Date (Phoenix dactylifera L.) Fruit Soluble Phenolics Composition and Anti-atherogenic Properties in Nine Israeli VarietiesClick to copy article linkArticle link copied!
Abstract
Date (Phoenix dactylifera L.) fruit soluble phenolics composition and anti-atherogenic properties were examined in nine diverse Israeli grown varieties. Ethanol and acetone extracts of ‘Amari’, ‘Barhi’, ‘Deglet Noor’, ‘Deri’, ‘Hadrawi’, ‘Hallawi’, ‘Hayani’, ‘Medjool’, and ‘Zahidi’ fruit were analyzed for phenolics composition by RP-HPLC and tested for anti-atherogenicity by measuring their effects on LDL susceptibility to copper ion- and free radical-induced oxidation, and on serum-mediated cholesterol efflux from macrophages. The most frequently detected phenolics were hydroxybenzoates, hydroxycinnamates, and flavonols. Significant differences in phenolics composition were established between varieties as well as extraction solvents. All extracts inhibited LDL oxidation, and most extracts also stimulated cholesterol removal from macrophages. Considerable varietal differences were measured in the levels of the bioactivities. Also, acetone extracts exhibited a significantly higher anti-atherogenic potency for most varieties. The presence of soluble ingredients with anti-atherogenic capacities in dates and the possible involvement of phenolics are discussed.
Cited By
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by ACS Publications if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
This article is cited by 21 publications.
- Hamutal Borochov-Neori, Sylvie Judeinstein, Amnon Greenberg, Nina Volkova, Mira Rosenblat, and Michael Aviram . Antioxidant and Antiatherogenic Properties of Phenolic Acid and Flavonol Fractions of Fruits of ‘Amari’ and ‘Hallawi’ Date (Phoenix dactylifera L.) Varieties. Journal of Agricultural and Food Chemistry 2015, 63
(12)
, 3189-3195. https://doi.org/10.1021/jf506094r
- Yaara Danino, Bettina Kochanek, Kamal Tyagi, Amnon Lichter. Postharvest ethanol vapor treatment reduces fungal load of Medjool dates. Postharvest Biology and Technology 2025, 227 , 113570. https://doi.org/10.1016/j.postharvbio.2025.113570
- Juan Ramón Jáudenes-Marrero, Soraya Paz-Montelongo, Javier Darias-Rosales, Dailos González-Weller, Ángel J. Gutiérrez, Arturo Hardisson, Carmen Rubio, Samuel Alejandro-Vega. Human Exposure to Trace Elements (Al, B, Ba, Cd, Cr, Li, Ni, Pb, Sr, V) from Consumption of Dried Fruits Acquired in Spain. Foods 2024, 13
(17)
, 2660. https://doi.org/10.3390/foods13172660
- Riyadh Musaed Naji, Mohamed A. Bashandy, Abdallah H. Fathy, . Ameliorative Effects of some Natural Antioxidants against Blood and Cardiovascular Toxicity of Oral Subchronic Exposure to Silicon Dioxide, Aluminum Oxide, or Zinc Oxide Nanoparticles in Wistar Rats. International Journal of Food Science 2023, 2023 , 1-17. https://doi.org/10.1155/2023/8373406
- Abdulmohsen Khalaf Dhahi Alsukaibi, Khalaf M. Alenezi, Ashanul Haque, Irfan Ahmad, Mohd Saeed, Mahima Verma, Irfan Ahmad Ansari, Ming-Fa Hsieh. Chemical, biological and in silico assessment of date (P. dactylifera L.) fruits grown in Ha’il region. Frontiers in Chemistry 2023, 11 https://doi.org/10.3389/fchem.2023.1138057
- Lena Sagi-Dain, Shlomi Sagi. The effect of late pregnancy date fruit consumption on delivery progress – A meta-analysis. EXPLORE 2021, 17
(6)
, 569-573. https://doi.org/10.1016/j.explore.2020.05.014
- Selma Silabdi, Mustapha Khali, Gian Carlo Tenore, Paola Stiuso, Daniela Vanacore, Ettore Novellino. Phoenix dactylifera polyphenols improve plasma lipid profile in hyperlipidemic rats and oxidative stress on HepG2 cells. Journal of Herbs, Spices & Medicinal Plants 2021, 27
(2)
, 161-176. https://doi.org/10.1080/10496475.2021.1891175
- Muneeba Z. Alam, Maryam S.R. Alhebsi, Sami Ghnimi, Afaf Kamal-Eldin. Inability of total antioxidant activity assays to accurately assess the phenolic compounds of date palm fruit (Phoenix dactylifera L.). NFS Journal 2021, 22 , 32-40. https://doi.org/10.1016/j.nfs.2021.01.001
- Heba I. Mohamed, Hossam S. El-Beltagi, S. Mohan Jain, Jameel M. Al-Khayri. Date palm (Phoenix dactylifera L.) secondary metabolites: Bioactivity and pharmaceutical potential. 2021, 483-531. https://doi.org/10.1016/B978-0-12-824109-7.00018-2
- Abdulrahman Khazim Al-Asmari, Mansour S. Al-Said, Rajamohamed Abbasmanthiri, Ahmed Al-Buraidi, Khalid Elfaki Ibrahim, Syed Rafatullah. Impact of date palm pollen (Phoenix dactylifera) treatment on paracetamol-induced hepatorenal toxicity in rats. Clinical Phytoscience 2020, 6
(1)
https://doi.org/10.1186/s40816-020-0151-x
- Ali Chaari, Basma Abdellatif, Faisal Nabi, Rizwan Hasan Khan. Date palm (Phoenix dactylifera L.) fruit's polyphenols as potential inhibitors for human amylin fibril formation and toxicity in type 2 diabetes. International Journal of Biological Macromolecules 2020, 164 , 1794-1808. https://doi.org/10.1016/j.ijbiomac.2020.08.080
- M. Iftikhar Hussain, Muhammad Farooq, Qamar Abbas Syed. Nutritional and biological characteristics of the date palm fruit (Phoenix dactylifera L.) – A review. Food Bioscience 2020, 34 , 100509. https://doi.org/10.1016/j.fbio.2019.100509
- Viviane Marques de Aguiar, Rodrigo Esquinelato Silva, Raquel A.C. Leão, Rodrigo Octávio Mendonça Alves de Souza, Raoni Schroeder B. Gonçalves, Leandro Soter de Mariz e Miranda. Studies on the laccases catalyzed oxidation of norbelladine like acetamides. Molecular Catalysis 2020, 485 , 110788. https://doi.org/10.1016/j.mcat.2020.110788
- Ji Hyun Kim, Sophie Fridman, Hamutal Borochov‐Neori, Tamar Sinai, Dina Zilberg. Evaluating the use of garlic (
Allium sativum)
for the remedy of
Cryptocaryon irritans
in guppies (
Poecilia reticulata
). Aquaculture Research 2019, 50
(2)
, 431-438. https://doi.org/10.1111/are.13904
- B. M. Gnanamangai, S. Saranya, P. Ponmurugan, S. Kavitha, Sudhagar Pitchaimuthu, P. Divya. Analysis of Antioxidants and Nutritional Assessment of Date Palm Fruits. 2019, 19-40. https://doi.org/10.1007/978-3-030-11345-2_2
- Farid Khallouki, Irvila Ricarte, Andrea Breuer, Robert W. Owen. Characterization of phenolic compounds in mature Moroccan Medjool date palm fruits ( Phoenix dactylifera ) by HPLC-DAD-ESI-MS. Journal of Food Composition and Analysis 2018, 70 , 63-71. https://doi.org/10.1016/j.jfca.2018.03.005
- Hooi Xian Lee, Fisal Ahmad, Bahruddin Saad, Mohd Nazri Ismail. Evaluation of extraction methods for the identification of proteins from date palm (
Phoenix dactylifera
L.) seed and flesh. Preparative Biochemistry & Biotechnology 2017, 47
(10)
, 998-1007. https://doi.org/10.1080/10826068.2017.1365250
- Sami Ghnimi, Syed Umer, Azharul Karim, Afaf Kamal-Eldin. Date fruit ( Phoenix dactylifera L.): An underutilized food seeking industrial valorization. NFS Journal 2017, 6 , 1-10. https://doi.org/10.1016/j.nfs.2016.12.001
- Anat Elmann, Elie Beit-Yannai, Alona Telerman, Rivka Ofir, Sharon Mordechay, Hilla Erlank, Hamutal Borochov-Neori. Pulicaria incisa infusion attenuates inflammatory responses of brain microglial cells. Journal of Functional Foods 2016, 25 , 110-122. https://doi.org/10.1016/j.jff.2016.05.012
- Mira Rosenblat, Nina Volkova, Hamutal Borochov-Neori, Sylvie Judeinstein, Michael Aviram. Anti-atherogenic properties of date vs. pomegranate polyphenols: the benefits of the combination. Food & Function 2015, 6
(5)
, 1496-1509. https://doi.org/10.1039/C4FO00998C
- Yuval Cohen, Baruch Glasner. Date Palm Status and Perspective in Israel. 2015, 265-298. https://doi.org/10.1007/978-94-017-9707-8_8
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.