Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect
ACS Publications. Most Trusted. Most Cited. Most Read
Chemical Analysis and Antihyperglycemic Activity of an Original Extract from Burdock Root (Arctium lappa)

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2014, 62, 31, 7738-7745
    Article

    Chemical Analysis and Antihyperglycemic Activity of an Original Extract from Burdock Root (Arctium lappa)
    Click to copy article linkArticle link copied!

    View Author Information
    † Université Montpellier I, 4 Boulevard Henri IV, Montpellier, France
    ‡ Université Montpellier II, Place Eugène Bataillon, 34095 Montpellier, France
    § EA 7288, Centre de Pharmacologie et Innovation dans le Diabète, UFR des Sciences Pharmaceutiques et Biologiques, 15 Avenue Charles Flahault, BP14491, 34093 Montpellier Cedex 5, France
    ∥ UMR 95 Qualisud, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France
    ⊥ INRA, UMR AGAP, Centre de Recherche de Montpellier, 2 Place Pierre Viala, F-34060 Montpellier, France
    # Laboratoire de Mesures Physiques, Service Commun de l’Université Montpellier 2, Plateau Technique de l’Institut des Biomolécules Max Mousseron, Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France
    *Tel: +33 4 11 75 94 89. Fax: +33 4 11 75 95 47. E-mail: [email protected]; UFR des Sciences Pharmaceutiques et Biologiques, Centre de Pharmacologie et Innovation dans le Diabète, EA7288, 15 avenue Charles Flahault, B.P. 14491, 34093 Montpellier cedex 5, FRANCE.
    Other Access Options

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2014, 62, 31, 7738–7745
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf500926v
    Published June 16, 2014
    Copyright © 2014 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    In the present study, we obtained a dried burdock root extract (DBRE) rich in caffeoylquinic acids derivatives. We performed the chemical characterization of DBRE and explored its antihyperglycemic potential in both in vitro and in vivo experiments. Chemical analysis of DBRE using LC–MS and GC–MS revealed the presence of a great majority of dicaffeoylquinic acid derivatives (75.4%) of which 1,5-di-O-caffeoyl-4-O-maloylquinic acid represents 44% of the extract. In the in vitro experiments, DBRE is able to increase glucose uptake in cultured L6 myocytes and to decrease glucagon-induced glucose output from rat isolated hepatocytes together with a reduction of hepatic glucose 6-phosphatase activity. DBRE did not increase insulin secretion in the INS-1 pancreatic β-cell line. In vivo, DBRE improves glucose tolerance both after intraperitoneal and oral subchronic administration. In conclusion, our data demonstrate that DBRE constitutes an original set of caffeoylquinic acid derivatives displaying antihyperglycemic properties.

    Copyright © 2014 American Chemical Society

    Subjects

    what are subjects

    Keywords

    what are keywords

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Cited By

    Click to copy section linkSection link copied!

    This article is cited by 26 publications.

    1. Wenwu Liu, Jingda Li, Xuemei Zhang, Yuxin Zu, Yue Yang, Wenjie Liu, Zihua Xu, Huan Gao, Xue Sun, Xiaowen Jiang, Qingchun Zhao. Current Advances in Naturally Occurring Caffeoylquinic Acids: Structure, Bioactivity, and Synthesis. Journal of Agricultural and Food Chemistry 2020, 68 (39) , 10489-10516. https://doi.org/10.1021/acs.jafc.0c03804
    2. Mukul Shyam, Evan Prince Sabina. Harnessing the power of Arctium lappa root: a review of its pharmacological properties and therapeutic applications. Natural Products and Bioprospecting 2024, 14 (1) https://doi.org/10.1007/s13659-024-00466-8
    3. Milan Malaník, Veronika Farková, Jitka Křížová, Alice Kresová, Karel Šmejkal, Tomáš Kašparovský, Kateřina Dadáková. Comparison of Metabolic Profiles of Fruits of Arctium lappa, Arctium minus, and Arctium tomentosum. Plant Foods for Human Nutrition 2024, 79 (2) , 497-502. https://doi.org/10.1007/s11130-024-01175-w
    4. Huichen Song, Huanhuan Shi, Mengru Ji, Jiaqi Ding, Lin Cong, Silin Chen, Jiahui Zhou, Xinyan Zha, Jinyang Ye, Runcheng Li, Xiaoyu Hou, Siyu Mao, Xiaohong Jiang, Wen Zhang, Jing Li, Yujing Zhang. Burdock miR8175 in diet improves insulin resistance induced by obesity in mice through food absorption. iScience 2024, 27 (5) , 109705. https://doi.org/10.1016/j.isci.2024.109705
    5. Narges Nikoomanesh, Mohsen Zandi, Ali Ganjloo. Development of Ohmic-assisted green extraction technique with ultrasonic and microwave pretreatments: Burdock (Arctium lappa L.) root extract. Chemical Engineering and Processing - Process Intensification 2024, 14 , 109749. https://doi.org/10.1016/j.cep.2024.109749
    6. Nermeen Yosri, Sultan M. Alsharif, Jianbo Xiao, Syed G. Musharraf, Chao Zhao, Aamer Saeed, Ruichang Gao, Noha S. Said, Alessandro Di Minno, Maria Daglia, Zhiming Guo, Shaden A.M. Khalifa, Hesham R. El-Seedi. Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine. Biomedicine & Pharmacotherapy 2023, 158 , 114104. https://doi.org/10.1016/j.biopha.2022.114104
    7. Shihori Watanabe, Shizuko Yamabe, Masako Shimada. Arctium lappa Lam. and Its Related Lignans Improve Hyperglycemia and Dyslipidemia in Diabetic Rodent Models: A Systematic Review and Meta-Analysis. Nutraceuticals 2022, 2 (4) , 335-349. https://doi.org/10.3390/nutraceuticals2040026
    8. Shakti Chandra Mondal, Jong-Bang Eun. Mechanistic insights on burdock (Arctium lappa L.) extract effects on diabetes mellitus. Food Science and Biotechnology 2022, 31 (8) , 999-1008. https://doi.org/10.1007/s10068-022-01091-2
    9. Yongjuan Ruan, Yanzhong Ding, Xiaowei Li, Chunyang Zhang, Mengyu Wang, Mengduan Liu, Lu Wang, Junhui Xing, Liang Hu, Xiaoyan Zhao, Zhongren Ding, Jianzeng Dong, Yangyang Liu. Saccharides from Arctium lappa L. root reduce platelet activation and thrombus formation in a laser injury thrombosis mouse model. Experimental and Therapeutic Medicine 2022, 23 (5) https://doi.org/10.3892/etm.2022.11274
    10. Thaisa de Menezes Alves Moro, Ana Paula Aparecida Pereira, Aline Sousa Lopes, Glaucia Maria Pastore, Maria Teresa Pedrosa Silva Clerici. Retention of bioactive compounds and bifidogenic activity of burdock roots subjected to different processes. International Journal of Gastronomy and Food Science 2022, 27 , 100448. https://doi.org/10.1016/j.ijgfs.2021.100448
    11. Armando Alcázar Magaña, Naofumi Kamimura, Amala Soumyanath, Jan F. Stevens, Claudia S. Maier. Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity. The Plant Journal 2021, 107 (5) , 1299-1319. https://doi.org/10.1111/tpj.15390
    12. Abdulmomem Awwad, Patrick Poucheret, Yanis A. Idres, Damien S. T. Tshibangu, Adrien Servent, Karine Ferrare, Françoise Lazennec, Luc P. R. Bidel, Guillaume Cazals, Didier Tousch. In Vitro Tests for a Rapid Evaluation of Antidiabetic Potential of Plant Species Containing Caffeic Acid Derivatives: A Validation by Two Well-Known Antidiabetic Plants, Ocimum gratissimum L. Leaf and Musanga cecropioides R. Br. ex Tedlie (Mu) Stem Bark. Molecules 2021, 26 (18) , 5566. https://doi.org/10.3390/molecules26185566
    13. Junjie Xia, Zili Guo, Sheng Fang, Jinping Gu, Xianrui Liang. Effect of Drying Methods on Volatile Compounds of Burdock (Arctium lappa L.) Root Tea as Revealed by Gas Chromatography Mass Spectrometry-Based Metabolomics. Foods 2021, 10 (4) , 868. https://doi.org/10.3390/foods10040868
    14. Thaísa M.A. Moro, Maria T.P.S. Clerici. Burdock (Arctium lappa L) roots as a source of inulin-type fructans and other bioactive compounds: Current knowledge and future perspectives for food and non-food applications. Food Research International 2021, 141 , 109889. https://doi.org/10.1016/j.foodres.2020.109889
    15. Elena Grosu, Mihael Cristin Ichim. Turning Meadow Weeds Into Valuable Species for the Romanian Ethnomedicine While Complying With the Environmentally Friendly Farming Requirements of the European Union’s Common Agricultural Policy. Frontiers in Pharmacology 2020, 11 https://doi.org/10.3389/fphar.2020.00529
    16. Abdulmonem Awwad, Patrick Poucheret, Arezki Yanis Idres, Luc Bidel, Didier Tousch. The bitter Asteraceae: An interesting approach to delay the metabolic syndrome progression. NFS Journal 2020, 18 , 29-38. https://doi.org/10.1016/j.nfs.2020.01.001
    17. Giuseppe Annunziata, Luigi Barrea, Roberto Ciampaglia, Carla Cicala, Angela Arnone, Silvia Savastano, Seyed Mohammad Nabavi, Gian Carlo Tenore, Ettore Novellino. Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: A critical review of in vitro and in vivo animal‐based studies. Phytotherapy Research 2019, 33 (9) , 2213-2220. https://doi.org/10.1002/ptr.6416
    18. Dongdong Wang, Alexandru Sabin Bădărau, Mallappa Kumara Swamy, Subrata Shaw, Filippo Maggi, Luiz Everson da Silva, Víctor López, Andy Wai Kan Yeung, Andrei Mocan, Atanas G. Atanasov. Arctium Species Secondary Metabolites Chemodiversity and Bioactivities. Frontiers in Plant Science 2019, 10 https://doi.org/10.3389/fpls.2019.00834
    19. Kangming Tian, Jun Wang, Zhimeng Zhang, Lei Cheng, Peng Jin, Suren Singh, Bernard A. Prior, Zheng-Xiang Wang. Enzymatic preparation of fructooligosaccharides-rich burdock syrup with enhanced antioxidative properties. Electronic Journal of Biotechnology 2019, 40 , 71-77. https://doi.org/10.1016/j.ejbt.2019.04.009
    20. Xiu-juan Zhang, Shao-fang Liu, Yan Lu, Jian-yue Wang, Kao-shan Chen. Immunomodulatory activity of a fructooligosaccharide isolated from burdock roots. RSC Advances 2019, 9 (20) , 11092-11100. https://doi.org/10.1039/C8RA10091H
    21. Thanh-Danh Nguyen, Thanh-Truc Vo, Cao-Hien Nguyen, Van-Dat Doan, Chi-Hien Dang. Biogenic palladium nanoclusters supported on hybrid nanocomposite 2-hydroxypropyl-β-cyclodextrin/alginate as a recyclable catalyst in aqueous medium. Journal of Molecular Liquids 2019, 276 , 927-935. https://doi.org/10.1016/j.molliq.2018.12.138
    22. , Saidbeg Satorov, Fazila Mirzoeva, , Shukhrat Satorov, , Manizha Vakhidova, , Vyacheslav Dushenkov, . COMPARATIVE CHARACTERISTICS OF ANTIBACTERIAL ACTIVITY OF PLANTS GROWING IN THE CENTRAL PART OF THE REPUBLIC OF TAJIKISTAN. AVICENNA BULLETIN 2019, 21 (4) , 643-654. https://doi.org/10.25005/2074-0581-2019-21-4-643-654
    23. Thi Thanh-Ngan Nguyen, Thanh-Truc Vo, Bich Ngoc-Huong Nguyen, Dinh-Truong Nguyen, Van-Su Dang, Chi-Hien Dang, Thanh-Danh Nguyen. Silver and gold nanoparticles biosynthesized by aqueous extract of burdock root, Arctium lappa as antimicrobial agent and catalyst for degradation of pollutants. Environmental Science and Pollution Research 2018, 25 (34) , 34247-34261. https://doi.org/10.1007/s11356-018-3322-2
    24. Karine Ferrare, Luc P.R. Bidel, Abdulmomem Awwad, Patrick Poucheret, Guillaume Cazals, Françoise Lazennec, Jacqueline Azay-Milhau, Michel Tournier, Anne-Dominique Lajoix, Didier Tousch. Increase in insulin sensitivity by the association of chicoric acid and chlorogenic acid contained in a natural chicoric acid extract (NCRAE) of chicory (Cichorium intybus L.) for an antidiabetic effect. Journal of Ethnopharmacology 2018, 215 , 241-248. https://doi.org/10.1016/j.jep.2017.12.035
    25. Lucia Pirvu, Isabela Nicorescu, Cristina Hlevca, Bujor Albu, Valentin Nicorescu. Burdock (Arctium lappa) Leaf Extracts Increase the In Vitro Antimicrobial Efficacy of Common Antibiotics on Gram-positive and Gram-negative Bacteria. Open Chemistry 2017, 15 (1) , 92-102. https://doi.org/10.1515/chem-2017-0012
    26. Fereshteh Ghorat, Mohammad Azizkhani, Shahriar Naji, Ali Ghorbani Ranjbary, Farzad Doostishoar. Histopathological Evaluation of Burdock (Arctium lappa) Root Hydroalcoholic Extract on Wound Healing. Iranian Red Crescent Medical Journal 2017, 19 (1) https://doi.org/10.5812/ircmj.43788
    Download PDF
    Go to Journal of Agricultural and Food Chemistry
    Get e-Alerts
    Get e-Alerts

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2014, 62, 31, 7738–7745
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf500926v
    Published June 16, 2014
    Copyright © 2014 American Chemical Society
    Request reuse permissions

    Article Views

    1161

    Altmetric

    -

    Citations

    26
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.