile in early juvenile teleost, Lates calcarifer, fed different dietary oils. Food Chemistry 2012, 134 (4) , 2057-2065. https://doi.org/10.1016/j.foodchem.2012.04.004
    55. Beitollah Alipoor, Mahdieh Khadem Haghighian, Bina Eftekhar Sadat, Mohammad Asghari. Effect of sesame seed on lipid profile and redox status in hyperlipidemic patients. International Journal of Food Sciences and Nutrition 2012, 63 (6) , 674-678. https://doi.org/10.3109/09637486.2011.652077
    56. Papiya Bigoniya, Ravi Nishad, Chandra Shekhar Singh. Preventive effect of sesame seed cake on hyperglycemia and obesity against high fructose-diet induced Type 2 diabetes in rats. Food Chemistry 2012, 133 (4) , 1355-1361. https://doi.org/10.1016/j.foodchem.2012.01.112
    57. N. Shivhare, N. Satsangee. Wonders of Sesame: Nutraceutical Uses and Health Benefits. 2012, 63-68. https://doi.org/10.1007/978-3-642-23394-4_13
    58. T. K. Lim. Sesamum indicum. 2012, 187-219. https://doi.org/10.1007/978-94-007-4053-2_26
    59. CLIFFORD HALL. Other natural antioxidants – rice bran oil, sesame oil, rosemary extract, flavonoids. 2012, 73-112. https://doi.org/10.1533/9780857097965.73
    60. S. Prakash Kochhar. Minor and Speciality Oils. 2011, 291-341. https://doi.org/10.1002/9781444339925.ch11
    61. Kinuyo Morimoto, Hyun-Jung Kim, Eiichiro Ono, Akio Kobayashi, Atsushi Okazawa, Honoo Satake. Effects of light on production of endogenous and exogenous lignans by Forsythia koreana wildtype and transgenic cells. Plant Biotechnology 2011, 28 (3) , 331-337. https://doi.org/10.5511/plantbiotechnology.11.0420a
    62. J.H.Y. Wu, J.M. Hodgson, I.B. Puddey, R. Belski, V. Burke, K.D. Croft. Sesame supplementation does not improve cardiovascular disease risk markers in overweight men and women. Nutrition, Metabolism and Cardiovascular Diseases 2009, 19 (11) , 774-780. https://doi.org/10.1016/j.numecd.2009.01.003
    63. H. J. Kim, E. Ono, K. Morimoto, T. Yamagaki, A. Okazawa, A. Kobayashi, H. Satake. Metabolic Engineering of Lignan Biosynthesis in Forsythia Cell Culture. Plant and Cell Physiology 2009, 50 (12) , 2200-2209. https://doi.org/10.1093/pcp/pcp156
    64. Karen D. Coulman, Zhen Liu, John Michaelides, Winston Quan Hum, Lilian U. Thompson. Fatty acids and lignans in unground whole flaxseed and sesame seed are bioavailable but have minimal antioxidant and lipid‐lowering effects in postmenopausal women. Molecular Nutrition & Food Research 2009, 53 (11) , 1366-1375. https://doi.org/10.1002/mnfr.200900032
    65. Tae-Shik Hahm, Sung-Jin Park, Y. Martin Lo. Effects of germination on chemical composition and functional properties of sesame (Sesamum indicum L.) seeds. Bioresource Technology 2009, 100 (4) , 1643-1647. https://doi.org/10.1016/j.biortech.2008.09.034
    66. Ali Moazzami, Afaf Kamal-Eldin. Sesame Seed Oil. 2009, 267-282. https://doi.org/10.1016/B978-1-893997-97-4.50014-0
    67. Takashi IDE, Jin Seon LIM, Tseye-Oidov ODBAYAR, Yasutaka NAKASHIMA. Comparative Study of Sesame Lignans (Sesamin, Episesamin and Sesamolin) Affecting Gene Expression Profile and Fatty Acid Oxidation in Rat Liver. Journal of Nutritional Science and Vitaminology 2009, 55 (1) , 31-43. https://doi.org/10.3177/jnsv.55.31
    68. Yoko Takahashi, Takashi Ide. Effects of soy protein and isoflavone on hepatic fatty acid synthesis and oxidation and mRNA expression of uncoupling proteins and peroxisome proliferator-activated receptor γ in adipose tissues of rats. The Journal of Nutritional Biochemistry 2008, 19 (10) , 682-693. https://doi.org/10.1016/j.jnutbio.2007.09.003
    69. Mitsuo Namiki. Nutraceutical Functions of Sesame: A Review. Critical Reviews in Food Science and Nutrition 2007, 47 (7) , 651-673. https://doi.org/10.1080/10408390600919114
    70. Bor-Sen Wang, Lee-Wen Chang, Wen-Jye Yen, Pin-Der Duh. Antioxidative effect of sesame coat on LDL oxidation and oxidative stress in macrophages. Food Chemistry 2007, 102 (1) , 351-360. https://doi.org/10.1016/j.foodchem.2006.05.026
    71. Wieland Peschel, Wilfried Dieckmann, Marlies Sonnenschein, Andreas Plescher. High antioxidant potential of pressing residues from evening primrose in comparison to other oilseed cakes and plant antioxidants. Industrial Crops and Products 2007, 25 (1) , 44-54. https://doi.org/10.1016/j.indcrop.2006.07.002
    72. Jin Seon Lim, Yoshikazu Adachi, Yoko Takahashi, Takashi Ide. Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. British Journal of Nutrition 2007, 97 (1) , 85-95. https://doi.org/10.1017/S0007114507252699
    73. Shylesh Bhaskaran, Nalini Santanam, Meera Penumetcha, Sampath Parthasarathy. Inhibition of Atherosclerosis in Low-Density Lipoprotein Receptor-Negative Mice by Sesame Oil. Journal of Medicinal Food 2006, 9 (4) , 487-490. https://doi.org/10.1089/jmf.2006.9.487
    74. Jinyoung Lee, Eunok Choe. Extraction of Lignan Compounds from Roasted Sesame Oil and their Effects on the Autoxidation of Methyl Linoleate. Journal of Food Science 2006, 71 (7) https://doi.org/10.1111/j.1750-3841.2006.00137.x
    75. Eiichiro Ono, Masaaki Nakai, Yuko Fukui, Namino Tomimori, Masako Fukuchi-Mizutani, Masayuki Saito, Honoo Satake, Takaharu Tanaka, Masumi Katsuta, Toshiaki Umezawa, Yoshikazu Tanaka. Formation of two methylenedioxy bridges by a Sesamum CYP81Q protein yielding a furofuran lignan, (+)-sesamin. Proceedings of the National Academy of Sciences 2006, 103 (26) , 10116-10121. https://doi.org/10.1073/pnas.0603865103
    76. Kinuko Ishiyama, Mayumi Nagashima, Tomoko Yasumoto, Yasuko Fukuda. Changes in Amounts of Lignan Compounds and Radical Scavenging Activities in Improved High-Lignan Breed of Sesame, “Gomazou”, during Germination. NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI 2006, 53 (1) , 8-16. https://doi.org/10.3136/nskkk.53.8
    77. Satoko YASUMOTO, Masumi KATSUTA. Breeding a High-Lignan-Content Sesame Cultivar in the Prospect of Promoting Metabolic Functionality. Japan Agricultural Research Quarterly: JARQ 2006, 40 (2) , 123-129. https://doi.org/10.6090/jarq.40.123
    78. Lilian Thompson. Flaxseed, Lignans, n-3 Fatty Acids, and Drug Synergy in the Prevention and Treatment of Cancer. 2005, 147-173. https://doi.org/10.1201/9781420038255.ch8
    79. Lucy Sun Hwang. Sesame Oil. 2005https://doi.org/10.1002/047167849X.bio031
    80. Karen D. Coulman, Zhen Liu, Winston Quan Hum, John Michaelides, Lilian U. Thompson. Whole Sesame Seed Is as Rich a Source of Mammalian Lignan Precursors as Whole Flaxseed. Nutrition and Cancer 2005, 52 (2) , 156-165. https://doi.org/10.1207/s15327914nc5202_6
    81. Takashi Ide, Dang Diem Hong, Pathmasiri Ranasinghe, Yoko Takahashi, Masayo Kushiro, Michihiro Sugano. Interaction of dietary fat types and sesamin on hepatic fatty acid oxidation in rats. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2004, 1682 (1-3) , 80-91. https://doi.org/10.1016/j.bbalip.2004.02.001
    82. . Sesamum indicum. , 487-505. https://doi.org/10.1007/978-1-59259-887-8_15

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect