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Mulberry Water Extracts Possess an Anti-obesity Effect and Ability To Inhibit Hepatic Lipogenesis and Promote Lipolysis

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Division of Basic Medical Science, Hungkuang University, Number 34, Chung Chie Road, Shalu County, Taichung 433, Taiwan
§ Institute of Biochemistry and Biotechnology, Chung-Shan Medical University, Number 110, Section 1, Chien-Kuo North Road, Taichung 402, Taiwan
Institute of Biotechnology, Hungkuang University, Number 34, Chung Chie Road, Shalu County, Taichung 433, Taiwan
Department of Internal Medicine, Chung-Shan Medical University Hospital, Number 110, Section 1, Chien-Kuo North Road, Taichung 402, Taiwan
# Department of Medical Research, Chung-Shan Medical University Hospital, Number 110, Section 1, Chien-Kuo North Road, Taichung 402, Taiwan
*Telephone: 866-4-24730022, ext. 11670. Fax: 866-4-23248167. E-mail: [email protected]
Cite this: J. Agric. Food Chem. 2011, 59, 6, 2663–2671
Publication Date (Web):March 1, 2011
Copyright © 2011 American Chemical Society

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    Obesity plays a critical role in dyslipidemia and related disorders. Mulberry water extracts (MWEs) contain polyphenols, including gallic acid, chlorogenic acid, rutin, and anthocyanins. In this study, using 6-week-old male hamsters, we investigated the anti-obese effect of MWEs. After 12 weeks of treatment, MWEs lowered high-fat diet (HFD)-induced body weight and visceral fat, accompanied with hypolipidemic effects by reducing serum triacylglycerol, cholesterol, free fatty acid, and the low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio (n = 8 for each group). MWEs decreased hepatic lipids, thus protected livers from impairment. The hepatic peroxisome proliferator-activated receptor α and carnitine palmitoyltransferase-1 were elevated, while fatty acid synthase and 3-hydroxy-3-methylglutaryl−coenzyme A (HMG−CoA) reductase were reduced by MWEs, indicating that MWEs regulated lipogenesis and lipolysis, which exerted the anti-obese and hypolipidemic effects. Noticeably, MWEs showed both efficacy and safety in vivo. In concluson, MWEs can be used to reduce body weight, serum, and liver lipids.

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