ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
CONTENT TYPES

Figure 1Loading Img

Cinnamon Bark Proanthocyanidins as Reactive Carbonyl Scavengers To Prevent the Formation of Advanced Glycation Endproducts

View Author Information
School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, Peopleʼs Republic of China; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), Hunan Normal University, Changsha, Peopleʼs Republic of China; Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901; and Graduate Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan
* Author to whom correspondence should be addressed (telephone 22990338 ; fax 22990340; e-mail [email protected]).
†The University of Hong Kong.
§Hunan Normal University.
#Rutgers University.
⊥National Taiwan University.
Cite this: J. Agric. Food Chem. 2008, 56, 6, 1907–1911
Publication Date (Web):February 20, 2008
https://doi.org/10.1021/jf073065v
Copyright © 2008 American Chemical Society

    Article Views

    2830

    Altmetric

    -

    Citations

    LEARN ABOUT THESE METRICS
    Other access options

    Abstract

    Cinnamon bark has been reported to be effective in the alleviation of diabetes through its antioxidant and insulin-potentiating activities. In this study, the inhibitory effect of cinnamon bark on the formation of advanced glycation endproducts (AGEs) was investigated in a bovine serum albumin (BSA)−glucose model. Several phenolic compounds, such as catechin, epicatechin, and procyanidin B2, and phenol polymers were identified from the subfractions of aqueous cinnamon extract. These compounds showed significant inhibitory effects on the formation of AGEs. Their antiglycation activities were not only brought about by their antioxidant activities but also related to their trapping abilities of reactive carbonyl species such as methylglyoxal (MGO), an intermediate reactive carbonyl of AGE formation. Preliminary study on the reaction between MGO and procyanidin B2 revealed that MGO−procyanidin B2 adducts are primary products which are supposed to be stereoisomers. This is the first report that proanthocyanidins can effectively scavenge reactive carbonyl species and thus inhibit the formation of AGEs. As proanthocyanidins behave in a similar fashion as aminoguanidine (AG), the first AGE inhibitor explored in clinical trials, they show great potential to be developed as agents to alleviate diabetic complications.

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    Cited By

    This article is cited by 191 publications.

    1. Xiaoyun Jiang, Dingmin Zhang, Yongling Lu, Lishuang Lv. Acrolein-Trapping Mechanism of Theophylline in Green Tea, Coffee, and Cocoa: Speedy and Successful. Journal of Agricultural and Food Chemistry 2020, 68 (36) , 9718-9724. https://doi.org/10.1021/acs.jafc.0c03895
    2. Huilin Liu, Xiaomo Chen, Dianwei Zhang, Jing Wang, Shuo Wang, and Baoguo Sun . Effects of Highland Barley Bran Extract Rich in Phenolic Acids on the Formation of Nε-Carboxymethyllysine in a Biscuit Model. Journal of Agricultural and Food Chemistry 2018, 66 (8) , 1916-1922. https://doi.org/10.1021/acs.jafc.7b04957
    3. Xiaoming Li, Tiesong Zheng, Shengmin Sang, and Lishuang Lv . Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal. Journal of Agricultural and Food Chemistry 2014, 62 (50) , 12152-12158. https://doi.org/10.1021/jf504132x
    4. Nozomi Nagahora, Yoshiaki Ito, and Takashi Nagasawa . Dietary Chinese Quince Polyphenols Suppress Generation of α-Dicarbonyl Compounds in Diabetic KK-Ay Mice. Journal of Agricultural and Food Chemistry 2013, 61 (27) , 6629-6635. https://doi.org/10.1021/jf401231j
    5. So-Youn Jeon , Sejong Oh , Eungseok Kim , Jee-Young Imm . α-Glucosidase Inhibiton and Antiglycation Activity of Laccase-Catalyzed Catechin Polymers. Journal of Agricultural and Food Chemistry 2013, 61 (19) , 4577-4584. https://doi.org/10.1021/jf400791r
    6. Liang Chen, Peng Sun, Ting Wang, Kaixian Chen, Qi Jia, Heyao Wang, and Yiming Li . Diverse Mechanisms of Antidiabetic Effects of the Different Procyanidin Oligomer Types of Two Different Cinnamon Species on db/db Mice. Journal of Agricultural and Food Chemistry 2012, 60 (36) , 9144-9150. https://doi.org/10.1021/jf3024535
    7. Te-Yu Hu, Cheng-Ling Liu, Charng-Cherng Chyau, and Miao-Lin Hu . Trapping of Methylglyoxal by Curcumin in Cell-Free Systems and in Human Umbilical Vein Endothelial Cells. Journal of Agricultural and Food Chemistry 2012, 60 (33) , 8190-8196. https://doi.org/10.1021/jf302188a
    8. Haiyan Liu and Liwei Gu . Phlorotannins from Brown Algae (Fucus vesiculosus) Inhibited the Formation of Advanced Glycation Endproducts by Scavenging Reactive Carbonyls. Journal of Agricultural and Food Chemistry 2012, 60 (5) , 1326-1334. https://doi.org/10.1021/jf204112f
    9. Xiaofang Peng, Jinyu Ma, Jianfei Chao, Zheng Sun, Raymond Chuen-Chung Chang, Iris Tse, Edmund T. S. Li, Feng Chen and Mingfu Wang . Beneficial Effects of Cinnamon Proanthocyanidins on the Formation of Specific Advanced Glycation Endproducts and Methylglyoxal-Induced Impairment on Glucose Consumption. Journal of Agricultural and Food Chemistry 2010, 58 (11) , 6692-6696. https://doi.org/10.1021/jf100538t
    10. Ka-Wing Cheng, Jian-Jun Shi, Shi-Yi Ou, Mingfu Wang and Yue Jiang . Effects of Fruit Extracts on the Formation of Acrylamide in Model Reactions and Fried Potato Crisps. Journal of Agricultural and Food Chemistry 2010, 58 (1) , 309-312. https://doi.org/10.1021/jf902529v
    11. Stéphanie Dudonné, Xavier Vitrac, Philippe Coutière, Marion Woillez and Jean-Michel Mérillon . Comparative Study of Antioxidant Properties and Total Phenolic Content of 30 Plant Extracts of Industrial Interest Using DPPH, ABTS, FRAP, SOD, and ORAC Assays. Journal of Agricultural and Food Chemistry 2009, 57 (5) , 1768-1774. https://doi.org/10.1021/jf803011r
    12. Takashi Tanaka, Yosuke Matsuo, Yuko Yamada and Isao Kouno. Structure of Polymeric Polyphenols of Cinnamon Bark Deduced from Condensation Products of Cinnamaldehyde with Catechin and Procyanidins. Journal of Agricultural and Food Chemistry 2008, 56 (14) , 5864-5870. https://doi.org/10.1021/jf800921r
    13. Edinilze S. C. Oliveira, Flávia L. D. Pontes, Leonard D. R. Acho, Bárbara Janaína P. da Silva, Alessandro S. do Rosário, Francisco Célio M. Chaves, Francinete R. Campos, Jaqueline de A. Bezerra, Emerson S. Lima, Marcos B. Machado. NMR and multivariate methods: Identification of chemical markers in extracts of pedra‐ume‐caá and their antiglycation, antioxidant, and enzymatic inhibition activities. Phytochemical Analysis 2024, 35 (3) , 552-566. https://doi.org/10.1002/pca.3312
    14. Seyed Morteza Tayebi, Saleh Motaghinasab, Rasoul Eslami, Somayeh Ahmadabadi, Aref Basereh, Iman Jamhiri. Impact of 8-week cold-and warm water swimming training combined with cinnamon consumption on serum METRNL, HDAC5, and insulin resistance levels in diabetic male rats. Heliyon 2024, 10 (8) , e29742. https://doi.org/10.1016/j.heliyon.2024.e29742
    15. Pronay Mandal, S. K. Kanthlal. Vascular targeting of constituents of commonly used spices and its molecular interactions in endothelial dysfunction: A review. Phytochemistry Reviews 2024, 23 https://doi.org/10.1007/s11101-024-09939-7
    16. Hebat Bakhach, Monika Nuffer, Shasta Tall Bull, Wesley Nuffer. A Systematic Review Evaluating Cinnamon's Effects on Glucose Utilizing a Ranking System to Assess Bias and Study Quality. Journal of Medicinal Food 2024, 1 https://doi.org/10.1089/jmf.2023.0277
    17. Lili Xu, Hui Liu, Lezhen Dong, Yahui Liu, Lingyi Liu, Hui Cao, Wei Wang, Lianliang Liu. Research advance on AGEs generation, detection, influencing factors and inhibition mechanism in bakery products processing. Food Bioscience 2024, 57 , 103404. https://doi.org/10.1016/j.fbio.2023.103404
    18. Beena Levakumar Abhirami, Anithakumari Aswathy Krishna, Abdul Rahim Muhammed Jasim, Alaganandam Kumaran. Acacia leucophloea (Roxb.). Willd.: Multi-targeted therapeutic efficacy against type 2 diabetes mellitus. European Journal of Integrative Medicine 2024, 66 , 102344. https://doi.org/10.1016/j.eujim.2024.102344
    19. Kilambi Pundarikakshudu, Madhavi G. Patel, Priya A. Shah. An overview of some Indian vegetables, fruits, and spices effective in diabetes and metabolic disorders: Current status and future scenarios. 2024, 75-139. https://doi.org/10.1016/B978-0-323-95719-9.00004-5
    20. Vinod Kumar Gauttam, Kavita Munjal, Hitesh Chopra, Aftab Ahmad, Mahesh Kumar Rana, Mohammad Amjad Kamal. A Mechanistic Review on Therapeutic Potential of Medicinal Plants and their Pharmacologically Active Molecules for Targeting Metabolic Syndrome. Current Pharmaceutical Design 2024, 30 (1) , 10-30. https://doi.org/10.2174/0113816128274446231220113957
    21. Baoping Shi, Huaixu Wang, Asad Nawaz, Iftikhar Ali Khan, Qi Wang, Danyue Zhao, Ka‐Wing Cheng. Dual functional roles of nutritional additives in nutritional fortification and safety of thermally processed food: Potential, limitations, and perspectives. Comprehensive Reviews in Food Science and Food Safety 2024, 23 (1) https://doi.org/10.1111/1541-4337.13268
    22. Yanlei Gao, Haonan Shi, Qing Xiong, Runlin Wu, Yang Hu, Ru Liu. A novel strategy for inhibiting AGEs in fried fish cakes: Grape seed extract surimi slurry coating. Food Control 2023, 154 , 109948. https://doi.org/10.1016/j.foodcont.2023.109948
    23. Jessica Brzezowska, Aneta Wojdyło, Paulina Nowicka, Igor Piotr Turkiewicz, Karolina Tkacz, Anna Michalska-Ciechanowska. How do the phenolics and amino acids affect the antioxidant, antidiabetic and antiglycation properties of selected fruit powders?. LWT 2023, 189 , 115454. https://doi.org/10.1016/j.lwt.2023.115454
    24. Zubair Hussain, Muawuz Ijaz, Yejun Zhang, Yuqiang Bai, Chengli Hou, Xin Li, Dequan Zhang. Combined Effect of Cinnamon Bark Oil and Packaging Methods on Quality of Fresh Lamb Meat Patties during Storage at 4 °C. Foods 2023, 12 (15) , 2916. https://doi.org/10.3390/foods12152916
    25. Somayyeh Mojtabavi, Amin Saed, Sajad Aboulfazli, Ali Kheirandish, Mojtaba Najafi, Majid Jafari-Sabet, Ali Ziar, Nima Ebrahimi, Seyedeh Habibeh Mirmajidi, Ramin Ataee. Evaluation of curcumin effect on Il6, Sirt1, TNFα and NFkB expression of liver tissues in diabetic mice with STZ. Journal of Diabetes & Metabolic Disorders 2023, 22 (1) , 205-215. https://doi.org/10.1007/s40200-022-01090-4
    26. Divya Shaji, Abhinav Das, Ryo Suzuki, Yoshinobu Nagura, Haruna Sabishiro, Noriyuki Kurita. Proposal of novel ApoE4 inhibitors from the natural spice Cinnamon for the treatment of Alzheimer's disease: Ab initio molecular simulations. Biophysical Chemistry 2023, 296 , 106990. https://doi.org/10.1016/j.bpc.2023.106990
    27. Shahid Rasool, Bassam Al Meslmani, Muaaz Alajlani. Determination of Hypoglycemic, Hypolipidemic and Nephroprotective Effects of Berberis Calliobotrys in Alloxan-Induced Diabetic Rats. Molecules 2023, 28 (8) , 3533. https://doi.org/10.3390/molecules28083533
    28. Slim Blidi, Antonio Dario Troise, Moira Ledbetter, Sarah Cottin, Keith Sturrock, Sabrina De Pascale, Andrea Scaloni, Alberto Fiore. α-Dicarbonyl compounds trapping ability and antiglycative effect of high-molecular-weight brewer's spent grain melanoidins. LWT 2023, 180 , 114679. https://doi.org/10.1016/j.lwt.2023.114679
    29. Sultan Alouffi, Farah Maarfi, Mohd Yasir Khan, Saif Khan, M. Salman Khan, Saheem Ahmad. Antiglycation and chemopreventive effects of leaf extracts of Ficus palmata Forssk. found in the Hail region of Saudi Arabia. Biotechnology and Genetic Engineering Reviews 2023, 2022 , 1-17. https://doi.org/10.1080/02648725.2023.2196477
    30. Hüseyin Boz. N ϵ ‐(carboxymethyl)lysine in bakery products: A review. Journal of Food Science 2023, 88 (3) , 901-908. https://doi.org/10.1111/1750-3841.16475
    31. Francisco J. Hidalgo, Rosario Zamora. Ketone-phenol reactions and the promotion of aromatizations by food phenolics. Food Chemistry 2023, 404 , 134554. https://doi.org/10.1016/j.foodchem.2022.134554
    32. Pei Hsuan Lee, Ii Hsuan Lin, Pao Chuan Hsieh. Measurement of bioactive compounds, antioxidants, and α-glucosidase and α-amylase inhibitory effects of Cinnamomum osmophloeum Kanehira extracted with various solvents. Measurement: Food 2023, 9 , 100069. https://doi.org/10.1016/j.meafoo.2022.100069
    33. Toshiyuki Oshitari. Advanced Glycation End-Products and Diabetic Neuropathy of the Retina. International Journal of Molecular Sciences 2023, 24 (3) , 2927. https://doi.org/10.3390/ijms24032927
    34. Omid Tanzidi-Roodi, Fatemeh Jafari, Mina AkbariRad, Javad Asili, Sepideh Elyasi. Evaluation of a new herbal formulation (Viabet®) efficacy in patients with type 2 diabetes as an adjuvant to metformin: A randomized, triple-blind, placebo-controlled clinical trial. Journal of Herbal Medicine 2023, 37 , 100617. https://doi.org/10.1016/j.hermed.2022.100617
    35. Nupur Mehrotra, Sara Anees Khan, Kaustubh Jadhav. Selected Indian Medicinal and Aromatic Plants for Prophylactic Therapy. 2023, 253-277. https://doi.org/10.1007/978-3-031-44914-7_13
    36. A. Thahira Banu, Janeline Lunghar. Cinnamon as a potential nutraceutical and functional food ingredient. 2023, 257-278. https://doi.org/10.1016/B978-0-323-90794-1.00021-1
    37. Wesley Nuffer, Shasta Tall Bull, Hebat Bakhach, Monika Nuffer. Sweetly Improving Sugars? Reviewing Cinnamon's Effects on Blood Glucose. Journal of Medicinal Food 2023, 26 (1) , 68-73. https://doi.org/10.1089/jmf.2022.0073
    38. Morvarid Noormohammadi, Farzad Shidfar. Natural Compounds with Pharmacological Properties in Clinical Trials. 2023, 1097-1116. https://doi.org/10.1007/978-3-031-28780-0_46
    39. Wenge Zheng, Huijuan Li, Yuyo Go, Xi Hui (Felicia) Chan, Qing Huang, Jianxin Wu. Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors. Nutrients 2022, 14 (21) , 4588. https://doi.org/10.3390/nu14214588
    40. Pratibha Atul Daroi, Shrikant Ninaji Dhage, Archana Ramesh Juvekar. p-Coumaric acid protects against D-galactose induced neurotoxicity by attenuating neuroinflammation and apoptosis in mice brain. Metabolic Brain Disease 2022, 37 (7) , 2569-2579. https://doi.org/10.1007/s11011-022-01007-3
    41. Indrapal Singh Aidhen, Sriranjani Srikanth, Heera Lal. The Emerging Promise with O/C‐Glycosides of Important Dietary Phenolic Compounds. European Journal of Organic Chemistry 2022, 2022 (35) https://doi.org/10.1002/ejoc.202200758
    42. Mengna Zhao, Ying Li, Xue Bai, Jia Feng, Xiufang Xia, Fangfei Li. Inhibitory Effect of Guava Leaf Polyphenols on Advanced Glycation End Products of Frozen Chicken Meatballs (−18 °C) and Its Mechanism Analysis. Foods 2022, 11 (16) , 2509. https://doi.org/10.3390/foods11162509
    43. Nianjie Feng, Fei Tang, Chuanqin Hu, Lei Cheng, Zhejuan Lv, Yang Shen, Wei Li, Gengsheng Xiao, Hao Dong, Qian Wu. Debate: Could the litchi pericarp oligomeric procyanidins bioconverted by Lactobacillus plantarum increase the inhibitory capacity on advanced glycation end products?. Frontiers in Nutrition 2022, 9 https://doi.org/10.3389/fnut.2022.961078
    44. Shenwan Wang, Lili Zheng, Xiaoyan Zheng, Yang Yang, Dao Xiao, Haide Zhang, Binling Ai, Zhanwu Sheng. Chitosan inhibits advanced glycation end products formation in chemical models and bakery food. Food Hydrocolloids 2022, 128 , 107600. https://doi.org/10.1016/j.foodhyd.2022.107600
    45. Maria Leonor Silva, Maria Alexandra Bernardo, Jaipaul Singh, Maria Fernanda de Mesquita. Cinnamon as a Complementary Therapeutic Approach for Dysglycemia and Dyslipidemia Control in Type 2 Diabetes Mellitus and Its Molecular Mechanism of Action: A Review. Nutrients 2022, 14 (13) , 2773. https://doi.org/10.3390/nu14132773
    46. Edinilze S.C. Oliveira, Leonard D.R. Acho, Bárbara Janaína P. da Silva, Ruben Dario Morales-Gamba, Flávia L.D. Pontes, Alessandro S. do Rosário, Jaqueline de A. Bezerra, Francinete R. Campos, José Fernando M. Barcellos, Emerson S. Lima, Marcos B. Machado. Hypoglycemic effect and toxicity of the dry extract of Eugenia biflora (L.) DC. leaves. Journal of Ethnopharmacology 2022, 293 , 115276. https://doi.org/10.1016/j.jep.2022.115276
    47. Qian Wu, Yinggang Liang, Yingfei Kong, Fen Zhang, Yingna Feng, Yu Ouyang, Chao Wang, Zhiqiang Guo, Juan Xiao, Nianjie Feng. Role of glycated proteins in vivo: Enzymatic glycated proteins and non-enzymatic glycated proteins. Food Research International 2022, 155 , 111099. https://doi.org/10.1016/j.foodres.2022.111099
    48. Remzi Çelik, Handan Mert, Bahat Comba, Nihat Mert. Effects of cinnamaldehyde on glucose-6-phosphate dehydrogenase activity, some biochemical and hematological parameters in diabetic rats. Biomarkers 2022, 27 (3) , 270-277. https://doi.org/10.1080/1354750X.2022.2032351
    49. Allisson Benatti Justino, Heitor Cappato Guerra Silva, Rodrigo Rodrigues Franco, Isabela de Oliveira Cavalcante Pimentel, Nicole Fernandes Silva, André Lopes Saraiva, Foued Salmen Espindola. Flavonoids and proanthocyanidins-rich fractions from Eugenia dysenterica fruits and leaves inhibit the formation of advanced glycation end-products and the activities of α-amylase and α-glucosidase. Journal of Ethnopharmacology 2022, 285 , 114902. https://doi.org/10.1016/j.jep.2021.114902
    50. Robert Mutagwanya, Christine Magala Nyago, Frederick Nelson Nakwagala. Effect of diabetes nutrition education on the dietary feeding practices and lifestyle of type 2 diabetic patients. European Journal of Clinical Nutrition 2022, 76 (2) , 270-276. https://doi.org/10.1038/s41430-021-00940-3
    51. Saheem Ahmad, Sultan Alouffi, Saif Khan, Mahvish Khan, Rihab Akasha, Jalaluddin Mohammad Ashraf, Mohd Farhan, Uzma Shahab, Mohd Yasir Khan, . Physicochemical Characterization of In Vitro LDL Glycation and Its Inhibition by Ellagic Acid (EA): An In Vivo Approach to Inhibit Diabetes in Experimental Animals. BioMed Research International 2022, 2022 , 1-15. https://doi.org/10.1155/2022/5583298
    52. Sharat Sarmah, Atanu Singha Roy. A review on prevention of glycation of proteins: Potential therapeutic substances to mitigate the severity of diabetes complications. International Journal of Biological Macromolecules 2022, 195 , 565-588. https://doi.org/10.1016/j.ijbiomac.2021.12.041
    53. Li Zhao, Xiaoling Zhu, Yue Yu, Langzhi He, Yubing Li, Li Zhang, Rui Liu. Comprehensive analysis of the anti-glycation effect of peanut skin extract. Food Chemistry 2021, 362 , 130169. https://doi.org/10.1016/j.foodchem.2021.130169
    54. Arleta Dołowacka-Jóźwiak, Adam Matkowski, Izabela Nawrot-Hadzik. Antiglycoxidative Properties of Extracts and Fractions from Reynoutria Rhizomes. Nutrients 2021, 13 (11) , 4066. https://doi.org/10.3390/nu13114066
    55. Solomon Idowu, Ademola Ezekiel Adekoya, Oluwakemi Osarumwense Igiehon, Anthony Temitope Idowu. Clove (Syzygium aromaticum) spices: a review on their bioactivities, current use, and potential application in dairy products. Journal of Food Measurement and Characterization 2021, 15 (4) , 3419-3435. https://doi.org/10.1007/s11694-021-00915-9
    56. Fida F. Al Adel, M. A. Gondal, Abul Lais, Reem K. Al-Dakheel, M. A. Dastageer. Spectrochemical Analysis of Cinnamon Using Advanced Analytical XPS and LIBS Techniques. Arabian Journal for Science and Engineering 2021, 46 (6) , 5993-6006. https://doi.org/10.1007/s13369-020-05251-6
    57. María Dolores del Castillo, Amaia Iriondo-DeHond, Maite Iriondo-DeHond, Ileana Gonzalez, Alejandra Medrano, Rosana Filip, Jaime Uribarri. Healthy eating recommendations: good for reducing dietary contribution to the body’s advanced glycation/lipoxidation end products pool?. Nutrition Research Reviews 2021, 34 (1) , 48-63. https://doi.org/10.1017/S0954422420000141
    58. Javad Sharifi-Rad, Abhijit Dey, Niranjan Koirala, Shabnum Shaheen, Nasreddine El Omari, Bahare Salehi, Tamar Goloshvili, Nathália Cristina Cirone Silva, Abdelhakim Bouyahya, Sara Vitalini, Elena M. Varoni, Miquel Martorell, Anna Abdolshahi, Anca Oana Docea, Marcello Iriti, Daniela Calina, Francisco Les, Víctor López, Constantin Caruntu. Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits. Frontiers in Pharmacology 2021, 12 https://doi.org/10.3389/fphar.2021.600139
    59. Roghayeh Siahbalaei, Gholamreza Kavoosi. In Vitro Anti-diabetic Activity of Free Amino Acid and Protein Amino Acid Extracts from Four Iranian Medicinal Plants. Iranian Journal of Science and Technology, Transactions A: Science 2021, 45 (2) , 443-454. https://doi.org/10.1007/s40995-020-01031-x
    60. Vítor Spínola, Paula C. Castilho. Assessing the In Vitro Inhibitory Effects on Key Enzymes Linked to Type-2 Diabetes and Obesity and Protein Glycation by Phenolic Compounds of Lauraceae Plant Species Endemic to the Laurisilva Forest. Molecules 2021, 26 (7) , 2023. https://doi.org/10.3390/molecules26072023
    61. Huawei Yu, Panpan Zhang, Hongbing Liu, Xiaojuan Sun, Jichao Liang, Lijuan Sun, Yong Chen. Hypoglycemic activity of Origanum vulgare L. and its main chemical constituents identified with HPLC-ESI-QTOF-MS. Food & Function 2021, 12 (6) , 2580-2590. https://doi.org/10.1039/D0FO03166F
    62. O.I. Adeniran, M.A. Mogale. In vitro inhibitory effect of selected parts of Moringa oleifera against the formation of major types of advanced glycation end-products. Acta Horticulturae 2021, 5 (1306) , 135-142. https://doi.org/10.17660/ActaHortic.2021.1306.16
    63. Roghayeh Siahbalaei, Gholamreza Kavoosi. Chemical composition and evaluation of anti-diabetic activity of oil extracts from Oliveria decumbens, Thymus kotschyanus, Trachyspermum ammi and Zataria multiflora. Journal of Food Measurement and Characterization 2021, 15 (1) , 276-287. https://doi.org/10.1007/s11694-020-00642-7
    64. Guna Ravichandran, Dinesh Kumar Lakshmanan, Selvakumar Murugesan, Abbirami Elangovan, Namakkal S. Rajasekaran, Sivasudha Thilagar. Attenuation of protein glycation by functional polyphenolics of dragon fruit (Hylocereus polyrhizus); an in vitro and in silico evaluation. Food Research International 2021, 140 , 110081. https://doi.org/10.1016/j.foodres.2020.110081
    65. Shehwaz Anwar, Shifa Khan, Ahmad Almatroudi, Amjad Ali Khan, Mohammed A. Alsahli, Saleh A. Almatroodi, Arshad Husain Rahmani. A review on mechanism of inhibition of advanced glycation end products formation by plant derived polyphenolic compounds. Molecular Biology Reports 2021, 48 (1) , 787-805. https://doi.org/10.1007/s11033-020-06084-0
    66. Espérance Moine, Manel Boukhallat, David Cia, Nathalie Jacquemot, Laurent Guillou, Thierry Durand, Joseph Vercauteren, Philippe Brabet, Céline Crauste. New lipophenols prevent carbonyl and oxidative stresses involved in macular degeneration. Free Radical Biology and Medicine 2021, 162 , 367-382. https://doi.org/10.1016/j.freeradbiomed.2020.10.316
    67. Alpana Pande, Lakshmi Mundkur, Anurag Pande, Sarang Bani, Muhammed Majeed, . Antiglycation potential of commercial available extracts of two Indian medicinal plants: Pterocarpus marsupium and Artocarpus lakoocha using advanced glycation end products (AGE) competitive fluorescence assay. Cogent Food & Agriculture 2021, 7 (1) https://doi.org/10.1080/23311932.2021.1914907
    68. Roghayeh Siahbalaei, Gholamreza Kavoosi, Raheleh Shakeri. In vitro antioxidant and antidiabetic activity of essential oils encapsulated in gelatin‐pectin particles against sugar, lipid and protein oxidation and amylase and glucosidase activity. Food Science & Nutrition 2020, 8 (12) , 6457-6466. https://doi.org/10.1002/fsn3.1935
    69. Nair Anaga, Basavaraja D, Billu Abraham, P. Nisha, Sunil Varughese, Purushothaman Jayamurthy, Sasidhar B. Somappa. Advanced glycation end-products (AGE) trapping agents: Design and synthesis of nature inspired indeno[2,1-c]pyridinones. Bioorganic Chemistry 2020, 105 , 104375. https://doi.org/10.1016/j.bioorg.2020.104375
    70. Mina Davari, Reza Hashemi, Parvin Mirmiran, Mehdi Hedayati, Shamim Sahranavard, Shohreh Bahreini, Rahele Tavakoly, Behrouz Talaei. Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial. Nutrition Journal 2020, 19 (1) https://doi.org/10.1186/s12937-019-0518-3
    71. Jiayang Gao, Yang Sun, Li Li, Qian Zhou, Mingfu Wang. The antiglycative effect of apple flowers in fructose/glucose-BSA models and cookies. Food Chemistry 2020, 330 , 127170. https://doi.org/10.1016/j.foodchem.2020.127170
    72. Maryam Aminizadeh, Gholamreza Kavoosi, Amina Kariminia. In vitro and ex vivo anti-diabetic and anti-hyperglycemic properties of Zataria multiflora essential oil. Molecular Biology Reports 2020, 47 (10) , 7805-7813. https://doi.org/10.1007/s11033-020-05857-x
    73. Remah Sobhy, Qian Shen, Ahmed A. Abd-Elrahman, Ibrahim Khalifa, Hongshan Liang, Bin Li. In vitro evaluation of anti-methylglyoxal/glyoxal activity of three phytosterols using glycated bovine serum albumin models. Steroids 2020, 161 , 108678. https://doi.org/10.1016/j.steroids.2020.108678
    74. Xiaoxi Liao, Andrew A. Brock, Brittany T. Jackson, Phillip Greenspan, Ronald B. Pegg. The cellular antioxidant and anti-glycation capacities of phenolics from Georgia peaches. Food Chemistry 2020, 316 , 126234. https://doi.org/10.1016/j.foodchem.2020.126234
    75. Wawaimuli Arozal, Melva Louisa, Vivian Soetikno. Selected Indonesian Medicinal Plants for the Management of Metabolic Syndrome: Molecular Basis and Recent Studies. Frontiers in Cardiovascular Medicine 2020, 7 https://doi.org/10.3389/fcvm.2020.00082
    76. Majid Khan, Huilin Liu, Jing Wang, Baoguo Sun. Inhibitory effect of phenolic compounds and plant extracts on the formation of advance glycation end products: A comprehensive review. Food Research International 2020, 130 , 108933. https://doi.org/10.1016/j.foodres.2019.108933
    77. Annayara Celestina Ferreira Fernandes, Isabela Mateus Martins, Débora Kono Taketa Moreira, Gabriela Alves Macedo. Use of agro‐industrial residues as potent antioxidant, antiglycation agents, and α‐amylase and pancreatic lipase inhibitory activity. Journal of Food Processing and Preservation 2020, 44 (4) https://doi.org/10.1111/jfpp.14397
    78. Qian Wu, Kuoquan Zhao, Yuanyuan Chen, Jinsong Xiao, Mengzhou Zhou, Dongshen Li, Nianjie Feng, Chao Wang. Ethanol as an accelerator for the formation of advanced glycation end products in glucose-lysine solution. LWT 2020, 124 , 109135. https://doi.org/10.1016/j.lwt.2020.109135
    79. Fazle Rabbi, Amir Zada, Amna Nisar, Muhammad Sohail, Saifullah Khan Khalil, Waheed Ali Shah. Bioassay-Guided Isolation, Identification of Compounds from Sterculia diversifolia and Investigation of Their Anti-Glycation and Antioxidant Activities. Pharmaceutical Chemistry Journal 2020, 53 (12) , 1137-1144. https://doi.org/10.1007/s11094-020-02137-7
    80. Yue Chen, Leilei Xu, Yajie Wang, Zhongqin Chen, Min Zhang, Pharkphoom Panichayupakaranant, Haixia Chen. Study on the active polyphenol constituents in differently colored Rubus Chingii Hu and the structure-activity relationship of the main ellagitannins and ellagic acid. LWT 2020, 121 , 108967. https://doi.org/10.1016/j.lwt.2019.108967
    81. Séverine Boisard, Youcef Shahali, Marie‐Christine Aumond, Séverine Derbré, Patricia Blanchard, Maryam Dadar, Anne‐Marie Le Ray, Pascal Richomme. Anti‐AGE activity of poplar‐type propolis: mechanism of action of main phenolic compounds. International Journal of Food Science & Technology 2020, 55 (2) , 453-460. https://doi.org/10.1111/ijfs.14284
    82. G. A. S. Premakumara, W. P. K. M. Abeysekera. Pharmacological Properties of Ceylon Cinnamon. 2020, 307-325. https://doi.org/10.1007/978-3-030-54426-3_12
    83. Lee Suan Chua, Farah Izana Abdullah, Mohd Azrie Awang. Potential of natural bioactive C-glycosyl flavones for antidiabetic properties. 2020, 241-261. https://doi.org/10.1016/B978-0-12-817903-1.00008-5
    84. Nicholas J. Hayward, Gordon J. McDougall, Sara Farag, J. William Allwood, Ceri Austin, Fiona Campbell, Graham Horgan, Viren Ranawana. Cinnamon Shows Antidiabetic Properties that Are Species-Specific: Effects on Enzyme Activity Inhibition and Starch Digestion. Plant Foods for Human Nutrition 2019, 74 (4) , 544-552. https://doi.org/10.1007/s11130-019-00760-8
    85. Parvin Mirmiran, Mina Davari, Reza Hashemi, Mehdi Hedayati, Shamim Sahranavard, Shohreh Bahreini, Rahele Tavakoly, Behrouz Talaei. A randomized controlled trial to determining the effect of cinnamon on the plasma levels of soluble forms of vascular adhesion molecules in type 2 diabetes mellitus. European Journal of Clinical Nutrition 2019, 73 (12) , 1605-1612. https://doi.org/10.1038/s41430-019-0523-9
    86. Mengyu Sun, Zhou Shen, Qian Zhou, Mingfu Wang. Identification of the antiglycative components of Hong Dou Shan (Taxus chinensis) leaf tea. Food Chemistry 2019, 297 , 124942. https://doi.org/10.1016/j.foodchem.2019.06.009
    87. Weixin Wang, Rui Yang, Huan Yao, Yun Wu, Weidong Pan, Ai-Qun Jia. Inhibiting the formation of advanced glycation end-products by three stilbenes and the identification of their adducts. Food Chemistry 2019, 295 , 10-15. https://doi.org/10.1016/j.foodchem.2019.02.137
    88. Walimuni Prabhashini Kaushalya Mendis Abeysekera, Sirimal Premakumara Galbada Arachchige, Walimuni Kanchana Subhashini Mendis Abeysekera, Wanigasekera Daya Ratnasooriya, Hela Medawattegedara Upeksha Indeewari Medawatta. Antioxidant and Glycemic Regulatory Properties Potential of Different Maturity Stages of Leaf of Ceylon Cinnamon ( Cinnamomum zeylanicum Blume) In Vitro. Evidence-Based Complementary and Alternative Medicine 2019, 2019 , 1-10. https://doi.org/10.1155/2019/2693795
    89. Ana R. Silva, Clara Grosso, Cristina Delerue-Matos, João M. Rocha. Comprehensive review on the interaction between natural compounds and brain receptors: Benefits and toxicity. European Journal of Medicinal Chemistry 2019, 174 , 87-115. https://doi.org/10.1016/j.ejmech.2019.04.028
    90. S M Mas’adah, Sunarno, M A Djaelani. Application of cinnamon and gotu kola supplements for increasing quail hematological status (Coturnixcoturnix-australica). Journal of Physics: Conference Series 2019, 1217 (1) , 012163. https://doi.org/10.1088/1742-6596/1217/1/012163
    91. Rashmi Saxena Pal, Yogendra Pal, Pranay Wal, Ankita Wal. Standardization and Detailed Aspects of Chopchinyadi Churna: A Potent Anti-Arthritic Medicine. Open Medicine Journal 2019, 6 (1) , 19-25. https://doi.org/10.2174/1874220301906010019
    92. Małgorzata Starowicz, Henryk Zieliński. Inhibition of Advanced Glycation End-Product Formation by High Antioxidant-Leveled Spices Commonly Used in European Cuisine. Antioxidants 2019, 8 (4) , 100. https://doi.org/10.3390/antiox8040100
    93. Yuzhen Wang, Huilin Liu, Dianwei Zhang, Jingmin Liu, Jing Wang, Shuo Wang, Baoguo Sun. Baijiu Vinasse Extract Scavenges Glyoxal and Inhibits the Formation of Nε-Carboxymethyllysine in Dairy Food. Molecules 2019, 24 (8) , 1526. https://doi.org/10.3390/molecules24081526
    94. Solomon Habtemariam. The chemical and pharmacological basis of cinnamon (Cinnamomum species) as potential therapy for type-2 diabetes and associated diseases. 2019, 505-550. https://doi.org/10.1016/B978-0-08-102922-0.00015-8
    95. Maria Leonor Tavares da Silva, Maria Alexandra Sardinha Bernardo, Jaipaul Singh, Maria Fernanda de Mesquita. Beneficial Uses of Cinnamon in Health and Diseases. 2019, 565-576. https://doi.org/10.1016/B978-0-12-813148-0.00033-5
    96. Yuanyuan Chen, Shimiao Tang, Yashu Chen, Roujie Zhang, Mengzhou Zhou, Chao Wang, Nianjie Feng, Qian Wu. Structure-activity relationship of procyanidins on advanced glycation end products formation and corresponding mechanisms. Food Chemistry 2019, 272 , 679-687. https://doi.org/10.1016/j.foodchem.2018.08.090
    97. Peipei Yin, Lingguang Yang, Qiang Xue, Miao Yu, Fan Yao, Liwei Sun, Yujun Liu. Identification and inhibitory activities of ellagic acid- and kaempferol-derivatives from Mongolian oak cups against α-glucosidase, α-amylase and protein glycation linked to type II diabetes and its complications and their influence on HepG2 cells’ viability. Arabian Journal of Chemistry 2018, 11 (8) , 1247-1259. https://doi.org/10.1016/j.arabjc.2017.10.002
    98. Pérez-Gutiérrez ROSA MARTHA, Enriquez-Alvirde SUSANA GABRIELA. Ursane derivatives isolated from leaves of Hylocereus undatus inhibit glycation at multiple stages. Chinese Journal of Natural Medicines 2018, 16 (11) , 856-865. https://doi.org/10.1016/S1875-5364(18)30127-4
    99. Christina M. Hochkogler, Julia K. Hoi, Barbara Lieder, Nicole Müller, Joachim Hans, Sabine Widder, Jakob P. Ley, Veronika Somoza. Cinnamyl Isobutyrate Decreases Plasma Glucose Levels and Total Energy Intake from a Standardized Breakfast: A Randomized, Crossover Intervention. Molecular Nutrition & Food Research 2018, 62 (17) https://doi.org/10.1002/mnfr.201701038
    100. Leda C.M. Cunha, Maria Lúcia G. Monteiro, José M. Lorenzo, Paulo E.S. Munekata, Voster Muchenje, Francisco Allan L. de Carvalho, Carlos A. Conte-Junior. Natural antioxidants in processing and storage stability of sheep and goat meat products. Food Research International 2018, 111 , 379-390. https://doi.org/10.1016/j.foodres.2018.05.041
    Load all citations

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect