ACS Publications. Most Trusted. Most Cited. Most Read
Antimutagenic Effect of Fruit and Vegetable Ethanolic Extracts against N-Nitrosamines Evaluated by the Ames Test
My Activity

Figure 1Loading Img
    Article

    Antimutagenic Effect of Fruit and Vegetable Ethanolic Extracts against N-Nitrosamines Evaluated by the Ames Test
    Click to copy article linkArticle link copied!

    View Author Information
    Departamento de Nutrición y Bromatología III, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, Spain
    Other Access Options

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 1999, 47, 8, 3257–3264
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf990166n
    Published July 15, 1999
    Copyright © 1999 American Chemical Society

    Abstract

    Click to copy section linkSection link copied!

    The inhibitory effect of nine fruit and vegetable ethanolic extracts against the mutagenicity of N-nitrosodimethylamine (NDMA), N-nitrosopyrrolidine (NPYR), N-nitrosodibutylamine (NDBA), and N-nitrosopiperidine (NPIP) was evaluated by means of the Ames test. Licorice ethanolic extract was the only one that showed an inhibitory effect (ranging from moderate to strong) against mutagenicity of all N-nitrosamines tested. This ethanolic extract showed the greatest inhibition effect against NPIP (72%), NDMA (45%), and NPYR (39%). The greatest inhibition effect (51%) of the mutagenicity of NDBA was shown by kiwi ethanolic extract. Vegetable and fruit ethanolic extracts that exhibited an antimutagenic effect (at the range 50−2000 μg/plate), in decreasing order, against NDMA and NPYR were as follows:  licorice > kiwi > carrot and licorice > broccoli > pineapple > kiwi, respectively. Decreasing orders against NDBA and NPIP were, respectively, kiwi > onion > licorice = garlic > green pepper > carrot and licorice > garlic > pineapple > carrot.

    Keywords: Vegetables; fruits; N-nitrosamines; mutagenicity; Ames test

    Copyright © 1999 American Chemical Society

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    *

     To whom correspondence should be addressed (fax 34-91-3943743; e-mail [email protected]).

    Cited By

    Click to copy section linkSection link copied!
    Citation Statements
    Explore this article's citation statements on scite.ai

    This article is cited by 103 publications.

    1. M. Antonia Murcia,, Isabel Egea,, Felix Romojaro,, Pilar Parras,, Antonia M. Jiménez, and, Magdalena Martínez-Tomé. Antioxidant Evaluation in Dessert Spices Compared with Common Food Additives. Influence of Irradiation Procedure. Journal of Agricultural and Food Chemistry 2004, 52 (7) , 1872-1881. https://doi.org/10.1021/jf0303114
    2. Xiao-Hong Wang,, Lia Andrae, and, Nicki J. Engeseth. Antimutagenic Effect of Various Honeys and Sugars against Trp-p-1. Journal of Agricultural and Food Chemistry 2002, 50 (23) , 6923-6928. https://doi.org/10.1021/jf025641n
    3. José Manuel Cruz,, José Manuel Domínguez,, Herminia Domínguez, and, Juan Carlos Parajó. Antioxidant and Antimicrobial Effects of Extracts from Hydrolysates of Lignocellulosic Materials. Journal of Agricultural and Food Chemistry 2001, 49 (5) , 2459-2464. https://doi.org/10.1021/jf001237h
    4. Lauren Standley,, Paula Winterton,, Jeanine L. Marnewick,, Wentzel C. A. Gelderblom,, Elizabeth Joubert, and, Trevor J. Britz. Influence of Processing Stages on Antimutagenic and Antioxidant Potentials of Rooibos Tea. Journal of Agricultural and Food Chemistry 2001, 49 (1) , 114-117. https://doi.org/10.1021/jf000802d
    5. Luis S. Muñoz-Carrillo, Eduardo Madrigal-Bujaidar, Sandra L. Hernández-Ojeda, José A. Morales-González, Eduardo O. Madrigal-Santillán, Isela Álvarez-González, J. Javier Espinosa-Aguirre. Studies of Piper auritum Kuntz’s Mutagenic and Antimutagenic Properties Using the Ames Test. Metabolites 2025, 15 (3) , 164. https://doi.org/10.3390/metabo15030164
    6. Héctor-Enrique Trujillo-Ruiz, Carmen-María López-Saiz, Alejandro-Monserrat García-Alegría, Idalia Osuna-Ruiz, Hisila Del Carmen Santacruz-Ortega, María-Mercedes Meza-Montenegro, Juan-Francisco Maldonado-Escalante, Susana-Gabriela Cruz-Ramirez, Armando Burgos Hernández. Detection and partial characterization of antimutagenic compounds from white shrimp ( Litopenaeus vannamei ) cephalothorax. CyTA - Journal of Food 2024, 22 (1) https://doi.org/10.1080/19476337.2024.2315990
    7. Sandra L Hernández-Ojeda, Javier Jesús Espinosa-Aguirre, Rafael Camacho-Carranza, Jessica Amacosta-Castillo, Ricardo Cárdenas-Ávila. Piper auritum ethanol extract is a potent antimutagen against food-borne aromatic amines: mechanisms of action and chemical composition. Mutagenesis 2024, 39 (6) , 301-309. https://doi.org/10.1093/mutage/geae011
    8. J.J. Espinosa-Aguirre, R. Camacho-Carranza, SL Hernández-Ojeda, R.I. Cárdenas-Ávila, R. Santes-Palacios. Apiole, an important constituent of parsley, is a mixed-type inhibitor of the CYP1A subfamily. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2024, 829 , 111881. https://doi.org/10.1016/j.mrfmmm.2024.111881
    9. Dania Marisol Esparza-Espinoza, Hisila del Carmen Santacruz-Ortega, Maribel Plascencia-Jatomea, Santiago P. Aubourg, Jesús Aarón Salazar-Leyva, Francisco Rodríguez-Felix, Josafat Marina Ezquerra-Brauer. Chemical-Structural Identification of Crude Gelatin from Jellyfish (Stomolophus meleagris) and Evaluation of Its Potential Biological Activity. Fishes 2023, 8 (5) , 246. https://doi.org/10.3390/fishes8050246
    10. Shuangyu Wang, Fenglin Sun, Shuhui Wang, Xiaojing Lv, Jinquan Zhao, Jie Wang, Weisen Yu, Hongwei Yu. N-nitrosamines in Qingdao dried aquatic products and dietary risk assessment. Food Additives & Contaminants: Part B 2023, 16 (2) , 120-129. https://doi.org/10.1080/19393210.2023.2177355
    11. Ishita Seal, Sidhanta Sil, Abhijit Das, Souvik Roy. Assessment of toxicity and genotoxic safety profile of novel fisetin ruthenium-p-cymene complex in mice. Toxicological Research 2023, 39 (2) , 213-229. https://doi.org/10.1007/s43188-022-00158-w
    12. Sidhanta Sil, Abhijit Das, Ishita Seal, Swarupananda Mukherjee, Souvik Roy. A toxicological evaluation for safety assessment of ruthenium-based diosmetin complex in rats. Regulatory Toxicology and Pharmacology 2023, 137 , 105303. https://doi.org/10.1016/j.yrtph.2022.105303
    13. F. Chamorro, M. Carpena, M. Fraga-Corral, J. Echave, Muhammad Shahid Riaz Rajoka, Francisco J. Barba, Hui Cao, Jianbo Xiao, M.A. Prieto, J. Simal-Gandara. Valorization of kiwi agricultural waste and industry by-products by recovering bioactive compounds and applications as food additives: A circular economy model. Food Chemistry 2022, 370 , 131315. https://doi.org/10.1016/j.foodchem.2021.131315
    14. Dania Marisol ESPARZA-ESPINOZA, Maribel PLASCENCIA-JATOMEA, Carmen María LÓPEZ-SAIZ, Norma Violeta PARRA-VERGARA, Angel Antonio CARBONELL-BARRACHINA, José CÁRDENAS-LÓPEZ, Josafat Marina EZQUERRA-BRAUER. Improving the shelf life of chicken burgers using Octopus vulgaris and Dosidicus gigas skin pigment extracts. Food Science and Technology 2022, 42 https://doi.org/10.1590/fst.18221
    15. Nurcihan HACIOĞLU, Neslihan DEMİR, Özer YILMAZ. Three species of Verbascum L. from Northwest Anatolia of Turkey as a source of biological activities. Turkish Journal of Analytical Chemistry 2021, 3 (1) , 19-26. https://doi.org/10.51435/turkjac.886692
    16. Nuray YILDIRIM, Neslihan DEMİR. DNA Interactions, Mutagenic, Anti-Mutagenic And Antimicrobial Activities of (E)-2-((3,5-Bis(Trifluoromethyl)Phenylimino)Methyl)-4,6- Dimethoxyphenol. Sakarya University Journal of Science 2021, 25 (2) , 339-348. https://doi.org/10.16984/saufenbilder.793776
    17. Xiao Li, Er Bei, Yu Qiu, Hao Xiao, Jun Wang, Pengfei Lin, Xiaojian Zhang, Chao Chen. Intake of volatile nitrosamines by Chinese residents in different provinces via food and drinking water. Science of The Total Environment 2021, 754 , 142121. https://doi.org/10.1016/j.scitotenv.2020.142121
    18. Soňa Felšöciová, Nenad Vukovic, Paweł Jeżowski, Miroslava Kačániová. Antifungal activity of selected volatile essential oils against Penicillium sp.. Open Life Sciences 2020, 15 (1) , 511-521. https://doi.org/10.1515/biol-2020-0045
    19. Marius Emil Rusu, Ionel Fizesan, Anca Pop, Andrei Mocan, Ana-Maria Gheldiu, Mihai Babota, Dan Cristian Vodnar, Ancuta Jurj, Ioana Berindan-Neagoe, Laurian Vlase, Daniela-Saveta Popa. Walnut (Juglans regia L.) Septum: Assessment of Bioactive Molecules and In Vitro Biological Effects. Molecules 2020, 25 (9) , 2187. https://doi.org/10.3390/molecules25092187
    20. I. Osuna-Ruíz, J. A. Salazar-Leyva, C. M. López-Saiz, A. Burgos-Hernández, E. Hernández-Garibay, J. Lizardi-Mendoza, M. A. Hurtado-Oliva. Enhancing antioxidant and antimutagenic activity of the green seaweed Rhizoclonium riparium by bioassay-guided solvent partitioning. Journal of Applied Phycology 2019, 31 (6) , 3871-3881. https://doi.org/10.1007/s10811-019-01886-7
    21. Masoud Modarresi, Marziyeh Hajialyani, Narges Moasefi, Farahnaz Ahmadi, Leila Hosseinzadeh. Evaluation of the Cytotoxic and Apoptogenic Effects of Glabridin and Its Effect on Cytotoxicity and Apoptosis Induced by Doxorubicin Toward Cancerous Cells. Advanced Pharmaceutical Bulletin 2019, 9 (3) , 481-489. https://doi.org/10.15171/apb.2019.057
    22. José Antonio Morales-González, Eduardo Madrigal-Bujaidar, Manuel Sánchez-Gutiérrez, Jeannett A. Izquierdo-Vega, María del Carmen Valadez-Vega, Isela Álvarez-González, Ángel Morales-González, Eduardo Madrigal-Santillán. Garlic (Allium sativum L.): A Brief Review of Its Antigenotoxic Effects. Foods 2019, 8 (8) , 343. https://doi.org/10.3390/foods8080343
    23. Zahira Fernández-Bedmar, Sebastián Demyda-Peyrás, Tania Merinas-Amo, Mercedes del Río-Celestino. Nutraceutic Potential of Two Allium Species and Their Distinctive Organosulfur Compounds: A Multi-Assay Evaluation. Foods 2019, 8 (6) , 222. https://doi.org/10.3390/foods8060222
    24. Juan J. Martínez Medina, Evelina G. Ferrer, Patricia A.M. Williams, Nora B. Okulik. Theoretical/experimental investigation and antimutagenic effect of the oxidovanadium(IV) baicalin coordination complex. Inorganica Chimica Acta 2019, 487 , 369-378. https://doi.org/10.1016/j.ica.2018.12.042
    25. David López-Romero, Jeannett A. Izquierdo-Vega, José Antonio Morales-González, Eduardo Madrigal-Bujaidar, Germán Chamorro-Cevallos, Manuel Sánchez-Gutiérrez, Gabriel Betanzos-Cabrera, Isela Alvarez-Gonzalez, Ángel Morales-González, Eduardo Madrigal-Santillán. Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin. Nutrients 2018, 10 (12) , 1954. https://doi.org/10.3390/nu10121954
    26. Chih‐Yuan Ko, Xiao‐Yu Chen, Wen‐Chang Chang, Yi‐Ming Zeng, Ru‐Hai Lin, Xiao‐Bin Zhang, James Swi‐Bea Wu, Szu‐Chuan Shen. Effects of Maillard reaction products in a glucose–glycine alcoholic solution on antioxidative and antimutagenic activities. Journal of the Science of Food and Agriculture 2018, 98 (14) , 5242-5247. https://doi.org/10.1002/jsfa.9062
    27. Essam Y. Abdul-Hafeez, Nazira S. Karamova, Olga N. Ilinskaya. Evaluation of mutagenic and antimutagenic potential of stem bark aqueous extracts of eight trees by the bacterial reverse mutation assay. Ecological genetics 2018, 16 (3) , 55-61. https://doi.org/10.17816/ecogen16355-61
    28. Rukiye Boran. Investigations of anti-aging potential of Hypericum origanifolium Willd. for skincare formulations. Industrial Crops and Products 2018, 118 , 290-295. https://doi.org/10.1016/j.indcrop.2018.03.058
    29. Manash Pratim Pathak, Rudragoud S. Policegoudra, Danswrang Goyary, Aparoop Das, Santa Mandal, Srijita Chakraborti, Nilutpal Sharma Bora, Johirul Islam, Pompy Patowary, P. Srinivas Raju, Pronobesh Chattopadhyay. Safety evaluation of an oat grain alkaloid gramine by genotoxicity assays. Drug and Chemical Toxicology 2018, 41 (2) , 147-154. https://doi.org/10.1080/01480545.2017.1322605
    30. Luca Mazzoni, Jessica Scalzo, Lucia Di Vittori, Bruno Mezzetti, Maurizio Battino. Berries. 2017, 833-908. https://doi.org/10.1002/9781119158042.ch41
    31. Sunil Pareek, Narashans Alok Sagar, Sunil Sharma, Vinay Kumar. Onion ( Allium cepa L .). 2017, 1145-1162. https://doi.org/10.1002/9781119158042.ch58
    32. Josafat Marina Ezquerra‐Brauer, José M Miranda, Jesús Enrique Chan‐Higuera, Jorge Barros‐Velázquez, Santiago P Aubourg. New icing media for quality enhancement of chilled hake ( Merluccius merluccius ) using a jumbo squid ( Dosidicus gigas ) skin extract. Journal of the Science of Food and Agriculture 2017, 97 (10) , 3412-3419. https://doi.org/10.1002/jsfa.8192
    33. Monthana Weerawatanakorn, Min-Hsiung Pan. Phytochemical components of C arissa carandas and the inhibitory effects of fruit juice on inducible nitric oxide synthase and cyclooxygenase-2. Journal of Food Biochemistry 2017, 41 (3) , e12343. https://doi.org/10.1111/jfbc.12343
    34. M.P.A. Carabajal, M.I. Isla, I.C. Zampini. Evaluation of antioxidant and antimutagenic activity of herbal teas from native plants used in traditional medicine in Argentina. South African Journal of Botany 2017, 110 , 258-265. https://doi.org/10.1016/j.sajb.2016.10.006
    35. S.C. Santosh Kumar, P.S. Negi, J.R. Manjunatha, B.K. Bettadaiah. Synthesis, antibacterial and antimutagenic activity of zerumbone-bicarbonyl analogues. Food Chemistry 2017, 221 , 576-581. https://doi.org/10.1016/j.foodchem.2016.11.136
    36. Jeannett Izquierdo‐Vega, José Morales‐González, Manuel SánchezGutiérrez, Gabriel Betanzos‐Cabrera, Sara Sosa‐Delgado, María Sumaya‐Martínez, Ángel Morales‐González, Rogelio Paniagua‐Pérez, Eduardo Madrigal‐Bujaidar, Eduardo Madrigal‐Santillán. Evidence of Some Natural Products with Antigenotoxic Effects. Part 1: Fruits and Polysaccharides. Nutrients 2017, 9 (2) , 102. https://doi.org/10.3390/nu9020102
    37. Nilanjan Ghosh, Rajendra Sandur, Deepanwita Ghosh, Souvik Roy, Suresh Janadri. Acute, 28 days sub acute and genotoxic profiling of Quercetin-Magnesium complex in Swiss albino mice. Biomedicine & Pharmacotherapy 2017, 86 , 279-291. https://doi.org/10.1016/j.biopha.2016.12.015
    38. Jasbir Kour, Md Niamat Ali, Hilal Ahmad Ganaie, Nahida Tabassum. Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of Equisetum arvense. Toxicology Reports 2017, 4 , 226-233. https://doi.org/10.1016/j.toxrep.2017.05.001
    39. Idalia Osuna-Ruiz, Carmen-María López-Saiz, Armando Burgos-Hernández, Carlos Velázquez, Mario Nieves-Soto, Miguel A. Hurtado-Oliva. Antioxidant, antimutagenic and antiproliferative activities in selected seaweed species from Sinaloa, Mexico. Pharmaceutical Biology 2016, 54 (10) , 2196-2210. https://doi.org/10.3109/13880209.2016.1150305
    40. Bo Yoon Chang, Seon Beom Kim, Mi Kyeong Lee, Hyun Park, Sung Yeon Kim. Nonclinical Safety Assessment of Morus alba L . Fruits: Study of 90‐D Toxicity in Sprague Dawley Rats and Genotoxicity in Salmonella. Journal of Food Science 2016, 81 (5) https://doi.org/10.1111/1750-3841.13285
    41. Mei Zhao, Guoliang Li, Weiheng Kong, Shuaimin Lu, Lian Xia, Guang Chen, Xianen Zhao, Yongning Wu, Jinmao You. Convenient and Sensitive HPLC Method for Determination of Nitrosamines in Foodstuffs Based on Pre-column Fluorescence Labeling. Chromatographia 2016, 79 (7-8) , 431-439. https://doi.org/10.1007/s10337-016-3040-1
    42. Denise C. Hunter, Margot A. Skinner, A. Ross Ferguson. Kiwifruit and health. 2016, 239-269. https://doi.org/10.1016/B978-0-12-802972-5.00012-3
    43. Carmen-María López-Saiz, Javier Hernández, Francisco-Javier Cinco-Moroyoqui, Carlos Velázquez, Víctor-Manuel Ocaño-Higuera, Maribel Plascencia-Jatomea, Maribel Robles-Sánchez, Lorena Machi-Lara, Armando Burgos-Hernández, . Antimutagenic Compounds of White Shrimp ( Litopenaeus vannamei ): Isolation and Structural Elucidation. Evidence-Based Complementary and Alternative Medicine 2016, 2016 (1) https://doi.org/10.1155/2016/8148215
    44. Yu-Lin Hsieh, Szu-Pei Wu, Li-Wen Fang, Tzann-Shun Hwang. Effects of Antrodia camphorata extracts on anti-oxidation, anti-mutagenesis and protection of DNA against hydroxyl radical damage. BMC Complementary and Alternative Medicine 2015, 15 (1) https://doi.org/10.1186/s12906-015-0768-3
    45. Ozgur Ceylan, Halime Alıc. Antibiofilm, Antioxidant, Antimutagenic Activities and Phenolic Compounds of Allium orientale BOISS.. Brazilian Archives of Biology and Technology 2015, 58 (6) , 935-943. https://doi.org/10.1590/S1516-89132015060309
    46. Gokce Nardemir, Derya Yanmis, Lokman Alpsoy, Medine Gulluce, Guleray Agar, Ali Aslan. Genotoxic, antigenotoxic and antioxidant properties of methanol extracts obtained from Peltigera horizontalis and Peltigera praetextata. Toxicology and Industrial Health 2015, 31 (7) , 602-613. https://doi.org/10.1177/0748233713480207
    47. Neha Babbar, Harinder Singh Oberoi, Simranjeet Kaur Sandhu. Therapeutic and Nutraceutical Potential of Bioactive Compounds Extracted from Fruit Residues. Critical Reviews in Food Science and Nutrition 2015, 55 (3) , 319-337. https://doi.org/10.1080/10408398.2011.653734
    48. Hafiz Ansar Rasul Suleria, Masood Sadiq Butt, Faqir Muhammad Anjum, Farhan Saeed, Nauman Khalid. Onion: Nature Protection Against Physiological Threats. Critical Reviews in Food Science and Nutrition 2015, 55 (1) , 50-66. https://doi.org/10.1080/10408398.2011.646364
    49. Hakan Ozkan, Derya Yanmis, Mehmet Karadayi, Tugba Bal, Ozlem Baris, Medine Gulluce. Determination of genotoxic and antigenotoxic properties of essential oil from Ferula orientalis L. using Ames/ Salmonella and E. coli WP2 bacterial test systems. Toxicology and Industrial Health 2014, 30 (8) , 714-723. https://doi.org/10.1177/0748233712462479
    50. Karolina Słoczyńska, Beata Powroźnik, Elżbieta Pękala, Anna M. Waszkielewicz. Antimutagenic compounds and their possible mechanisms of action. Journal of Applied Genetics 2014, 55 (2) , 273-285. https://doi.org/10.1007/s13353-014-0198-9
    51. Aida Garcia-Rodríguez, Clàudia Fontàs, Víctor Matamoros. Formation potential of N-nitrosamines during the disinfection of treated wastewaters with sodium hypochlorite. Desalination and Water Treatment 2014, 52 (16-18) , 3019-3026. https://doi.org/10.1080/19443994.2013.797663
    52. Sweta Jaiswal, N. Mansa, M.S. Pallavi Prasad, Bhabani Sankar Jena, Pradeep Singh Negi. Antibacterial and antimutagenic activities of Dillenia indica extracts. Food Bioscience 2014, 5 , 47-53. https://doi.org/10.1016/j.fbio.2013.11.005
    53. Nurdan Saraç, Burak Şen. Antioxidant, mutagenic, antimutagenic activities, and phenolic compounds of Liquidambar orientalis Mill. var. orientalis. Industrial Crops and Products 2014, 53 , 60-64. https://doi.org/10.1016/j.indcrop.2013.12.015
    54. Renata Nowak, Marta Olech, Natalia Nowacka. Plant Polyphenols as Chemopreventive Agents. 2014, 1289-1307. https://doi.org/10.1016/B978-0-12-398456-2.00086-4
    55. Keiko Inami, Masashi Takada, Kei Itoh, Satoko Ishikawa, Masataka Mochizuki. Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against N-Alkyl-N-nitrosoureas-induced Mutagenicity Using the umu Test. Genes and Environment 2014, 36 (2) , 33-38. https://doi.org/10.3123/jemsge.2014.003
    56. Jin Tatsuzaki, Yang Jinwei, Yukiko Kojo, Yusuke Mine, Satoko Ishikawa, Masataka Mochizuki, Keiko Inami. Antimutagenicity Screening of Extracts from Medicinal and Edible Plants against N-Methyl-N-nitrosourea by the Ames Assay. Genes and Environment 2014, 36 (2) , 39-46. https://doi.org/10.3123/jemsge.2014.007
    57. Mounira Krifa, Ines Bouhlel, Ines Skandrani, Leila Chekir-Ghedira, Kamel Ghedira. Antioxidant, mutagenic and antimutagenic activities of an aqueous extract of Limoniastrum guyonianum gall. Drug and Chemical Toxicology 2014, 37 (1) , 76-82. https://doi.org/10.3109/01480545.2013.806535
    58. Hiu-Ying Lau, Chit-Ming Leung, Yap-Hang Chan, Anne Wing-Mui Lee, Dora Lai-Wan Kwong, Maria Li Lung, Tai-Hing Lam. Secular trends of salted fish consumption and nasopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents. BMC Cancer 2013, 13 (1) https://doi.org/10.1186/1471-2407-13-298
    59. Sandeep Kumar Gupta, Praveena Bhatt, Gilbert Stanley Joseph, Pradeep Singh Negi, Mandyam Chakravarthy Varadaraj. Phenolic constituents and biological activities of leaf extracts of traditional medicinal plant Plectranthus amboinicus Benth (Lamiaceae). TANG [HUMANITAS MEDICINE] 2013, 3 (4) , 32.1-32.6. https://doi.org/10.5667/tang.2013.0027
    60. S.C. Santosh Kumar, P. Srinivas, P.S. Negi, B.K. Bettadaiah. Antibacterial and antimutagenic activities of novel zerumbone analogues. Food Chemistry 2013, 141 (2) , 1097-1103. https://doi.org/10.1016/j.foodchem.2013.04.021
    61. Lidiane Coffacci, Lucia Codognoto, Luciana F. Fleuri, Giuseppina P. P. Lima, Valber A. Pedrosa. Determination of Total Nitrosamines in Vegetables Cultivated Organic and Conventional Using Diamond Electrode. Food Analytical Methods 2013, 6 (4) , 1122-1127. https://doi.org/10.1007/s12161-012-9518-z
    62. J.R. Manjunatha, B.K. Bettadaiah, P.S. Negi, P. Srinivas. Synthesis of amino acid conjugates of tetrahydrocurcumin and evaluation of their antibacterial and anti-mutagenic properties. Food Chemistry 2013, 139 (1-4) , 332-338. https://doi.org/10.1016/j.foodchem.2013.01.081
    63. Stephen J.M. Skinner, Denise Hunter, Suengmok Cho, Margot Skinner. The Potential Health Benefits of the Subtropical Fruits Kiwifruit, Feijoa and Tamarillo. 2013, 169-195. https://doi.org/10.1002/9781118635551.ch8
    64. A. Satish, R. Punith Kumar, D. Rakshith, S. Satish, Faiyaz Ahmed. Antimutagenic and antioxidant activity of Ficus benghalensis stem bark and Moringa oleifera root extract. International Journal of Chemical and Analytical Science 2013, 4 (2) , 45-48. https://doi.org/10.1016/j.ijcas.2013.03.008
    65. Federica Pellati, Renato Bruni, Davide Righi, Alessandro Grandini, Massimilano Tognolini, Francesco Pio Prencipe, Ferruccio Poli, Stefania Benvenuti, Daniele Del Rio, Damiano Rossi. Metabolite profiling of polyphenols in a Terminalia chebula Retzius ayurvedic decoction and evaluation of its chemopreventive activity. Journal of Ethnopharmacology 2013, 147 (2) , 277-285. https://doi.org/10.1016/j.jep.2013.02.025
    66. C. Lorentz, G. Pencreac’h, S. Soultani-Vigneron, C. Rondeau-Mouro, M. de Carvalho, B. Pontoire, F. Ergan, P. Le Bail. Coupling lipophilization and amylose complexation to encapsulate chlorogenic acid. Carbohydrate Polymers 2012, 90 (1) , 152-158. https://doi.org/10.1016/j.carbpol.2012.05.008
    67. A. Aslan, M. Gulluce, G. Agar, M. Karadayi, S. Bozari, F. Orhan. Mutagenic and antimutagenic properties of some lichen species grown in the Eastern Anatolia Region of Turkey. Cytology and Genetics 2012, 46 (5) , 291-296. https://doi.org/10.3103/S0095452712050039
    68. Keith Singletary. Kiwifruit. Nutrition Today 2012, 47 (3) , 133-147. https://doi.org/10.1097/NT.0b013e31825744bc
    69. Yu-Ling Tsai, Shiow-Ying Chiou, Kung-Chi Chan, Jih-Min Sung, Sheng-Dun Lin. Caffeic acid derivatives, total phenols, antioxidant and antimutagenic activities of Echinacea purpurea flower extracts. LWT - Food Science and Technology 2012, 46 (1) , 169-176. https://doi.org/10.1016/j.lwt.2011.09.026
    70. Xiaoqin Wang, Bochao Zhang, Bingfang Wang, Xuewu Zhang. Volatile components of ethanolic extract from broccolini leaves. Natural Product Research 2012, 26 (7) , 680-683. https://doi.org/10.1080/14786419.2010.544024
    71. Sudhanshu Saxena, Satyendra Gautam, Girish Maru, Dhananjay Kawle, Arun Sharma. Suppression of error prone pathway is responsible for antimutagenic activity of honey. Food and Chemical Toxicology 2012, 50 (3-4) , 625-633. https://doi.org/10.1016/j.fct.2012.01.003
    72. Klaus Peter Latté, Klaus-Erich Appel, Alfonso Lampen. Health benefits and possible risks of broccoli – An overview. Food and Chemical Toxicology 2011, 49 (12) , 3287-3309. https://doi.org/10.1016/j.fct.2011.08.019
    73. Ozlem Baris, Mehmet Karadayi, Derya Yanmis, Zuhal Guvenalp, Tugba Bal, Medine Gulluce. Isolation of 3 Flavonoids from Mentha longifolia (L.) Hudson subsp. longifolia and Determination of Their Genotoxic Potentials by Using the E. coli WP2 Test System. Journal of Food Science 2011, 76 (9) https://doi.org/10.1111/j.1750-3841.2011.02405.x
    74. Bojana Žegura, David Dobnik, Maša Hojnik Niderl, Metka Filipič. Antioxidant and antigenotoxic effects of rosemary (Rosmarinus officinalis L.) extracts in Salmonella typhimurium TA98 and HepG2 cells. Environmental Toxicology and Pharmacology 2011, 32 (2) , 296-305. https://doi.org/10.1016/j.etap.2011.06.002
    75. Biljana Nikolić, Dragana Mitić-Ćulafić, Branka Vuković-Gačić, Jelena Knežević-Vukčević. Modulation of genotoxicity and DNA repair by plant monoterpenes camphor, eucalyptol and thujone in Escherichia coli and mammalian cells. Food and Chemical Toxicology 2011, 49 (9) , 2035-2045. https://doi.org/10.1016/j.fct.2011.05.015
    76. Medine Gulluce, Guleray Agar, Ali Aslan, Mehmet Karadayi, Sedat Bozari, Furkan Orhan. Protective effects of methanol extracts from Cladonia rangiformis and Umbilicaria vellea against known mutagens sodium azide and 9-aminoacridine. Toxicology and Industrial Health 2011, 27 (8) , 675-682. https://doi.org/10.1177/0748233710395343
    77. M. Ben Sghaier, J. Boubaker, I. Skandrani, I. Bouhlel, I. Limem, K. Ghedira, L. Chekir-Ghedira. Antimutagenic, antigenotoxic and antioxidant activities of phenolic-enriched extracts from Teucrium ramosissimum: Combination with their phytochemical composition. Environmental Toxicology and Pharmacology 2011, 31 (1) , 220-232. https://doi.org/10.1016/j.etap.2010.11.001
    78. Biljana Nikolic, Dragana Mitic-Culafic, Branka Vukovic-Gacic, Jelena Knezevic-Vukcevic. The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO- and t-BOOH-induced mutagenesis in coli. Archives of Biological Sciences 2011, 63 (1) , 117-128. https://doi.org/10.2298/ABS1101117N
    79. Plernchai TANGKANAKUL, Gassinee TRAKOONTIVAKORN, Janpen SAENGPRAKAI, Payom AUTTAVIBOONKUL, Boonma NIYOMWIT, Ngamjit LOWVITOON, Kazuhiko NAKAHARA. Antioxidant Capacity and Antimutagenicity of Thermal Processed Thai Foods. Japan Agricultural Research Quarterly: JARQ 2011, 45 (2) , 211-218. https://doi.org/10.6090/jarq.45.211
    80. P. S. Negi, G. K. Jayaprakasha, B. S. Jena. Evaluation of Antioxidant and Antimutagenic Activities of the Extracts from the Fruit Rinds of Garcinia cowa. International Journal of Food Properties 2010, 13 (6) , 1256-1265. https://doi.org/10.1080/10942910903050383
    81. Medine Gulluce, Guleray Agar, Ozlem Baris, Mehmet Karadayi, Furkan Orhan, Fikrettin Sahin. Mutagenic and antimutagenic effects of hexane extract of some Astragalus species grown in the eastern Anatolia region of Turkey. Phytotherapy Research 2010, 24 (7) , 1014-1018. https://doi.org/10.1002/ptr.3059
    82. K.S. Parvathy, P.S. Negi, P. Srinivas. Curcumin–amino acid conjugates: Synthesis, antioxidant and antimutagenic attributes. Food Chemistry 2010, 120 (2) , 523-530. https://doi.org/10.1016/j.foodchem.2009.10.047
    83. Neda Mimica-Dukić, Dušan Bugarin, Slavenko Grbović, Dragana Mitić-Ćulafić, Branka Vuković-Gačić, Dejan Orčić, Emilija Jovin, Maria Couladis. Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents. Molecules 2010, 15 (4) , 2759-2770. https://doi.org/10.3390/molecules15042759
    84. Denise C. Hunter, Margot A. Skinner, A. Ross Ferguson, Lesley M. Stevenson. Kiwifruit and Health. 2010, 565-580. https://doi.org/10.1016/B978-0-12-374628-3.00037-2
    85. K.S. Parvathy, P.S. Negi, P. Srinivas. Antioxidant, antimutagenic and antibacterial activities of curcumin-β-diglucoside. Food Chemistry 2009, 115 (1) , 265-271. https://doi.org/10.1016/j.foodchem.2008.12.036
    86. Lim Chin Keong, Ahmad Sukari Halim. In Vitro Models in Biocompatibility Assessment for Biomedical-Grade Chitosan Derivatives in Wound Management. International Journal of Molecular Sciences 2009, 10 (3) , 1300-1313. https://doi.org/10.3390/ijms10031300
    87. D. Mitić-Ćulafić, B. Žegura, B. Nikolić, B. Vuković-Gačić, J. Knežević-Vukčević, M. Filipič. Protective effect of linalool, myrcene and eucalyptol against t-butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells. Food and Chemical Toxicology 2009, 47 (1) , 260-266. https://doi.org/10.1016/j.fct.2008.11.015
    88. N. Arranz, A.I. Haza, A. García, L. Möller, J. Rafter, P. Morales. Protective effects of organosulfur compounds towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. Food and Chemical Toxicology 2007, 45 (9) , 1662-1669. https://doi.org/10.1016/j.fct.2007.02.032
    89. K. Nirmala, T. Prasanna Krishna, K. Polasa. In vivo Antimutagenic Potential of Ginger on Formation and Excretion of Urinary Mutagens in Rats. International Journal of Cancer Research 2007, 3 (3) , 134-142. https://doi.org/10.3923/ijcr.2007.134.142
    90. G.K. Jayaprakasha, P.S. Negi, B.S. Jena, L. Jagan Mohan Rao. Antioxidant and antimutagenic activities of Cinnamomum zeylanicum fruit extracts. Journal of Food Composition and Analysis 2007, 20 (3-4) , 330-336. https://doi.org/10.1016/j.jfca.2006.07.006
    91. R.A. Isbrucker, G.A. Burdock. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regulatory Toxicology and Pharmacology 2006, 46 (3) , 167-192. https://doi.org/10.1016/j.yrtph.2006.06.002
    92. Nuria Arranz, Ana I. Haza, Almudena García, Lennart Möller, Joseph Rafter, Paloma Morales. Retracted: Protective effects of isothiocyanates towardsN-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. Journal of Applied Toxicology 2006, 26 (6) , 493-499. https://doi.org/10.1002/jat.1168
    93. Nuria Arranz, Ana I. Haza, Almudena García, Lennart Möller, Joseph Rafter, Paloma Morales. Protective effects of isothiocyanates towards N‐nitrosamine‐induced DNA damage in the single‐cell gel electrophoresis (SCGE)/HepG2 assay. Journal of Applied Toxicology 2006, 26 (5) , 466-473. https://doi.org/10.1002/jat.1163
    94. G.K. Jayaprakasha, P.S. Negi, B.S. Jena. Antioxidative and antimutagenic activities of the extracts from the rinds of Garcinia pedunculata. Innovative Food Science & Emerging Technologies 2006, 7 (3) , 246-250. https://doi.org/10.1016/j.ifset.2006.01.001
    95. M.G. Evandri, L. Battinelli, C. Daniele, S. Mastrangelo, P. Bolle, G. Mazzanti. The antimutagenic activity of Lavandula angustifolia (lavender) essential oil in the bacterial reverse mutation assay. Food and Chemical Toxicology 2005, 43 (9) , 1381-1387. https://doi.org/10.1016/j.fct.2005.03.013
    96. D.A. VATTEM, K. SHETTY. BIOLOGICAL FUNCTIONALITY OF ELLAGIC ACID: A REVIEW. Journal of Food Biochemistry 2005, 29 (3) , 234-266. https://doi.org/10.1111/j.1745-4514.2005.00031.x
    97. A Singh, A Arora, Y Shukla. Modulation of altered hepatic foci induction by diallyl sulphide in Wistar rats. European Journal of Cancer Prevention 2004, 13 (4) , 263-269. https://doi.org/10.1097/01.cej.0000127633.89678.fb
    98. Min He, Kyle Openo, Marji McCullough, Dean P. Jones. Total Equivalent of Reactive Chemicals in 142 Human Food Items Is Highly Variable Within and Between Major Food Groups. The Journal of Nutrition 2004, 134 (5) , 1114-1119. https://doi.org/10.1093/jn/134.5.1114
    99. P.S. Negi, G.K. Jayaprakasha, B.S. Jena. Antioxidant and antimutagenic activities of pomegranate peel extracts. Food Chemistry 2003, 80 (3) , 393-397. https://doi.org/10.1016/S0308-8146(02)00279-0
    100. Yogeshwer Shukla, Pankaj Taneja. Antimutagenic effects of garlic extract on chromosomal aberrations. Cancer Letters 2002, 176 (1) , 31-36. https://doi.org/10.1016/S0304-3835(01)00774-1
    Load all citations

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 1999, 47, 8, 3257–3264
    Click to copy citationCitation copied!
    https://doi.org/10.1021/jf990166n
    Published July 15, 1999
    Copyright © 1999 American Chemical Society

    Article Views

    989

    Altmetric

    -

    Citations

    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.