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Composition of a Chemopreventive Proanthocyanidin-Rich Fraction from Cranberry Fruits Responsible for the Inhibition of 12-O-Tetradecanoyl Phorbol-13-acetate (TPA)-Induced Ornithine Decarboxylase (ODC) Activity

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Department of Plant Biology and Department of Natural Resources and Environmental Sciences, University of Illinois, Urbana, Illinois 61801, and Department of Medical Chemistry and Pharmacognosy, University of Illinois, Chicago, Illinois 60612
Cite this: J. Agric. Food Chem. 2002, 50, 5, 1063–1069
Publication Date (Web):February 1, 2002
https://doi.org/10.1021/jf011136z
Copyright © 2002 American Chemical Society
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    Abstract

    Phenolics from the American cranberry (Vaccinium macrocarpon) were fractionated into a series of proanthocyanidins and other flavonoid compounds by vacuum chromatography on a hydrophilic, porous polyvinylic gel permeation polymer. Antioxidant activity was not restricted to a particular class of components in the extract but was found in a wide range of the fractions. Significant chemopreventive activity, as indicated by an ornithine decarboxylase assay, was localized in one particular proanthocyanidin-rich fraction from the initial fractionation procedure. Further fractionation of the active anticarcinogenic fraction revealed the following components:  seven flavonoids, mainly quercetin, myricetin, the corresponding 3-O-glycosides, (−)-epicatechin, (+)-catechin, and dimers of both gallocatechin and epigallocatechin types, and a series of oligomeric proanthocyanidins.

    Keywords: Anticarcinogenic activity; antioxidants; catechin; condensed tannins; cranberry; epicatechin; FRAP assay; ODC assay; proanthocyanidins; Vaccinium macrocarpon Ait.

    †

     Department of Plant Biology.

    *

     Author to whom correspondence should be addressed [telephone (217) 333-5154; fax (217) 244-3469; e-mail [email protected]].

    ‡

     Department of Natural Resources and Environmental Sciences.

    §

     Department of Medical Chemistry and Pharmacognosy.

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