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Chemical Analysis and Antihyperglycemic Activity of an Original Extract from Burdock Root (Arctium lappa)

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Université Montpellier I, 4 Boulevard Henri IV, Montpellier, France
Université Montpellier II, Place Eugène Bataillon, 34095 Montpellier, France
§ EA 7288, Centre de Pharmacologie et Innovation dans le Diabète, UFR des Sciences Pharmaceutiques et Biologiques, 15 Avenue Charles Flahault, BP14491, 34093 Montpellier Cedex 5, France
UMR 95 Qualisud, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France
INRA, UMR AGAP, Centre de Recherche de Montpellier, 2 Place Pierre Viala, F-34060 Montpellier, France
# Laboratoire de Mesures Physiques, Service Commun de l’Université Montpellier 2, Plateau Technique de l’Institut des Biomolécules Max Mousseron, Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France
*Tel: +33 4 11 75 94 89. Fax: +33 4 11 75 95 47. E-mail: [email protected]; UFR des Sciences Pharmaceutiques et Biologiques, Centre de Pharmacologie et Innovation dans le Diabète, EA7288, 15 avenue Charles Flahault, B.P. 14491, 34093 Montpellier cedex 5, FRANCE.
Cite this: J. Agric. Food Chem. 2014, 62, 31, 7738–7745
Publication Date (Web):June 16, 2014
https://doi.org/10.1021/jf500926v
Copyright © 2014 American Chemical Society

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    Abstract

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    In the present study, we obtained a dried burdock root extract (DBRE) rich in caffeoylquinic acids derivatives. We performed the chemical characterization of DBRE and explored its antihyperglycemic potential in both in vitro and in vivo experiments. Chemical analysis of DBRE using LC–MS and GC–MS revealed the presence of a great majority of dicaffeoylquinic acid derivatives (75.4%) of which 1,5-di-O-caffeoyl-4-O-maloylquinic acid represents 44% of the extract. In the in vitro experiments, DBRE is able to increase glucose uptake in cultured L6 myocytes and to decrease glucagon-induced glucose output from rat isolated hepatocytes together with a reduction of hepatic glucose 6-phosphatase activity. DBRE did not increase insulin secretion in the INS-1 pancreatic β-cell line. In vivo, DBRE improves glucose tolerance both after intraperitoneal and oral subchronic administration. In conclusion, our data demonstrate that DBRE constitutes an original set of caffeoylquinic acid derivatives displaying antihyperglycemic properties.

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    Cited By

    This article is cited by 24 publications.

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