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    Chlorogenic Acid and Coffee Prevent Hypoxia-Induced Retinal Degeneration
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    † Department of Food Science, Cornell University, Ithaca, New York 14850, United States
    ‡ Functional Food Center, Korea Institute of Science and Technology (KIST), Daejeon-dong, Gangneung 210-340, Republic of Korea
    § Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Republic of Korea
    *E-mail: [email protected]. Phone: +82-33-650-3653. Fax: +82-33-650-3679.
    *E-mail: [email protected]. Phone: +1-607-255-0114. Fax: +1-607-254-4868.
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2014, 62, 1, 182–191
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    https://doi.org/10.1021/jf404285v
    Published December 2, 2013
    Copyright © 2013 American Chemical Society
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    Abstract

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    This study explored whether chlorogenic acid (CGA) and coffee have protective effects against retinal degeneration. Under hypoxic conditions, the viability of transformed retinal ganglion (RGC-5) cells was significantly reduced by treatment with the nitric oxide (NO) donor S-nitroso-N-acetylpenicillamine (SNAP). However, pretreatment with CGA attenuated cell death in a concentration-dependent manner. In addition, CGA prevented the up-regulation of apoptotic proteins such as Bad and cleaved caspase-3. Similar beneficial effects of both CGA and coffee extracts were observed in mice that had undergone an optic nerve crush (ONC) procedure. CGA and coffee extract reduced cell death by preventing the down-regulation of Thy-1. Our in vitro and in vivo studies demonstrated that coffee and its major component, CGA, significantly reduce apoptosis of retinal cells induced by hypoxia and NO, and that coffee consumption may help in preventing retinal degeneration.

    Copyright © 2013 American Chemical Society

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    Cite this: J. Agric. Food Chem. 2014, 62, 1, 182–191
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf404285v
    Published December 2, 2013
    Copyright © 2013 American Chemical Society
    Request reuse permissions

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