logo

OR SEARCH CITATIONS

My Activity
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2001, 49, 5, 2472-2479
RETURN TO ISSUEPREVArticleNEXT

Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms

View Author Information
Department of Medicinal Chemistry and Pharmacognosy, Program for Collaborative Research in the Pharmaceutical Sciences, UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, M/C 781, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, and Department of Surgical Oncology, University of Illinois at Chicago, 840 South Wood Street, Chicago, Illinois 60612
Cite this: J. Agric. Food Chem. 2001, 49, 5, 2472–2479
Publication Date (Web):March 24, 2001
https://doi.org/10.1021/jf0014157
Copyright © 2001 American Chemical Society
RIGHTS & PERMISSIONS
Article Views
2715
Altmetric
-
Citations
271
LEARN ABOUT THESE METRICS

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.

Read OnlinePDF (118 KB)
SUBJECTS:

Abstract

Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus L.), and hops (Humulus lupulus L.) showed significant competitive binding to estrogen receptors α (ERα) and β (ERβ). With cultured Ishikawa (endometrial) cells, red clover and hops exhibited estrogenic activity as indicated by induction of alkaline phosphatase (AP) activity and up-regulation of progesterone receptor (PR) mRNA. Chasteberry also stimulated PR expression, but no induction of AP activity was observed. In S30 breast cancer cells, pS2 (presenelin-2), another estrogen-inducible gene, was up-regulated in the presence of red clover, hops, and chasteberry. Interestingly, extracts of Asian ginseng (Panax ginseng C.A. Meyer) and North American ginseng (Panax quinquefolius L.) induced pS2 mRNA expression in S30 cells, but no significant ER binding affinity, AP induction, or PR expression was noted in Ishikawa cells. Dong quai [Angelica sinensis (Oliv.) Diels] and licorice (Glycyrrhiza glabra L.) showed only weak ER binding and PR and pS2 mRNA induction. Black cohosh [Cimicifuga racemosa (L.) Nutt.] showed no activity in any of the above in vitro assays. Bioassay-guided isolation utilizing ER competitive binding as a monitor and screening using ultrafiltration LC-MS revealed that genistein was the most active component of red clover. Consistent with this observation, genistein was found to be the most effective of four red clover isoflavones tested in the above in vitro assays. Therefore, estrogenic components of plant extracts can be identified using assays for estrogenic activity along with screening and identification of the active components using ultrafiltration LC-MS. These data suggest a potential use for some dietary supplements, ingested by human beings, in the treatment of menopausal symptoms.

Keywords: Estrogen receptor; alkaline phosphatase; progesterone receptor; pS2; dietary supplement; phytoestrogens; isoflavones

†

 Department of Medicinal Chemistry and Pharmacognosy and Program for Collaborative Research in the Pharmaceutical Sciences.

‡

 Department of Surgical Oncology.

*

 Author to whom correspondence should be addressed [fax (312) 966-7107; e-mail [email protected]].

Cited By

This article is cited by 271 publications.

  1. Judy L. Bolton, Tareisha L. Dunlap, Atieh Hajirahimkhan, Obinna Mbachu, Shao-Nong Chen, Luke Chadwick, Dejan Nikolic, Richard B. van Breemen, Guido F. Pauli, Birgit M. Dietz. The Multiple Biological Targets of Hops and Bioactive Compounds. Chemical Research in Toxicology 2019, 32 (2) , 222-233. https://doi.org/10.1021/acs.chemrestox.8b00345
  2. Atieh Hajirahimkhan, Obinna Mbachu, Charlotte Simmler, Sarah G. Ellis, Huali Dong, Dejan Nikolic, David C. Lankin, Richard B. van Breemen, Shao-Nong Chen, Guido F. Pauli, Birgit M. Dietz, Judy L. Bolton. Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication. Journal of Natural Products 2018, 81 (4) , 966-975. https://doi.org/10.1021/acs.jnatprod.7b01070
  3. Serhat S. Cicek, Sophia Khom, Barbara Taferner, Steffen Hering, and Hermann Stuppner. Bioactivity-Guided Isolation of GABAA Receptor Modulating Constituents from the Rhizomes of Actaea racemosa. Journal of Natural Products 2010, 73 (12) , 2024-2028. https://doi.org/10.1021/np100479w
  4. Bolan Yu, Zhihui Qin, Gihani T. Wijewickrama, Praneeth Edirisinghe, Judy L. Bolton and Gregory R. J. Thatcher. Comparative Methods for Analysis of Protein Covalent Modification by Electrophilic Quinoids Formed from Xenobiotics. Bioconjugate Chemistry 2009, 20 (4) , 728-741. https://doi.org/10.1021/bc800435m
  5. Sharla L. Powell, Tanja Gödecke, Dejan Nikolic, Shao-Nong Chen, Soyoun Ahn, Birgit Dietz, Norman R. Farnsworth, Richard B. van Breemen, David C. Lankin, Guido F. Pauli and Judy L. Bolton. In Vitro Serotonergic Activity of Black Cohosh and Identification of Nω-Methylserotonin as a Potential Active Constituent. Journal of Agricultural and Food Chemistry 2008, 56 (24) , 11718-11726. https://doi.org/10.1021/jf803298z
  6. Nicolette J. D. Verhoog,, Elizabeth Joubert, and, Ann Louw. Evaluation of the Phytoestrogenic Activity of Cyclopia genistoides (Honeybush) Methanol Extracts and Relevant Polyphenols. Journal of Agricultural and Food Chemistry 2007, 55 (11) , 4371-4381. https://doi.org/10.1021/jf063588n
  7. Mee-Ra Rhyu,, Jian Lu,, Donna E. Webster,, Daniel S. Fabricant,, Norman R. Farnsworth, and, Z. Jim Wang. Black Cohosh (Actaea racemosa, Cimicifuga racemosa) Behaves as a Mixed Competitive Ligand and Partial Agonist at the Human μ Opiate Receptor. Journal of Agricultural and Food Chemistry 2006, 54 (26) , 9852-9857. https://doi.org/10.1021/jf062808u
  8. Bei Jiang,, Fredi Kronenberg,, Paiboon Nuntanakorn,, Ming-Hua Qiu, and, Edward J. Kennelly. Evaluation of the Botanical Authenticity and Phytochemical Profile of Black Cohosh Products by High-Performance Liquid Chromatography with Selected Ion Monitoring Liquid Chromatography−Mass Spectrometry. Journal of Agricultural and Food Chemistry 2006, 54 (9) , 3242-3253. https://doi.org/10.1021/jf0606149
  9. Tina T. X. Dong,, Kui J. Zhao,, Qiu T. Gao,, Zhao N. Ji,, Ting T. Zhu,, Jun Li,, Ran Duan,, Anna W. H. Cheung, and, Karl W. K. Tsim. Chemical and Biological Assessment of a Chinese Herbal Decoction Containing Radix Astragali and Radix Angelicae Sinensis:  Determination of Drug Ratio in Having Optimized Properties. Journal of Agricultural and Food Chemistry 2006, 54 (7) , 2767-2774. https://doi.org/10.1021/jf053163l
  10. Shixin Deng,, Shao-Nong Chen,, Ping Yao,, Dejan Nikolic,, Richard B. van Breemen,, Judy L. Bolton,, Harry H. S. Fong,, Norman R. Farnsworth, and, Guido F. Pauli. Serotonergic Activity-Guided Phytochemical Investigation of the Roots of Angelica sinensis. Journal of Natural Products 2006, 69 (4) , 536-541. https://doi.org/10.1021/np050301s
  11. Nancy L. Booth,, Cassia R. Overk,, Ping Yao,, Steve Totura,, Yunfan Deng,, A. S. Hedayat,, Judy L. Bolton,, Guido F. Pauli, and, Norman R. Farnsworth. Seasonal Variation of Red Clover (Trifolium pratense L., Fabaceae) Isoflavones and Estrogenic Activity. Journal of Agricultural and Food Chemistry 2006, 54 (4) , 1277-1282. https://doi.org/10.1021/jf052927u
  12. Ewald E. Swinny and, Ken G. Ryan. Red Clover Trifolium pratense L. Phytoestrogens:  UV-B Radiation Increases Isoflavone Yield, and Postharvest Drying Methods Change the Glucoside Conjugate Profiles. Journal of Agricultural and Food Chemistry 2005, 53 (21) , 8273-8278. https://doi.org/10.1021/jf051431+
  13. Cassia R. Overk,, Ping Yao,, Lucas R. Chadwick,, Dejan Nikolic,, Yongkai Sun,, Muriel A. Cuendet,, Yunfan Deng,, A. S. Hedayat,, Guido F. Pauli,, Norman R. Farnsworth,, Richard B. van Breemen, and, Judy L. Bolton. Comparison of the in Vitro Estrogenic Activities of Compounds from Hops (Humulus lupulus) and Red Clover (Trifolium pratense). Journal of Agricultural and Food Chemistry 2005, 53 (16) , 6246-6253. https://doi.org/10.1021/jf050448p
  14. Birgit M. Dietz,, Young-Hwa Kang,, Guowen Liu,, Aimee L. Eggler,, Ping Yao,, Lucas R. Chadwick,, Guido F. Pauli,, Norman R. Farnsworth,, Andrew D. Mesecar,, Richard B. van Breemen, and, Judy L. Bolton. Xanthohumol Isolated from Humulus lupulus Inhibits Menadione-Induced DNA Damage through Induction of Quinone Reductase. Chemical Research in Toxicology 2005, 18 (8) , 1296-1305. https://doi.org/10.1021/tx050058x
  15. Yongkai Sun, Chungang Gu, Xuemei Liu, Wenzhong Liang, Ping Yao, Judy L. Bolton, Richard B. van Breemen. Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors. Journal of the American Society for Mass Spectrometry 2005, 16 (2) , 271-279. https://doi.org/10.1021/jasms.8b02358
  16. Hong Liu,, Ju Liu,, Richard B. van Breemen,, Gregory R. J. Thatcher, and, Judy L. Bolton. Bioactivation of the Selective Estrogen Receptor Modulator Desmethylated Arzoxifene to Quinoids:  4‘-Fluoro Substitution Prevents Quinoid Formation. Chemical Research in Toxicology 2005, 18 (2) , 162-173. https://doi.org/10.1021/tx049776u
  17. Chenchugari Sridhar,, Gottumukkala V. Subbaraju,, Yenamandra Venkateswarlu, and, Raju T. Venugopal. New Acylated Iridoid Glucosides from Vitex altissima. Journal of Natural Products 2004, 67 (12) , 2012-2016. https://doi.org/10.1021/np040117r
  18. Lucas R. Chadwick,, Dejan Nikolic,, Joanna E. Burdette,, Cassia R. Overk,, Judy L. Bolton,, Richard B. van Breemen,, Roland Fröhlich,, Harry H. S. Fong,, Norman R. Farnsworth, and, Guido F. Pauli. Estrogens and Congeners from Spent Hops (Humulus lupulus). Journal of Natural Products 2004, 67 (12) , 2024-2032. https://doi.org/10.1021/np049783i
  19. Joanna E. Burdette,, Jianghua Liu,, Shao-nong Chen,, Daniel S. Fabricant,, Colleen E. Piersen,, Eric L. Barker,, John M. Pezzuto,, Andrew Mesecar,, Richard B. van Breemen,, Norman R. Farnsworth, and, Judy L. Bolton. Black Cohosh Acts as a Mixed Competitive Ligand and Partial Agonist of the Serotonin Receptor. Journal of Agricultural and Food Chemistry 2003, 51 (19) , 5661-5670. https://doi.org/10.1021/jf034264r
  20. Xuemei Liu,, Emily Pisha,, Debra A. Tonetti,, Dan Yao,, Yan Li,, Jiaqin Yao,, Joanna E. Burdette, and, Judy L. Bolton. Antiestrogenic and DNA Damaging Effects Induced by Tamoxifen and Toremifene Metabolites. Chemical Research in Toxicology 2003, 16 (7) , 832-837. https://doi.org/10.1021/tx030004s
  21. Xuemei Liu,, Fagen Zhang,, Hong Liu,, Joanna E. Burdette,, Yan Li,, Cassia R. Overk,, Emily Pisha,, Jiaqin Yao,, Richard B. van Breemen,, Steven M. Swanson, and, Judy L. Bolton. Effect of Halogenated Substituents on the Metabolism and Estrogenic Effects of the Equine Estrogen, Equilenin. Chemical Research in Toxicology 2003, 16 (6) , 741-749. https://doi.org/10.1021/tx030001f
  22. Stephen M. Boué,, Thomas E. Wiese,, Suzanne Nehls,, Matthew E. Burow,, Steven Elliott,, Carol H. Carter-Wientjes,, Betty Y. Shih,, John A. McLachlan, and, Thomas E. Cleveland. Evaluation of the Estrogenic Effects of Legume Extracts Containing Phytoestrogens. Journal of Agricultural and Food Chemistry 2003, 51 (8) , 2193-2199. https://doi.org/10.1021/jf021114s
  23. Kui J. Zhao,, Tina T. X. Dong,, Peng F. Tu,, Zong H. Song,, Chun K. Lo, and, Karl W. K. Tsim. Molecular Genetic and Chemical Assessment of Radix Angelica (Danggui) in China. Journal of Agricultural and Food Chemistry 2003, 51 (9) , 2576-2583. https://doi.org/10.1021/jf026178h
  24. Xuemei Liu,, Jiaqin Yao,, Emily Pisha,, Yanan Yang,, Yousheng Hua,, Richard B. van Breemen, and, Judy L. Bolton. Oxidative DNA Damage Induced by Equine Estrogen Metabolites:  Role of Estrogen Receptor α. Chemical Research in Toxicology 2002, 15 (4) , 512-519. https://doi.org/10.1021/tx0101649
  25. Benjamin M. Johnson,, Judy L. Bolton, and, Richard B. van Breemen. Screening Botanical Extracts for Quinoid Metabolites. Chemical Research in Toxicology 2001, 14 (11) , 1546-1551. https://doi.org/10.1021/tx010106n
  26. Cuncun Lu, Ming Liu, Wenru Shang, Yuan Yuan, Meixuan Li, Xiuxiu Deng, Huijuan Li, Kehu Yang. Knowledge Mapping of Angelica sinensis (Oliv.) Diels (Danggui) Research: A Scientometric Study. Frontiers in Pharmacology 2020, 11 https://doi.org/10.3389/fphar.2020.00294
  27. H. Labiad, M. El Jemli, I. Marmouzi, A. Chaouch, M. Ghanmi, B. Satrani, A.E. Aljaiyash, M. Fadli. Étude toxicologique et activité psychotrope des huiles essentielles de Laurus nobilis et de Vitex agnus-castus. Phytothérapie 2019, 17 (5) , 276-282. https://doi.org/10.3166/phyto-2018-0028
  28. Minxia Fan, Guilin Chen, Baoqing Sun, Jianlin Wu, Na Li, Satyajit D. Sarker, Lutfun Nahar, Mingquan Guo. Screening for natural inhibitors of human topoisomerases from medicinal plants with bio-affinity ultrafiltration and LC–MS. Phytochemistry Reviews 2019, 33 https://doi.org/10.1007/s11101-019-09635-x
  29. Xi He, Liu Yang, Xintong Liu, Wei Wei, Ce Shi, Baoquan Li, Jiang Li. Ginsenoside Rb1 Upregulating AQP5 Protein Expression and Alleviating Salivary Secretion Impairment in Ovariectomized Sjögren’s Syndrome Mice. Chemical Research in Chinese Universities 2019, 35 (3) , 418-426. https://doi.org/10.1007/s40242-019-9056-y
  30. Ardeshir Arzi, Hoda Mojiri Forushani, Neda Sistani Karampour. Evaluation of the Anxiolytic Effect of Vitex agnus-castus on Female Mice and Possible Role of Estrogen Receptors. Jundishapur Journal of Natural Pharmaceutical Products 2019, In Press (In Press) https://doi.org/10.5812/jjnpp.63570
  31. Anastasia V. Balakireva, Natalia V. Kuznetsova, Anastasiia I. Petushkova, Lyudmila V. Savvateeva, Andrey A. Zamyatnin Jr.. Trends and Prospects of Plant Proteases in Therapeutics. Current Medicinal Chemistry 2019, 26 (3) , 465-486. https://doi.org/10.2174/0929867325666171123204403
  32. Sandra L. Gray, Brett R. Lackey. Optimizing a recombinant estrogen receptor binding assay for analysis of herbal extracts. Journal of Herbal Medicine 2019, 15 , 100252. https://doi.org/10.1016/j.hermed.2018.12.002
  33. Alauddin, Swati Chaturvedi, Mohd Yaseen Malik, Lubna Azmi, Ila Shukla, Zaiba Naseem, ChandanaVenkateswara Rao, Naresh Kumar Agarwal. Formononetin and biochanin A protects against ritonavir induced hepatotoxicity via modulation of NfκB/pAkt signaling molecules. Life Sciences 2018, 213 , 174-182. https://doi.org/10.1016/j.lfs.2018.10.023
  34. Axel Wiebrecht. Hormonwirkungen chinesischer Arzneidrogen. Chinesische Medizin / Chinese Medicine 2018, 33 (2) , 67-87. https://doi.org/10.1007/s00052-018-0183-1
  35. Luã Reis, Magnus da Silva, Silvia Costa, Eudes Velozo, Ronan Batista, Suzana da Cunha Lima. Estrogen and Thyroid Hormone Receptor Activation by Medicinal Plants from Bahia, Brazil. Medicines 2018, 5 (1) , 8. https://doi.org/10.3390/medicines5010008
  36. Lenka Applová, Jana Karlíčková, Michal Říha, Tomáš Filipský, Kateřina Macáková, Jiřina Spilková, Přemysl Mladěnka. The isoflavonoid tectorigenin has better antiplatelet potential than acetylsalicylic acid. Phytomedicine 2017, 35 , 11-17. https://doi.org/10.1016/j.phymed.2017.08.023
  37. Sayaka Suzuki, Noe Nakashima, Masakatsu Kageyama, Kazuo Yamagata. A phytoestrogen supplement prevents the altered gene expression associated with pregnancy implantation induced by IL-1β in endometrial epithelial cells. Reproductive Biology 2017, 17 (3) , 259-267. https://doi.org/10.1016/j.repbio.2017.06.001
  38. Linlin Ye, Yanling Xue, Yudan Wang, Juncheng Qi, Tiqiao Xiao. Identification of ginseng root using quantitative X-ray microtomography. Journal of Ginseng Research 2017, 41 (3) , 290-297. https://doi.org/10.1016/j.jgr.2016.05.004
  39. LIANET MONZOTE, ALEXANDRA LACKOVA, KATRIN STANIEK, SILVIA STEINBAUER, GERALD PICHLER, WALTER JÄGER, LARS GILLE. The antileishmanial activity of xanthohumol is mediated by mitochondrial inhibition. Parasitology 2017, 144 (6) , 747-759. https://doi.org/10.1017/S0031182016002389
  40. Ashley Clark, Kelly Haas, Raja Sivamani. Edible Plants and Their Influence on the Gut Microbiome and Acne. International Journal of Molecular Sciences 2017, 18 (5) , 1070. https://doi.org/10.3390/ijms18051070
  41. Jing Lin, Xue-lian Li, Hui Song, Qian Li, Ming-yan Wang, Xue-min Qiu, Da-jin Li, Ling Wang. A general description for Chinese medicine in treating premature ovarian failure. Chinese Journal of Integrative Medicine 2017, 23 (2) , 91-97. https://doi.org/10.1007/s11655-016-2642-7
  42. Sunil C. Kaul, Sukant Garg, Kazuya Tamura, Teruo Wada, Zeenia Kaul, Renu Wadhwa. Establishment of Hydroponic Cultivation of Ashwagandha for Active Ingredient Enriched Leaves. 2017,,, 495-508. https://doi.org/10.1007/978-3-319-59192-6_24
  43. Hui-Peng Song, Hong Wang, Jin-Xiu Liang, Cheng Qian, Si-Qi Wu, Wen-Jun Xu, Bin Wu, Xin-Guang Liu, Ping Li, Hua Yang. Integration of Multiple Analytical and Computational Tools for the Discovery of High-Potency Enzyme Inhibitors from Herbal Medicines. ChemMedChem 2016, 11 (23) , 2588-2597. https://doi.org/10.1002/cmdc.201600489
  44. Y. B. Jiang, Y. R. Yang. Trifolium pratense isoflavones improve pulmonary vascular remodelling in broiler chickens. Journal of Animal Physiology and Animal Nutrition 2016, 100 (6) , 1159-1168. https://doi.org/10.1111/jpn.12424
  45. Birgit M. Dietz, Atieh Hajirahimkhan, Tareisha L. Dunlap, Judy L. Bolton, . Botanicals and Their Bioactive Phytochemicals for Women’s Health. Pharmacological Reviews 2016, 68 (4) , 1026-1073. https://doi.org/10.1124/pr.115.010843
  46. Aldo Tava, Anna Stochmal, Luciano Pecetti. Isoflavone Content in Subterranean Clover Germplasm from Sardinia. Chemistry & Biodiversity 2016, 13 (8) , 1038-1045. https://doi.org/10.1002/cbdv.201500360
  47. K. Ghedira, P. Goetz. Gattilier. Phytothérapie 2016, 14 (4) , 264-268. https://doi.org/10.1007/s10298-016-1061-4
  48. Yang Liu, Jahir Garzon, J. Brent Friesen, Yu Zhang, James B. McAlpine, David C. Lankin, Shao-Nong Chen, Guido F. Pauli. Countercurrent assisted quantitative recovery of metabolites from plant-associated natural deep eutectic solvents. Fitoterapia 2016, 112 , 30-37. https://doi.org/10.1016/j.fitote.2016.04.019
  49. Renata Dobrucka, Jolanta Długaszewska. Biosynthesis and antibacterial activity of ZnO nanoparticles using Trifolium pratense flower extract. Saudi Journal of Biological Sciences 2016, 23 (4) , 517-523. https://doi.org/10.1016/j.sjbs.2015.05.016
  50. K. T. Heffron, K. F. Gaines, J. M. Novak, T. Canam, D. A. Collard. 17β-Estradiol influent and effluent concentrations in wastewater: demographic influences and the risk to environmental health. Environmental Monitoring and Assessment 2016, 188 (5) https://doi.org/10.1007/s10661-016-5292-5
  51. Li De-qiang, Jing Zhao, Dong Wu, Li Shao-ping. Discovery of active components in herbs using chromatographic separation coupled with online bioassay. Journal of Chromatography B 2016, 1021 , 81-90. https://doi.org/10.1016/j.jchromb.2016.02.004
  52. Tao WANG, Hong-Guo SUN, Yong-Li HUA, Peng-Ling LI, Yan-Ming WEI. Urine metabonomic study for blood-replenishing mechanism of Angelica sinensis in a blood-deficient mouse model. Chinese Journal of Natural Medicines 2016, 14 (3) , 210-219. https://doi.org/10.1016/S1875-5364(16)30018-8
  53. Bin Qian, Feng Li, Lin-Xia Zhao, Yu-Lin Dong, Yong-Jing Gao, Zhi-Jun Zhang. Ligustilide Ameliorates Inflammatory Pain and Inhibits TLR4 Upregulation in Spinal Astrocytes Following Complete Freund’s Adjuvant Peripheral Injection. Cellular and Molecular Neurobiology 2016, 36 (1) , 143-149. https://doi.org/10.1007/s10571-015-0228-0
  54. Hina Zahid, Ghazala H. Rizwani, Sumaira Ishaqe. Phytopharmacological Review on Vitex agnus-castus: A Potential Medicinal Plant. Chinese Herbal Medicines 2016, 8 (1) , 24-29. https://doi.org/10.1016/S1674-6384(16)60004-7
  55. Łukasz Cieśla, Ruin Moaddel. Comparison of analytical techniques for the identification of bioactive compounds from natural products. Natural Product Reports 2016, 33 (10) , 1131-1145. https://doi.org/10.1039/C6NP00016A
  56. Kainat Khan, Subhashis Pal, Manisha Yadav, Rakesh Maurya, Arun Kumar Trivedi, Sabyasachi Sanyal, Naibedya Chattopadhyay. Prunetin signals via G-protein-coupled receptor, GPR30(GPER1): Stimulation of adenylyl cyclase and cAMP-mediated activation of MAPK signaling induces Runx2 expression in osteoblasts to promote bone regeneration. The Journal of Nutritional Biochemistry 2015, 26 (12) , 1491-1501. https://doi.org/10.1016/j.jnutbio.2015.07.021
  57. Juergen Drewe, Kathleen A Bucher, Catherine Zahner. A systematic review of non-hormonal treatments of vasomotor symptoms in climacteric and cancer patients. SpringerPlus 2015, 4 (1) https://doi.org/10.1186/s40064-015-0808-y
  58. Chelsea N Powers, William N Setzer. A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements. In Silico Pharmacology 2015, 3 (1) https://doi.org/10.1186/s40203-015-0008-z
  59. Catherine Ulbricht, Regina C. Windsor. An Evidence-Based Systematic Review of Black cohosh ( Cimicifuga racemosa , Actaea racemosa ) by the Natural Standard Research Collaboration. Journal of Dietary Supplements 2015, 12 (3) , 265-358. https://doi.org/10.3109/19390211.2014.946731
  60. Willow J.H. Liu. What has been overlooked on study of Chinese materia medica in the West?. Chinese Journal of Integrative Medicine 2015, 21 (7) , 483-492. https://doi.org/10.1007/s11655-015-2081-x
  61. Claus Schulte-Uebbing, Michael Weber, Beate Strittmatter, Ioan Doru Craiut. INTEGRATIVE AKUPUNKTUR, OHR-AKUPUNKTUR UND PHYTOTHERAPIE ZUR BEHANDLUNG VON MORBUS HASHIMOTO. Akupunktur & Aurikulomedizin 2015, 41 (2) , 15-23. https://doi.org/10.1007/s15009-015-5331-2
  62. Sun Haeng Lee, Hyung Joong Kim, Eun Ju Lee, Gyu Tae Chang. The Review of the Herbal Medicines with Phytoestrogenic Effect. The Journal of Korean Oriental Pediatrics 2015, 29 (2) , 59-77. https://doi.org/10.7778/jpkm.2015.29.2.059
  63. Peng-ling Li, Hong-guo Sun, Yong-li Hua, Peng Ji, Ling Zhang, Jin-xia Li, Yanming Wei. Metabolomics study of hematopoietic function of Angelica sinensis on blood deficiency mice model. Journal of Ethnopharmacology 2015, 166 , 261-269. https://doi.org/10.1016/j.jep.2015.03.010
  64. R. Ismail, L. Taylor-Swanson, A. Thomas, J. G. Schnall, L. Cray*, E. S. Mitchell, N. F. Woods. Effects of herbal preparations on symptom clusters during the menopausal transition. Climacteric 2015, 18 (1) , 11-28. https://doi.org/10.3109/13697137.2014.900746
  65. Dejan Nikolić, David C. Lankin, Tamara Cisowska, Shao-Nong Chen, Guido F. Pauli, Richard B. van Breemen. Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities. 2015,,, 31-75. https://doi.org/10.1007/978-3-319-20397-3_2
  66. Derek A. Schreihofer. Neuroprotection by Dietary Isoflavones and Their Role in Cerebral Ischemia. 2015,,, 385-394. https://doi.org/10.1016/B978-0-12-411462-3.00039-4
  67. Ana Belen Lopez-Rodriguez, Marco Ávila-Rodriguez, Nelson E. Vega-Vela, Francisco Capani, Janneth Gonzalez, Luis Miguel García-Segura, George E. Barreto. Neuroprotection by Exogenous Estrogenic Compounds Following Traumatic Brain Injury. 2015,,, 73-90. https://doi.org/10.1016/B978-0-12-801479-0.00006-1
  68. Dejan Nikolić, Jinghu Li, Richard B. van Breemen. Metabolism of N ω -methylserotonin, a serotonergic constituent of black cohosh ( Cimicifuga racemosa , L. (Nutt.)), by human liver microsomes. Biomedical Chromatography 2014, 28 (12) , 1647-1651. https://doi.org/10.1002/bmc.3197
  69. Heather Greenlee, Lynda G. Balneaves, Linda E. Carlson, Misha Cohen, Gary Deng, Dawn Hershman, Matthew Mumber, Jane Perlmutter, Dugald Seely, Ananda Sen, Suzanna M. Zick, Debu Tripathy, . Clinical Practice Guidelines on the Use of Integrative Therapies as Supportive Care in Patients Treated for Breast Cancer. JNCI Monographs 2014, 2014 (50) , 346-358. https://doi.org/10.1093/jncimonographs/lgu041
  70. Evelyn H. Wang, Kevin A. Schug. Natural Product Drug Discovery and Analysis Using Mass Spectrometry and Affinity-Based Technologies. 2014,,, 475-506. https://doi.org/10.1002/9781118876015.ch13
  71. Paola Spagnuolo, Emanuela Rasini, Alessandra Luini, Massimiliano Legnaro, Marcello Luzzani, Enrico Casareto, Massimiliano Carreri, Silvano Paracchini, Franca Marino, Marco Cosentino. Isoflavone content and estrogenic activity of different batches of red clover (Trifolium pratense L.) extracts: An in vitro study in MCF-7 cells. Fitoterapia 2014, 94 , 62-69. https://doi.org/10.1016/j.fitote.2014.01.027
  72. Lin-Xia Zhao, Bao-Chun Jiang, Xiao-Bo Wu, De-Li Cao, Yong-Jing Gao. Ligustilide attenuates inflammatory pain via inhibition of NFκB-mediated chemokines production in spinal astrocytes. European Journal of Neuroscience 2014, 39 (8) , 1391-1402. https://doi.org/10.1111/ejn.12502
  73. Pui Chan, Wendy Zhang, Chung-Ho Lau, Chi Cheung, Hector Keun, Karl Tsim, Henry Lam. Metabonomic Analysis of Water Extracts from Different Angelica Roots by 1H-Nuclear Magnetic Resonance Spectroscopy. Molecules 2014, 19 (3) , 3460-3470. https://doi.org/10.3390/molecules19033460
  74. Stefanie Lutter, Katja Schmalbach, Harald L. Esch, Leane Lehmann. The isoflavone irilone contributes to the estrogenic potential of dietary supplements containing red clover. Archives of Toxicology 2014, 88 (2) , 309-321. https://doi.org/10.1007/s00204-013-1114-5
  75. Yanqi Yang, Alice Chin, Linkun Zhang, Jiajing Lu, Ricky Wing Kit Wong. The Role of Traditional Chinese Medicines in Osteogenesis and Angiogenesis. Phytotherapy Research 2014, 28 (1) , 1-8. https://doi.org/10.1002/ptr.4959
  76. Feng Qiu, James B. McAlpine, Elizabeth C. Krause, Shao-Nong Chen, Guido F. Pauli. Pharmacognosy of Black Cohosh: The Phytochemical and Biological Profile of a Major Botanical Dietary Supplement. 2014,,, 1-68. https://doi.org/10.1007/978-3-319-04900-7_1
  77. T. K. Lim. Trifolium pratense. 2014,,, 925-948. https://doi.org/10.1007/978-94-007-7395-0_75
  78. Xiangyu Wu, Ning Li, Hongde Li, Huiru Tang. An optimized method for NMR-based plant seed metabolomic analysis with maximized polar metabolite extraction efficiency, signal-to-noise ratio, and chemical shift consistency. The Analyst 2014, 139 (7) , 1769-1778. https://doi.org/10.1039/C3AN02100A
  79. Chengwei Niu, Junming Wang, Lili Ji, Zhengtao Wang. Protection of Angelica sinensis (Oliv) Diels against hepatotoxicity induced by Dioscorea bulbifera L. and its mechanism. BioScience Trends 2014, 8 (5) , 253-259. https://doi.org/10.5582/bst.2014.01076
  80. Birgit Dietz, Judy Bolton. Anti-Inflammatory Botanical Dietary Supplements for Women’s Health. 2013,,, 529-548. https://doi.org/10.1201/b15323-37
  81. Ma HaiRong, Wei HuaBo, Chen Zhen, Yang Yi, Wang ZhengHua, Habasi Madina, Cao Xu, Aisa Haji Akber. The Estrogenic Activity of Isoflavones Extracted from Chickpea Cicer arietinum L Sprouts in Vitro. Phytotherapy Research 2013, 27 (8) , 1237-1242. https://doi.org/10.1002/ptr.4858
  82. Atieh Hajirahimkhan, Charlotte Simmler, Yang Yuan, Jeffrey R. Anderson, Shao-Nong Chen, Dejan Nikolić, Birgit M. Dietz, Guido F. Pauli, Richard B. van Breemen, Judy L. Bolton, . Evaluation of Estrogenic Activity of Licorice Species in Comparison with Hops Used in Botanicals for Menopausal Symptoms. PLoS ONE 2013, 8 (7) , e67947. https://doi.org/10.1371/journal.pone.0067947
  83. Guang Zheng, Junping Zhan, Hongtao Guo, Miao Jiang, Cheng Lu, Aiping Lu. Exploring associated rules of Danggui in traditional Chinese medicine through text mining. 2013,,, 198-203. https://doi.org/10.1109/ICSESS.2013.6615287
  84. Fang Yu, Huali Li, Yu Meng, Di Yang. Extraction optimization of Angelica sinensis polysaccharides and its antioxidant activity in vivo. Carbohydrate Polymers 2013, 94 (1) , 114-119. https://doi.org/10.1016/j.carbpol.2013.01.050
  85. Tatiana Visnevschi-Necrasov, Miguel A. Faria, Sara C. Cunha, J. Harris, Harald W. E. Meimberg, Manuel A. C. Curto, M. Graça Pereira, M. Beatriz P. P. Oliveira, Eugénia Nunes. Isoflavone synthase (IFS) gene phylogeny in Trifolium species associated with plant isoflavone contents. Plant Systematics and Evolution 2013, 299 (2) , 357-367. https://doi.org/10.1007/s00606-012-0726-1
  86. Beatrice J. Edwards, Jin Li. Endocrinology of menopause. Periodontology 2000 2013, 61 (1) , 177-194. https://doi.org/10.1111/j.1600-0757.2011.00407.x
  87. Chun Shi, Ning Na, Xiaoming Zhu, Jie Xu. Estrogenic effect of Ginsenoside Rg1 on APP processing in post-menopausal platelets. Platelets 2013, 24 (1) , 51-62. https://doi.org/10.3109/09537104.2012.654839
  88. R. Sharma. Herbal Supplements or Herbs in Heart Disease. 2013,,, 29-61. https://doi.org/10.1016/B978-0-12-396485-4.00001-3
  89. . How to use the monographs. 2013,,, 353-961. https://doi.org/10.1016/B978-0-443-06992-5.00010-4
  90. Michael T. Murray. Angelica Species. 2013,,, 587-590. https://doi.org/10.1016/B978-1-4377-2333-5.00065-1
  91. Miaomiao Tian, Wei Feng, Juanjuan Ye, Qiong Jia. Preparation of [email protected]/graphene oxide magnetic microspheres for microchip-based preconcentration of estrogens in milk and milk powder samples. Analytical Methods 2013, 5 (16) , 3984. https://doi.org/10.1039/c3ay40662h
  92. Olivier Potterat, Matthias Hamburger. Concepts and technologies for tracking bioactive compounds in natural product extracts: generation of libraries, and hyphenation of analytical processes with bioassays. Natural Product Reports 2013, 30 (4) , 546. https://doi.org/10.1039/c3np20094a
  93. Wendy L. Zhang, Ken Y. Z. Zheng, Kevin Y. Zhu, Janis Y. X. Zhan, Cathy W. C. Bi, J. P. Chen, Tina T. X. Dong, Roy C. Y. Choi, David T. W. Lau, Karl W. K. Tsim. Chemical and Biological Assessment of Angelica Roots from Different Cultivated Regions in a Chinese Herbal Decoction Danggui Buxue Tang. Evidence-Based Complementary and Alternative Medicine 2013, 2013 , 1-10. https://doi.org/10.1155/2013/483286
  94. Angela Mari, Paola Montoro, Cosimo Pizza, Sonia Piacente. Liquid chromatography tandem mass spectrometry determination of chemical markers and principal component analysis of Vitex agnus-castus L. fruits (Verbenaceae) and derived food supplements. Journal of Pharmaceutical and Biomedical Analysis 2012, 70 , 224-230. https://doi.org/10.1016/j.jpba.2012.07.001
  95. Kyeong-Ok Choi, Inae Lee, Sae-Yeol-Rim Paik, Dong Eun Kim, Jung Dae Lim, Wie-Soo Kang, Sanghoon Ko. Ultrafine Angelica gigas Powder Normalizes Ovarian Hormone Levels and Has Antiosteoporosis Properties in Ovariectomized Rats: Particle Size Effect. Journal of Medicinal Food 2012, 15 (10) , 863-872. https://doi.org/10.1089/jmf.2011.2047
  96. Sang Min Lee, Hye-Jin Kim, Young Pyo Jang. Chemometric Classification of Morphologically Similar Umbelliferae Medicinal Herbs by DART-TOF-MS Fingerprint. Phytochemical Analysis 2012, 23 (5) , 508-512. https://doi.org/10.1002/pca.2348
  97. Courtney S. Snelten, Birgit Dietz, Judy L. Bolton. Modulation of estrogen chemical carcinogenesis by botanical supplements used for postmenopausal women's health. Drug Discovery Today: Disease Mechanisms 2012, 9 (1-2) , e47-e54. https://doi.org/10.1016/j.ddmec.2012.11.001
  98. Kornél Nagy, Marie-Claude Courtet-Compondu, Gary Williamson, Serge Rezzi, Martin Kussmann, Andreas Rytz. Non-covalent binding of proteins to polyphenols correlates with their amino acid sequence. Food Chemistry 2012, 132 (3) , 1333-1339. https://doi.org/10.1016/j.foodchem.2011.11.113
  99. M.F. Toh, J. Sohn, S.N. Chen, P. Yao, J.L. Bolton, J.E. Burdette. Biological characterization of non-steroidal progestins from botanicals used for women’s health. Steroids 2012, 77 (7) , 765-773. https://doi.org/10.1016/j.steroids.2012.03.013
  100. W. Du, Y. Yue, X. Tian. Variation of isoflavones production in red clover as related to environment, growth stage and year. Acta Alimentaria 2012, 41 (2) , 211-220. https://doi.org/10.1556/AAlim.41.2012.2.8
  101. Catherine Ulbricht, Ethan Basch, Samuel Basch, Wendy Chao, Julie Conquer, Dawn Costa, Samantha Culwell, Cynthia Dacey, Jacquelyn Guilford, Paul Hammerness, Elizabeth R.B. Higdon, Richard Isaac, Margaret Lynch, Carolyn Williams Orlando, Erica Rusie, Minney Varghese, Mamta Vora, Regina C. Windsor, Jen Woods. Hops ( Humulus lupulus ): An Evidence-Based Systematic Review by the Natural Standard Research Collaboration. Alternative and Complementary Therapies 2012, 18 (2) , 98-108. https://doi.org/10.1089/act.2012.18204
  102. Jelena Cvejić, Mira Bursać, Milica Atanacković. Phytoestrogens: “Estrogene-Like” Phytochemicals. 2012,,, 1-35. https://doi.org/10.1016/B978-0-444-59530-0.00001-0
  103. Luis G Valerio. In silicotoxicology models and databases as FDA Critical Path Initiative toolkits. Human Genomics 2011, 5 (3) https://doi.org/10.1186/1479-7364-5-3-200
  104. Susanne Andres, Klaus Abraham, Klaus Erich Appel, Alfonso Lampen. Risks and benefits of dietary isoflavones for cancer. Critical Reviews in Toxicology 2011, 41 (6) , 463-506. https://doi.org/10.3109/10408444.2010.541900
  105. Serhat S. Cicek, Anita Aberham, Markus Ganzera, Hermann Stuppner. Quantitative analysis of cycloartane glycosides in black cohosh rhizomes and dietary supplements by RRLC-ELSD and RRLC-qTOF-MS. Analytical and Bioanalytical Chemistry 2011, 400 (8) , 2597-2605. https://doi.org/10.1007/s00216-010-4068-y
  106. Shao-Nong Chen, J. Brent Friesen, Donna Webster, Dejan Nikolic, Richard B. van Breemen, Z. Jim Wang, Harry H.S. Fong, Norman R. Farnsworth, Guido F. Pauli. Phytoconstituents from Vitex agnus-castus fruits. Fitoterapia 2011, 82 (4) , 528-533. https://doi.org/10.1016/j.fitote.2010.12.003
  107. Di Chen, Jiping Tang, Nikan H. Khatibi, Mei Zhu, Yingbo Li, Chengyuan Wang, Rong Jiang, Liu Tu, Shali Wang. Treatment with Z-Ligustilide, a Component of Angelica sinensis , Reduces Brain Injury after a Subarachnoid Hemorrhage in Rats. Journal of Pharmacology and Experimental Therapeutics 2011, 337 (3) , 663-672. https://doi.org/10.1124/jpet.110.177055
  108. E. L. Howard, S. P. Whittock, J. Jakše, J. Carling, P. D. Matthews, G. Probasco, J. A. Henning, P. Darby, A. Cerenak, B. Javornik, A. Kilian, A. Koutoulis. High-throughput genotyping of hop (Humulus lupulus L.) utilising diversity arrays technology (DArT). Theoretical and Applied Genetics 2011, 122 (7) , 1265-1280. https://doi.org/10.1007/s00122-011-1529-4
  109. Martin J. Spiering, Lori A. Urban, Donald L. Nuss, Vivek Gopalan, Arlin Stoltzfus, Edward Eisenstein. Gene identification in black cohosh (Actaea racemosa L.): expressed sequence tag profiling and genetic screening yields candidate genes for production of bioactive secondary metabolites. Plant Cell Reports 2011, 30 (4) , 613-629. https://doi.org/10.1007/s00299-010-0979-5
  110. Vittoria Di Viesti, Gianluca Carnevale, Manuela Zavatti, Augusta Benelli, Paola Zanoli. Increased sexual motivation in female rats treated with Humulus lupulus L. extract. Journal of Ethnopharmacology 2011, 134 (2) , 514-517. https://doi.org/10.1016/j.jep.2010.12.040
  111. Sun-Hye Lim, Tae-Youl Ha, Jiyun Ahn, Suna Kim. Estrogenic activities of Psoralea corylifolia L. seed extracts and main constituents. Phytomedicine 2011, 18 (5) , 425-430. https://doi.org/10.1016/j.phymed.2011.02.002
  112. Yun-Jan Wang, Jinhui Dou, Kevin P. Cross, Luis G. Valerio. Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms. Regulatory Toxicology and Pharmacology 2011, 59 (1) , 111-124. https://doi.org/10.1016/j.yrtph.2010.09.012
  113. Judy L. Bolton. Mechanisms of Estrogen Carcinogenesis: Modulation by Botanical Natural Products. 2011,,, 75-93. https://doi.org/10.1007/978-1-61737-995-6_4
  114. May Fern Toh, Joanna E. Burdette. Identifying botanical mechanisms of action. Fitoterapia 2011, 82 (1) , 67-70. https://doi.org/10.1016/j.fitote.2010.09.003
  115. Amy Lu, Jacinta C. Beehner, Nancy M. Czekala, Andreas Koenig, Eileen Larney, Carola Borries. Phytochemicals and reproductive function in wild female Phayre's leaf monkeys (Trachypithecus phayrei crepusculus). Hormones and Behavior 2011, 59 (1) , 28-36. https://doi.org/10.1016/j.yhbeh.2010.09.012
  116. Kapil K. Soni, Temitope O. Lawal, Tracie D. Locklear, Gail B. Mahady. Black Cohosh for Menopause: Safety and Efficacy Issues and Future Perspectives. Drug Information Journal 2011, 45 (1) , 37-44. https://doi.org/10.1177/009286151104500104
  117. Wen-Wan Chao, Bi-Fong Lin. Bioactivities of major constituents isolated from Angelica sinensis (Danggui). Chinese Medicine 2011, 6 (1) , 29. https://doi.org/10.1186/1749-8546-6-29
  118. Leila Kolios, Florian Daub, Stephan Sehmisch, Karl-Heinz Frosch, Mohammed Tezval, Klaus Michael Stuermer, Wolfgang Wuttke, Ewa Klara Stuermer. Absence of positive effect of black cohosh (Cimicifuga racemosa) on fracture healing in osteopenic rodent model. Phytotherapy Research 2010, 24 (12) , 1796-1806. https://doi.org/10.1002/ptr.3176
  119. Willow J. H. Liu. Introduction to Traditional Herbal Medicines and their Study. 2010,,, 1-26. https://doi.org/10.1002/9780470921340.ch1
  120. Willow J. H. Liu. Bioassays for Screening and Functional Elucidation of Herbal Medicines. 2010,,, 225-269. https://doi.org/10.1002/9780470921340.ch5
  121. Chun-fu Wu, Fang Wang, Chun-li Li. Functional Evaluation of Herbal Medicines by Animal Experiments. 2010,,, 271-301. https://doi.org/10.1002/9780470921340.ch6
  122. Renata Mazaro-Costa, Monica L. Andersen, Helena Hachul, Sergio Tufik. Medicinal Plants as Alternative Treatments for Female Sexual Dysfunction: Utopian Vision or Possible Treatment in Climacteric Women?. The Journal of Sexual Medicine 2010, 7 (11) , 3695-3714. https://doi.org/10.1111/j.1743-6109.2010.01987.x
  123. A Rao, Amir Al-Weshahy. Functional Foods and Men’s Health. 2010,,, 123-146. https://doi.org/10.1201/b10264-7
  124. Richard B. van Breemen, Andrew G. Newsome, Jeffrey H. Dahl. Mass Spectrometry and Drug Discovery. 2010,,https://doi.org/10.1002/0471266949.bmc012.pub2
  125. Gail Mahady, Joanna Michel, Kapil Soni. Chaste Tree. 2010,,, 129-135. https://doi.org/10.1201/b14669-19
  126. Jing Shi, Xiaoyu Zhang, Zhongjun Ma, Min Zhang, Fang Sun. Characterization of Aromatase Binding Agents from the Dichloromethane Extract of Corydalis yanhusuo Using Ultrafiltration and Liquid Chromatography Tandem Mass Spectrometry. Molecules 2010, 15 (5) , 3556-3566. https://doi.org/10.3390/molecules15053556
  127. Kunal Sharan, Gaurav Swarnkar, Jawed A. Siddiqui, Avinash Kumar, Preeti Rawat, Manmeet Kumar, Geet K. Nagar, Lakshmi Manickavasagam, Sheelendra P. Singh, Geetanjali Mishra, Wahajuddin, Girish K. Jain, Rakesh Maurya, Naibedya Chattopadhyay. A novel flavonoid, 6-C-β-d-glucopyranosyl-(2S,3S)-(+)-3′,4′,5,7-tetrahydroxyflavanone, isolated from Ulmus wallichiana Planchon mitigates ovariectomy-induced osteoporosis in rats. Menopause 2010, , 1. https://doi.org/10.1097/gme.0b013e3181d2ce7f
  128. R B van Breemen, W Liang, S Banuvar, L P Shulman, Y Pang, Y Tao, D Nikolic, K M Krock, D S Fabricant, S-N Chen, S Hedayat, J L Bolton, G F Pauli, C E Piersen, E C Krause, S E Geller, N R Farnsworth. Pharmacokinetics of 23-Epi-26-Deoxyactein in Women After Oral Administration of a Standardized Extract of Black Cohosh. Clinical Pharmacology & Therapeutics 2010, 87 (2) , 219-225. https://doi.org/10.1038/clpt.2009.251
  129. Hoang Ngoc Ai Tran, Soo-Young Bae, Bang-Ho Song, Bang-Hyo Lee, Young-Seok Bae, Young-Ho Kim, Ephraim Philip Lansky, Robert A. Newman. Pomegranate ( Punica granatum ) Seed Linolenic Acid Isomers: Concentration-Dependent Modulation of Estrogen Receptor Activity. Endocrine Research 2010, 35 (1) , 1-16. https://doi.org/10.3109/07435800903524161
  130. Hsu-Fang Chou, Kun-Hung Chuang, Yi-Shan Tsai, Yi-Ju Chen. Genistein inhibits glucose and sulphate transport in isolated rat liver lysosomes. British Journal of Nutrition 2010, 103 (2) , 197-205. https://doi.org/10.1017/S0007114509991693
  131. Hye-Yeong Kim, Johann Sohn, Gihani T. Wijewickrama, Praneeth Edirisinghe, Teshome Gherezghiher, Madhubani Hemachandra, Pei-Yi Lu, R. Esala Chandrasena, Mary Ellen Molloy, Debra A. Tonetti, Gregory R.J. Thatcher. Click synthesis of estradiol–cyclodextrin conjugates as cell compartment selective estrogens. Bioorganic & Medicinal Chemistry 2010, 18 (2) , 809-821. https://doi.org/10.1016/j.bmc.2009.11.046
  132. Sukanda Tianniam, Takeshi Bamba, Eiichiro Fukusaki. Pyrolysis GC-MS-based metabolite fingerprinting for quality evaluation of commercial Angelica acutiloba roots. Journal of Bioscience and Bioengineering 2010, 109 (1) , 89-93. https://doi.org/10.1016/j.jbiosc.2009.06.025
  133. Pauline M. Maki, Leah H. Rubin, Deanne Fornelli, Lauren Drogos, Suzanne Banuvar, Lee P. Shulman, Stacie E. Geller. Effects of botanicals and combined hormone therapy on cognition in postmenopausal women. Menopause 2009, 16 (6) , 1167-1177. https://doi.org/10.1097/gme.0b013e3181ace484
  134. Stacie E. Geller, Lee P. Shulman, Richard B. van Breemen, Suzanne Banuvar, Ying Zhou, Geena Epstein, Samad Hedayat, Dejan Nikolic, Elizabeth C. Krause, Colleen E. Piersen, Judy L. Bolton, Guido F. Pauli, Norman R. Farnsworth. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms. Menopause 2009, 16 (6) , 1156-1166. https://doi.org/10.1097/gme.0b013e3181ace49b
  135. Masamichi Noguchi, Mitsutoshi Yuzurihara, Yasushi Ikarashi, Naoko Tsuchiya, Tomoko Hibino, Akihito Mase, Yoshio Kase. Effects of the traditional Japanese medicine Tokaku-jyoki-to in rat-models for menopausal hot flash. Journal of Ethnopharmacology 2009, 126 (1) , 96-101. https://doi.org/10.1016/j.jep.2009.08.005
  136. Norman R. Farnsworth, Gail B. Mahady. Research highlights from the UIC/NIH Center for Botanical Dietary Supplements Research for Women’s Health: Black cohosh from the field to the clinic. Pharmaceutical Biology 2009, 47 (8) , 755-760. https://doi.org/10.1080/13880200902988637
  137. Sukanda Tianniam, Takeshi Bamba, Eiichiro Fukusaki. Non-targeted metabolite fingerprinting of oriental folk medicine Angelica acutiloba roots by ultra performance liquid chromatography time-of-flight mass spectrometry. Journal of Separation Science 2009, 32 (13) , 2233-2244. https://doi.org/10.1002/jssc.200900121
  138. Joseph M. Betz, Linda Anderson, Mark I. Avigan, Joanne Barnes, Norman R. Farnsworth, Barbro Gerdén, Leigh Henderson, Edward J. Kennelly, Uwe Koetter, Stephanie Lessard, Tieraona Low Dog, Michelle McLaughlin, Belal Naser, Ruediger G. W. Osmers, Linda S. Pellicore, John R. Senior, Richard B. van Breemen, Wolfgang Wuttke, John H. Cardellina. Black Cohosh. Nutrition Today 2009, 44 (4) , 155-162. https://doi.org/10.1097/NT.0b013e3181af63f9
  139. Lian ZHANG, Jun-Rong DU, Jin WANG, Dong-Ke YU, Ya-Shu CHEN, Yao HE, Chen-Yuan WANG. Z-ligustilide Extracted from Radix Angelica Sinensis Decreased Platelet Aggregation Induced by ADP Ex Vivo and Arterio-venous Shunt Thrombosis In Vivo in Rats. YAKUGAKU ZASSHI 2009, 129 (7) , 855-859. https://doi.org/10.1248/yakushi.129.855
  140. Sun-Hye Lim, Tae-Youl Ha, Sung-Ran Kim, Jiyun Ahn, Hyun Jin Park, Suna Kim. Ethanol extract of Psoralea corylifolia L. and its main constituent, bakuchiol, reduce bone loss in ovariectomised Sprague–Dawley rats. British Journal of Nutrition 2009, 101 (7) , 1031-1039. https://doi.org/10.1017/S0007114508066750
  141. Tanja Gödecke, Dejan Nikolic, David C. Lankin, Shao-Nong Chen, Sharla L. Powell, Birgit Dietz, Judy L. Bolton, Richard B. van Breemen, Norman R. Farnsworth, Guido F. Pauli. Phytochemistry of cimicifugic acids and associated bases in Cimicifuga racemosa root extracts. Phytochemical Analysis 2009, 20 (2) , 120-133. https://doi.org/10.1002/pca.1106
  142. Miroslava G. Varadinova, Diana I. Docheva-Drenska, Nadka I. Boyadjieva. Effects of anthocyanins on learning and memory of ovariectomized rats. Menopause 2009, 16 (2) , 345-349. https://doi.org/10.1097/gme.0b013e3181847619
  143. Corinne Patching van der Sluijs, Alan Bensoussan, Sungwon Chang, Rodney Baber. A randomized placebo-controlled trial on the effectiveness of an herbal formula to alleviate menopausal vasomotor symptoms. Menopause 2009, 16 (2) , 336-344. https://doi.org/10.1097/gme.0b013e3181883dc1
  144. M. Ludwig. Vitex agnus castus. Gynäkologische Endokrinologie 2009, 7 (1) , 33-38. https://doi.org/10.1007/s10304-008-0285-2
  145. Debra L. Barton, Aditya Bardia, Charles Loprinzi. Menopausal Symptoms. 2009,,, 227-248. https://doi.org/10.1007/978-1-59745-291-5_13
  146. Katharina E. Effenberger, Johannes Westendorf. Hop-Derived Phytoestrogens Alter Osteoblastic Phenotype and Gene Expression. 2009,,, 735-745. https://doi.org/10.1016/B978-0-12-373891-2.00074-2
  147. Johanna R. Rochester, Kirk C. Klasing, Lindsay Stevenson, Michael S. Denison, Wallace Berry, James R. Millam. Dietary red clover (Trifolium pratense) induces oviduct growth and decreases ovary and testes growth in Japanese quail chicks. Reproductive Toxicology 2009, 27 (1) , 63-71. https://doi.org/10.1016/j.reprotox.2008.11.056
  148. Evelyne Reiter, Evelyne Reiter, Verena Beck, Svjetlana Medjakovic, Alois Jungbauer. Isoflavones are safe compounds for therapeutical applications – Evaluation of in vitro data. Gynecological Endocrinology 2009, 25 (9) , 554-580. https://doi.org/10.1080/09513590802596461
  149. Mi-Kyung Park, Hyeok-Yi Kwon, Woong-Shick Ahn, Sumi Bae, Mee-Ra Rhyu, YoungJoo Lee. Estrogen Activities and the Cellular Effects of Natural Progesterone from Wild Yam Extract in MCF-7 Human Breast Cancer Cells. The American Journal of Chinese Medicine 2009, 37 (01) , 159-167. https://doi.org/10.1142/S0192415X09006746
  150. Young-Ae Lee, Mi-Hyang Kim. Effects of Sea Tangle Extract on Formation of Collagen and Collagen Cross-link in Ovariectomized Rats. Journal of Life Science 2008, 18 (11) , 1578-1583. https://doi.org/10.5352/JLS.2008.18.11.1578
  151. Cassia R. Overk, Jian Guo, Lucas R. Chadwick, Daniel D. Lantvit, Alberto Minassi, Giovanni Appendino, Shao-Nong Chen, David C. Lankin, Norman R. Farnsworth, Guido F. Pauli, Richard B. van Breemen, Judy L. Bolton. In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin. Chemico-Biological Interactions 2008, 176 (1) , 30-39. https://doi.org/10.1016/j.cbi.2008.06.005
  152. Francesco Occhiuto, Giuseppe Zangla, Stefania Samperi, Dora Rita Palumbo, Annalisa Pino, Rita De Pasquale, Clara Circosta. The phytoestrogenic isoflavones from Trifolium pratense L. (Red clover) protects human cortical neurons from glutamate toxicity. Phytomedicine 2008, 15 (9) , 676-682. https://doi.org/10.1016/j.phymed.2008.04.007
  153. Nancy E. Reame, Jane L. Lukacs, Vasantha Padmanabhan, Aimee D. Eyvazzadeh, Yolanda R. Smith, Jon-Kar Zubieta. Black cohosh has central opioid activity in postmenopausal women. Menopause 2008, 15 (5) , 832-840. https://doi.org/10.1097/gme.0b013e318169332a
  154. Bei Jiang, Kurt A. Reynertson, Amy C. Keller, Linda S. Einbond, Debra L. Bemis, I. Bernard Weinstein, Fredi Kronenberg, Edward J. Kennelly. Extraction Methods Play a Critical Role in Chemical Profile and Biological Activities of Black Cohosh. Natural Product Communications 2008, 3 (9) , 1934578X0800300. https://doi.org/10.1177/1934578X0800300925
  155. Jin-Han Park. Evidence-based herbal medicine in efficacy and safety assessments. Oriental Pharmacy and Experimental Medicine 2008, 8 (2) , 103-110. https://doi.org/10.3742/OPEM.2008.8.2.103
  156. Stacie E Geller, Laura Studee. The effects of hormone therapy and botanicals and dietary supplementson the endometrium. 2008,,, 771-784. https://doi.org/10.3109/9780203091500.053
  157. Paola Zanoli, Manuela Zavatti. Pharmacognostic and pharmacological profile of Humulus lupulus L.. Journal of Ethnopharmacology 2008, 116 (3) , 383-396. https://doi.org/10.1016/j.jep.2008.01.011
  158. Mi-Kyung Park, Mee-ra Rhyu, Byung-Koo Yoon, Hyeok yi Kwon, Siyoul Jang, Young Joo Lee. Modulation of the genomic estrogen receptor pathway by water extracts of Cirsium japonicum. Archives of Pharmacal Research 2008, 31 (2) , 225-230. https://doi.org/10.1007/s12272-001-1145-y
  159. Norman R Farnsworth, Elizabeth C Krause, Judy L Bolton, Guido F Pauli, Richard B van Breemen, James G Graham. The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women's Health: from plant to clinical use. The American Journal of Clinical Nutrition 2008, 87 (2) , 504S-508S. https://doi.org/10.1093/ajcn/87.2.504S
  160. Melissa Emery Thompson, Michael L. Wilson, Grace Gobbo, Martin N. Muller, Anne E. Pusey. Hyperprogesteronemia in response to Vitex fischeri consumption in wild chimpanzees ( Pan troglodytes schweinfurthii ). American Journal of Primatology 2008, , n/a-n/a. https://doi.org/10.1002/ajp.20600
  161. Niina MM Saviranta, Mikko J Anttonen, Atte von Wright, Reijo O Karjalainen. Red clover (Trifolium pratense L.) isoflavones: determination of concentrations by plant stage, flower colour, plant part and cultivar. Journal of the Science of Food and Agriculture 2008, 88 (1) , 125-132. https://doi.org/10.1002/jsfa.3056
  162. Francesco Occhiuto, Dora Rita Palumbo, Stefania Samperi, Giuseppe Zangla, Annalisa Pino, Rita De Pasquale, Clara Circosta. The isoflavones mixture from Trifolium pratense L. protects HCN 1-A neurons from oxidative stress. Phytotherapy Research 2008, , n/a-n/a. https://doi.org/10.1002/ptr.2584
  163. Ahmed Y Shahin, Alaa M Ismail, Kamal M Zahran, Ahmad M Makhlouf. Adding phytoestrogens to clomiphene induction in unexplained infertility patients – a randomized trial. Reproductive BioMedicine Online 2008, 16 (4) , 580-588. https://doi.org/10.1016/S1472-6483(10)60465-8
  164. A. R. Carmichael. Can Vitex Agnus castus Be Used for the Treatment of Mastalgia? What Is the Current Evidence?. Evidence-Based Complementary and Alternative Medicine 2008, 5 (3) , 247-250. https://doi.org/10.1093/ecam/nem074
  165. Rachel L. Ruhlen, Grace Y. Sun, Edward R. Sauter. Black Cohosh: Insights into its Mechanism(s) of Action. Integrative Medicine Insights 2008, 3 , 117863370800300. https://doi.org/10.4137/117863370800300002
  166. Marci Goldstein Adams, Stacie Geller, Laura Studee. Menopause and Midlife. 2007,,https://doi.org/10.1201/9781420043013.ch6
  167. Lilian U. Thompson, Beatrice A. Boucher, Michelle Cotterchio, Nancy Kreiger, Zhen Liu. Dietary Phytoestrogens, Including Isoflavones, Lignans, and Coumestrol, in Nonvitamin, Nonmineral Supplements Commonly Consumed by Women in Canada. Nutrition and Cancer 2007, 59 (2) , 176-184. https://doi.org/10.1080/01635580701420616
  168. Cassia R. Overk, Kuan-Wei Peng, Rezene T. Asghodom, Irida Kastrati, Daniel D. Lantvit, Zhihui Qin, Jonna Frasor, Judy L. Bolton, Gregory R. J. Thatcher. Structure–Activity Relationships for a Family of Benzothiophene Selective Estrogen Receptor Modulators Including Raloxifene and Arzoxifene. ChemMedChem 2007, 2 (10) , 1520-1526. https://doi.org/10.1002/cmdc.200700104
  169. Anna Rita Bilia, Federico Eterno, Franco Francesco Vincieri. Black Cohosh and Climacteric Symptoms: Growing Knowledge about the Efficacy and Safety. Natural Product Communications 2007, 2 (10) , 1934578X0700201. https://doi.org/10.1177/1934578X0700201013
  170. Katayoon Pakzad, Beatrice A. Boucher, Nancy Kreiger, Michelle Cotterchio. The Use of Herbal and Other Non-vitamin, Non-mineral Supplements among Pre- and Post-menopausal Women in Ontario. Canadian Journal of Public Health 2007, 98 (5) , 383-388. https://doi.org/10.1007/BF03405424
  171. James P. Higham, Caroline Ross, Ymke Warren, Michael Heistermann, Ann M. MacLarnon. Reduced reproductive function in wild baboons (Papio hamadryas anubis) related to natural consumption of the African black plum (Vitex doniana). Hormones and Behavior 2007, 52 (3) , 384-390. https://doi.org/10.1016/j.yhbeh.2007.06.003
  172. Yuan Hu, Ting-Ting Hou, Qiao-Yan Zhang, Hai-Liang Xin, Han-Chen Zheng, Lu-Ping Qin, Khalid Rahman. Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. Journal of Pharmacy and Pharmacology 2007, 59 (9) , 1307-1312. https://doi.org/10.1211/jpp.59.9.0016
  173. Marinella Farré, Marina Kuster, Rikke Brix, Fernando Rubio, María-J. López de Alda, Damià Barceló. Comparative study of an estradiol enzyme-linked immunosorbent assay kit, liquid chromatography–tandem mass spectrometry, and ultra performance liquid chromatography–quadrupole time of flight mass spectrometry for part-per-trillion analysis of estrogens in water samples. Journal of Chromatography A 2007, 1160 (1-2) , 166-175. https://doi.org/10.1016/j.chroma.2007.05.032
  174. Hirao Kohno, Katsuyasu Kouda, Rikio Tokunaga, Yoshiaki Sonoda. Detection of estrogenic activity in herbal teas by in vitro reporter assays. European Food Research and Technology 2007, 225 (5-6) , 913-920. https://doi.org/10.1007/s00217-006-0506-7
  175. Debra A. Tonetti, Yiyun Zhang, Huiping Zhao, Sok-Bee Lim, Andreas I. Constantinou. The Effect of the Phytoestrogens Genistein, Daidzein, and Equol on the Growth of Tamoxifen-Resistant T47D/PKCα. Nutrition and Cancer 2007, 58 (2) , 222-229. https://doi.org/10.1080/01635580701328545
  176. Hani P. Nissan, Jian Lu, Nancy L. Booth, Henry I. Yamamura, Norman R. Farnsworth, Z. Jim Wang. A red clover (Trifolium pratense) phase II clinical extract possesses opiate activity. Journal of Ethnopharmacology 2007, 112 (1) , 207-210. https://doi.org/10.1016/j.jep.2007.02.006
  177. Junrong Du, Yan Yu, Ya Ke, Chenyuen Wang, Li Zhu, Zhong Ming Qian. Ligustilide attenuates pain behavior induced by acetic acid or formalin. Journal of Ethnopharmacology 2007, 112 (1) , 211-214. https://doi.org/10.1016/j.jep.2007.02.007
  178. Nathalie Dijsselbloem, Stanislas Goriely, Valentina Albarani, Sarah Gerlo, Sarah Francoz, Jean-Christophe Marine, Michel Goldman, Guy Haegeman, Wim Vanden Berghe. A Critical Role for p53 in the Control of NF-κB-Dependent Gene Expression in TLR4-Stimulated Dendritic Cells Exposed to Genistein. The Journal of Immunology 2007, 178 (8) , 5048-5057. https://doi.org/10.4049/jimmunol.178.8.5048
  179. Timothy R. Rebbeck, Andrea B. Troxel, Sandra Norman, Greta R. Bunin, Angela DeMichele, Mona Baumgarten, Michelle Berlin, Rita Schinnar, Brian L. Strom. A retrospective case–control study of the use of hormone-related supplements and association with breast cancer. International Journal of Cancer 2007, 120 (7) , 1523-1528. https://doi.org/10.1002/ijc.22485
  180. P. Goetz. Le rôle du houblon et de ses constituants dans le traitement de la ménopause. Phytothérapie 2007, 5 (2) , 83-85. https://doi.org/10.1007/s10298-007-0216-8
  181. Olga Horvat, Aleksandar Raskovic, Vida Jakovljevic, Jan Sabo, Janos Berenji. Interaction of alcoholic extracts of hops with cocaine and paracetamol in mice. European Journal of Drug Metabolism and Pharmacokinetics 2007, 32 (1) , 39-44. https://doi.org/10.1007/BF03190988
  182. F. Occhiuto, R. De Pasquale, G. Guglielmo, D.R. Palumbo, G. Zangla, S. Samperi, A. Renzo, C. Circosta. Effects of phytoestrogenic isoflavones from red clover (Trifolium pratense L.) on experimental osteoporosis. Phytotherapy Research 2007, 21 (2) , 130-134. https://doi.org/10.1002/ptr.2037
  183. Jun-Rong Du, Yan Yu, Yao Yao, Bo Bai, Xu Zong, Yang Lei, Cheng-Yuan Wang, Zhong-Ming Qian. Ligustilide Reduces Phenylephrine Induced-Aortic Tension In Vitro but has No Effect on Systolic Pressure in Spontaneously Hypertensive Rats. The American Journal of Chinese Medicine 2007, 35 (03) , 487-496. https://doi.org/10.1142/S0192415X07005004
  184. Xingbin Yang, Yan Zhao, Yanjuan Zhou, You Lv, Jieli Mao, Ping Zhao. . Biological & Pharmaceutical Bulletin 2007,,, 1884. https://doi.org/10.1248/bpb.30.1884
  185. Jiepin Wang, Fujun Shang, Ru Jiang, Li Liu, Siwang Wang, Jin Hou, Menglei Huan, Qibing Mei. Nitric Oxide-Donating Genistein Prodrug: Design, Synthesis, and Bioactivity on MC3T3-E1 Cells. Journal of Pharmacological Sciences 2007, 104 (1) , 82-89. https://doi.org/10.1254/jphs.FP0061549
  186. Junrong Du, Bo Bai, Xi Kuang, Yan Yu, Chenyuen Wang, Ya Ke, Youjia Xu, Alexander H.C. Tzang, Zhong Ming Qian. Ligustilide inhibits spontaneous and agonists- or K+ depolarization-induced contraction of rat uterus. Journal of Ethnopharmacology 2006, 108 (1) , 54-58. https://doi.org/10.1016/j.jep.2006.04.011
  187. Stacie E. Geller, Laura Studee. Contemporary alternatives to plant estrogens for menopause. Maturitas 2006, 55 , S3-S13. https://doi.org/10.1016/j.maturitas.2006.06.012
  188. D. Seidlová-Wuttke, L. Pitzel, P. Thelen, W. Wuttke. Inhibition of 5α-reductase in the rat prostate by Cimicifuga racemosa. Maturitas 2006, 55 , S75-S82. https://doi.org/10.1016/j.maturitas.2006.06.019
  189. Hye-Sook Seo, David G. DeNardo, Yves Jacquot, Ioanna Laïos, Doris Salazar Vidal, Carmen Rojas Zambrana, Guy Leclercq, Powel H. Brown. Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha. Breast Cancer Research and Treatment 2006, 99 (2) , 121-134. https://doi.org/10.1007/s10549-006-9191-2
  190. Lei Xu, Ashwani Kumar, Karen Lamb, Linda Layton. Recovery of isoflavones from red clover flowers by a membrane-based process. Innovative Food Science & Emerging Technologies 2006, 7 (3) , 251-256. https://doi.org/10.1016/j.ifset.2005.12.001
  191. Mandy L. King, Stuart R. Adler, Laura L. Murphy. Extraction-Dependent Effects of American Ginseng (Panax quinquefolium) on Human Breast Cancer Cell Proliferation and Estrogen Receptor Activation. Integrative Cancer Therapies 2006, 5 (3) , 236-243. https://doi.org/10.1177/1534735406291341
  192. Pamela Echeverria, Jyotsna Sahni. Women's Health. 2006,,https://doi.org/10.1201/9781420003413.ch6
  193. Jian Guo, Dejan Nikolic, Lucas R. Chadwick, Guido F. Pauli, Richard B. van Breemen. IDENTIFICATION OF HUMAN HEPATIC CYTOCHROME P450 ENZYMES INVOLVED IN THE METABOLISM OF 8-PRENYLNARINGENIN AND ISOXANTHOHUMOL FROM HOPS ( HUMULUS LUPULUS L.). Drug Metabolism and Disposition 2006, 34 (7) , 1152-1159. https://doi.org/10.1124/dmd.105.008250
  194. Theresa L. Charrois, Gagan Sandhu, Sunita Vohra. Black Cohosh Practical Management of Adverse Effects and Drug Interactions. Canadian Pharmacists Journal / Revue des Pharmaciens du Canada 2006, 139 (4) , 33-35. https://doi.org/10.1177/171516350613900407
  195. Barbara A. Pockaj, James G. Gallagher, Charles L. Loprinzi, Philip J. Stella, Debra L. Barton, Jeff A. Sloan, Beth I. Lavasseur, Radha M. Rao, Tom R. Fitch, Kendrith M. Rowland, Paul J. Novotny, Patrick J. Flynn, Elliott Richelson, Abdul H. Fauq. Phase III Double-Blind, Randomized, Placebo-Controlled Crossover Trial of Black Cohosh in the Management of Hot Flashes: NCCTG Trial N01CC 1. Journal of Clinical Oncology 2006, 24 (18) , 2836-2841. https://doi.org/10.1200/JCO.2005.05.4296
  196. D.E. Webster, J. Lu, S.-N. Chen, N.R. Farnsworth, Z. Jim Wang. Activation of the μ-opiate receptor by Vitex agnus-castus methanol extracts: Implication for its use in PMS. Journal of Ethnopharmacology 2006, 106 (2) , 216-221. https://doi.org/10.1016/j.jep.2005.12.025
  197. Caining Zhang, Xiaozhe Zhang, Yan Zhang, Qing Xu, Hongbin Xiao, Xinmiao Liang. Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography. Journal of Ethnopharmacology 2006, 105 (1-2) , 223-228. https://doi.org/10.1016/j.jep.2005.10.029
  198. Wen-Fang Chen, Wai-Sum Lau, Pik-Yuen Cheung, De-An Guo, Man-Sau Wong. Activation of insulin-like growth factor I receptor-mediated pathway by ginsenoside Rg1. British Journal of Pharmacology 2006, 147 (5) , 542-551. https://doi.org/10.1038/sj.bjp.0706640
  199. Nancy L. Booth, Cassia R. Overk, Ping Yao, Joanna E. Burdette, Dejan Nikolic, Shao-Nong Chen, Judy L. Bolton, Richard B. van Breemen, Guido F. Pauli, Norman R. Farnsworth. The Chemical and Biologic Profile of a Red Clover ( Trifolium pratense L.) Phase II Clinical Extract. The Journal of Alternative and Complementary Medicine 2006, 12 (2) , 133-139. https://doi.org/10.1089/acm.2006.12.133
  200. Haichao Wang, Wei Li, Jianhua Li, Beatriz Rendon-Mitchell, Mahendar Ochani, Mala Ashok, Lihong Yang, Huan Yang, Kevin J. Tracey, Ping Wang, Andrew E. Sama. The Aqueous Extract of a Popular Herbal Nutrient Supplement, Angelica sinensis, Protects Mice against Lethal Endotoxemia and Sepsis. The Journal of Nutrition 2006, 136 (2) , 360-365. https://doi.org/10.1093/jn/136.2.360
  201. . Herbal medicines. 2006,,, 23-299. https://doi.org/10.1201/b13984-5
  202. L.R. Chadwick, G.F. Pauli, N.R. Farnsworth. The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties. Phytomedicine 2006, 13 (1-2) , 119-131. https://doi.org/10.1016/j.phymed.2004.07.006
  203. Uppuluri Venkata Mallavadhani, Kilambi Narasimhan, Akella Venkata Subrahmanya Sudhakar, Anita Mahapatra, Wenkui Li, Richard Bruce van Breemen. . CHEMICAL & PHARMACEUTICAL BULLETIN 2006,,, 740. https://doi.org/10.1248/cpb.54.740
  204. Katherine Hanna, Alice Day, Sheila O'Neill, Carla Patterson, Philippa Lyons-Wall. Does scientific evidence support the use of non-prescription supplements for treatment of acute menopausal symptoms such as hot flushes?. Nutrition <html_ent glyph="@amp;" ascii="&"/> Dietetics 2005, 62 (4) , 138-151. https://doi.org/10.1111/j.1747-0080.2005.00022.x
  205. . Effects of Mulberry Fruits on Collagen Content of Connective Tissues in Ovariectomized Rats. Journal of Life Science 2005,,, 1022-1027. https://doi.org/10.5352/JLS.2005.15.6.1022
  206. Lei Xu, Ashwani Kumar, Karen Lamb, Linda Layton. Production of an Isoflavone Concentrate from Red Clover Flowers. Journal of Food Science 2005, 70 (8) , s558-s562. https://doi.org/10.1111/j.1365-2621.2005.tb11534.x
  207. Jianghua Liu, Steve Carr, Kurt Rinaldi, Wayne Chandler. Screening estrogenic oxidized by-products by combining ER binding and ultrafiltration. Environmental Toxicology and Pharmacology 2005, 20 (2) , 269-278. https://doi.org/10.1016/j.etap.2005.01.008
  208. Katharina E. Effenberger, Steven A. Johnsen, David G. Monroe, Thomas C. Spelsberg, Johannes J. Westendorf. Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens. The Journal of Steroid Biochemistry and Molecular Biology 2005, 96 (5) , 387-399. https://doi.org/10.1016/j.jsbmb.2005.04.038
  209. Mee-Ra Rhyu, Jung-Hyun Kim, Eun-Young Kim. Radix Angelica Elicits Both Nitric Oxide-Dependent and Calcium Influx-Mediated Relaxation in Rat Aorta. Journal of Cardiovascular Pharmacology 2005, 46 (1) , 99-104. https://doi.org/10.1097/01.fjc.0000164092.88821.49
  210. C.Z. Zhang, S.X. Wang, Y. Zhang, J.P. Chen, X.M. Liang. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Journal of Ethnopharmacology 2005, 98 (3) , 295-300. https://doi.org/10.1016/j.jep.2005.01.033
  211. V. Beck, U. Rohr, A. Jungbauer. Phytoestrogens derived from red clover: An alternative to estrogen replacement therapy?. The Journal of Steroid Biochemistry and Molecular Biology 2005, 94 (5) , 499-518. https://doi.org/10.1016/j.jsbmb.2004.12.038
  212. Peter H. Canter, Howard Thomas, Edzard Ernst. Bringing medicinal plants into cultivation: opportunities and challenges for biotechnology. Trends in Biotechnology 2005, 23 (4) , 180-185. https://doi.org/10.1016/j.tibtech.2005.02.002
  213. H. Jarry, P. Thelen, V. Christoffel, B. Spengler, W. Wuttke. Cimicifuga racemosa extract BNO 1055 inhibits proliferation of the human prostate cancer cell line LNCaP. Phytomedicine 2005, 12 (3) , 178-182. https://doi.org/10.1016/j.phymed.2004.02.006
  214. Tieraona Low Dog. Endometriosis. 2005,,, 51-63. https://doi.org/10.1016/B978-0-443-06639-9.50011-3
  215. Tieraona Low Dog. Menopause. 2005,,, 64-89. https://doi.org/10.1016/B978-0-443-06639-9.50012-5
  216. Stacie E. Geller, Laura Studee. . Journal of Women s Health 2005,,, 634. https://doi.org/10.1089/jwh.2005.14.634
  217. Gail B Mahady. Black Cohosh (Actaea/Cimicifuga racemosa). Treatments in Endocrinology 2005, 4 (3) , 177-184. https://doi.org/10.2165/00024677-200504030-00006
  218. Gail Mahady, Brigit Dietz, Joanna Michel, Jan Engle, Rosalie Sagraves. Chasteberry (Vitex agnus castus). 2004,,, 95-103. https://doi.org/10.1201/b13959-13
  219. Alyson Huntley. The safety of black cohosh (Actaea racemosa, Cimicifuga racemosa). Expert Opinion on Drug Safety 2004, 3 (6) , 615-623. https://doi.org/10.1517/14740338.3.6.615
  220. Susan E Fugate, Chelsea O Church. Nonestrogen Treatment Modalities for Vasomotor Symptoms Associated with Menopause. Annals of Pharmacotherapy 2004, 38 (9) , 1482-1499. https://doi.org/10.1345/aph.1D610
  221. Dalia Somjen, Esther Knoll, Jacob Vaya, Naftali Stern, Snait Tamir. Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo. The Journal of Steroid Biochemistry and Molecular Biology 2004, 91 (3) , 147-155. https://doi.org/10.1016/j.jsbmb.2004.04.003
  222. Sandra L. Gray, Brett R. Lackey, Patricia L. Tate, Melissa B. Riley, N. Dwight Camper. Mycotoxins in Root Extracts of American and Asian Ginseng Bind Estrogen Receptors α and β. Experimental Biology and Medicine 2004, 229 (6) , 560-568. https://doi.org/10.1177/153537020422900615
  223. Jane L Limer, Valerie Speirs. Phyto-oestrogens and breast cancer chemoprevention. Breast Cancer Research 2004, 6 (3) https://doi.org/10.1186/bcr781
  224. Mary Lake Polan, Richard B. Hochberg, Aileen S. Trant, Hank C.K. Wuh. Estrogen Bioassay of Ginseng Extract and ArginmaxR, a Nutritional Supplement for the Enhancement of Female Sexual Function. Journal of Women's Health 2004, 13 (4) , 427-430. https://doi.org/10.1089/154099904323087114
  225. Cornelia Bodinet, Johannes Freudenstein. Influence of marketed herbal menopause preparations on MCF-7 cell proliferation. Menopause 2004, 11 (3) , 281-289. https://doi.org/10.1097/01.GME.0000094209.15096.2B
  226. K. Hostanska, T. Nisslein, J. Freudenstein, J. Reichling, R. Saller. Cimicifuga racemosa Extract Inhibits Proliferation of Estrogen Receptor-positive and Negative Human Breast Carcinoma Cell Lines by Induction of Apoptosis. Breast Cancer Research and Treatment 2004, 84 (2) , 151-160. https://doi.org/10.1023/B:BREA.0000018413.98636.80
  227. . Effects of Porphyra tenera Extracts on Formation of Collagen Cross-link in Ovariectomized Rats. Journal of the Korean Society of Food Science and Nutrition 2004,,, 324-330. https://doi.org/10.3746/jkfn.2004.33.2.324
  228. Olga Makri, Spiridon Kintzios, Maria Barberaki. Terrestrical plant species with anticancer activity. 2004,,, 35-194. https://doi.org/10.1201/9781420023718.ch3
  229. Lorraine A. Fitzpatrick. Phytoestrogens. 2004,,, 593-614. https://doi.org/10.1007/978-1-59259-740-6_32
  230. E Parvu. Trifolium pratense for breast disease: a case series. Homeopathy 2004, 93 (1) , 45-50. https://doi.org/10.1016/j.homp.2003.09.001
  231. J. Liu, J.E. Burdette, Y. Sun, S. Deng, S.M. Schlecht, W. Zheng, D. Nikolic, G. Mahady, R.B. van Breemen, H.H.S. Fong, J.M. Pezzuto, J.L. Bolton, N.R. Farnsworth. Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry). Phytomedicine 2004, 11 (1) , 18-23. https://doi.org/10.1078/0944-7113-00331
  232. Barbara A. Pockaj, Charles L. Loprinzi, Jeff A. Sloan, Paul J. Novotny, Debra L. Barton, Andrea Hagenmaier, Huayan Zhang, George H. Lambert, Kristine A. Reeser, Joyce A. Wisbey. Pilot Evaluation of Black Cohosh for the Treatment of Hot Flashes in Women. Cancer Investigation 2004, 22 (4) , 515-521. https://doi.org/10.1081/CNV-200026394
  233. Judith S. Jacobson, Victor R. Grann. Can an Herbal Agent Replace Estrogen for Hot Flashes?. Cancer Investigation 2004, 22 (4) , 645-647. https://doi.org/10.1081/CNV-200027171
  234. &NA;. Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society. Menopause 2004, 11 (1) , 11-33. https://doi.org/10.1097/01.GME.0000108177.85442.71
  235. Jo Marsden, Nigel Sacks. The Role of Hormone Replacement Therapy and Alternative Treatments. American Journal of Cancer 2004, 3 (2) , 67-78. https://doi.org/10.2165/00024669-200403020-00001
  236. Edwin Rock, Angela DeMichele. Nutritional Approaches to Late Toxicities of Adjuvant Chemotherapy in Breast Cancer Survivors. The Journal of Nutrition 2003, 133 (11) , 3785S-3793S. https://doi.org/10.1093/jn/133.11.3785S
  237. Ermanno Federici, André Touché, Sandie Choquart, Ornella Avanti, Laurent Fay, Elizabeth Offord, Didier Courtois. High isoflavone content and estrogenic activity of 25 year-old Glycine max tissue cultures. Phytochemistry 2003, 64 (3) , 717-724. https://doi.org/10.1016/S0031-9422(03)00379-0
  238. . The Effects of Sedum sarmentosum Bunge on Collagen Content of Connective Tissues in Ovariectomized Rats. Journal of the Korean Society of Food Science and Nutrition 2003,,, 1114-1119. https://doi.org/10.3746/jkfn.2003.32.7.1114
  239. Andreana L. Ososki, Edward J. Kennelly. Phytoestrogens: a review of the present state of research. Phytotherapy Research 2003, 17 (8) , 845-869. https://doi.org/10.1002/ptr.1364
  240. Lorraine A Fitzpatrick. Alternatives to estrogen. Medical Clinics of North America 2003, 87 (5) , 1091-1113. https://doi.org/10.1016/S0025-7125(03)00116-0
  241. Rhonda K. Dailey, Anne Victoria Neale, Justin Northrup, Patricia West, Kendra L. Schwartz. Herbal Product Use and Menopause Symptom Relief in Primary Care Patients: A MetroNet Study. Journal of Women's Health 2003, 12 (7) , 633-641. https://doi.org/10.1089/154099903322404285
  242. Keith I. Block, Mark N. Mead. Immune System Effects of Echinacea, Ginseng, and Astragalus: A Review. Integrative Cancer Therapies 2003, 2 (3) , 247-267. https://doi.org/10.1177/1534735403256419
  243. F. Borrelli, A.A. Izzo, E. Ernst. Pharmacological effects of Cimicifuga racemosa. Life Sciences 2003, 73 (10) , 1215-1229. https://doi.org/10.1016/S0024-3205(03)00378-3
  244. Tieraona Low Dog, Kara L. Powell, Steven M. Weisman. Critical evaluation of the safety of Cimicifuga racemosa in menopause symptom relief. Menopause 2003, 10 (4) , 299-313. https://doi.org/10.1097/01.GME.0000056039.51813.21
  245. Adriane Fugh-Berman. “Bust Enhancing” Herbal Products. Obstetrics & Gynecology 2003, 101 (6) , 1345-1349. https://doi.org/10.1097/00006250-200306000-00032
  246. Colleen E. Piersen. Phytoestrogens in Botanical Dietary Supplements: Implications for Cancer. Integrative Cancer Therapies 2003, 2 (2) , 120-138. https://doi.org/10.1177/1534735403002002004
  247. Hubertus Jarry, Maria Metten, Barbara Spengler, Volker Christoffel, Wolfgang Wuttke. In vitro effects of the Cimicifuga racemosa extract BNO 1055. Maturitas 2003, 44 , S31-S38. https://doi.org/10.1016/S0378-5122(02)00346-8
  248. Lorraine A Fitzpatrick. Phytoestrogens—mechanism of action and effect on bone markers and bone mineral density. Endocrinology and Metabolism Clinics of North America 2003, 32 (1) , 233-252. https://doi.org/10.1016/S0889-8529(02)00085-3
  249. YoungJoo Lee, YoungRan Jin, WonChung Lim, SangMi Ji, Songho Choi, Siyoul Jang, SeungKi Lee. A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. The Journal of Steroid Biochemistry and Molecular Biology 2003, 84 (4) , 463-468. https://doi.org/10.1016/S0960-0760(03)00067-0
  250. Keith I. Block. Integrative Physician's Perspective. Integrative Cancer Therapies 2003, 2 (1) , 85-90. https://doi.org/10.1177/1534735403002001012
  251. Yuan S. Chang, Eun-Kyoung Seo, Charlotte Gyllenhaal, Keith I. Block. Panax ginseng: A Role in Cancer Therapy?. Integrative Cancer Therapies 2003, 2 (1) , 13-33. https://doi.org/10.1177/1534735403251167
  252. Richard B. van Breemen. Mass Spectrometry and Drug Discovery. 2003,,https://doi.org/10.1002/0471266949.bmc012
  253. Luling Zhang, Ikhlas A. Khan, Kristine L. Willett, Christy M. Foran. In vivo Effects of Black Cohosh and Genistein on Estrogenic Activity and Lipid Peroxidation in Japanese Medaka ( Oryzias latipes ). Journal of Herbal Pharmacotherapy 2003, 3 (3) , 33-50. https://doi.org/10.1080/J157v03n03_04
  254. Jannette Wober, Ina Weißwange, Günter Vollmer. Stimulation of alkaline phosphatase activity in Ishikawa cells induced by various phytoestrogens and synthetic estrogens. The Journal of Steroid Biochemistry and Molecular Biology 2002, 83 (1-5) , 227-233. https://doi.org/10.1016/S0960-0760(02)00252-2
  255. W Wuttke, H Jarry, S Westphalen, V Christoffel, D Seidlová-Wuttke. Phytoestrogens for hormone replacement therapy?. The Journal of Steroid Biochemistry and Molecular Biology 2002, 83 (1-5) , 133-147. https://doi.org/10.1016/S0960-0760(02)00259-5
  256. Gail B. Mahady, Daniel Fabricant, Lucas R. Chadwick, Birgit Dietz. Black Cohosh: An Alternative Therapy for Menopause?. Nutrition in Clinical Care 2002, 5 (6) , 283-289. https://doi.org/10.1046/j.1523-5408.2002.05603.x
  257. Tait D. Shanafelt, Debra L. Barton, Alex A. Adjei, Charles L. Loprinzi. Pathophysiology and Treatment of Hot Flashes. Mayo Clinic Proceedings 2002, 77 (11) , 1207-1218. https://doi.org/10.4065/77.11.1207
  258. Qing Yang, Stephen M Populo, Jianying Zhang, Guoguang Yang, Hiroyuki Kodama. Effect of Angelica sinensis on the proliferation of human bone cells. Clinica Chimica Acta 2002, 324 (1-2) , 89-97. https://doi.org/10.1016/S0009-8981(02)00210-3
  259. Alois Jungbauer, Verena Beck. Yeast reporter system for rapid determination of estrogenic activity. Journal of Chromatography B 2002, 777 (1-2) , 167-178. https://doi.org/10.1016/S1570-0232(02)00083-1
  260. Peter H.M. van de Weijer, Ronald Barentsen. Isoflavones from red clover (Promensil®) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002, 42 (3) , 187-193. https://doi.org/10.1016/S0378-5122(02)00080-4
  261. Retha Newbold a, Wendy Jefferson a, Elizabeth Padilla-Banks a, Bill Bullock b, Barry Delclos, Thomas Badger, Martin Ronis, Reza Hakkak, Sohelia Korourian, oel Rotstein a, G Sarwar Gilani b. Public Health Implications of Dietary Phytoestrogens. 2002,,https://doi.org/10.1201/9781439822197.ch12
  262. Mark A Moyad. Complementary/alternative therapies for reducing hot flashes in prostate cancer patients: reevaluating the existing indirect data from studies of breast cancer and postmenopausal women. Urology 2002, 59 (4) , 20-33. https://doi.org/10.1016/S0090-4295(02)01641-2
  263. Hong Liu, Woo-Chan Park, David J. Bentrem, Kevin P. McKian, Alexander De Los Reyes, Jessica A. Loweth, Jennifer MacGregor Schafer, James W. Zapf, V. Craig Jordan. Structure-Function Relationships of the Raloxifene-Estrogen Receptor-α Complex for Regulating Transforming Growth Factor-α Expression in Breast Cancer Cells. Journal of Biological Chemistry 2002, 277 (11) , 9189-9198. https://doi.org/10.1074/jbc.M108335200
  264. Benjamin M. Johnson, Dejan Nikolic, Richard B. van Breemen. Applications of pulsed ultrafiltration-mass spectrometry. Mass Spectrometry Reviews 2002, 21 (2) , 76-86. https://doi.org/10.1002/mas.10020
  265. E.J. Kennelly, S. Baggett, P. Nuntanakorn, A.L. Ososki, S.A. Mori, J. Duke, M. Coleton, F. Kronenberg. Analysis of thirteen populations of Black Cohosh for formononetin. Phytomedicine 2002, 9 (5) , 461-467. https://doi.org/10.1078/09447110260571733
  266. Jamie Nelsen, Catherine Ulbricht, Ernie Paul Barrette, David Sollars Mac, Candy Tsouronis, Adrianne Rogers, Samuel Basch, Sadaf Hashmi, Steve Bent, Ethan Basch. Red Clover (Trifolium pratense) Monograph. Journal of Herbal Pharmacotherapy 2002, 2 (3) , 49-72. https://doi.org/10.1080/J157v02n03_06
  267. Joanna E. Burdette, Jianghua Liu, Dan Lantvit, Eula Lim, Nancy Booth, Krishna P. L. Bhat, Samad Hedayat, Richard B. Van Breemen, Andreas I. Constantinou, John M. Pezzuto, Norman R. Farnsworth, Judy L. Bolton. Trifolium pratense (Red Clover) Exhibits Estrogenic Effects In Vivo in Ovariectomized Sprague-Dawley Rats. The Journal of Nutrition 2002, 132 (1) , 27-30. https://doi.org/10.1093/jn/132.1.27
  268. Zhiwu Fang, Scott H. Carlson, Y. F. Chen, S. Oparil, J. Michael Wyss. Estrogen depletion induces NaCl-sensitive hypertension in female spontaneously hypertensive rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2001, 281 (6) , R1934-R1939. https://doi.org/10.1152/ajpregu.2001.281.6.R1934
  269. Richard B. van Breemen. Introduction to Mass Spectrometry for Food Chemistry. Current Protocols in Food Analytical Chemistry 2001, 2 (1) , A.3A.1-A.3A.7. https://doi.org/10.1002/0471142913.fax03as02
  270. Young Geun Shin, Richard B. van Breemen. Analysis and screening of combinatorial libraries using mass spectrometry. Biopharmaceutics & Drug Disposition 2001, 22 (7-8) , 353-372. https://doi.org/10.1002/bdd.278
  271. O. Sticher. Isoprenoide als Inhaltsstoffe. ,,, 809-914. https://doi.org/10.1007/978-3-540-34281-6_23

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

OOPS

You have to login with your ACS ID befor you can login with your Mendeley account.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect

This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy.

CONTINUE