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Resistant Starch, Fermented Resistant Starch, and Short-Chain Fatty Acids Reduce Intestinal Fat Deposition in Caenorhabditis elegans

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† Veterinary Science Department
‡ School of Human Ecology
# Food Science Department, LSU AgCenter
Louisiana State University, Baton Rouge, Louisiana 70803
§ Geriatric Endocrinology and Metabolism Laboratory, Veteran's Administration Medical Center, Washington, D.C. 20422
⊥ Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808
⊗ Department of Biology, University of Louisiana at Monroe, Monroe, Louisiana 71209
*Address correspondence to either author [(J.Z.) Veterinary Science Department, Louisiana State University, LSU AgCenter, Baton Rouge, LA 70803 (telephone/fax (225) 578-9227, e-mail [email protected]); (R.J.M.) Human Nutrition and Food Division, School of Human Ecology, Louisiana State University, LSU AgCenter, Baton Rouge, LA 70803 (telephone (225) 578-1704, fax (225) 578-4443, e-mail [email protected]].
Cite this: J. Agric. Food Chem. 2010, 58, 8, 4744–4748
Publication Date (Web):March 30, 2010
https://doi.org/10.1021/jf904583b
Copyright © 2010 American Chemical Society
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Abstract

Obesity is a growing global public health dilemma. The objective of this project is to develop and validate a screening mechanism for bioactive compounds that may reduce body fat and promote health. Resistant starch (RS) reduces body fat in rodents. Amylose starch that has a high content of RS, endogenous compounds obtained from the ceca of amylose starch fed mice (fermented RS), and individual short-chain fatty acids (SCFA) were tested. The Caenorhabditis elegans model and Nile red staining were selected to determine the intestinal fat deposition response to bioactive components. The fluorescence intensity of Nile red was reduced to 76.5% (amylose starch), 78.8% (fermented RS), 63.6% (butyrate), or 28−80% (SCFAs) of controls, respectively (P < 0.001). The reduced intestinal fat deposition suggests reduced food intake or increased energy expenditure. C. elegans is a practical animal model to screen for bioactive compounds that may prevent or treat obesity.

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