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Anti-inflammatory Potential of Flavonoid Contents from Dried Fruit of Crataegus pinnatifida in Vitro and in Vivo

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    Anti-inflammatory Potential of Flavonoid Contents from Dried Fruit of Crataegus pinnatifida in Vitro and in Vivo
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    Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Chien Kuao N. Road, Taichung, 402 Taiwan; Departments of Pathology and Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan; and School of Applied Chemistry, College of Health Management, Chung Shan Medical University, No. 110, Sec. 1, Chien Kuao N. Road, Taichung, 402 Taiwan
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2005, 53, 2, 430–436
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    https://doi.org/10.1021/jf040231f
    Published December 17, 2004
    Copyright © 2005 American Chemical Society
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    Abstract

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    The dried fruits of Crataegus pinnatifida, a local soft drink material and medical herb, demonstrated antioxidant effect in a previous study. The present study investigates the anti-inflammatory potential of flavonoid contents from dried fruit of C. pinnatifida (CF-Fs). The preliminary investigation showed that CF-Fs (0.25−0.75 mg/mL) decreased the release of PGE2 and nitric oxide as induced by lipopolysaccharide (LPS, an endotoxin) in macrophage RAW 264.7 cells. The in vivo assay showed that pretreatment of rats with CF-Fs (50−200 mg/kg dosed by gavage) for 5 days significantly decreased the serum levels of the hepatic enzyme markers alanine aminotransferase and aspartate aminotransferase induced by the 6-h treatment with LPS (ip; 5 mg/kg). Histopathological evaluation of the rat livers revealed that CF-Fs reduced the incidence of liver lesions such as neutrophil infiltration and necrosis induced by LPS. Furthermore, it was found that pretreatment with CF-Fs decreased the hepatic expression of iNOS and COX-2 induced by LPS in rats. These results demonstrate that CF-Fs present anti-inflammatory potential in vitro and in vivo and that they may play a role in hepatoprotection.

    Keywords: Crataegus pinnatifida; macrophage; lipopolysaccharide; inducible nitric oxide synthase; cyclooxygenase-2

    Copyright © 2005 American Chemical Society

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    †

     Institute of Biochemistry and Biotechnology.

    ‡

     Department of Pathology.

    #

     Department of Laboratory.

    *

     Corresponding author (telephone 886-4-24730022; fax 886-4-23248189; e-mail [email protected]).

    §

     School of Applied Chemistry.

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    Cite this: J. Agric. Food Chem. 2005, 53, 2, 430–436
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    Published December 17, 2004
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