ACS Publications. Most Trusted. Most Cited. Most Read
Influence of Tripolyphosphate Cross-Linking on the Physical Stability and Lipase Digestibility of Chitosan-Coated Lipid Droplets

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2010, 58, 2, 1283-1289
    Article

    Influence of Tripolyphosphate Cross-Linking on the Physical Stability and Lipase Digestibility of Chitosan-Coated Lipid Droplets
    Click to copy article linkArticle link copied!

    View Author Information
    Biopolymers and Colloids Laboratory, Department of Food Science, University of Massachusetts, Amherst, Massachusetts 01003
    *Corresponding author. Phone: 413-545-1010. Fax: 413-545-1262. E-mail: [email protected]
    Other Access Options

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2010, 58, 2, 1283–1289
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf903270y
    Published November 18, 2009
    Copyright © 2009 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    The impact of cross-linking chitosan with tripolyphosphate (TPP) on the physical stability and lipase digestibility of chitosan-coated lipid droplets was investigated. Relatively, high TPP levels (≥0.004 wt %) promoted droplet aggregation and gravitational separation, which was attributed to charge neutralization and interdroplet cross-linking. Cross-linked chitosan-coated lipid droplets were formed at lower TPP levels that were relatively small (d ≈ 450 nm), cationic (ζ ≈ +60 mV), and stable to particle aggregation and gravitational separation (pH 3, 21 days). However, these droplets were highly unstable at pH 7 because of a reduction in net particle charge and weakened electrostatic repulsion. An in vitro lipid digestion model was used to study the impact of the chitosan coating on the digestibility of lipid droplets by pancreatic lipase (pH 7, bile salts, pancreatic lipase, and 5.0 mM CaCl2). The rate of lipid digestion decreased when the lipid droplets were coated with chitosan and decreased further when the chitosan coating was cross-linked with TPP. Indeed, both cross-linked and noncross-linked chitosan coatings were able to prevent lipid digestion under conditions simulating the small intestine. This study has important implications for the design of structured emulsions with controlled lipid digestibility and for the targeted delivery of lipophilic functional components to specific regions within the gastrointestinal tract.

    Copyright © 2009 American Chemical Society

    Subjects

    what are subjects

    Keywords (keywords)

    what are keywords

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Cited By

    Click to copy section linkSection link copied!

    This article is cited by 48 publications.

    1. Weilin Liu, Jianhua Liu, Wei Liu, Ti Li, and Chengmei Liu . Improved Physical and in Vitro Digestion Stability of a Polyelectrolyte Delivery System Based on Layer-by-Layer Self-Assembly Alginate–Chitosan-Coated Nanoliposomes. Journal of Agricultural and Food Chemistry 2013, 61 (17) , 4133-4144. https://doi.org/10.1021/jf305329n
    2. N. P. Aditya, Myeongkuk Shim, Inae Lee, YoungJoo Lee, Moo-Hyeog Im, and Sanghoon Ko . Curcumin and Genistein Coloaded Nanostructured Lipid Carriers: in Vitro Digestion and Antiprostate Cancer Activity. Journal of Agricultural and Food Chemistry 2013, 61 (8) , 1878-1883. https://doi.org/10.1021/jf305143k
    3. Uri Lesmes, Prune Baudot and David Julian McClements . Impact of Interfacial Composition on Physical Stability and In Vitro Lipase Digestibility of Triacylglycerol Oil Droplets Coated with Lactoferrin and/or Caseinate. Journal of Agricultural and Food Chemistry 2010, 58 (13) , 7962-7969. https://doi.org/10.1021/jf100703c
    4. Paloma Barajas-Álvarez, José Nabor Haro-González, Marisela González-Ávila, Hugo Espinosa-Andrews. Gum Arabic/Chitosan Coacervates for Encapsulation and Protection of Lacticaseibacillus rhamnosus in Storage and Gastrointestinal Environments. Probiotics and Antimicrobial Proteins 2024, 16 (6) , 2073-2084. https://doi.org/10.1007/s12602-023-10152-9
    5. Ahasanul Karim, Leila Mohammadi, Emmanuel Freddy Osse, Mohammed Aider, Milena Saqui-Salces, Seddik Khalloufi. Effect of polysaccharide-induced viscosity on the digestion of proteins, fats, and carbohydrates in food: A comprehensive review and future perspectives. Trends in Food Science & Technology 2024, 153 , 104757. https://doi.org/10.1016/j.tifs.2024.104757
    6. Shahzad Farooq, Muhammad Ijaz Ahmad, Usman Ali, Hui Zhang. Fabrication of curcumin-loaded oleogels using camellia oil bodies and gum arabic/chitosan coatings for controlled release applications. International Journal of Biological Macromolecules 2024, 254 , 127758. https://doi.org/10.1016/j.ijbiomac.2023.127758
    7. Junpeng Sun, Jiaqun Du, Xiaobang Liu, Jinyu An, Yingqiao Li, Yanan Yu, Minghui Li, Li Zheng, Chao Wu, Lili Hu. Preparation of chitosan-coated hollow tin dioxide nanoparticles and their application in improving the oral bioavailability of febuxostat. International Journal of Pharmaceutics: X 2023, 6 , 100199. https://doi.org/10.1016/j.ijpx.2023.100199
    8. Ben Yu, Qianqian Chen, Joe M. Regenstein, Changwen Ye, Lufeng Wang. The lipid digestion behavior of oil-in-water emulsions stabilized by different particle-sized insoluble dietary fiber from citrus peel. Food Chemistry: X 2023, 19 , 100831. https://doi.org/10.1016/j.fochx.2023.100831
    9. Marwa Hasanein Asfour, Abeer A.A. Salama. Coating with tripolyphosphate-crosslinked chitosan as a novel approach for enhanced stability of emulsomes following oral administration: Rutin as a model drug with improved anti-hyperlipidemic effect in rats. International Journal of Pharmaceutics 2023, 644 , 123314. https://doi.org/10.1016/j.ijpharm.2023.123314
    10. Yadong Yang, Vijai Kumar Gupta, Hamid Amiri, Junting Pan, Mortaza Aghbashlo, Meisam Tabatabaei, Ahmad Rajaei. Recent developments in improving the emulsifying properties of chitosan. International Journal of Biological Macromolecules 2023, 239 , 124210. https://doi.org/10.1016/j.ijbiomac.2023.124210
    11. Shahzad Farooq, Muhammad Ijaz Ahmad, Yipeng Zhang, Hui Zhang. Impact of interfacial layer number and Schiff base cross-linking on the microstructure, rheological properties and digestive lipolysis of plant-derived oil bodies-based oleogels. Food Hydrocolloids 2023, 138 , 108473. https://doi.org/10.1016/j.foodhyd.2023.108473
    12. Barbara V. Pimenta, Rafael R.M. Madrid, Patrick D. Mathews, Karin A. Riske, Watson Loh, Borislav Angelov, Angelina Angelova, Omar Mertins. Interaction of polyelectrolyte-shell cubosomes with serum albumin for triggering drug release in gastrointestinal cancer. Journal of Materials Chemistry B 2023, 11 (11) , 2490-2503. https://doi.org/10.1039/D2TB02670H
    13. Minmin Weng, Chunmiao Xia, Sheng Xu, Qingzhong Liu, Yuan Liu, Huan Liu, Chaofei Huo, Rongli Zhang, Cuige Zhang, Zongcheng Miao. Lipase/chitosan nanoparticle-stabilized pickering emulsion for enzyme catalysis. Colloid and Polymer Science 2022, 300 (1) , 41-50. https://doi.org/10.1007/s00396-021-04923-5
    14. Marwa Hasanein Asfour, Abeer A.A. Salama, Amira Mohamed Mohsen. Fabrication of All-Trans Retinoic Acid loaded Chitosan/Tripolyphosphate Lipid Hybrid Nanoparticles as a Novel Oral Delivery Approach for Management of Diabetic Nephropathy in Rats. Journal of Pharmaceutical Sciences 2021, 110 (9) , 3208-3220. https://doi.org/10.1016/j.xphs.2021.05.007
    15. Nattapong Prichapan, David Julian McClements, Utai Klinkesorn. Utilization of multilayer-technology to enhance encapsulation efficiency and osmotic gradient tolerance of iron-loaded W1/O/W2 emulsions: Saponin-chitosan coatings. Food Hydrocolloids 2021, 112 , 106334. https://doi.org/10.1016/j.foodhyd.2020.106334
    16. Myeongsu Jo, Choongjin Ban, Kelvin K.T. Goh, Young Jin Choi. Enhancement of the gut-retention time of resveratrol using waxy maize starch nanocrystal-stabilized and chitosan-coated Pickering emulsions. Food Hydrocolloids 2021, 112 , 106291. https://doi.org/10.1016/j.foodhyd.2020.106291
    17. Alejandra Acevedo-Fani, Qing Guo, Noha Nasef, Harjinder Singh. Aspects of food structure in digestion and bioavailability of LCn-3PUFA-rich lipids. 2021, 427-448. https://doi.org/10.1016/B978-0-12-821391-9.00003-X
    18. Shabbar Abbas, Dawei Chang, Naveeda Riaz, Abid Aslam Maan, Muhammad Kashif Iqbal Khan, Ishtiaque Ahmad, Suliman A. Alsagaby, Ahmed El-Ghorab, Mazhar Ali, Muhammad Imran, Azmat Ullah, Tahir Mehmood, Muhammad Zeeshan Hyder, Muhammad Sajjad, Muhammad Umer, Asghar Shabbir, Muhammad Inam Afzal. In-vitro stress stability, digestibility and bioaccessibility of curcumin-loaded polymeric nanocapsules. Journal of Experimental Nanoscience 2021, 16 (1) , 229-245. https://doi.org/10.1080/17458080.2021.1952185
    19. Saddam Saqib, Wajid Zaman, Fazal Ullah, Imran Majeed, Asma Ayaz, Muhammad Farooq Hussain Munis. Organometallic assembling of chitosan‐Iron oxide nanoparticles with their antifungal evaluation against Rhizopus oryzae. Applied Organometallic Chemistry 2019, 33 (11) https://doi.org/10.1002/aoc.5190
    20. Myeongsu Jo, Choongjin Ban, Kelvin K.T. Goh, Young Jin Choi. Influence of chitosan-coating on the stability and digestion of emulsions stabilized by waxy maize starch crystals. Food Hydrocolloids 2019, 94 , 603-612. https://doi.org/10.1016/j.foodhyd.2019.04.010
    21. Arun Augustine, Amita Tanwar, Rejean Tremblay, Shashi Kumar. Flocculation processes optimization for reuse of culture medium without pH neutralization. Algal Research 2019, 39 , 101437. https://doi.org/10.1016/j.algal.2019.101437
    22. Yuanfeng Wei, Jianjun Zhang, Yazhen Zheng, Yaxiang Gong, Meng Fu, Chengran Liu, Liang Xu, Changquan Calvin Sun, Yuan Gao, Shuai Qian. Cubosomes with surface cross-linked chitosan exhibit sustained release and bioavailability enhancement for vinpocetine. RSC Advances 2019, 9 (11) , 6287-6298. https://doi.org/10.1039/C8RA10302J
    23. Xin Li, Xu Wang, Jiawei Liu, Duoxia Xu, Yanping Cao, Baoguo Sun. The effect of unadsorbed proteins on the physiochemical properties of the heteroaggregates of oppositely charged lactoferrin coated lutein droplets and whey protein isolate coated DHA droplets. Food & Function 2018, 9 (7) , 3956-3964. https://doi.org/10.1039/C8FO00371H
    24. Ezzeddin M.A. Hejjaji, Alan M. Smith, Gordon A. Morris. The potential of chitosan-tripolyphosphate microparticles in the visualisation of latent fingermarks. Food Hydrocolloids 2017, 71 , 290-298. https://doi.org/10.1016/j.foodhyd.2016.12.020
    25. Enmin Chen, Shan Wu, David Julian McClements, Bin Li, Yan Li. Influence of pH and cinnamaldehyde on the physical stability and lipolysis of whey protein isolate-stabilized emulsions. Food Hydrocolloids 2017, 69 , 103-110. https://doi.org/10.1016/j.foodhyd.2017.01.028
    26. Dingkui Qin, Xiaojun Yang, Songran Gao, Junhu Yao, David Julian McClements. Influence of dietary fibers on lipid digestion: Comparison of single-stage and multiple-stage gastrointestinal models. Food Hydrocolloids 2017, 69 , 382-392. https://doi.org/10.1016/j.foodhyd.2017.03.004
    27. Sung Jin Park, Coralia V. Garcia, Gye Hwa Shin, Jun Tae Kim. Development of nanostructured lipid carriers for the encapsulation and controlled release of vitamin D3. Food Chemistry 2017, 225 , 213-219. https://doi.org/10.1016/j.foodchem.2017.01.015
    28. Chi Rac Hong, Gyu Whan Lee, Hyun-Dong Paik, Pahn-Shick Chang, Seung Jun Choi. Influence of lysolecithin and Tween 80 on the colloidal stability of branched chain amino acids in a nanosuspension system. Food Chemistry 2017, 221 , 606-612. https://doi.org/10.1016/j.foodchem.2016.11.131
    29. Dingkui Qin, Xiaojun Yang, Songran Gao, Junhu Yao, David Julian McClements. Influence of Hydrocolloids (Dietary Fibers) on Lipid Digestion of Protein‐Stabilized Emulsions: Comparison of Neutral, Anionic, and Cationic Polysaccharides. Journal of Food Science 2016, 81 (7) https://doi.org/10.1111/1750-3841.13361
    30. Xudong Yao, Craig Bunt, Jillian Cornish, Siew-Young Quek, Jingyuan Wen. Oral Delivery of Bovine Lactoferrin Using Pectin- and Chitosan-Modified Liposomes and Solid Lipid Particles: Improvement of Stability of Lactoferrin. Chemical Biology & Drug Design 2015, 86 (4) , 466-475. https://doi.org/10.1111/cbdd.12509
    31. Shabbar Abbas, Eric Karangwa, Mohanad Bashari, Khizar Hayat, Xiao Hong, Hafiz Rizwan Sharif, Xiaoming Zhang. Fabrication of polymeric nanocapsules from curcumin-loaded nanoemulsion templates by self-assembly. Ultrasonics Sonochemistry 2015, 23 , 81-92. https://doi.org/10.1016/j.ultsonch.2014.10.006
    32. Ralf Greiner, Volker Gräf, Anna Burcza, Birgit Hetzer, Johanna Milsmann, Elke Walz. Engineered Nanomaterials in the Food Sector. 2015, 579-616. https://doi.org/10.1016/B978-0-444-63340-8.00011-X
    33. Rajendran Senthilkumar, Didem Şen Karaman, Preethy Paul, Emma M. Björk, Magnus Odén, John E. Eriksson, Jessica M. Rosenholm. Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect. Biomaterials Science 2015, 3 (1) , 103-111. https://doi.org/10.1039/C4BM00278D
    34. Shiqing Ma, Zhen Chen, Feng Qiao, Yingchun Sun, Xiaoping Yang, Xuliang Deng, Lian Cen, Qing Cai, Mingyao Wu, Xu Zhang, Ping Gao. Guided bone regeneration with tripolyphosphate cross-linked asymmetric chitosan membrane. Journal of Dentistry 2014, 42 (12) , 1603-1612. https://doi.org/10.1016/j.jdent.2014.08.015
    35. Utai Klinkesorn. The Role of Chitosan in Emulsion Formation and Stabilization. Food Reviews International 2013, 29 (4) , 371-393. https://doi.org/10.1080/87559129.2013.818013
    36. Duoxia Xu, Fang Yuan, Yanxiang Gao, D. Julian McClements, Eric A. Decker. Influence of pH, metal chelator, free radical scavenger and interfacial characteristics on the oxidative stability of β-carotene in conjugated whey protein–pectin stabilised emulsion. Food Chemistry 2013, 139 (1-4) , 1098-1104. https://doi.org/10.1016/j.foodchem.2013.02.027
    37. Gozde Unsoy, Serap Yalcin, Rouhollah Khodadust, Gungor Gunduz, Ufuk Gunduz. Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications. Journal of Nanoparticle Research 2012, 14 (11) https://doi.org/10.1007/s11051-012-0964-8
    38. David Julian McClements. Advances in fabrication of emulsions with enhanced functionality using structural design principles. Current Opinion in Colloid & Interface Science 2012, 17 (5) , 235-245. https://doi.org/10.1016/j.cocis.2012.06.002
    39. Olivier Kamtchueng Simo, Yingyi Mao, Tanushree Tokle, Eric Andrew Decker, David Julian McClements. Novel strategies for fabricating reduced fat foods: Heteroaggregation of lipid droplets with polysaccharides. Food Research International 2012, 48 (2) , 337-345. https://doi.org/10.1016/j.foodres.2012.04.018
    40. Jui-Yang Lai. Biocompatibility of Genipin and Glutaraldehyde Cross-Linked Chitosan Materials in the Anterior Chamber of the Eye. International Journal of Molecular Sciences 2012, 13 (9) , 10970-10985. https://doi.org/10.3390/ijms130910970
    41. Baoru Yin, Wei Deng, Keke Xu, Luwen Huang, Ping Yao. Stable nano-sized emulsions produced from soy protein and soy polysaccharide complexes. Journal of Colloid and Interface Science 2012, 380 (1) , 51-59. https://doi.org/10.1016/j.jcis.2012.04.075
    42. Hande Kaya-Celiker, Kumar Mallikarjunan. Better Nutrients and Therapeutics Delivery in Food Through Nanotechnology. Food Engineering Reviews 2012, 4 (2) , 114-123. https://doi.org/10.1007/s12393-012-9050-3
    43. Tanushree Tokle, Uri Lesmes, Eric Andrew Decker, David Julian McClements. Impact of dietary fiber coatings on behavior of protein-stabilized lipid droplets under simulated gastrointestinal conditions. Food Funct. 2012, 3 (1) , 58-66. https://doi.org/10.1039/C1FO10129C
    44. David Julian McClements, Hang Xiao. Potential biological fate of ingested nanoemulsions: influence of particle characteristics. Food Funct. 2012, 3 (3) , 202-220. https://doi.org/10.1039/C1FO10193E
    45. Jianing Meng, Timothy F. Sturgis, Bi-Botti C. Youan. Engineering tenofovir loaded chitosan nanoparticles to maximize microbicide mucoadhesion. European Journal of Pharmaceutical Sciences 2011, 44 (1-2) , 57-67. https://doi.org/10.1016/j.ejps.2011.06.007
    46. Yan Liu, Young-Kyung Kim, Lin Dai, Nan Li, Sara O. Khan, David H. Pashley, Franklin R. Tay. Hierarchical and non-hierarchical mineralisation of collagen. Biomaterials 2011, 32 (5) , 1291-1300. https://doi.org/10.1016/j.biomaterials.2010.10.018
    47. David Julian McClements, Yan Li. Structured emulsion-based delivery systems: Controlling the digestion and release of lipophilic food components. Advances in Colloid and Interface Science 2010, 159 (2) , 213-228. https://doi.org/10.1016/j.cis.2010.06.010
    48. David Julian McClements, Yan Li. Review of in vitro digestion models for rapid screening of emulsion-based systems. Food & Function 2010, 1 (1) , 32. https://doi.org/10.1039/c0fo00111b
    Download PDF
    Go to Journal of Agricultural and Food Chemistry
    Get e-Alerts
    Get e-Alerts

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2010, 58, 2, 1283–1289
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf903270y
    Published November 18, 2009
    Copyright © 2009 American Chemical Society
    Request reuse permissions

    Article Views

    1424

    Altmetric

    -

    Citations

    48
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.