Inhibitory Effects of Wild Blueberry Anthocyanins and Other Flavonoids on Biomarkers of Acute and Chronic Inflammation in Vitro
Abstract

Wild lowbush blueberries (Vaccinium angustifolium Ait) are a rich source of anthocyanins and other flavonoids with anti-inflammatory activities; however, their individual effects on cellular signaling remain to be elucidated. This study determined the capacity of blueberry bioactives to protect murine RAW 264.7 macrophages from lipopolysaccharide-induced inflammation. Fractionation of the crude extract (CE) into polyphenol-rich (PPR), anthocyanin-rich (ANC), and proanthocyanidin-rich (PAC) fractions and an ethyl acetate fraction (EA) revealed that PPR, ANC, and PAC components most effectively suppressed mRNA biomarkers of acute inflammation (Cox-2, iNOS, and IL-1β). Among major polyphenols found in the wild blueberries, malvidin-3-glucoside was significantly more effective than epicatechin or chlorogenic acid in reducing the expression of pro-inflammatory genes in vitro.
Cited By
This article is cited by 78 publications.
- Elvira Gonzalez de Mejia, Vermont P. Dia, Leslie West, Megan West, Vijay Singh, Zhaoqin Wang, and Charlotte Allen . Temperature Dependency of Shelf and Thermal Stabilities of Anthocyanins from Corn Distillers’ Dried Grains with Solubles in Different Ethanol Extracts and a Commercially Available Beverage. Journal of Agricultural and Food Chemistry 2015, 63 (45) , 10032-10041. https://doi.org/10.1021/acs.jafc.5b03888
- Jonathan C. Valdez, Junhyo Cho, Bradley W. Bolling. Aronia berry inhibits disruption of Caco-2 intestinal barrier function. Archives of Biochemistry and Biophysics 2020, 688 , 108409. https://doi.org/10.1016/j.abb.2020.108409
- Martha Reyes-Becerril, Perla Ginera, Jorge Silva-Jara, Adriana Macias, Carlos Velazquez-Carriles, Lilia Alcaraz-Meléndez, Carlos Angulo. Assessment of chemical, biological and immunological properties of “Damiana de California” Turnera diffusa Willd extracts in Longfin yellowtail (Seriola rivoliana) leukocytes. Fish & Shellfish Immunology 2020, 100 , 418-426. https://doi.org/10.1016/j.fsi.2020.03.045
- Han-Seok Seo, Sean H. Adams, Luke R. Howard, Cindy Brownmiller, Victoria Hogan, Jin-Ran Chen, Ragita C. Pramudya. Children’s liking and wanting of foods vary over multiple bites/sips of consumption: A case study of foods containing wild blueberry powder in the amounts targeted to deliver bioactive phytonutrients for children. Food Research International 2020, 131 , 108981. https://doi.org/10.1016/j.foodres.2020.108981
- Michelle Debnath-Canning, Scott Unruh, Poorva Vyas, Noriko Daneshtalab, Abir U. Igamberdiev, John T. Weber. Fruits and leaves from wild blueberry plants contain diverse polyphenols and decrease neuroinflammatory responses in microglia. Journal of Functional Foods 2020, 68 , 103906. https://doi.org/10.1016/j.jff.2020.103906
- Ali R. Bastin, Asie Sadeghi, Moslem Abolhassani, Amir H. Doustimotlagh, Abbas Mohammadi. Malvidin prevents lipopolysaccharide-induced oxidative stress and inflammation in human peripheral blood mononuclear cells. IUBMB Life 2020, 22 https://doi.org/10.1002/iub.2286
- Laura Lavefve, Cindi Brownmiller, Luke Howard, Donovon Reeves, Sean H. Adams, Jin-Ran Chen, Eva C. Diaz, Andy Mauromoustakos. Changes in Polyphenolics during Storage of Products Prepared with Freeze-Dried Wild Blueberry Powder. Foods 2020, 9 (4) , 466. https://doi.org/10.3390/foods9040466
- Mayra Sousa Gomes, Ruthineia Diógenes Alves Uchoa Lins, Silvana Maria Zucolotto Langassner, Éricka Janine Dantas da Silveira, Thais Gomes de Carvalho, Maria Luiza Diniz de Sousa Lopes, Lorena de Souza Araújo, Caroline Addison Carvalho Xavier de Medeiros, Renata Ferreira de Carvalho Leitão, Gerlane Coelho Bernardo Guerra, Raimundo Fernandes de Araújo Junior, Aurigena Antunes de Araújo. Anti-inflammatory and antioxidant activity of hydroethanolic extract of Spondias mombin leaf in an oral mucositis experimental model. Archives of Oral Biology 2020, 111 , 104664. https://doi.org/10.1016/j.archoralbio.2020.104664
- Mandeep Tayal, Pavel Somavat, Isabella Rodriguez, Tina Thomas, Bradley Christoffersen, Rupesh Kariyat. Polyphenol-Rich Purple Corn Pericarp Extract Adversely Impacts Herbivore Growth and Development. Insects 2020, 11 (2) , 98. https://doi.org/10.3390/insects11020098
- Marco Nuno De Canha, Slavko Komarnytsky, Lenka Langhansova, Namrita Lall. Exploring the Anti-Acne Potential of Impepho [Helichrysum odoratissimum (L.) Sweet] to Combat Cutibacterium acnes Virulence. Frontiers in Pharmacology 2020, 10 https://doi.org/10.3389/fphar.2019.01559
- Mandeep Tayal, Pavel Somavat, Isabella Rodriguez, Leilani Martinez, Rupesh Kariyat. Cascading effects of polyphenol-rich purple corn pericarp extract on pupal, adult, and offspring of tobacco hornworm ( Manduca sexta L.). Communicative & Integrative Biology 2020, 13 (1) , 43-53. https://doi.org/10.1080/19420889.2020.1735223
- Rasika Hudlikar, Renyi Wu, David Cheng, Dina Hsiao-Chen Kuo, Lujing Wang, Rebecca Peter, Ran Yin, Shanyi Li, Ah-Ng Kong. Anthocyanins and Cancer Prevention. 2020,,, 351-373. https://doi.org/10.1007/978-3-030-39855-2_11
- Sónia R. Pereira, Leonor M. Almeida, Teresa C.P. Dinis. Improving the anti-inflammatory activity of 5-aminosalicylic acid by combination with cyanidin-3-glucoside: An in vitro study. Journal of Functional Foods 2019, 63 , 103586. https://doi.org/10.1016/j.jff.2019.103586
- Kathleen R. Walter, Xi Lin, Sheila K. Jacobi, Tobias Käser, Debora Esposito, Jack Odle. Dietary arachidonate in milk replacer triggers dual benefits of PGE2 signaling in LPS-challenged piglet alveolar macrophages. Journal of Animal Science and Biotechnology 2019, 10 (1) https://doi.org/10.1186/s40104-019-0321-1
- Weixiang Liu, Yiping Mao, Jacob Schoenborn, Zhihong Wang, Guiliang Tang, Xiaoqing Tang. Whole blueberry protects pancreatic beta-cells in diet-induced obese mouse. Nutrition & Metabolism 2019, 16 (1) https://doi.org/10.1186/s12986-019-0363-6
- Kaikai Li, Mengying Zhang, Haoze Chen, Jinming Peng, Fan Jiang, Xin Shi, Yilin Bai, Min Jian, Yangyang Jia. Anthocyanins from black peanut skin protect against UV-B induced keratinocyte cell and skin oxidative damage through activating Nrf 2 signaling. Food & Function 2019, 10 (10) , 6815-6828. https://doi.org/10.1039/C9FO00706G
- Mohammad Hosein Farzaei, Amit Kumar Singh, Ramesh Kumar, Courtney R. Croley, Abhay K. Pandey, Ericsson Coy-Barrera, Jayanta Kumar Patra, Gitishree Das, Rout George Kerry, Giuseppe Annunziata, Gian Carlo Tenore, Haroon Khan, Matteo Micucci, Roberta Budriesi, Saeideh Momtaz, Seyed Mohammad Nabavi, Anupam Bishayee. Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders. International Journal of Molecular Sciences 2019, 20 (19) , 4957. https://doi.org/10.3390/ijms20194957
- Debora Esposito, John Overall, Mary H. Grace, Slavko Komarnytsky, Mary Ann Lila. Alaskan Berry Extracts Promote Dermal Wound Repair Through Modulation of Bioenergetics and Integrin Signaling. Frontiers in Pharmacology 2019, 10 https://doi.org/10.3389/fphar.2019.01058
- Hsiao-Chen Dina Kuo, Renyi Wu, Shanyi Li, Anne Yuqing Yang, Ah-Ng Kong. Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway. The AAPS Journal 2019, 21 (5) https://doi.org/10.1208/s12248-019-0355-5
- Franco Van de Velde, Debora Esposito, Mary H. Grace, María E. Pirovani, Mary A. Lila. Anti-inflammatory and wound healing properties of polyphenolic extracts from strawberry and blackberry fruits. Food Research International 2019, 121 , 453-462. https://doi.org/10.1016/j.foodres.2018.11.059
- Daniela Mayumi Usuda Prado Rocha, Ana Paula Silva Caldas, Bárbara Pereira da Silva, Helen Hermana Miranda Hermsdorff, Rita de Cássia Gonçalves Alfenas. Effects of blueberry and cranberry consumption on type 2 diabetes glycemic control: A systematic review. Critical Reviews in Food Science and Nutrition 2019, 59 (11) , 1816-1828. https://doi.org/10.1080/10408398.2018.1430019
- Jinming Peng, Yan Jia, Xia Du, Yue Wang, Zimu Yang, Kaikai Li. Study of physicochemical stability of anthocyanin extracts from black peanut skin and their digestion enzyme and adipogenesis inhibitory activities. LWT 2019, 107 , 107-116. https://doi.org/10.1016/j.lwt.2019.03.016
- Roberta Targino Hoskin, Jia Xiong, Debora Araújo Esposito, Mary Ann Lila. Blueberry polyphenol-protein food ingredients: The impact of spray drying on the in vitro antioxidant activity, anti-inflammatory markers, glucose metabolism and fibroblast migration. Food Chemistry 2019, 280 , 187-194. https://doi.org/10.1016/j.foodchem.2018.12.046
- Mary H. Grace, Jia Xiong, Debora Esposito, Mark Ehlenfeldt, Mary Ann Lila. Simultaneous LC-MS quantification of anthocyanins and non-anthocyanin phenolics from blueberries with widely divergent profiles and biological activities. Food Chemistry 2019, 277 , 336-346. https://doi.org/10.1016/j.foodchem.2018.10.101
- Jiao Ge, Xueyang Yue, Shuo Wang, Jinpeng Chi, Jin Liang, Yue Sun, Xueling Gao, Pengxiang Yue. Nanocomplexes composed of chitosan derivatives and β-Lactoglobulin as a carrier for anthocyanins: Preparation, stability and bioavailability in vitro. Food Research International 2019, 116 , 336-345. https://doi.org/10.1016/j.foodres.2018.08.045
- Joanna Bowtell, Vincent Kelly. Fruit-Derived Polyphenol Supplementation for Athlete Recovery and Performance. Sports Medicine 2019, 49 (S1) , 3-23. https://doi.org/10.1007/s40279-018-0998-x
- Dhafir Q Masheta, Shafq K Al-Azzawi. Antioxidant and Anti-Inflammatory Effects of Delphinidin on Glial Cells and Lack of Effect on Secretase Enzyme. IOP Conference Series: Materials Science and Engineering 2018, 454 , 012061. https://doi.org/10.1088/1757-899X/454/1/012061
- Maha I. Alkhalf, Fares K. Khalifa. Blueberry extract attenuates γ-radiation-induced hepatocyte damage by modulating oxidative stress and suppressing NF-κB in male rats. Saudi Journal of Biological Sciences 2018, 25 (7) , 1272-1277. https://doi.org/10.1016/j.sjbs.2018.07.002
- Jiu-Liang Zhang, Chun-Li Luo, Qing Zhou, Zi-Cheng Zhang. Isolation and identification of two major acylated anthocyanins from purple sweet potato ( Ipomoea batatas L. cultivar Eshu No. 8) by UPLC-QTOF-MS/MS and NMR. International Journal of Food Science & Technology 2018, 53 (8) , 1932-1941. https://doi.org/10.1111/ijfs.13780
- Vincenzo D’Amelia, Riccardo Aversano, Pasquale Chiaiese, Domenico Carputo. The antioxidant properties of plant flavonoids: their exploitation by molecular plant breeding. Phytochemistry Reviews 2018, 17 (3) , 611-625. https://doi.org/10.1007/s11101-018-9568-y
- Adriaan Witol, Melanie Lemire, Stephanie Dudonné, Brendan Walshe-Roussel, Yves Desjardins, Alain Cuerrier, Cory S. Harris. Profiling the phenolic acids, flavonoids and tannins in skunk currants (Ribes glandulosum) of Northern Québec, Canada. Journal of Berry Research 2018, 8 (2) , 119-127. https://doi.org/10.3233/JBR-170282
- Sage Haggard, Diego Luna-Vital, Leslie West, John A. Juvik, Laura Chatham, Michael Paulsmeyer, Elvira Gonzalez de Mejia. Comparison of chemical, color stability, and phenolic composition from pericarp of nine colored corn unique varieties in a beverage model. Food Research International 2018, 105 , 286-297. https://doi.org/10.1016/j.foodres.2017.11.038
- Andrew Ferguson, Elisabete Carvalho, Geraldine Gourlay, Vincent Walker, Stefan Martens, Juha-Pekka Salminen, C. Peter Constabel. Phytochemical analysis of salal berry ( Gaultheria shallon Pursh.), a traditionally-consumed fruit from western North America with exceptionally high proanthocyanidin content. Phytochemistry 2018, 147 , 203-210. https://doi.org/10.1016/j.phytochem.2018.01.002
- Jiao Ge, Pengxiang Yue, Jinpeng Chi, Jin Liang, Xueling Gao. Formation and stability of anthocyanins-loaded nanocomplexes prepared with chitosan hydrochloride and carboxymethyl chitosan. Food Hydrocolloids 2018, 74 , 23-31. https://doi.org/10.1016/j.foodhyd.2017.07.029
- Hyemee Kim, Sunday Y. Simbo, Chuo Fang, Lilly McAlister, Andrea Roque, Nivedita Banerjee, Stephen T. Talcott, Hongwei Zhao, Richard B. Kreider, Susanne U. Mertens-Talcott. Açaí ( Euterpe oleracea Mart.) beverage consumption improves biomarkers for inflammation but not glucose- or lipid-metabolism in individuals with metabolic syndrome in a randomized, double-blinded, placebo-controlled clinical trial. Food & Function 2018, 9 (6) , 3097-3103. https://doi.org/10.1039/C8FO00595H
- Kamila Kasprzak, Tomasz Oniszczuk, Agnieszka Wójtowicz, Monika Waksmundzka-Hajnos, Marta Olech, Renata Nowak, Renata Polak, Anna Oniszczuk. Phenolic Acid Content and Antioxidant Properties of Extruded Corn Snacks Enriched with Kale. Journal of Analytical Methods in Chemistry 2018, 2018 , 1-7. https://doi.org/10.1155/2018/7830546
- Dimitra Kelepouri, Athanasios Mavropoulos, Dimitrios P. Bogdanos, Lazaros I. Sakkas. The Role of Flavonoids in Inhibiting Th17 Responses in Inflammatory Arthritis. Journal of Immunology Research 2018, 2018 , 1-11. https://doi.org/10.1155/2018/9324357
- Patricio Orellana-Palma, Guillermo Petzold, María Guerra-Valle, Marianela Astudillo-Lagos. Impact of block cryoconcentration on polyphenol retention in blueberry juice. Food Bioscience 2017, 20 , 149-158. https://doi.org/10.1016/j.fbio.2017.10.006
- Jia XIONG, Mary H GRACE, Debora ESPOSITO, Slavko KOMARNYTSKY, Fei WANG, Mary Ann LILA. Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities. Chinese Journal of Natural Medicines 2017, 15 (11) , 816-824. https://doi.org/10.1016/S1875-5364(18)30015-3
- Roberta Correia, Mary H. Grace, Debora Esposito, Mary Ann Lila. Wild blueberry polyphenol-protein food ingredients produced by three drying methods: Comparative physico-chemical properties, phytochemical content, and stability during storage. Food Chemistry 2017, 235 , 76-85. https://doi.org/10.1016/j.foodchem.2017.05.042
- Anna M. Amini, Karolin Muzs, Jeremy PE. Spencer, Parveen Yaqoob. Pelargonidin-3- O -glucoside and its metabolites have modest anti-inflammatory effects in human whole blood cultures. Nutrition Research 2017, 46 , 88-95. https://doi.org/10.1016/j.nutres.2017.09.006
- Qian Li, Pavel Somavat, Vijay Singh, Laura Chatham, Elvira Gonzalez de Mejia. A comparative study of anthocyanin distribution in purple and blue corn coproducts from three conventional fractionation processes. Food Chemistry 2017, 231 , 332-339. https://doi.org/10.1016/j.foodchem.2017.03.146
- Michael A. Timmers, Mary H. Grace, Gad G. Yousef, Mary Ann Lila. Inter- and intra-seasonal changes in anthocyanin accumulation and global metabolite profiling of six blueberry genotypes. Journal of Food Composition and Analysis 2017, 59 , 105-110. https://doi.org/10.1016/j.jfca.2017.02.019
- Bo-Wen Lin, Cheng-Chen Gong, Hai-Fei Song, Ying-Yu Cui. Effects of anthocyanins on the prevention and treatment of cancer. British Journal of Pharmacology 2017, 174 (11) , 1226-1243. https://doi.org/10.1111/bph.13627
- Wumei Lin, Zhigang Li. Blueberries inhibit cyclooxygenase-1 and cyclooxygenase-2 activity in human epithelial ovarian cancer. Oncology Letters 2017, 13 (6) , 4897-4904. https://doi.org/10.3892/ol.2017.6094
- Perla Pizzi Argentato, Carina Almeida Morais, Aline Boveto Santamarina, Helena de Cássia César, Débora Estadella, Veridiana Vera de Rosso, Luciana Pellegrini Pisani. Jussara ( Euterpe edulis Mart.) supplementation during pregnancy and lactation modulates UCP-1 and inflammation biomarkers induced by trans-fatty acids in the brown adipose tissue of offspring. Clinical Nutrition Experimental 2017, 12 , 50-65. https://doi.org/10.1016/j.yclnex.2016.12.002
- John Overall, Mary Ann Lila, Slavko Komarnytsky. Anthocyanins in metabolic health and disease. 2017,,, 92-124. https://doi.org/10.1002/9781119101277.ch5
- Sónia R. Pereira, Rita Pereira, Isabel Figueiredo, Victor Freitas, Teresa C. P. Dinis, Leonor M. Almeida, . Comparison of anti-inflammatory activities of an anthocyanin-rich fraction from Portuguese blueberries (Vaccinium corymbosum L.) and 5-aminosalicylic acid in a TNBS-induced colitis rat model. PLOS ONE 2017, 12 (3) , e0174116. https://doi.org/10.1371/journal.pone.0174116
- , H. Mortas, N. Sanlier, . Nutritional evaluation of commonly consumed berries: composition and health effects. Fruits 2017, 72 (1) , 5-23. https://doi.org/10.17660/th2017/72.1.1
- Milica Veljković, Dragana R. Pavlović, Nenad Stojiljković, Sonja Ilić, Ivan Jovanović, Nataša Poklar Ulrih, Violeta Rakić, Ljubinka Veličković, Dušan Sokolović. Bilberry: Chemical Profiling, in Vitro and in Vivo Antioxidant Activity and Nephroprotective Effect against Gentamicin Toxicity in Rats. Phytotherapy Research 2017, 31 (1) , 115-123. https://doi.org/10.1002/ptr.5738
- Noha M. Sorour, Ahmed A. Tayel, Rateb N. Abbas, Osama M. Abonama. Microbial Biosynthesis of Health-Promoting Food Ingredients. 2017,,, 55-93. https://doi.org/10.1016/B978-0-12-811372-1.00002-6
- Yu Song, Lili Huang, Jianfeng Yu. Effects of blueberry anthocyanins on retinal oxidative stress and inflammation in diabetes through Nrf2/HO-1 signaling. Journal of Neuroimmunology 2016, 301 , 1-6. https://doi.org/10.1016/j.jneuroim.2016.11.001
- Cristian Del Bo', Martin Roursgaard, Marisa Porrini, Steffen Loft, Peter Møller, Patrizia Riso. Different effects of anthocyanins and phenolic acids from wild blueberry ( Vaccinium angustifolium ) on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment. Molecular Nutrition & Food Research 2016, 60 (11) , 2355-2366. https://doi.org/10.1002/mnfr.201600178
- Mary H. Grace, Debora Esposito, Michael A. Timmers, Jia Xiong, Gad Yousef, Slavko Komarnytsky, Mary Ann Lila. Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts. Food Chemistry 2016, 210 , 85-95. https://doi.org/10.1016/j.foodchem.2016.04.088
- Carina Almeida Morais, Veridiana Vera de Rosso, Débora Estadella, Luciana Pellegrini Pisani. Anthocyanins as inflammatory modulators and the role of the gut microbiota. The Journal of Nutritional Biochemistry 2016, 33 , 1-7. https://doi.org/10.1016/j.jnutbio.2015.11.008
- Wei Xu, Qing Zhou, Yong Yao, Xing Li, Jiu-liang Zhang, Guan-hua Su, Ai-ping Deng. Inhibitory effect of Gardenblue blueberry (Vaccinium ashei Reade) anthocyanin extracts on lipopolysaccharide-stimulated inflammatory response in RAW 264.7 cells. Journal of Zhejiang University-SCIENCE B 2016, 17 (6) , 425-436. https://doi.org/10.1631/jzus.B1500213
- Jie Yu, Xiaojuan Bi, Bing Yu, Daiwen Chen. Isoflavones: Anti-Inflammatory Benefit and Possible Caveats. Nutrients 2016, 8 (6) , 361. https://doi.org/10.3390/nu8060361
- Bárbara Cabral, Emerson M.S. Siqueira, Mariana A.O. Bitencourt, Maíra C.J.S. Lima, Ana K. Lima, Caroline F. Ortmann, Vitor C. Chaves, Matheus F. Fernandes-Pedrosa, Hugo A.O. Rocha, Katia C. Scortecci, Flávio H. Reginatto, Raquel B. Giordani, Silvana M. Zucolotto. Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves. Revista Brasileira de Farmacognosia 2016, 26 (3) , 304-311. https://doi.org/10.1016/j.bjp.2016.02.002
- Jia Xiong, Mary H. Grace, Debora Esposito, Fei Wang, Mary Ann Lila. Phytochemical Characterization and Anti-inflammatory Properties of Acacia mearnsii Leaves. Natural Product Communications 2016, 11 (5) , 1934578X1601100. https://doi.org/10.1177/1934578X1601100524
- Yong Wang, Liang Zhao, Yazhen Huo, Feng Zhou, Wei Wu, Feng Lu, Xue Yang, Xiaoxuan Guo, Peng Chen, Qianchun Deng, Baoping Ji. Protective Effect of Proanthocyanidins from Sea Buckthorn (Hippophae Rhamnoides L.) Seed against Visible Light-Induced Retinal Degeneration in Vivo. Nutrients 2016, 8 (5) , 245. https://doi.org/10.3390/nu8050245
- . References. 2016,,, 441-567. https://doi.org/10.1201/b19653-5
- Franco Van de Velde, Mary H. Grace, Debora Esposito, María Élida Pirovani, Mary Ann Lila. Quantitative comparison of phytochemical profile, antioxidant, and anti-inflammatory properties of blackberry fruits adapted to Argentina. Journal of Food Composition and Analysis 2016, 47 , 82-91. https://doi.org/10.1016/j.jfca.2016.01.008
- Tao Wu, Jinjin Yin, Guohua Zhang, Hairong Long, Xiaodong Zheng. Mulberry and cherry anthocyanin consumption prevents oxidative stress and inflammation in diet-induced obese mice. Molecular Nutrition & Food Research 2016, 60 (3) , 687-694. https://doi.org/10.1002/mnfr.201500734
- Floirendo P. Flores, Rakesh K. Singh, Fanbin Kong. Anthocyanin extraction, microencapsulation, and release properties during in vitro digestion. Food Reviews International 2016, 32 (1) , 46-67. https://doi.org/10.1080/87559129.2015.1041185
- Mary H. Grace, Debora Esposito, Michael A. Timmers, Jia Xiong, Gad Yousef, Slavko Komarnytsky, Mary Ann Lila. In vitro lipolytic, antioxidant and anti-inflammatory activities of roasted pistachio kernel and skin constituents. Food & Function 2016, 7 (10) , 4285-4298. https://doi.org/10.1039/C6FO00867D
- Yunen Liu, Dehong Tan, Changci Tong, Yubiao Zhang, Ying Xu, Xinwei Liu, Yan Gao, Mingxiao Hou. Blueberry anthocyanins ameliorate radiation-induced lung injury through the protein kinase RNA-activated pathway. Chemico-Biological Interactions 2015, 242 , 363-371. https://doi.org/10.1016/j.cbi.2015.11.001
- Stéphanie Dudonné, Pascal Dubé, Fernando Forato Anhê, Geneviève Pilon, André Marette, Mélanie Lemire, Cory Harris, Eric Dewailly, Yves Desjardins. Comprehensive analysis of phenolic compounds and abscisic acid profiles of twelve native Canadian berries. Journal of Food Composition and Analysis 2015, 44 , 214-224. https://doi.org/10.1016/j.jfca.2015.09.003
- Carina Almeida Morais, Lila Missae Oyama, Ricardo de Moura Conrado, Veridiana Vera de Rosso, Claudia Oller do Nascimento, Luciana Pellegrini Pisani. Polyphenols-rich fruit in maternal diet modulates inflammatory markers and the gut microbiota and improves colonic expression of ZO-1 in offspring. Food Research International 2015, 77 , 186-193. https://doi.org/10.1016/j.foodres.2015.06.043
- Leonel E. Rojo, Pablo A. Gaspar, H. Silva, L. Risco, Pamela Arena, Karen Cubillos-Robles, Belen Jara. Metabolic syndrome and obesity among users of second generation antipsychotics: A global challenge for modern psychopharmacology. Pharmacological Research 2015, 101 , 74-85. https://doi.org/10.1016/j.phrs.2015.07.022
- Carola I.F. Janssen, Valerio Zerbi, Martina P.C. Mutsaers, Mieke Jochems, Claudia A. Vos, Julle O. Vos, Brian M. Berg, Eric A.F. van Tol, Gabriele Gross, Zeina E. Jouni, Arend Heerschap, Amanda J. Kiliaan. Effect of perinatally supplemented flavonoids on brain structure, circulation, cognition, and metabolism in C57BL/6J mice. Neurochemistry International 2015, 89 , 157-169. https://doi.org/10.1016/j.neuint.2015.05.002
- Gabsik Yang, Se-Yun Cheon, Kyung-Sook Chung, Sung-Jin Lee, Chul-Hee Hong, Kyung-Tae Lee, Dae-Sik Jang, Jin-Cheol Jeong, Oh-Keun Kwon, Jung-Hwan Nam, Hyo-Jin An. Solanum tuberosum L. cv Jayoung Epidermis Extract Inhibits Mite Antigen-Induced Atopic Dermatitis in NC/Nga Mice by Regulating the Th1/Th2 Balance and Expression of Filaggrin. Journal of Medicinal Food 2015, 18 (9) , 1013-1021. https://doi.org/10.1089/jmf.2014.3338
- Joshua Kellogg, Debora Esposito, Mary H. Grace, Slavko Komarnytsky, Mary Ann Lila. Alaskan seaweeds lower inflammation in RAW 264.7 macrophages and decrease lipid accumulation in 3T3-L1 adipocytes. Journal of Functional Foods 2015, 15 , 396-407. https://doi.org/10.1016/j.jff.2015.03.049
- Fabiano B. Carvalho, Jessié M. Gutierres, Crystiani Bohnert, Adriana M. Zago, Fátima H. Abdalla, Juliano M. Vieira, Heloisa E. Palma, Sara M. Oliveira, Roselia M. Spanevello, Marta M. Duarte, Sonia T.A. Lopes, Graciane Aiello, Marta G. Amaral, Ney Luis Pippi, Cinthia M. Andrade. Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination. The Journal of Nutritional Biochemistry 2015, 26 (4) , 378-390. https://doi.org/10.1016/j.jnutbio.2014.11.006
- Yingjie Zhong, Ye Wang, Jun Guo, Haifeng Chu, Yong Gao, Limin Pang. Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study. The Tohoku Journal of Experimental Medicine 2015, 237 (3) , 183-191. https://doi.org/10.1620/tjem.237.183
- Mary H. Grace, Gad G. Yousef, Debora Esposito, Ilya Raskin, Mary Ann Lila. Bioactive Capacity, Sensory Properties, and Nutritional Analysis of a Shelf Stable Protein-rich Functional Ingredient with Concentrated Fruit and Vegetable Phytoactives. Plant Foods for Human Nutrition 2014, 69 (4) , 372-378. https://doi.org/10.1007/s11130-014-0444-7
- Sabine Kuntz, Clemens Kunz, Johannes Herrmann, Christian H. Borsch, Georg Abel, Bettina Fröhling, Helmut Dietrich, Silvia Rudloff. Anthocyanins from fruit juices improve the antioxidant status of healthy young female volunteers without affecting anti-inflammatory parameters: results from the randomised, double-blind, placebo-controlled, cross-over ANTHONIA (ANTHOcyanins in Nutrition Investigation Alliance) study. British Journal of Nutrition 2014, 112 (6) , 925-936. https://doi.org/10.1017/S0007114514001482
- Wu-Yang Huang, Ya-Mei Liu, Jian Wang, Xing-Na Wang, Chun-Yang Li. Anti-Inflammatory Effect of the Blueberry Anthocyanins Malvidin-3-Glucoside and Malvidin-3-Galactoside in Endothelial Cells. Molecules 2014, 19 (8) , 12827-12841. https://doi.org/10.3390/molecules190812827
- Carina Almeida Morais, Lila Missae Oyama, Juliana Lopez de Oliveira, Márcia Carvalho Garcia, Veridiana Vera de Rosso, Laís Sousa Mendes Amigo, Claudia Maria Oller do Nascimento, Luciana Pellegrini Pisani. Jussara ( Euterpe edulis Mart.) Supplementation during Pregnancy and Lactation Modulates the Gene and Protein Expression of Inflammation Biomarkers Induced by trans -Fatty Acids in the Colon of Offspring. Mediators of Inflammation 2014, 2014 , 1-11. https://doi.org/10.1155/2014/987927



